Nanoparticles
have
been
developed
to
overcome
the
limitation
of
free
therapeutics
and
enable
targeting
specific
sites
in
a
controlled
manner;
they
proven
be
effective
as
drug
carriers
diagnostic
tools.
Pulmonary
delivery
is
greatly
preferred
treatment
lung
diseases
has
its
advantages
over
other
routes
systemic
well.
However,
delivering
nanoparticles
hindered
by
their
physical
instability
poor
deposition
efficiency
due
particle-particle
interaction
low
inertia,
respectively.
Developing
inhalable
part
an
solid
state
dry
powder
combines
pulmonary
nanoparticle
systems
offers
unique
advantages.
Several
particle
engineering
techniques
utilized
combine
within
form
micron-scale
carrier
with
improved
handling
aerosolization
properties
ability
release
upon
lungs.
This
chapter
will
describe
different
classes
nano-in-micro
frameworks.
The
used
for
developing
these
frameworks
also
discussed.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(13), P. 2928 - 2928
Published: July 1, 2023
The
limitations
associated
with
the
conventional
treatment
of
cancer
have
necessitated
design
and
development
novel
drug
delivery
systems
based
mainly
on
nanotechnology.
These
include
various
kinds
nanoparticles,
such
as
polymeric
solid
lipid
nanostructured
carriers,
hydrogels,
micelles.
Among
systems,
chitosan-based
nanoparticles
attracted
attention
researchers
to
treat
cancer.
Chitosan
is
a
polycationic
polymer
generated
from
chitin
characteristics
biocompatibility,
biodegradability,
non-toxicity,
mucoadhesiveness,
making
it
an
ideal
fabricate
systems.
However,
chitosan
poorly
soluble
in
water
acidic
aqueous
solutions.
Furthermore,
owing
presence
reactive
amino
groups,
can
be
chemically
modified
improve
its
physiochemical
properties.
derivatives
employed
which
are
used
most
frequently
pharmaceutical
sector
due
their
possession
nanosize,
appropriate
pharmacokinetic
pharmacodynamic
properties,
non-immunogenicity,
improved
stability,
loading
capacity.
capable
delivering
nucleic
acids,
chemotherapeutic
medicines,
bioactives
using
chitosan.
derivative-based
targeted
specific
sites
via
active
passive
mechanisms.
Based
many
anticancer
drugs
now
better
effectiveness,
potency,
cytotoxicity,
or
biocompatibility.
tailored
derivatives,
well
use
therapy,
will
examined
this
review.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 889 - 889
Published: March 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(10), P. 1360 - 1360
Published: Sept. 26, 2023
The
World
Health
Organization
identifies
tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis,
as
a
leading
infectious
killer.
Although
conventional
treatments
for
TB
exist,
they
come
with
challenges
such
heavy
pill
regimen,
prolonged
treatment
duration,
and
strict
schedule,
to
multidrug-resistant
(MDR)
extensively
drug-resistant
(XDR)
strains.
rise
of
MDR
strains
endangers
future
control.
Despite
these
concerns,
the
hunt
an
efficient
continues.
One
breakthrough
has
been
use
nanotechnology
in
medicines,
presenting
novel
approach
treatment.
Nanocarriers,
lipid
nanoparticles,
nanosuspensions,
liposomes,
polymeric
micelles,
facilitate
targeted
delivery
anti-TB
drugs.
benefits
nanocarriers
include
reduced
drug
doses,
fewer
side
effects,
improved
solubility,
better
bioavailability,
patient
compliance,
speeding
up
recovery.
Additionally,
can
be
made
even
more
linking
them
ligands
mannose
or
hyaluronic
acid.
This
review
explores
innovative
treatments,
including
studies
on
containing
drugs
related
patents.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(8), P. 1108 - 1108
Published: Aug. 4, 2023
Resistance
to
isoniazid
(INH)
is
common
and
increases
the
possibility
of
acquiring
multidrug-resistant
tuberculosis.
For
this
study,
isoniazid-loaded
nanostructured
lipid
carriers
(INH-NLCs)
were
developed
effectively
functionalized
with
mannose
(Man)
enhance
residence
time
drug
within
lungs
via
specific
delivery
increase
therapeutic
efficacy
formulation.
The
mannose-functionalized
carrier
(Man-INH-NLC)
formulation
was
evaluated
respect
various
parameters,
namely,
encapsulation
efficiency
(EE),
loading
(DL),
average
particle
size
(PS),
zeta
potential
(ZP),
polydispersity
index
(PDI),
in
vitro
release
(DR),
kinetics.
inhalation
behavior
after
nebulization
investigated
using
an
Andersen
cascade
impactor
estimation
mass
median
aerosolized
diameter
(MMAD)
geometric
aerodynamic
(GAD)
subsequently
found
be
suitable
for
effective
lung
delivery.
An
vivo
pharmacokinetic
study
carried
out
a
guinea
pig
animal
model,
it
demonstrated
that
Man-INH-NLC
has
longer
improved
pharmacokinetics
when
compared
unfunctionalized
INH-NLC,
indicating
enhanced
Histopathological
analysis
led
us
determine
extent
tissue
damage
more
severe
case
pure
solution
nebulization.
