Advances in materials-based therapeutic strategies against osteoporosis

Biomaterials, Journal Year: 2023, Volume and Issue: 296, P. 122066 - 122066

Published: Feb. 20, 2023

Language: Английский

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MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

Molecular Therapy, Journal Year: 2022, Volume and Issue: 30(10), P. 3176 - 3192

Published: June 9, 2022

Parkinson's disease is a neurodegenerative characterized by the loss of dopaminergic neurons in substantia nigra with no effective cure available. MicroRNA-124 has been regarded as promising therapeutic entity for due to its pro-neurogenic and neuroprotective roles. However, efficient delivery brain remains challenging. Here, we used umbilical cord blood mononuclear cell-derived extracellular vesicles biological vehicle deliver microRNA (miR)-124-3p evaluate effects mouse model disease. In vitro, miR-124-3p-loaded small induced neuronal differentiation subventricular zone neural stem cell cultures protected N27 cells against 6-hydroxydopamine-induced toxicity. vivo, intracerebroventricularly administered were detected lining lateral ventricles striatum nigra, regions most affected Most importantly, although did not increase number new 6-hydroxydopamine-lesioned striatum, formulation striatal fibers, which fully counteracted motor behavior symptoms. Our findings reveal novel application agents miR-124-3p context

Language: Английский

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Osteopontin, a bridge links osteoarthritis and osteoporosis

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 28, 2022

Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular subchondral bone joints. Osteoporosis (OP) another systemic skeletal low mass mineral density (BMD) accompanied microarchitectural deterioration tissue increased fragility fracture risk. Both OA OP are mainly affected on elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role metabolism homeostasis. OPN involves these biological activities through participating proliferation, migration, differentiation, adhesion several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, marrow mesenchymal stem cells (MSCs). has been demonstrated to be closely related occurrence development many diseases, such as OP. This review summarizes regulating inflammation activity Furthermore, some drugs targeted treat also summarized review. However, complex mechanism not fully elucidated, which drives us explore depth effect two diseases.

Language: Английский

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Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 3859 - 3899

Published: Jan. 1, 2024

Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve medication hormone therapy. However, these lack directionality are often ineffective for locally severe osteoporosis, with the potential complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as most promising approaches. This review proposes twelve microenvironmental targets osteoporosis-related pathological changes, including local accumulation of inflammatory factors reactive oxygen species (ROS), mitochondrial dynamics, insulin resistance, disruption cell autophagy, apoptosis, changes in neural secretions, aging cells, increased tissue vascular destruction, decreased regeneration. Additionally, this examines current research status effective biophysical biochemical stimuli based on summarizes advantages optimal parameters different bioengineering to support preclinical clinical osteoporosis Finally, addresses ongoing challenges future prospects.

Language: Английский

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Bone Targeting Nanoparticles for the Treatment of Osteoporosis

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1363 - 1383

Published: Feb. 1, 2024

Osteoporosis (OP) affects millions of people worldwide, especially postmenopausal women and the elderly. Although current available anti-OP agents can show promise in slowing down bone resorption, most are not specifically delivered to hard tissue, causing significant toxicity. A bone-targeted nanodrug delivery system reduce side effects precisely deliver drug candidates bone. This review focuses on progress nanoparticles OP therapy. We enumerate existing medications, types categorize pairs common bone-targeting functional groups. Finally, we summarize potential use treatment. Ongoing research into development targeted ligands nanocarriers will continue expand possibilities OP-targeted therapies clinical application.

Language: Английский

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Bone targeted nano-drug and nano-delivery

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 4, 2024

Language: Английский

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Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 19, 2024

Abstract Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric magnetic fields, temperature, compressive stress, among others, micro/nanostructures induce macrophage polarization, thereby increasing therapeutic potential. However, it is difficult find a concise review of the interaction between stimuli, advanced micro/nanostructures, polarization. This examines present research stimuli‐induced polarization micro/nanoplatforms, emphasizing synergistic fabricated structure stimulation for regeneration. A overview advancements investigating impact including forces, fluid shear photothermal multiple stimulations macrophages within complex engineered structures, provided. The prospective implications these strategies regenerative medicine immunotherapeutic approaches are highlighted. will aid creating stimuli‐responsive platforms immunomodulation

Language: Английский

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Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 30, 2025

Abstract Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding complexities of tumor development and mutation need hour for advancement targeted therapies cancer care. A significant innovation this area use nanotechnology, specifically nanoparticles, tackle various challenges treatment. Iron oxide nanoparticles stand out both therapeutic diagnostic applications, offering versatile platform drug delivery, hyperthermia, magneto-thermal therapy, combinational therapy using modulation ferroptosis pathways. These are easy synthesize, non-toxic, biocompatible, display enhanced circulation time within system. They can also be easily conjugated anti-cancer drugs, targeting agents, or genetic vectors that respond specific stimuli pH changes. The surface functionalization these bioactive molecules unveils promising effective nanoparticle system assisting osteosarcoma therapy. This review will summarize current conventional their disadvantages, synthesis modification iron documented literature, cellular uptake mechanism, with focus on natural biomaterials application strategies towards management osteosarcoma. compiles translational future prospects must addressed clinical advancements based treatment future. Graphical abstract

Language: Английский

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Materials-based nanotherapeutics for injured and diseased bone

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 135, P. 101087 - 101087

Published: Feb. 3, 2023

Language: Английский

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MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 29, 2023

Abstract Background Progression of senile osteoporosis is associated with deteriorated regenerative potential bone marrow-derived mesenchymal stem/stromal cells (BMSCs). According to the recent results, senescent phenotype osteoporotic strongly correlates impaired regulation mitochondria dynamics. Moreover, due ageing population and growing incidence, more efficient methods concerning BMSCs rejuvenation are intensely investigated. Recently, miR-21-5p was reported play a vital role in turnover, but its therapeutic mechanisms progenitor delivered from patients remain unclear. Therefore, goal this paper investigate for first time process mitochondrial network stemness restoration using unique model isolated SAM/P6 mice model. Methods were healthy BALB/c mice. We analysed impact on expression crucial markers related cells’ viability, reconstruction autophagy progression. Further, we established homeostasis, as well defined composition extracellular matrix osteogenic cultures. The miR-21 vivo also investigated critical-size cranial defect by computed microtomography SEM–EDX imaging. Results MiR-21 upregulation improved viability drove dynamics evidenced intensification fission processes. Simultaneously, enhanced differentiation increased Runx-2 downregulated Trap , calcification matrix. Importantly, analyses indicated greater ratio newly formed tissue after application, upregulated content calcium phosphorus within site. Conclusions Our results demonstrate that regulates fusion processes facilitates BMSCs. At same time, it enhances RUNX-2, while reduces TRAP accumulation phenotype. may bring novel molecular strategy diagnostics treatment.

Language: Английский

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