Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(6), P. 887 - 939

Published: Jan. 11, 2019

Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma longa belonging to the family zingiberaceae. Growing experimental evidence revealed that curcumin exhibit multitarget biological implications signifying its crucial role health and disease. The current review highlights recent progress mechanisms underlying wide range pharmacological effects against numerous diseases like neuronal, cardiovascular, metabolic, kidney, endocrine, skin, respiratory, infectious, gastrointestinal cancer. ability modulate functions multiple signal transductions are linked with attenuation acute chronic diseases. Numerous preclinical clinical studies have modulates several molecules cell transduction pathway including PI3K, Akt, mTOR, ERK5, AP-1, TGF-β, Wnt, β-catenin, Shh, PAK1, Rac1, STAT3, PPARγ, EBPα, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 MyD-88. has potential prevent and/or manage various due anti-inflammatory, anti-oxidant anti-apoptotic properties an excellent safety profile. In contrast, anti-cancer reflected induction growth arrest apoptosis premalignant malignant cells. This also carefully emphasized pharmacokinetics interaction other drugs. Clinical shown safe at doses 12 g/day but exhibits poor systemic bioavailability. use adjuvant piperine, liposomal curcumin, nanoparticles phospholipid complex enhanced bioavailability therapeutic potential. Further warranted prove ailments.

Language: Английский

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Encapsulation of Curcumin Nanoparticles with MMP9-Responsive and Thermos-Sensitive Hydrogel Improves Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2018, Volume and Issue: 10(19), P. 16315 - 16326

Published: April 24, 2018

Impaired wound healing in diabetics usually leads to life-threatening complications. To develop a system for fastening skin efficiently and safely diabetics, thermos-sensitive hydrogel containing the nanodrug, loaded form of gelatin microspheres (GMs), was designed deliver curcumin (Cur) as therapeutic drug. Cur is naturally existing polyphenolic compound with broad range biological functions useful potential therapies. Because molecule has weakness both bioavailability vivo stability, delivery requires assistance from other molecules act carrier vehicles sustained manner use. At first, self-assembly nanoparticles (CNPs) done improve bioavailability. The CNPs were further enclosed into GMs responding matrix metalloproteinases (MMPs) that overexpress at diabetic nonhealing sites. finally proved capacity specially induced drug release bed, which promoted efficacy standardized wounds streptozotocin-induced mice. Our results indicated successfully developed CNP had significantly promote healing, suggested it could have become dressing properties antioxidants promotions cell migration.

Language: Английский

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Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology

Plants, Journal Year: 2021, Volume and Issue: 10(12), P. 2751 - 2751

Published: Dec. 14, 2021

There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and West from Former Han era. various beneficial effects licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, immunodeficiency. On other hand, traditional medicines getting attraction to treat many diseases. Therefore, it is vital screen medicinal plants find potential new compounds chronic diseases cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, toxicology licorice, which will serve a resource for future fundamental studies. An attempt has been made establish pharmacological effect different In addition, focus this review article on molecular mechanism extracts their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, glabridin) pharmacologic activities. Licorice could be natural alternative current therapy exterminate emerging disorders with mild side effects. provide systematic insights into ancient drug further development use.

Language: Английский

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Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs

International Journal of Biological Sciences, Journal Year: 2019, Volume and Issue: 15(6), P. 1200 - 1214

Published: Jan. 1, 2019

Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on rise throughout world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes patients with cancer, it crucial identify novel, highly efficacious pharmacological agents. Curcumin, a hydrophobic polyphenol extracted from turmeric, has gained increasing attention due its powerful properties. Curcumin can inhibit growth, invasion and metastasis of various cancers. The mechanisms curcumin have been extensively studied. effects are mainly mediated through regulation multiple cellular signaling pathways, including Wnt/β-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 NF-ĸB pathways. Moreover, also orchestrates expression activity oncogenic tumor-suppressive miRNAs. this review, we summarized these pathways different We discussed modulatory function downregulation miRNAs upregulation An in-depth understanding will be helpful for developing promising compound as agent clinical management cancer.

