Cytotoxicity of ZnO nanoparticles in human melanocyte cells in the presence or absence of UV radiation: A preliminary comparative study with TiO2 nanoparticles

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: 106, P. 106051 - 106051

Published: March 12, 2025

Language: Английский

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The Effect of Pregnancy on Dermatological Disorders: A Systematic Review

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(4), P. 68 - 68

Published: March 21, 2025

Background: Pregnancy induces hormonal, immunologic, and vascular changes that profoundly affect dermatologic health. This systematic review aimed to assess the impact of pregnancy on dermatological disorders in terms disease incidence, severity, maternal-fetal outcomes, optimal management strategies. Methods: A search was performed PubMed, MEDLINE, Web Science databases, following PRISMA guidelines. Studies evaluating pregnant women with disorders, pregnancy-related dermatoses, pre-existing morbidities, were included. The collaboratively extracted data included patient demographics, treatment approaches, outcomes. Results: total 8490 cases conditions caused by studied. divided into physiological changes, exacerbation skin conditions, pregnancy-specific dermatoses. Intrahepatic cholestasis pemphigoid gestationis associated increased rates adverse fetal outcomes patients specific including preterm birth distress rates. atopic eruption polymorphic highly relevant, but their effect health minimal. efficacy safety modalities, corticosteroids, antihistamines, ursodeoxycholic acid, variable. Conclusions: drastically affects health, nature depends condition. Optimal maternal rely early diagnosis individualized More randomized controlled trials are required develop standardized diagnostic guidelines enhance quality care during pregnancy.

Language: Английский

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Clinical Efficacy of CGF Combined With Periodic Supramolecular Salicylic Acid in the Treatment of Chloasma

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(4)

Published: March 26, 2025

ABSTRACT Objective To investigate the clinical efficacy of CGF combined with supramolecular salicylic acid cycle injection for melasma. Methods Twenty patients chloasma admitted to our hospital were selected and treated facial injection. After each injection, was given once. one treatment, severity melasma skin parameters before after treatment compared using modified Area Severity index (MASI) VISIA image analysis system, respectively. At same time, patients' self‐satisfaction investigated. Results The total effective rate in 95%. Compared scores spots, UV brown red areas, wrinkles, texture, pore porphyrins significantly increased treatment. MASI score reduced (4.70 ± 2.47 vs. 15.30 4.01, p < 0.001). results showed that satisfaction improvement 95.00%. Conclusion has an obvious effect on comprehensive overall aging patients, can effectively accelerate speed lesion repair pigment elimination, which is worthy promotion application.

Language: Английский

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Evaluation of the safety and efficacy of the thulium 1927 laser in aesthetic health: an integrative review

Journal of Cosmetic and Laser Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 3, 2025

Advances in aesthetics and dermatology bring alternatives for the treatment of pigmentary dysfunctions photoaging. The thulium laser combines characteristics ablative non-ablative lasers, standing out its high precision epidermal penetration, promoting cell renewal, pigment removal stimulation collagen production, with good tolerability. This study conducted an integrative review on safety efficacy 1927 nm fractional Thulium aesthetic dysfunctions. Searches were databases MEDLINE/PubMed, Science Direct, Scopus, Google Scholar Capes Journals between 2014 2024, to select studies that demonstrate results application this treatment. carried showed conditions such as melasma, scars skin rejuvenation, low adverse effects patient satisfaction. Although comparisons other technologies, Er:YAG Alexandrite lasers indicate some differences results, offers advantages shorter recovery time lower incidence effects. However, methodological sampling limitations suggest need more robust clinical trials consolidate their applications. It is concluded represents a promising tool health, offering effective safe

Language: Английский

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SkinIncept: an ensemble transfer learning-based approach for multiclass skin disease classification using InceptionV3 and InceptionResNetV2

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(5)

Published: May 2, 2025

Language: Английский

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Efficacy and safety of laser‐related therapy for melasma: A systematic review and network meta‐analysis

Journal of Cosmetic Dermatology, Journal Year: 2023, Volume and Issue: 22(11), P. 2910 - 2924

