Xianglian Pill combined with 5-fluorouracil enhances antitumor activity and reduces gastrointestinal toxicity in gastric cancer by regulating the p38 MAPK/NF-κB signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117988 - 117988

Published: Feb. 28, 2024

Language: Английский

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Synergistic Enhancement of Carboplatin Efficacy through pH-Sensitive Nanoparticles Formulated Using Naturally Derived Boswellia Extract for Colorectal Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1282 - 1282

Published: Sept. 30, 2024

Carboplatin (Cp) is a potent chemotherapeutic agent, but its effectiveness constrained by associated side effects. Frankincense, an oleo-gum resin from the

Language: Английский

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Maslinic acid improves mitochondrial function and inhibits oxidative stress and autophagy in human gastric smooth muscle cells

Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Functional dyspepsia (FD) is a chronic disease that occurs in the gastroduodenal region and significantly impacts human health. Maslinic acid (MA), pentacyclic triterpene acid, primary bioactive ingredient Chinese medicinal herbs such as hawthorn, which exhibits beneficial on regulation of various progressions. However, specific functions associated pathways MA FD progression remain unclear require further investigation. In this work, it was demonstrated enhanced cell viability gastric smooth muscle cells (HGSMCs). addition, mitochondrial dysfunctions induced by carbonyl cyanide 3-chlorophenylhydrazone (CCCP) were rescued after treatment. Furthermore, autophagy increased following CCCP treatment, but phenomenon counteracted The oxidative stress, elevated alleviated addition. Finally, AMPK/SIRT1 pathway suppressed stimulation re-activated conclusion, uncovered accelerated HGSMC improved function, inhibited autophagy, stimulated pathway. This discovery may offer new insight into therapeutic effects progression.

Language: Английский

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Potential mechanisms by which oleanic and maslinic acids from Cola lateritia K. Schum (Sterculiaceae) twigs inhibit prostate cancer cell growth

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 52 - 66

Published: April 16, 2025

Language: Английский

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Conjugation of Triterpenic Acids of Ursane and Oleanane Types with Mitochondria-Targeting Cation F16 Synergistically Enhanced Their Cytotoxicity against Tumor Cells

Membranes, Journal Year: 2023, Volume and Issue: 13(6), P. 563 - 563

Published: May 30, 2023

The present work shows the cytotoxic effects of novel conjugates ursolic, oleanolic, maslinic, and corosolic acids with penetrating cation F16 on cancer cells (lung adenocarcinoma A549 H1299, breast cell lines MCF-7 BT474) non-tumor human fibroblasts. It has been established that have a significantly enhanced toxicity against tumor-derived compared to native also demonstrate selectivity some cells. toxic effect is shown be due ROS hyperproduction in cells, induced by mitochondria. caused dysfunction isolated rat liver mitochondria and, particular, decrease efficiency oxidative phosphorylation, membrane potential, an overproduction organelles. paper discusses how membranotropic- mitochondria-targeted may related their effects.

Language: Английский

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Identifying therapeutic effect of kombucha Pirdot (Saurauia vulcani Korth.) against colorectal cancer: The experimental data and in silico approach

Medicine in Microecology, Journal Year: 2024, Volume and Issue: 20, P. 100105 - 100105

Published: April 7, 2024

This study pioneers the evaluation of Kombucha Pirdot (KP) in combating colorectal cancer through combined vivo and silico methods. It involved categorizing rats into four groups (n = 6) consisting control, benzo(a)pyrene (B[a]P) treated, KP group, a combination therapy for 30 days. The research focused on interaction S.vulcani compounds with signaling, using protein-protein networks, molecular docking dynamic simulation to assess compound affinity target proteins. Furthermore, epitope was aligned kombucha microorganism explore cross-reactivity. experimental data demonstrated that B[a]P impaired colon histoarchitecture elevated interleukin1β, whereas countered these effects. pinpointed key proteins notable S. vulcani linked cancer. Moreover, six candidates were obtained which have an identity 65%–95 % query coverage Lactiplantibacillus plantarum Saccharomyces cerevisiae bind fluctuate stability core regions HLA- A*0101 HLA-DRB1*0101. Overall, results underscore KP's potential as viable option developing treatments.

