Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 26, 2025
Chemoresistance
is
a
critical
factor
compromising
the
survival
of
patients
with
colorectal
cancer
(CRC).
The
"Zhi-Zhen"
formula
(ZZF),
traditional
prescription
developed
by
Chinese
national
medicine
masters,
has
been
extensively
used
in
clinical
practice
to
treat
gastrointestinal
cancer.
Notably,
ZZF
potential
enhance
tumor
sensitivity
chemotherapy.
Although
previous
vitro
studies
have
demonstrated
efficacy
overcoming
chemoresistance
(CRC),
its
precise
molecular
mechanisms
remain
poorly
understood.
We
an
integrated
approach
bioinformatics
and
network
pharmacology
predict
active
ingredients
targets
alleviating
chemoresistance.
top
five
identified
degree
analysis
were
validated
using
mass
spectrometry.
then
established
oxaliplatin-resistant
CRC
cell
model
explore
regulatory
through
which
overcomes
at
cellular
level.
Network
analyses
jointly
29
compounds
13
key
ZZF,
associated
Among
these
targets,
differential
expression
CASP7
significantly
affected
progression-free
CRC.
two
lines
observed
upregulation
resistant
cells.
Furthermore,
increases
activation
cells,
promoting
apoptosis,
thereby
ameliorating
Additionally,
β-catenin
knockdown
led
expression,
whereas
Wnt/β-catenin
signaling
pathway
reduced
protein
levels.
decreases
activity
decreasing
transcription
nuclear
localization.
value
treatment
inhibiting
localization
β-catenin,
increasing
enhancing
apoptotic
response
chemoresistant
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: June 18, 2024
Abstract
The
Wnt/β-catenin
signaling
pathway
plays
a
crucial
role
in
various
physiological
processes,
encompassing
development,
tissue
homeostasis,
and
cell
proliferation.
Under
normal
conditions,
the
is
meticulously
regulated.
However,
aberrant
activation
of
this
downstream
target
genes
can
occur
due
to
mutations
key
components
pathway,
epigenetic
modifications,
crosstalk
with
other
pathways.
Consequently,
these
dysregulations
contribute
significantly
tumor
initiation
progression.
Therapies
targeting
transduction
have
exhibited
promising
prospects
potential
for
treatment.
An
increasing
number
medications
are
continuously
being
developed
validated.
This
comprehensive
review
aims
summarize
latest
advances
our
understanding
played
by
carcinogenesis
targeted
therapy,
providing
valuable
insights
into
acknowledging
current
opportunities
challenges
associated
cancer
research
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 2, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
malignant
liver
tumor
and
one
of
leading
causes
cancer-related
deaths
worldwide.
The
Wnt/β-Catenin
signaling
pathway
a
highly
conserved
involved
in
several
biological
processes,
including
improper
regulation
that
leads
to
tumorigenesis
progression
cancer.
New
studies
have
found
abnormal
activation
major
cause
HCC
tumorigenesis,
progression,
resistance
therapy.
perspectives
approaches
treating
will
arise
from
understanding
this
pathway.
This
article
offers
thorough
analysis
pathway’s
function
its
therapeutic
implications
HCC.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4140 - 4140
Published: April 9, 2024
Despite
incessant
research,
colorectal
cancer
(CRC)
is
still
one
of
the
most
common
causes
fatality
in
both
men
and
women
worldwide.
Over
time,
advancements
medical
treatments
have
notably
enhanced
survival
rates
patients
with
cancer.
Managing
metastatic
CRC
involves
a
complex
tradeoff
between
potential
benefits
adverse
effects
treatment,
considering
factors
like
disease
progression,
treatment
toxicity,
drug
resistance,
overall
impact
on
patient's
quality
life.
An
increasing
body
evidence
highlights
significance
stem
cell
(CSC)
concept,
proposing
that
CSCs
occupy
central
role
triggering
been
focal
point
extensive
research
variety
types,
including
CRC.
Colorectal
cells
(CCSCs)
play
crucial
tumor
initiation,
metastasis,
therapy
making
them
targets.
Various
methods
exist
for
isolating
CCSCs,
understanding
mechanisms
resistance
associated
crucial.
This
paper
offers
an
overview
current
pertaining
to
comprehension
Cancers,
Journal Year:
2023,
Volume and Issue:
16(1), P. 40 - 40
Published: Dec. 20, 2023
Ovarian
cancer
is
the
most
lethal
gynaecological
and
eighth
common
female
cancer.
The
early
diagnosis
of
ovarian
remains
a
clinical
problem
despite
significant
development
technology.
Nearly
70%
patients
with
are
diagnosed
stages
III–IV
metastatic
disease.
Reliable
diagnostic
prognostic
biomarkers
currently
lacking.
recurrence
resistance
to
chemotherapy
pose
vital
problems
translate
into
poor
outcomes.
Cancer
stem
cells
appear
be
responsible
for
tumour
resulting
from
chemotherapeutic
resistance.
These
also
crucial
initiation
due
ability
self-renew,
differentiate,
avoid
immune
destruction,
promote
inflammation
angiogenesis.
Studies
have
confirmed
an
association
between
CSC
occurrence
chemotherapy,
subsequent
metastases,
relapses.
Therefore,
elimination
CSCs
appears
important
overcoming
drug
improving
prognoses.
This
review
focuses
on
expression
selected
markers,
including
CD133,
CD44,
CD24,
CD117,
aldehyde
dehydrogenase
1,
which
show
potential
significance.
Some
markers
expressed
surface
correlate
features
can
used
prognosis
However,
heterogeneity
plasticity
CSCs,
determination
specific
phenotypes
difficult.
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(5)
Published: May 6, 2024
Abstract
Background
The
pathogenesis
and
treatment
of
colorectal
cancer
(CRC)
continue
to
be
areas
ongoing
research,
especially
the
benefits
traditional
Chinese
medicine
(TCM)
in
slowing
progression
CRC.
This
study
was
conducted
investigate
effectiveness
mechanism
action
modified
Lichong
decoction
(MLCD)
inhibiting
CRC
progression.
Methods
We
established
animal
models
using
azoxymethane/dextran
sodium
sulfate
(AOM/DSS)
administered
high,
medium,
or
low
doses
MLCD
mesalazine
(MS)
for
9
weeks
observe
alleviation
optimal
dose
group
then
subjected
metagenomic
RNA
sequencing
(RNA-seq)
explore
differentially
abundant
flora
genes
control,
model
groups.
Finally,
verified
WB,
qRT‒PCR,
immunohistochemistry
TUNEL
staining.
Results
inhibited
CRC,
effect
observed
at
high
doses.
regulated
structure
function
intestinal
by
decreasing
abundance
harmful
bacteria
increasing
that
beneficial
bacteria.
expressed
were
mainly
associated
with
Wnt/β-catenin
pathway
cell
cycle.
Molecular
biology
analysis
indicated
suppressed
epithelial–mesenchymal
transition
(EMT),
abnormal
proliferation
promoted
epithelial
apoptosis.
Conclusion
mitigated
growth
cells
apoptosis,
thereby
inhibition
accomplished
modifying
microbiota
disrupting
EMT.
Therefore,
could
serve
as
a
potential
component
TCM
prescriptions
treatment.