Thus,
safe,
forming
sound
basis
enhancing
management
treatment
pulmonary
Saudi Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
31(9), P. 101727 - 101727
Published: Aug. 2, 2023
In
the
past,
curcumin
was
go-to
medication
for
diabetes,
but
recent
studies
have
shown
that
tetrahydrocurcumin
is
more
effective.
The
problem
it's
not
very
soluble
in
water
or
bioavailable.
So,
our
research
aims
to
increase
bioavailability
and
anti-diabetic
efficacy
of
streptozotocin-induced
diabetic
rats
by
synthesizing
tetrahydrocurcumin-loaded
solid
lipid
nanoparticles.
Box
Behnken
Design
employed
optimization
nanoparticles
(THC-SLNs).
optimal
formulation
determined
doing
an
ANOVA
examine
relationship
between
independent
variables
(drug-to-lipid
ratio,
surfactant
concentration,
co-surfactant
concentration)
dependent
(particle
size,
percent
entrapment
efficiency,
PDI).
Particle
PDI,
efficiency
all
showed
statistical
significance
based
on
F-values
p-values.
optimized
batch
prepared
using
a
drug-to-lipid
ratio
(1:4.16),
1.21%
concentration
surfactant,
0.4775%
(observed
with
particle
size
147.1
nm,
83.58
±
0.838
%
0.265
values
were
found
close
predicted
ones.
As
THC
peak
vanishes
from
DSC
thermogram
improved
formulation,
this
indicates
drug
has
been
transformed
its
crystalline
form
into
amorphous
state.
TEM
analysis
demonstrated
mono-dispersed
particles
average
145
nm
which
are
closely
related
zetasizer's
results.
In-vitro
release
study
burst
followed
sustained
up
71.04%
throughout
24
hrs.
Increased
adjusted
THC-SLN
vivo
pharmacokinetics
9.47
folds
higher
AUC(0-t)
compared
plain
THC-suspension.
Additionally,
pharmacodynamic
experiments
marked
decrease
blood
glucose
level
63.7%
increased
body
weight
195.8
7.223
231.2
7.653
28th
day
better
effect
than
suspension.
Results
stability
revealed
can
be
stored
longer
periods
at
room
temperature.
Tetrahydrocurcumin
effectively
administered
SLN
treatment
diabetes.
Processes,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2698 - 2698
Published: Sept. 9, 2023
This
research
presents
a
straightforward,
effective,
and
eco-friendly
method
for
the
production
of
silver
nanoparticles
(AgNPs)
copper
oxide
(CuONPs)
using
dried
fruit
Amomum
subulatum
as
reducing,
stabilizing,
capping
agent.
The
formation
AgNPs
CuONPs
is
supported
by
presence
surface
plasmon
resonance
band
(SPR)
at
440
nm
245
CuONPs.
Additionally,
identification
specific
biomolecules
responsible
synthesis
was
confirmed
through
FTIR
spectra
analysis.
Transmission
electron
microscope
(TEM)
images
demonstrated
that
had
spherical
shapes,
with
mean
particle
diameters
20.6
24.7
nm,
respectively.
X-ray
diffraction
selected
area
(SAED)
analyses
provided
evidence
crystalline
nature
synthesized
elements
observed
energy-dispersive
spectroscopy
(EDS)
Furthermore,
antibacterial
activity
found
to
be
superior
against
human
pathogens
such
Escherichia
coli,
Staphylococcus
aureus,
Bacillus
subtilis.
cytotoxic
biosynthesized
(NPs)
evaluated
in
vitro
cervical
cells
(HeLa)
breast
(MCF-7).
In
MCF-7
cells,
IC50
value
estimated
39.79
µg/mL,
while
83.89
µg/mL.
HeLa
45.5
CuONPs,
it
97.07
For
first
time,
an
from
extract
has
been
discussed
along
their
comparative
evaluation
study.
These
results
highlight
promising
applications
effective
agents
microbial
infections
potential
candidates
cancer
therapy.
Nanomedicine,
Journal Year:
2023,
Volume and Issue:
18(4), P. 303 - 315
Published: Feb. 1, 2023
Aims:
To
evaluate
the
role
of
nanoparticles
(NP)
in
sputum
samples
active
smokers
as
markers
inflammation
and
disease.
Materials
&
methods:
29
were
included
(14
with
chronic
obstructive
pulmonary
disease
[COPD])
underwent
clinical
assessment,
function
tests,
induction
(with
NP
analysis)
blood
sampling.
Results:
Higher
particle
concentrations
smaller
mean
size
directly
correlated
parameters
such
COPD
Assessment
Test
score
impulse
oscillometry
results.
Similar
correlations
found
between
NPs
increased
IL-1β,
IL-6
TNF-α.
Among
patients,
higher
IL-8
lower
IL-10
serum
levels
also
concentrations.
Conclusion:
This
proof-of-concept
study
shows
potential
airway
