ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(47)
Published: Sept. 8, 2023
Chronic
diabetic
wounds
are
a
significant
global
healthcare
challenge.
Current
strategies,
such
as
biomaterials,
cell
therapies,
and
medical
devices,
however,
only
target
few
pathological
features
have
limited
efficacy.
A
powerful
platform
technology
combining
magneto-responsive
hydrogel,
cells,
wireless
magneto-induced
dynamic
mechanical
stimulation
(MDMS)
is
developed
to
accelerate
wound
healing.
The
hydrogel
encapsulates
U.S.
Food
Drug
Administration
(FDA)-approved
fibroblasts
keratinocytes
achieve
∼3-fold
better
closure
in
mouse
model.
MDMS
acts
nongenetic
mechano-rheostat
activate
fibroblasts,
resulting
∼240%
proliferation,
∼220%
more
collagen
deposition,
improved
keratinocyte
paracrine
profiles
via
the
Ras/MEK/ERK
pathway
boost
angiogenesis.
property
also
enables
on-demand
insulin
release
for
spatiotemporal
glucose
regulation
through
increasing
network
deformation
interstitial
flow.
By
mining
scRNAseq
data,
mechanosensitive
fibroblast
subpopulation
identified
that
can
be
mechanically
tuned
enhanced
proliferation
production,
maximizing
therapeutic
impact.
"all-in-one"
system
addresses
major
factors
associated
with
single
platform,
potential
applications
other
challenging
types.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7487 - 7487
Published: April 19, 2023
Wound
healing
(WH)
is
a
complex
multistep
process
in
which
failure
could
lead
to
chronic
wound
(CW).
CW
major
health
problem
and
includes
leg
venous
ulcers,
diabetic
foot
pressure
ulcers.
difficult
treat
affects
vulnerable
pluripathological
patients.
On
the
other
hand,
excessive
scarring
leads
keloids
hypertrophic
scars
causing
disfiguration
sometimes
itchiness
pain.
Treatment
of
WH
cleaning
careful
handling
injured
tissue,
early
treatment
prevention
infection,
promotion
healing.
underlying
conditions
use
special
dressings
promote
The
patient
at
risk
areas
should
avoid
injury
as
much
possible.
This
review
aims
summarize
role
physical
therapies
complementary
treatments
scarring.
article
proposes
translational
view,
opening
opportunity
develop
these
an
optimal
way
clinical
management,
many
them
are
emerging.
laser,
photobiomodulation,
photodynamic
therapy,
electrical
stimulation,
ultrasound
others
highlighted
practical
comprehensive
approach.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(9), P. 8172 - 8189
Published: Feb. 20, 2023
Wound
healing
is
a
complex
and
dynamic
physiological
process
consisting
of
series
cellular
molecular
events
that
initiate
immediately
after
tissue
lesion,
to
reconstruct
the
skin
layer.
It
indubitable
patients
with
chronic
wounds,
severely
infected
or
any
metabolic
disorder
wound
microenvironment
always
endure
severe
pain
discomfort
affect
their
quality
life.
essential
treat
wounds
for
conserving
physical
as
well
mental
well-being
affected
convalescing
improve
For
supporting
augmenting
process,
selection
pertinent
dressing
essential.
A
substantial
reduction
in
duration,
disability,
associated
cost,
risk
recurrent
infections
can
be
achieved
via
engineering
dressings.
Hydrogels
play
leading
role
path
ideal
Hydrogels,
comprising
water
large
extent,
providing
moist
environment,
being
comfortable
patients,
having
biocompatible
biodegradable
properties,
have
found
success
suitable
dressings
market.
The
exploitation
hydrogels
increasing
perpetually
substantiation
broader
therapeutic
actions
owing
resemblance
dermal
tissues,
capability
stimulate
partial
regeneration,
ability
incorporate
moieties
promoting
healing.
This
review
entails
properties
hydrogel
healing,
types
hydrogels,
cross-linking
mechanisms,
design
considerations,
formulation
strategies
engineering.
Various
categories
fabricated
recently
are
discussed
based
on
gel
network
composition,
degradability,
chemical
which
provide
an
outlook
regarding
importance
tailoring
physicochemical
hydrogels.
examples
marketed
also
incorporated
along
future
perspectives
challenges
them.
