Influence of stent-induced vessel deformation on hemodynamic feature of bloodstream inside ICA aneurysms

Biomechanics and Modeling in Mechanobiology, Journal Year: 2023, Volume and Issue: 22(4), P. 1193 - 1207

Published: March 22, 2023

Abstract One of the effective treatment options for intracranial aneurysms is stent-assisted coiling. Though, previous works have demonstrated that stent usage would result in deformation local vasculature. The effect simple on blood hemodynamics still uncertain. In this work, hemodynamic features stream four different ICA aneurysm with/without interventional are investigated. To estimate relative impacts vessel deformation, distinctive simulated by one-way FSI technique. Four factors velocity, wall pressure and WSS compared peak systolic stage to disclose impact defamation two conditions. decrease almost all mentioned parameters, except OSI. Stenting reduces neck inflow rate, while was not consistent among aneurysms. an has a strong influence aneurysm. This outcome ignored most preceding investigations, which focused pre-interventional state studying relationship between stents. Present results show application without coiling improve factors, especially when high enough.

Language: Английский

---

Biodegradable chitosan-graphene oxide as an affective green filler for improving of properties in epoxy nanocomposites

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123550 - 123550

Published: Feb. 3, 2023

Language: Английский

---

Water decolorization and antifouling melioration of a novel PEBA1657/PES TFC membrane using chitosan-decorated graphene oxide fillers

Journal of environmental chemical engineering, Journal Year: 2023, Volume and Issue: 11(3), P. 109955 - 109955

Published: April 18, 2023

Language: Английский

---

Synthesis of Gelatin/Polyacrylamide/Carboxymethyl chitosan triple-network hydrogels and evaluation of their properties for potential biomedical applications

Materials Science and Engineering B, Journal Year: 2023, Volume and Issue: 295, P. 116597 - 116597

Published: May 23, 2023

Language: Английский

---

Chitosan-supported metal nanocatalysts for the reduction of nitroaromatics

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124135 - 124135

Published: March 23, 2023

Language: Английский

---

Computational study of the blood hemodynamic inside the cerebral double dome aneurysm filling with endovascular coiling

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 19, 2023

The rupture of the aneurysm wall is highly associated with hemodynamic feature bloodstream as well geometrical aneurysm. Coiling known most conventional technique for treatment intracranial cerebral aneurysms (ICA) in which blood stream obstructed from entering sac In this study, comprehensive efforts are done to disclose impacts coiling on progress and risk rupture. computational fluid dynamic method used analysis hemodynamics specific ICA. pulsatile high-risk region also explained. Wall shear Stress (WSS) Oscillatory index (OSI) factors compared different viscosities conditions. According our hematocrit test (Hct) effect evident (25% reduction maximum WSS) two first stages (maximum acceleration peak systolic). Our findings present that porosity 0.89 0.79 would decrease WSS by about 8% both HCT

Language: Английский

---

Preparation and Evaluation of Chitosan Coated PLGA Nanoparticles Encapsulating Ivosidenib with Enhanced Cytotoxicity Against Human Liver Cancer Cells

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3461 - 3473

Published: April 1, 2024

Purpose: Ivosidenib (IVO), an isocitrate dehydrogenase-1 (IDH1) used for treatment of acute myeloid leukemia (AML) and cholangiocarcinoma.However, poor solubility, low bioavailability, high dose side effects limit clinical application IVO.Methods: Ivosidenib-loaded PLGA nanoparticles (IVO-PLGA-NPs) chitosan coated (IVO-CS-PLGA-NPs) were prepared using emulsification solvent evaporation method the liver cancer. Results:The developed IVO-PLGA-NPs evaluated their particle size (171.7±4.9 nm), PDI (0.333), ZP (-23.0±5.8 mV), EE (96.3±4.3%), DL (9.66±1.1%);similarly, IVO-CS-PLGA-NPs (177.3±5.2 (0.311), +25.9±5.7 mV, (90.8±5.7%), (9.42±0.7%).The coating was evidenced by increase in mean positive value.Because coating, showed a more stable prolonged release IVO than IVO-PLGA-NPs.In comparison to pure-IVO, found be effective against HepG2 cells, with IC 50 values MTT assay being approximately half those pure-IVO.In expressions caspase-3, caspase-9, p53 significantly (p < 0.05) elevated.Conclusion: Overall, these findings suggest that improves delivery efficacy ivosidenib cancer treatment.

Language: Английский

---

Investigation of the effects of porosity and volume fraction on the atomic behavior of cancer cells and microvascular cells of 3DN5 and 5OTF macromolecular structures during hematogenous metastasis using the molecular dynamics method

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 158, P. 106832 - 106832

Published: April 5, 2023

Language: Английский

---

Preparation, characterization, cytotoxicity and pharmacokinetics of niosomes containing gemcitabine: In vitro, in vivo, and simulation studies

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104505 - 104505

Published: April 23, 2023

Language: Английский

---

Electrochemical sensor based on graphene quantum dot/gold nanoparticles and thiol-containing organic compound for measuring methotrexate anti-cancer drug

Diamond and Related Materials, Journal Year: 2023, Volume and Issue: 136, P. 109954 - 109954

Published: April 20, 2023

Language: Английский

---