Diabetologia,
Journal Year:
2020,
Volume and Issue:
63(11), P. 2359 - 2371
Published: Sept. 7, 2020
The
aim
of
this
study
was
to
use
Mendelian
randomisation
(MR)
identify
the
causal
risk
factors
for
type
2
diabetes.We
first
conducted
a
review
meta-analyses
and
articles
pinpoint
possible
diabetes.
Around
170
were
identified
which
97
with
available
genetic
instrumental
variables
included
in
MR
analyses.
To
reveal
more
that
not
our
analyses,
we
published
studies
For
used
summary-level
data
from
DIAbetes
Genetics
Replication
And
Meta-analysis
consortium
(74,124
diabetes
cases
824,006
controls
European
ancestry).
Potential
associations
replicated
using
FinnGen
(11,006
82,655
inverse-variance
weighted
method
as
main
analysis.
Multivariable
analysis
assess
whether
observed
mediated
by
BMI.
We
Benjamini-Hochberg
false
discovery
rate
multiple
testing.We
found
evidence
between
34
exposures
(19
15
protective
factors)
Insomnia
novel
factor
(OR
1.17
[95%
CI
1.11,
1.23]).
other
18
depression,
systolic
BP,
smoking
initiation,
lifetime
smoking,
coffee
(caffeine)
consumption,
plasma
isoleucine,
valine
leucine,
liver
alanine
aminotransferase,
childhood
adulthood
BMI,
body
fat
percentage,
visceral
mass,
resting
heart
rate,
four
fatty
acids.
associated
decreased
alanine,
HDL-
total
cholesterol,
age
at
menarche,
testosterone
levels,
sex
hormone
binding
globulin
levels
(adjusted
BMI),
birthweight,
height,
lean
mass
(for
women),
acids,
circulating
25-hydroxyvitamin
D
education
years.
Eight
remained
after
adjustment
additionally
21
suggestive
(p
<
0.05),
such
alcohol
breakfast
skipping,
daytime
napping,
short
sleep,
urinary
sodium,
certain
amino
acids
inflammatory
factors.The
present
verified
several
previously
reported
potential
Prevention
strategies
should
be
considered
perspectives
on
obesity,
mental
health,
sleep
quality,
level,
birthweight
smoking.
Circulation Research,
Journal Year:
2016,
Volume and Issue:
118(11), P. 1723 - 1735
Published: May 26, 2016
Obesity
and
diabetes
mellitus
have
reached
epidemic
proportions
in
the
past
few
years.
During
2011
to
2012,
more
than
one-third
of
US
population
was
obese.
Although
recent
trend
data
indicate
that
has
leveled
off,
prevalence
abdominal
obesity
continues
rise,
especially
among
adults.
As
seen
for
obesity,
decades
a
doubling
incidence
with
an
increasing
number
type
2
cases
being
diagnosed
children.
Significant
racial
ethnic
disparities
exist
trends
mellitus.
In
general,
both
adults
children,
non-Hispanic
blacks
Mexican
Americans
seem
be
at
high
risk
their
white
counterparts.
Secular
changes
agricultural
policies,
diet,
food
environment,
physical
activity,
sleep
all
contributed
upward
diabesity
epidemic.
Despite
marginal
improvements
activity
environment
changed
drastically
obesogenic
one
increased
portion
sizes
limited
access
healthy
choices
disadvantaged
populations.
Interventions
improve
are
critical
as
raise
cardiovascular
disease
by
≈2-fold.
Among
those
mellitus,
significant
sex
differences
occur
such
completely
eliminates
or
attenuates
advantages
female.
Given
substantial
burden
future
research
efforts
should
adopt
translational
approach
find
sustainable
holistic
solutions
preventing
these
costly
diseases.
SLEEP,
Journal Year:
2015,
Volume and Issue:
38(8), P. 1161 - 1183
Published: July 31, 2015
The
American
Academy
of
Sleep
Medicine
and
Research
Society
recently
released
a
Consensus
Statement
regarding
the
recommended
amount
sleep
to
promote
optimal
health
in
adults.
This
paper
describes
methodology,
background
literature,
voting
process,
results
for
consensus
statement.
In
addition,
we
address
important
assumptions
challenges
encountered
during
process.
Finally,
outline
future
directions
that
will
advance
our
understanding
need
place
duration
broader
context
health.
Sleep Medicine Reviews,
Journal Year:
2017,
Volume and Issue:
39, P. 25 - 36
Published: July 4, 2017
We
examined
the
dose–response
relationship
between
long
sleep
duration
and
health
outcomes
including
mortality
incidence
of
diabetes
mellitus,
hypertension,
cardiovascular
diseases,
stroke,
coronary
heart
obesity,
depression
dyslipidemia.
collected
data
from
5,134,036
participants
137
prospective
cohort
studies.
For
independent
variable,
we
categorized
at
baseline
as
having
or
normal
duration.
Risk
ratios
(RRs)
for
incident
conditions
during
follow-up
were
calculated
through
meta-analyses
adjusted
individual
Meta-regression
analyses
performed
to
investigate
association
each
outcome
specific
thresholds
sleep.
Long
was
significantly
associated
with
(RR,
1.39;
95%
CI,
1.31–1.47),
mellitus
(1.26,
1.11–1.43),
disease
(1.25,
1.14–1.37),
stroke
(1.46,
1.26–1.69),
(1.24,
1.13–1.37),
obesity
(1.08,
1.02–1.15).
not
related
hypertension
(1.01,
0.95–1.07).