Published: Sept. 22, 2023

Abstract Background Melasma is a prevalent, persistent hyperpigmentation disorder that negatively affects the psychological health of patients. However, treatment outcome remains unsatisfactory due to complexity pathogenesis, recurrence characteristics, and relatively high morbidity. Objectives To compare performance laser‐related therapies in improving melasma area severity index (MASI) score occurrence adverse effects by network meta‐analysis (NMA). Methods From inception November 2022, eligible randomized controlled trials were identified. Two investigators independently searched relevant studies from PUBMED, EMBASE, Cochrane Library database. Results A total 39 clinical with 1394 participants for enrollment. For efficacy, NMA demonstrated Q‐switched Nd: YAG laser + topical medications (QSND+TM) was superior Nd:YAG (QSND) [MD = −4.21 (−6.80, −1.63)], Er: (ERYL+TM) ‐3.52 (−6.84, −0.19)], picosecond (PICO+TM) −4.80 (−9.33, −0.27)]. The microneedling (MN+TM) (PICO) −5.26 (−10.44, −0.08)] (TM) −5.22 (−9.20, −1.23)]. top five surface under cumulative ranking curve value (SUCRA) are (QSND+TM 85.9%), oral tranexamic acid (oTA 80.1%), (MN+TM 79.7%), intense pulse light (QSND+IPL 78.9%), fractional carbon dioxide (FCDL+TM 70.5%). Conclusions In conclusion, Qs‐Nd:YAG first choice treating according SUCRA value. Among three modalities, namely MN TM, PICO, our recommendation favors MN+TM as enhancing curative efficacy melasma. actual should also take into account effects, skin type patient, duration disease, other factors.

Language: Английский

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Global research trends on melasma: a bibliometric and visualized study from 2014 to 2023

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 25, 2024

Melasma, a prevalent pigmentary disorder, is characterized by its complex etiology, propensity for recurrence, and resistance to treatment. However, there currently no research on melasma through bibliometrics visualisation. This study analyses the hotspots trends in field based 2,709 publications from Web of Science Core Collection (WOSCC). We carried out bibliometric using Citespace software different countries/regions, institutions, authors, keywords. References were also analysed VoSviewer. The results indicate that overall, has been an increase related since 2014. According analysis collaborative network diagram, United States, Egyptian Knowledge Bank, Benjakul Soottawat are most contributing countries, respectively. Reference keyword have identified pathogenesis treatment as topic recent years. And how find new options more effective therapeutic drugs future trend. first visual melasma-related literature explore trends.

Language: Английский

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Photobiomodulation for melasma treatment: Integrative review and state of the art

Photodermatology Photoimmunology & Photomedicine, Journal Year: 2023, Volume and Issue: 40(1)

Published: Nov. 28, 2023

Photobiomodulation therapy (PBM) is a versatile technique for treating skin diseases. Melasma, chronic hyperpigmentation condition, has recently been associated with vascular features and dermal photoaging poses significant management challenges. We review the recent literature on melasma etiology evidence supporting PBM as therapeutic modality treatment.

Language: Английский

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Comparison of the efficacy of Hydroquinone cream versus Hydroquinone cream plus Danggui Shaoyao powder in the treatment of melasma

Advances in Dermatology and Allergology, Journal Year: 2024, Volume and Issue: 41(1), P. 66 - 71

Published: Jan. 1, 2024

AMA Cheng Y, Peng R, Luo H, Zhao W. Comparison of the efficacy Hydroquinone cream versus plus Danggui Shaoyao powder in treatment melasma. Advances Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2024;41(1):66-71. doi:10.5114/ada.2023.135613. APA Cheng, Y., Peng, R., Luo, H., & Zhao, (2024). Alergologii, 41(1), 66-71. https://doi.org/10.5114/ada.2023.135613 Chicago Yuan-Yuan, Rui-rui Hao Wei Zhao. 2024. "Comparison melasma". Alergologii 41 (1): Harvard pp.66-71. MLA Yuan-Yuan et al. melasma." vol. 41, no. 1, 2024, pp. Vancouver

Language: Английский

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Experience using 675 nm laser on three cases of Fitzpatrick skin type IV‐V with melasma