Language: Английский

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Perspectives on the Role of Isoliquiritigenin in Cancer

Cancers, Journal Year: 2021, Volume and Issue: 13(1), P. 115 - 115

Published: Jan. 1, 2021

Isoliquiritigenin (2′,4′,4-trihydroxychalcone, ISL), one of the most important bioactive compounds with a chalcone structure, is derived from licorice root. Licorice commonly known as Glycyrrhiza, including Glycyrrhiza uralensis, radix, and glabra, which are generally available in common foods Chinese herbal medicines based on wide variety biological functions pharmacological effects, its derivative (ISL) utilized food additive adjunct disease treatment. In this review, we summarized progress over last 10 years targeted pathways molecular mechanisms ISL that involved regulation onset progression different types cancers.

Language: Английский

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Curcumin nanoformulations: Beneficial nanomedicine against cancer

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(3), P. 1156 - 1181

Published: Feb. 7, 2022

Abstract Curcumin is a phytochemical achieved from the plant turmeric. It extensively utilized for treatment of several types diseases such as cancers. Nevertheless, its efficiency has been limited because rapid metabolism, low bioavailability, poor water solubility, and systemic elimination. Scientists have tried to solve these problems by exploring novel drug delivery systems lipid‐based nanoparticles (NPs) (e.g., solid lipid NPs, nanostructured carriers, liposomes), polymeric micelles, nanogels, cyclodextrin, gold, mesoporous silica NPs. Among these, liposomes most expansively studied. This review mainly focuses on different curcumin nanoformulations their use in cancer therapy vitro, vivo, clinical studies. Despite development curcumin‐containing NPs cancer, potentially serious side effects, including interactions with other drugs, some toxicity aspects may occur that require more high‐quality investigations firmly establish efficacy.

Language: Английский

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Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

Frontiers in Aging Neuroscience, Journal Year: 2017, Volume and Issue: 9

Published: July 20, 2017

Stroke is the most common type of cerebrovascular disease and a leading cause disability death. Ischemic stroke accounts for approximately 80% all strokes. The remaining 20% strokes are hemorrhagic in nature. To date, therapeutic options acute ischemic very limited. Recent research suggests that shifting microglial phenotype from pro-inflammatory M1 state toward anti-inflammatory tissue-reparative M2 may be an effective strategy stroke. dietary phytochemical curcumin has shown promise experimental models, but its effects on polarization long-term recovery after unknown. Here we address these gaps by subjecting mice to distal middle cerebral artery occlusion (dMCAO) administering intraperitoneally (150 mg/kg) immediately ischemia 24 hours later. Histological studies revealed post-treatment significantly reduced damage 3 days dMCAO. Sensorimotor functions—as measured adhesive removal test modified Garcia scores—were superior curcumin-treated at 3, 5, 7, 10 RT-PCR measurements elevation microglia/macrophage phenotypic markers reduction brains Immunofluorescent staining further showed treatment increased number CD206+Iba1+ microglia/macrophages CD16+Iba1+ cells In vitro using BV2 cell line confirmed inhibited lipopolysaccharide (LPS) interferon-γ (IFN-γ)-induced polarization. Curcumin concentration-dependently expression cytokines, including TNF-α, IL-6, IL-12p70, absence any toxic effect survival. conclusion, demonstrate profound regulatory responses, promoting inhibiting microglia-mediated responses. reduces stroke-induced brain improves functional outcomes, providing new evidence might promising

Language: Английский

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Targeting regulatory T cells by curcumin: A potential for cancer immunotherapy

Pharmacological Research, Journal Year: 2019, Volume and Issue: 147, P. 104353 - 104353

Published: July 12, 2019

Language: Английский

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Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis

Gastroenterology, Journal Year: 2018, Volume and Issue: 155(3), P. 668 - 673

Published: May 24, 2018

Language: Английский

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Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies

Materials Science and Engineering C, Journal Year: 2019, Volume and Issue: 99, P. 417 - 429

Published: Jan. 29, 2019

Language: Английский

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