Gels,
Journal Year:
2024,
Volume and Issue:
10(5), P. 331 - 331
Published: May 14, 2024
Human
defense
against
infection
remains
a
global
topic.
In
addition
to
developing
novel
anti-infection
drugs,
therapeutic
drug
delivery
strategies
are
also
crucial
achieving
higher
efficacy
and
lower
toxicity
of
these
drugs
for
treatment.
The
application
hydrogels
has
been
proven
be
an
effective
localized
approach
treating
infections
without
generating
significant
systemic
adverse
effects.
recent
emerging
dynamic
further
show
power
as
injectable
formulations,
giving
new
tools
clinical
treatments.
this
review,
we
delve
into
the
potential
applications
in
antibacterial
antiviral
treatments
elaborate
on
their
molecular
designs
practical
implementations.
By
outlining
chemical
underlying
hydrogels,
discuss
how
choice
bonds
affects
stimulus
responsiveness,
self-healing
capabilities,
mechanical
properties.
Afterwards,
focus
endow
with
comparing
different
drug-loading
methods,
highlight
advantages
sustained
controlled
release.
Moreover,
include
design
principles
uses
that
possess
inherent
anti-infective
Furthermore,
explore
Finally,
briefly
summarize
current
challenges
faced
by
present
forward-looking
vision
future
development.
Through
expect
draw
more
attention
among
scientists
working
chemistry,
materials,
well
pharmaceutics.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 27, 2024
Abstract
The
skin
is
intrinsically
a
cell-membrane-compartmentalized
hydrogel
with
high
mechanical
strength,
potent
antimicrobial
ability,
and
robust
immunological
competence,
which
provide
multiple
protective
effects
to
the
body.
Methods
capable
of
preparing
hydrogels
that
can
simultaneously
mimic
structure
function
are
highly
desirable
but
have
been
proven
be
challenge.
Here,
dual
structurally
functionally
skin-mimicking
generated
by
crosslinking
cell-membrane
compartments.
crosslinked
network
formed
via
free
radical
polymerization
using
olefinic
double
bond-functionalized
extracellular
vesicles
as
crosslinker.
Due
dissipation
stretching
energy
mediated
vesicular
deformation,
obtained
compartment-crosslinked
shows
enhanced
strength
compared
regular
divinyl
monomers.
Biomimetic
also
exhibit
specific
antibacterial
activity
adequate
ability
promote
maturation
activation
dendritic
cells
given
existence
numerous
vesicle-associated
bioactive
substances.
In
addition,
versatility
this
approach
tune
both
resulting
demonstrated
through
introducing
second
catalyst-free
click
reaction-mediated
between
alkyne-double-ended
polymers
azido-decorated
vesicles.
This
study
provides
platform
develop
structure-
function-controllable
skin-inspired
biomaterials.
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(10), P. 105968 - 105968
Published: Aug. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2733 - 2754
Published: March 1, 2024
Abstract:
Nanohydrogels
(NH)
are
biodegradable
polymers
that
have
been
extensively
studied
and
utilized
for
various
biomedical
applications.
Drugs
in
a
topical
medication
absorbed
via
the
skin
carried
to
intended
location,
where
they
metabolized
eliminated
from
body.
With
focus
on
their
pertinent
contemporary
treatments,
this
review
aims
give
complete
overview
of
recent
advances
creation
application
polymer
NH
biomedicine.
We
will
explore
key
features
driven
nanotechnology
discuss
significance
nanohydrogel-based
formulations
as
vehicles
delivering
therapeutic
agents
topically.
The
also
cover
latest
findings
references
literature
support
advancements
nanotechnological
technology
related
preparation
NH.
In
addition,
we
unique
properties
potential
applications
drug
delivery
systems
(DDS)
applications,
underscoring
effective
delivery.
challenge
lies
efficiently
drugs
through
skin's
barrier
specific
areas
with
high
control.
Environmentally
sensitive
systems,
like
polymer-based
NH,
show
promise
treating
dermatological
conditions.
Polymers
pivotal
developing
these
offering
advantages
such
versatile
loading,
controlled
release,
enhanced
penetration.
Keywords:
nanohydrogels,
system,
polymers,
mechanisms
Regenerative Therapy,
Journal Year:
2024,
Volume and Issue:
26, P. 635 - 645
Published: June 1, 2024
Hydrogels
are
biomolecules
made
of
artificial
and
natural
polymers.
Their
quasi-three-dimensional
structure
has
created
unique
features.
They
very
hydrophilic,
in
addition
to
the
high
inflation
rate,
they
also
have
excellent
water
maintenance
capacity,
biodegradability,
biocompatibility,
strong
mechanical
properties.
These
properties
used
many
tissue
engineering
applications.
All
these
features
scaffolds
widely
as
attractive
structures
world
regeneration
medicine.
In
research,
entered
field
medicine
expected
play
a
significant
role
repair
tissues
future.
This
study
aims
review
various
polymers
involved
hydrogel
fabrication
their
application
diverse
clinical
trials.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(20), P. 4952 - 4952
Published: Oct. 19, 2024
A
series
of
hybrid
hydrogels
poly(ethylene
glycol)
(PEG)
were
synthesized
using
gelatin
as
a
crosslinker
and
investigated
for
controlled
delivery
the
first-generation
cephalosporin
antibiotic,
Cefazedone
sodium
(CFD).
commercially
available
4-arm-PEG-OH
was
first
modified
to
obtain
four-arm-PEG-succinimidyl
glutarate
(4-arm-PEG-SG),
which
formed
gelatin-PEG
composite
(S
