Molecular Process of Stem Cells in Modern Biology DOI Open Access

Amina Shahid,

Haris Abdul Rehman,

Noorulain Hyder

et al.

Published: Sept. 30, 2022

Stem cells have a wide range of traits, including the ability to self-renewal and differential interactions between various cell types that vary with their location within tissue immediate surroundings. Inhibitors both are influenced by cycle, genes involved in chromosomal rearrangements, critical developmental proteins, signaling pathways. Wnt, Notch, Hedgehog Pathways, BMI-1, OCT3/4, ARF, NANOG, p16Ink4a, this includes HOXB4, SOX2, homologous paralog, govern self-renewal. molecular pathways regulate differentiation hold great promise for theoretical practical studies. Keyword: gene regulation stem OCT3, OCT4, microenvironment, ARF protein proteins 1 (hedgehog), 2 (Wnt.), receptors 3 (notch).

Language: Английский

Traumatic brain injury: Mechanisms, manifestations, and visual sequelae DOI Creative Commons

Steve H. Rauchman,

Aarij Zubair,

Benna Jacob

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 23, 2023

Traumatic brain injury (TBI) results when external physical forces impact the head with sufficient intensity to cause damage brain. TBI can be mild, moderate, or severe and may have long-term consequences including visual difficulties, cognitive deficits, headache, pain, sleep disturbances, post-traumatic epilepsy. Disruption of normal functioning leads a cascade effects molecular anatomical changes, persistent neuronal hyperexcitation, neuroinflammation, loss. Destructive processes that occur at cellular level lead inflammation, oxidative stress, calcium dysregulation, apoptosis. Vascular damage, ischemia loss blood barrier integrity contribute destruction tissue. This review focuses on incited during frequently life-altering lasting this vision, cognition, balance, sleep. The wide range complaints associated are addressed repair where there is potential for intervention preservation highlighted.

Language: Английский

Citations

45
Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases DOI Open Access
Gordana Velikić, D Marić, Dušica Marić

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 993 - 993

Published: Jan. 12, 2024

Regenerative medicine harnesses the body's innate capacity for self-repair to restore malfunctioning tissues and organs. Stem cell therapies represent a key regenerative strategy, but effectively harness their potential necessitates nuanced understanding of stem niche. This specialized microenvironment regulates critical behaviors including quiescence, activation, differentiation, homing. Emerging research reveals that dysfunction within endogenous neural niches contributes neurodegenerative pathologies impedes regeneration. Strategies such as modifying signaling pathways, or epigenetic interventions niche homeostasis signaling, hold promise revitalizing neurogenesis repair in diseases like Alzheimer's Parkinson's. Comparative studies highly species provide evolutionary clues into niche-mediated renewal mechanisms. Leveraging bioelectric cues crosstalk between gut, brain, vascular further illuminates promising therapeutic opportunities. techniques single-cell transcriptomics, organoids, microfluidics, artificial intelligence, silico modeling, transdifferentiation will continue unravel complexity. By providing comprehensive synthesis integrating diverse views on components, developmental transitions, dynamics, this review unveils new layers complexity integral behavior function, which unveil novel prospects modulate function revolutionary treatments diseases.

Language: Английский

Citations

18
The Current Update of Conventional and Innovative Treatment Strategies for Central Nervous System Injury DOI Creative Commons
Meng-Hsuan Tsai,

Chi-Ying Wu,

Chao‐Hsin Wu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1894 - 1894

Published: Aug. 19, 2024

This review explores the complex challenges and advancements in treatment of traumatic brain injury (TBI) spinal cord (SCI). Traumatic injuries to central nervous system (CNS) trigger intricate pathophysiological responses, frequently leading profound enduring disabilities. article delves into dual phases injury-primary impacts subsequent secondary biochemical cascades-that worsen initial damage. Conventional treatments have traditionally prioritized immediate stabilization, surgical interventions, supportive medical care manage both primary damage associated with injuries. We explore current management strategies, emphasizing crucial role rehabilitation promising potential stem cell therapies immune modulation. Advances therapy, gene editing, neuroprosthetics are revolutionizing approaches, providing opportunities not just for recovery but also regeneration impaired neural tissues. aims emphasize emerging therapeutic strategies that hold promise enhancing outcomes improving quality life affected individuals worldwide.

Language: Английский

Citations

4
Cellular Stem Cell Therapy for Treating Traumatic Brain Injury: Strategies for Enhancement of Therapeutic Efficacy DOI
Ali Q. Khazaal, Haneen M. Ismaeel, Pike-See Cheah

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

0
An overview of stem cells and cell products involved in trauma injury DOI
Pardis Saeedi,

Leila Sadat Nilchiani,

Behrouz Zand

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 60 - 76

Published: March 11, 2025

Language: Английский

Citations

0
Bone Tissue and the Nervous System: What Do They Have in Common? DOI Creative Commons
Arianna Minoia, Luca Dalle Carbonare, Jens C. Schwamborn

et al.