Language: Английский

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Lupeol-3-carbamate Derivatives: Synthesis and Biological Evaluation as Potential Antitumor Agents

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 3990 - 3990

Published: Aug. 23, 2024

In the following study, a series of new lupeol-3-carbamate derivatives were synthesized, and structures all newly derived compounds characterized. The screened to determine their anti-proliferative activity against human lung cancer cell line A549, liver HepG2, breast MCF-7. Most found show better in vitro than lupeol. Among them, obvious anti-proliferation (IC50 = 5.39~9.43 μM) was exhibited by compound 3i three tumor lines. addition, salt reaction performed on 3k 13.98 it observed that water solubility 3k·CH3I 3.13 μM), significantly enhanced subsequent formation process. preliminary mechanistic studies demonstrated apoptosis HepG2 cells induced through inhibition PI3K/AKT/mTOR pathway. conclusion, synthesized via structural modification C-3 site lupeol, thus laying theoretical foundation for design this anticancer drug.

Language: Английский

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Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-κB Pathways

The American Journal of Chinese Medicine, Journal Year: 2023, Volume and Issue: 51(04), P. 929 - 951

Published: Jan. 1, 2023

Maslinic acid (MA) is a pentacyclic triterpene obtained from the peel of olives that exhibits anti-inflammatory and antioxidant properties in several conditions. Our previous study revealed MA exerted cardioprotective effect by repressing inflammation apoptosis during myocardial ischemia-reperfusion injury (MIRI). However, data regarding antioxidative effects on MIRI remains limited. This aims to elucidate roles underlying mechanisms MIRI. The left anterior descending coronary artery rats was subjected ligate for induction ischemia/reperfusion (I/R) model H9c2 cells were exposed hydrogen peroxide (H2O2) mimic oxidative stress. results showed reduced I/R-induced H2O2-induced cardiomyocyte death dose-dependent manner. Meanwhile, increased activities glutathione superoxide dismutase both vitro vivo while lowering levels reactive oxygen species malondialdehyde. Mechanistically, could facilitate Nrf2 nuclear translocation, activate Nrf2/HO-1 signaling pathway, repress NF-[Formula: see text]B pathway I/R- Besides, promoted intranuclear HO-1 expression, which part be improved QNZ (NF-[Formula: inhibitor) H2O2-insulted cells. Conversely, markedly p65 TNF-[Formula: text] partially abolished ML385 (Nrf2 inhibitor). Overall, our indicate MA, manner, mitigated stress via activating inhibiting activation. Furthermore, exerts its through regulating crosstalk between pathways.

Language: Английский

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Low and high doses of oral maslinic acid protect against Parkinson’s disease via distinct gut microbiota-related mechanisms

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115100 - 115100

Published: July 6, 2023

The use of oral agents that can modify the gut microbiota (GM) could be a novel preventative or therapeutic option for Parkinson's disease (PD). Maslinic acid (MA), pentacyclic triterpene with GM-dependent biological activities when it is taken orally, has not yet been reported to effective against PD. present study found both low and high dose MA treatment significantly prevented dopaminergic neuronal loss in classical chronic PD mouse model by ameliorating motor functions improving tyrosine hydroxylase expressions substantia nigra pars compacta (SNpc) increasing dopamine its metabolite homovanillic levels striatum. However, effects mice were dose-responsive, since similar beneficial doses observed. Further mechanism studies indicated administration favored probiotic bacterial growth mice, which helped increase striatal serotonin, 5-hydroxyindole acetic acid, γ-aminobutyric levels. High did influence GM composition but inhibited neuroinflammation as reduced tumor necrosis factor alpha interleukin 1β SNpc; moreover, these mainly mediated microbially-derived colon. In conclusion, at different protected via distinct mechanisms related GM. Nevertheless, our lacked in-depth investigations underlying involved; future will designed further delineate signaling pathways involved interactive actions between

Language: Английский

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Progress in Antimelanoma Research of Natural Triterpenoids and Their Derivatives: Mechanisms of Action, Bioavailability Enhancement and Structure Modifications

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7763 - 7763

Published: Nov. 24, 2023

Melanoma is one of the most dangerous forms skin cancer, characterized by early metastasis and rapid development. In search for effective treatment options, much attention given to triterpenoids plant origin, which are considered promising drug candidates due their well described anticancer properties relatively low toxicity. This paper comprehensively summarizes antimelanoma potential natural triterpenoids, that also used as scaffolds development more derivatives. These include betulin, betulinic acid, ursolic maslinic oleanolic celastrol lupeol. Some lesser-known deserve in this context 22β-hydroxytingenone, cucurbitacins, geoditin A ganoderic acids. Recently mechanisms action presented, together with results preclinical vitro vivo studies, use delivery systems pharmaceutical technologies improve bioavailability triterpenoids. reviews structural modifications, based on structure–activity observations. conclusion, origin some semi-synthetic derivatives exert significant cytotoxic, antiproliferative chemopreventive effects can be beneficial melanoma treatment. Recent data indicate poor solubility water, thus bioavailability, overcome complexing cyclodextrins, or nanoparticles ethosomes, making these compounds further

Language: Английский

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