Frontiers in Network Physiology, Journal Year: 2024, Volume and Issue: 4
Published: Aug. 7, 2024
Epilepsy is one of the most common neurological disorders, affecting over 65 million people worldwide. Despite medical management with anti-seizure medications (ASMs), many patients fail to achieve seizure freedom, one-third having drug-resistant epilepsy (DRE). Even surgical through resective surgery and/or neuromodulatory interventions, 50
Language: Английский
Journal of the Neurological Sciences, Journal Year: 2023, Volume and Issue: 452, P. 120766 - 120766
Published: Aug. 14, 2023
Language: Английский
Citations
36
Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(11), P. 6476 - 6529
Published: July 17, 2023
Language: Английский
Citations
23
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(1), P. 71 - 71
Published: Jan. 10, 2024
Epilepsy represents a condition in which abnormal neuronal discharges or the hyperexcitability of neurons occur with synchronicity, presenting significant public health challenge. Prognostic factors, such as etiology, electroencephalogram (EEG) abnormalities, type and number seizures before treatment, well initial unsatisfactory effects medications, are important considerations. Although there several third-generation antiepileptic drugs currently available, their multiple side can negatively affect patient quality life. The inheritance etiology epilepsy complex, involving underlying genetic epigenetic mechanisms. Different neurotransmitters play crucial roles maintaining normal physiology different neurons. Dysregulations neurotransmission, due to transmitter levels changes receptors, result seizures. In this review, we address played by various receptors pathophysiology epilepsy. Furthermore, extensively explore neurological mechanisms involved development progression epilepsy, along its risk factors. highlight new therapeutic targets, pharmacological non-pharmacological strategies employed treatment epileptic syndromes, including drug interventions clinical trials related
Language: Английский
Citations
17
Seizure, Journal Year: 2025, Volume and Issue: 127, P. 77 - 87
Published: March 6, 2025
Language: Английский
Citations
1
Epilepsy and Paroxysmal Conditions, Journal Year: 2025, Volume and Issue: 17(1), P. 59 - 70
Published: May 2, 2025
To date, despite the complexity and risks of not removing seizures hippocampal resection is only effective solution to overcome drug resistance in epilepsy. Recently, a significant amount data has been accumulated on mechanisms development, which allows develop innovative strategies it. New antiepileptic drugs have emerging, directly aimed at acting disease etiological substrate (many them are stage clinical trials). Targeted therapy extensively introduced, coupled with precision medicine methods can potentially aid finding personalized approach each individual patient. Migraine models also achieve qualitatively new level, providing researchers an opportunity highly systems for identifying previously unknown components, as well assessing effect drugs. The aim this review was highlight current approaches treatment epilepsy overcoming resistance.
Language: Английский
Citations
1
Epilepsy & Behavior, Journal Year: 2022, Volume and Issue: 130, P. 108666 - 108666
Published: March 25, 2022
Language: Английский
Citations
33
JCI Insight, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 8, 2024
Epilepsy has a profound impact on quality of life. Despite the development new antiseizure medications (ASMs), approximately one-third affected patients have drug-refractory epilepsy and are nonresponsive to medical treatment. Nearly all currently approved ASMs target neuronal activity through ion channel modulation. Recent human animal model studies implicated immunotherapeutic metabolomic approaches that may benefit with epilepsy. In this Review, we detail proinflammatory immune landscape contrast immunosuppressive microenvironment in glioma-related tumor setting, excessive facilitates immunosuppression, thereby contributing subsequent glioma progression. Metabolic modulation IDH1-mutant pathway provides dual for reversing suppression dampening seizure activity. Elucidating relationship between neurons immunoreactivity is an area prioritization next era ASMs.
Language: Английский
Citations
8
Chinese Medicine, Journal Year: 2022, Volume and Issue: 17(1)
Published: Nov. 19, 2022
Abstract Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for symptomatic relief epilepsy. The refractory epilepsy dose-dependent neurotoxicity AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, other side effects major bottlenecks in treatment. In low- middle-income countries (LMICs), patients failed to adhere regimens consider complementary alternative medicines (CAMs) relieve pain due (SE). Plant-based CAMs widely employed across globe including Ethiopia. current review documented around 96 plant species (PS) often used It also described vivo anticonvulsant activities toxicity profiles antiepileptic medicinal plants (MPs). Moreover, phytochemical constituents MPs profound were assessed. result reiterated lot has be done show association between herbal-based pharmacological regarding their mechanism action (MOA), profiles, bioactive so they can advance into clinics serve option
Language: Английский
Citations
25
Medicina, Journal Year: 2023, Volume and Issue: 59(8), P. 1389 - 1389
Published: July 28, 2023
Cenobamate (CNB), ([(R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl], is a novel tetrazole alkyl carbamate derivative. In November 2019, the Food and Drug Administration approved Xcopri®, marketed by SK Life Science Inc., (Paramus, NJ, USA) for adult focal seizures. The European Medicines Agency Ontozry® Arvelle Therapeutics Netherlands B.V.(Amsterdam, Neatherlands) in March 2021. medication that could potentially change perspectives regarding management prognosis of refractory epilepsy. this way, study aims to review literature on CNB's pharmacological properties, pharmacokinetics, efficacy, safety. CNB highly effective drug managing onset seizures, with more than twenty percent individuals drug-resistant epilepsy achieving seizure freedom. This finding remarkable antiseizure literature. mechanism action still poorly understood, but it associated transient persistent sodium currents GABAergic neurotransmission. animal studies, showed sustained efficacy potency 6 Hz test regardless stimulus intensity. was revealed be most cost-effective among different third-generation medications. Also, have neuroprotective effects. However, there are concerns its potential abuse suicidality risk, which future studies should clearly assess, after protocols changed. major drawback therapy slow complex titration maintenance phases preventing wide use new agent clinical practice.
Language: Английский
Citations
14
Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 174, P. 105872 - 105872
Published: Sept. 22, 2022
Drug resistance is a major challenge in the treatment of epilepsy. Drug-resistant epilepsy (DRE) accounts for 30% all cases and matter great concern because its uncontrollability high burden, mortality rate, degree damage. At present, considerable research has focused on development predictors to aid early identification DRE an effort promote prompt initiation individualized treatment. While multiple risk factors have been identified, there are currently no standard that can be used guide clinical management DRE. In this review, we discuss several potential related may become future perform evidence rating analysis identify reliable predictors.
Language: Английский
Citations
17