Cells, Journal Year: 2022, Volume and Issue: 12(1), P. 51 - 51

Published: Dec. 22, 2022

Degenerative diseases affecting bone tissues and the brain represent important problems with high socio-economic impact. Certain diseases, such as osteoporosis, are considered risk factors for progression of neurological disorders. Often, patients neurodegenerative have fractures or reduced mobility linked to osteoarthritis. The is a dynamic tissue involved not only in movement but also maintenance mineral metabolism. Bone associated generation both hematopoietic stem cells (HSCs), thus immune system, mesenchymal (MSCs). marrow lymphoid organ contains MSCs HSCs, which health via production cytokines endocrine functions. Hence, it seems clear that regulation neuronal system vice versa. This review summarizes recent knowledge on interactions between nervous highlights importance interaction nerve cells. In addition, experimental models study skeletal discussed, innovative suggested better evaluate molecular these two cell types.

Language: Английский

Citations

11
Nature vs. Manmade: Comparing Exosomes and Liposomes for Traumatic Brain Injury DOI

Kate Hennigan,

Erin Lavik

The AAPS Journal, Journal Year: 2023, Volume and Issue: 25(5)

Published: Aug. 23, 2023

Language: Английский

Citations

6
Traumatic Brain Injury and Immunological Outcomes: the double-edged Killer DOI Creative Commons
Souvik Datta, Feng Lin, L. Jones

et al.

Future Science OA, Journal Year: 2023, Volume and Issue: 9(6)

Published: May 9, 2023

Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide resulting from falls, car accidents, sports, blast injuries. TBI characterized by severe, life-threatening consequences due to neuroinflammation in the brain. Contact collision sports lead higher disability death rates among young adults. Unfortunately, no therapy or drug protocol currently addresses complex pathophysiology TBI, leading long-term chronic neuroinflammatory assaults. However, immune response plays crucial role tissue-level repair. This review aims provide better understanding TBI's immunobiology management protocols an immunopathological perspective. It further elaborates on risk factors, disease outcomes, preclinical studies design precisely targeted interventions for enhancing outcomes.

Language: Английский

Citations

4
VEGF Expression in Umbilical Cord MSC Depends on the Patient’s Health, the Week of Pregnancy in Which the Delivery Took Place, and the Body Weight of the Newborn – Preliminary Report DOI Creative Commons
Karolina Bieńko, Monika Leszcz, Marta Więckowska-Deroń

et al.

Stem Cells and Cloning Advances and Applications, Journal Year: 2023, Volume and Issue: Volume 16, P. 5 - 18

Published: April 1, 2023

Cells collected from Wharton's jelly are a rich source of mesenchymal stem cells. They can be easily obtained and grown using the adhesive method. produce many types proteins, including VEGF. Their role is to participate in angiogenesis, vasodilation, stimulation cells migrate, chemotactic activity. The aim this study was evaluate expression genes vascular endothelial growth factor family: VEGFA, VEGFB VEGFC MSC analysis dependence studied on clinical factors related course pregnancy childbirth, health mother child.The research material an umbilical cord 40 patients hospitalized Department Obstetrics Pathology Pregnancy Independent Public Clinical Hospital No.1 Lublin. age women 21-46, all gave birth by cesarean section. Some suffered hypertension hypothyroidism. Material immediately after delivery subjected enzymatic digestion with type I collagenase. isolated were then cultured adherent conditions, gene assessed qPCR immunophenotype cytometrically.Conducted studies have shown significant differences VEGF family depending condition child. Significant VEGF-family level hypothyroidism, hypertension, time labor weight baby shown.Probably due hypoxia (caused, for example, hypothyroidism or hypertension), MSCs found may react increased compensatory increase amount secreted factor, which is, i.a., vasodilation blood supply fetus through vessels.

Language: Английский

Citations

3
Comparative Study of the Protective and Neurotrophic Effects of Neuronal and Glial Progenitor Cells-Derived Conditioned Media in a Model of Glutamate Toxicity In Vitro DOI Creative Commons
Georgy Leonov, Diana Salikhova,

Margarita Shedenkova

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(12), P. 1784 - 1784

Published: Dec. 13, 2023

Cell therapy represents a promising approach to the treatment of neurological diseases, offering potential benefits not only by cell replacement but also through paracrine secretory activities. However, this includes number limiting factors, primarily related safety. The use conditioned stem media can serve as an equivalent while avoiding its disadvantages. present study was comparative investigation antioxidant, neuroprotective and neurotrophic effects obtained from neuronal glial progenitor cells (NPC-CM GPC-CM) on PC12 line in vitro. Neuronal were iPSCs directed differentiation using small molecules. GPC-CM reduced apoptosis, ROS levels increased viability, expressions antioxidant response genes HMOX1 NFE2L2 model glutamate-induced oxidative stress. effect evidenced change morphology pheochromocytoma neuron-like phenotype. Moreover, neurite outgrowth, expression GAP43, TUBB3, MAP2, SYN1 corresponding MAP2 TUBB3 proteins. Treatment with NPC-CM showed moderate antiapoptotic improved viability. This demonstrated application CM field regenerative medicine.

Language: Английский

Citations

3