Insufficient
available
found
statistically
significant
linear
associations
longer
increased
disease.
Future
studies
should
address
whether
is
causal
modifiable.
BMC Medicine,
Journal Year:
2017,
Volume and Issue:
15(1)
Published: July 4, 2017
Environmental
and
lifestyle
changes,
in
addition
to
the
ageing
of
populations,
are
generally
believed
account
for
rapid
global
increase
type
2
diabetes
prevalence
incidence
recent
decades.
In
this
review,
we
present
a
comprehensive
overview
factors
contributing
risk,
including
aspects
diet
quality
quantity,
little
physical
activity,
increased
monitor
viewing
time
or
sitting
general,
exposure
noise
fine
dust,
short
disturbed
sleep,
smoking,
stress
depression,
low
socioeconomic
status.
these
promote
an
body
mass
index.
Since
loss
β-cell
function
is
ultimate
cause
developing
overt
diabetes,
environmental
changes
must
have
resulted
higher
risk
damage
those
at
genetic
risk.
Multiple
mechanistic
pathways
may
come
into
play.
Strategies
prevention
should
aim
promoting
'diabetes-protective
lifestyle'
whilst
simultaneously
enhancing
resistance
human
organism
pro-diabetic
factors.
More
research
on
diabetes-protective
mechanisms
seems
warranted.
Endocrine Reviews,
Journal Year:
2016,
Volume and Issue:
37(6), P. 584 - 608
Published: Oct. 20, 2016
Abstract
Circadian
(∼24-hour)
timing
systems
pervade
all
kingdoms
of
life
and
temporally
optimize
behavior
physiology
in
humans.
Relatively
recent
changes
to
our
environments,
such
as
the
introduction
artificial
lighting,
can
disorganize
circadian
system,
from
level
molecular
clocks
that
regulate
cellular
activities
synchronization
between
daily
cycles
solar
day.
Sleep/wake
are
intertwined
with
global
trends
indicate
these,
too,
increasingly
subject
disruption.
A
large
proportion
world's
population
is
at
increased
risk
environmentally
driven
rhythm
sleep
disruption,
a
minority
individuals
also
genetically
predisposed
misalignment
disorders.
The
consequences
disruption
system
profound
include
myriad
metabolic
ramifications,
some
which
may
be
compounded
by
adverse
effects
on
dietary
choices.
If
not
addressed,
deleterious
will
continue
cause
widespread
health
problems;
therefore,
implementation
numerous
behavioral
pharmaceutical
interventions
help
restore
alignment
enhance
important.
Journal of the American Heart Association,
Journal Year:
2017,
Volume and Issue:
6(9)
Published: Sept. 10, 2017
Background
Effects
of
extreme
sleep
duration
on
risk
mortality
and
cardiovascular
outcomes
remain
controversial.
We
aimed
to
quantify
the
dose‐response
relationships
with
all‐cause
mortality,
total
disease,
coronary
heart
stroke.
Methods
Results
PubMed
Embase
were
systematically
searched
for
prospective
cohort
studies
published
before
December
1,
2016,
that
examined
associations
between
at
least
1
4
in
generally
healthy
populations.
U‐shaped
indicated
all
outcomes,
lowest
observed
≈7‐hour
per
day,
which
was
varied
little
by
sex.
For
when
<7
hours
pooled
relative
(RR)
1.06
(95%
CI
,
1.04–1.07)
1‐hour
reduction;
>7
RR
1.13
1.11–1.15)
increment.
1.03–1.08)
reduction
1.12
1.08–1.16)
increment
duration.
1.07
1.03–1.12)
1.05
1.00–1.10)
stroke,
1.01–1.09)
1.18
1.14–1.21)
Conclusions
Our
findings
indicate
both
short
long
is
associated
an
increased
events.
RAND Corporation eBooks,
Journal Year:
2016,
Volume and Issue:
unknown
Published: Jan. 1, 2016
The
Centers
for
Disease
Control
and
Prevention
(CDC)
in
the
United
States
has
declared
insufficient
sleep
a
"public
health
problem."
Indeed,
according
to
recent
CDC
study,
more
than
third
of
American
adults
are
not
getting
enough
on
regular
basis.
However,
is
exclusively
US
problem,
equally
concerns
other
industrialised
countries
such
as
Kingdom,
Japan,
Germany,
or
Canada.
According
some
evidence,
proportion
people
sleeping
less
recommended
hours
rising
associated
with
lifestyle
factors
related
modern
24/7
society,
psychosocial
stress,
alcohol
consumption,
smoking,
lack
physical
activity
excessive
electronic
media
use,
among
others.
This
alarming
been
found
be
range
negative
social
outcomes,
including
success
at
school
labour
market.
Over
last
few
decades,
example,
there
growing
evidence
suggesting
strong
association
between
short
duration
elevated
mortality
risks.
Given
potential
adverse
effects
health,
well-being
productivity,
consequences
sleep-deprivation
have
far-reaching
economic
consequences.
Hence,
order
raise
awareness
scale
public-health
issue,
comparative
quantitative
figures
need
provided
policy-
decision-makers,
well
recommendations
solutions
that
can
help
tackling
problem.