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Dear Editor, Melasma, predominantly affecting darker skin types, especially those within Fitzpatrick phototypes IV-V.1 The treatment approach is further complicated by high recurrence rates and the significant impact melasma can have on patients' quality of life.2 Laser treatments are a component in management melasma, they generally considered as second-line following first-line use topical therapies. Many studies suggests that low-fluence Q-switched Nd:YAG picosecond laser highlighted potentially effective option this condition when combined with other treatments.3 However, there higher risk post-inflammatory hyperpigmentation (PIH) light treatments. Therefore, these should be used caution therapy after treatments.3, 4 A new non-ablative wavelength 675 nm has been found to significantly improve patients which histologically preclinical shown presence selective damage melanin-rich areas.5, 6 aim article present outcomes types IV-V melasma. By exploring efficacy through clinical cases, we seek contribute limited pool for color provide insights into potential specific managing minimal adverse effects. This prospective case series involved three Indonesian female Skin Types IV-V, presenting facial Exclusion criteria included hypersensitivity light, photosensitizing agents, seizure disorders triggered pregnancy, personal or family history cancer, recent sun exposure, tattoos treated areas, any previous 2 months. system (RedTouch, Deka M.E.L.A., Calenzano, Italy) study, was specifically chosen its effectiveness targeting melanin stimulating collagen remodeling.7 equipped scanning shapes square it adjustable parameters: power, time exposure (dwell time), spot spacing, an integrated cooling feature maintained at 5°C. Before each session, faces were cleansed mild soap water. energy adjusted according patient's type tolerance, determined test area. endpoint erythema oedema, observable 5–10 min. Each patient underwent sessions, spaced 1 month apart. parameters power (5–7 W), dwell (150 ms), spacing (2500 µm), stack (5°C). transparent conductive gel administer treatment. During treatment, handpiece passed over surface contact mode, ensuring consecutive spots without overlapping. Topical anesthesia optional and, if used, thoroughly removed before After cooled cold water-soaked gauzes. nonsteroidal anti-inflammatory cream containing vitamin B12 applied twice daily weeks. Patients instructed total block mineral sunscreen throughout follow-up period. primary outcome change severity, assessed using modified Melasma Area Severity Index (mMASI) scores. Scores recorded start 3 months last session. Digital photographs analyzer (Janus, PIE, Gyeonggi-do, South Korea) taken visually document changes. safety profile evaluated monitoring appearance side effects, including erythematous reactions, blistering, scarring, burns, hypopigmentation, hyperpigmentation. (Figures 1, 2, 3) showed noticeable improvement photographic evidence consistent quantitative mMASI score reductions, confirming treatment's effectiveness. Throughout study duration, no serious effects reported, treating IV-V. Minor transient erythema, resolved intervention. No instances observed. line expectations settings. An informal assessment satisfaction indicated levels outcomes. reported improvements their expressed ease comfort process. absence downtime contributed overall positive experience. demonstrates types. Studies pigmentary improvements, marking condition​​.8 aligns observed involving where notable lesions documented. reduction scores across all cases underscores laser's addressing hyperpigmentation​​. Additionally, corroborated research highlighting low interaction hemoglobin, thereby minimizing risks associated such types​​​​.6, 9 Red-spectrum emission effectively targets fibers, showing strong affinity chromophores. In contrast, interacts minimally vascular chromophore.10 Histologically, induce remodeling collagen, promoting proliferation fibers. plays crucial role pivotal hyperpigmentation​​.5, not superficial but extends substantial dermal changes, evidenced increased production rearrangement areas compared untreated ones. Such histological provides deeper understanding mechanism action, contributing melasma​​.9 While promising, considerations regarding protocols crucial. Adjustments careful essential cater individual needs minimize hyperpigmentation, types​​.6, 7 Furthermore, feedback well downtime, positively experience​​. presents promising referenced indicate enhanced appearance. Importantly, well-suited reducing initial results encouraging, ongoing larger-scale validate findings optimize broader application long-term individuals type. Conceptualization, Ruri D. Pamela, Massimo DF. Vitale, Kyu-Ho Yi; methodology, software, validation, Yi, Tiziano Zingoni; formal analysis, investigation, re-sources, data curation, writing—original draft preparation writing—review editing, Zingoni, Irene Fusco; visualization, supervision, project administration, funding acquisition, All authors read agreed published version manuscript. Authors T.Z. I.F. employed El.En. Group. remaining confirm commercial financial relationships could construed conflict interest existed during research. accordance Declaration Helsinki Ethical Principles Medical Research human subjects. approval necessary device already CE marked since 2019.

Language: Английский

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