Gels,
Journal Year:
2024,
Volume and Issue:
10(2), P. 147 - 147
Published: Feb. 14, 2024
Wound
healing
is
a
physiological
process
occurring
after
the
onset
of
skin
lesion
aiming
to
reconstruct
dermal
barrier
between
external
environment
and
body.
Depending
on
nature
duration
process,
wounds
are
classified
as
acute
(e.g.,
trauma,
surgical
wounds)
chronic
diabetic
ulcers)
wounds.
The
latter
take
several
months
heal
or
do
not
(non-healing
wounds),
usually
prone
microbial
infection
represent
an
important
source
morbidity
since
they
affect
millions
people
worldwide.
Typical
wound
treatments
comprise
debridement,
grafts/flaps)
non-surgical
topical
formulations,
dressings)
methods.
Modern
experimental
approaches
include
among
others
three
dimensional
(3D)-(bio)printed
dressings.
present
paper
reviews
recently
developed
3D
(bio)printed
hydrogels
for
applications,
especially
focusing
results
their
in
vitro
vivo
assessment.
advanced
hydrogel
constructs
were
printed
using
different
types
bioinks
natural
and/or
synthetic
polymers
mixtures
with
biological
materials)
printing
methods
extrusion,
digital
light
processing,
coaxial
microfluidic
bioprinting,
etc.)
incorporated
various
bioactive
agents
growth
factors,
antibiotics,
antibacterial
agents,
nanoparticles,
cells
fibroblasts,
keratinocytes,
mesenchymal
stem
cells,
endothelial
etc.).
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 2660 - 2676
Published: May 9, 2024
Wound
healing,
particularly
for
chronic
wounds,
presents
a
considerable
difficulty
due
to
differences
in
biochemical
and
cellular
processes
that
occur
different
types
of
wounds.
Recent
technological
breakthroughs
have
notably
advanced
the
understanding
diagnostic
therapeutic
approaches
wound
healing.
The
evolution
care
has
seen
transition
from
traditional
textile
dressings
variety
alternatives,
including
self-healing
hydrogels,
hydrofibers,
foams,
hydrocolloids,
environment
responsive
dressings,
growth
factor-based
therapy,
bioengineered
skin
substitutes,
stem
cell
gene
therapy.
Technological
advancements,
such
as
3D
printing
electronic
(e-skin)
contribute
customization
Despite
these
effectively
managing
wounds
remains
challenging.
This
necessitates
development
treatments
consider
performance,
risk–benefit
balance,
cost-effectiveness.
review
discusses
innovative
strategies
healing
Incorporating
biomarkers
into
coupled
with
corresponding
biosensors
drug
delivery
formulations,
enables
theranostic
approach
treatment
Furthermore,
integrating
power
sources
user
interfaces
like
near-field
communication,
radio
frequency
identification,
Bluetooth
enhances
real-time
monitoring
on-demand
delivery.
It
also
provides
thorough
evaluation
advantages,
patient
compliance,
costs,
durability
emphasizing
smart
formulations
their
preparation
methods.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(22), P. 14726 - 14741
Published: May 22, 2024
The
management
of
diabetic
wound
healing
remains
a
severe
clinical
challenge
due
to
the
complicated
microenvironments,
including
abnormal
immune
regulation,
excessive
reactive
oxygen
species
(ROS),
and
repeated
bacterial
infections.
Herein,
we
report
an
extracellular
matrix
(ECM)-mimetic
coating
derived
from
scallop
byssal
protein
(Sbp9Δ),
which
can
be
assembled
in
situ
within
30
min
under
trigger
Ca2+
driven
by
strong
coordination
interaction.
biocompatible
Sbp9Δ
genetically
programmable
LL37-fused
exhibit
outstanding
antioxidant,
antibacterial,
regulatory
properties
vitro.
Proof-of-concept
applications
demonstrate
that
reliably
promote
animal
models,
mice
rabbits,
ex
vivo
human
skins,
Staphylococcus
aureus-infected
mice.
In-depth
mechanism
investigation
indicates
improved
microenvironments
accelerated
repair,
alleviated
infection,
lessened
inflammation,
appearance
abundant
M2-type
macrophages,
removal
ROS,
promoted
angiogenesis,
re-epithelialization.
Collectively,
our
provides
situ,
convenient,
effective
approach
for
repair.
