An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study DOI Creative Commons
Shuai Yuan, Susanna C. Larsson

Diabetologia, Journal Year: 2020, Volume and Issue: 63(11), P. 2359 - 2371

Published: Sept. 7, 2020

The aim of this study was to use Mendelian randomisation (MR) identify the causal risk factors for type 2 diabetes.We first conducted a review meta-analyses and articles pinpoint possible diabetes. Around 170 were identified which 97 with available genetic instrumental variables included in MR analyses. To reveal more that not our analyses, we published studies For used summary-level data from DIAbetes Genetics Replication And Meta-analysis consortium (74,124 diabetes cases 824,006 controls European ancestry). Potential associations replicated using FinnGen (11,006 82,655 inverse-variance weighted method as main analysis. Multivariable analysis assess whether observed mediated by BMI. We Benjamini-Hochberg false discovery rate multiple testing.We found evidence between 34 exposures (19 15 protective factors) Insomnia novel factor (OR 1.17 [95% CI 1.11, 1.23]). other 18 depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine leucine, liver alanine aminotransferase, childhood adulthood BMI, body fat percentage, visceral mass, resting heart rate, four fatty acids. associated decreased alanine, HDL- total cholesterol, age at menarche, testosterone levels, sex hormone binding globulin levels (adjusted BMI), birthweight, height, lean mass (for women), acids, circulating 25-hydroxyvitamin D education years. Eight remained after adjustment additionally 21 suggestive (p < 0.05), such alcohol breakfast skipping, daytime napping, short sleep, urinary sodium, certain amino acids inflammatory factors.The present verified several previously reported potential Prevention strategies should be considered perspectives on obesity, mental health, sleep quality, level, birthweight smoking.

Language: Английский

Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression DOI
Osamu Itani, Maki Jike, Norio Watanabe

et al.

Sleep Medicine, Journal Year: 2016, Volume and Issue: 32, P. 246 - 256

Published: Sept. 2, 2016

Language: Английский

Citations

994

Epidemiology of Obesity and Diabetes and Their Cardiovascular Complications DOI Open Access
Shilpa N. Bhupathiraju, Frank B. Hu

Circulation Research, Journal Year: 2016, Volume and Issue: 118(11), P. 1723 - 1735

Published: May 26, 2016

Obesity and diabetes mellitus have reached epidemic proportions in the past few years. During 2011 to 2012, more than one-third of US population was obese. Although recent trend data indicate that has leveled off, prevalence abdominal obesity continues rise, especially among adults. As seen for obesity, decades a doubling incidence with an increasing number type 2 cases being diagnosed children. Significant racial ethnic disparities exist trends mellitus. In general, both adults children, non-Hispanic blacks Mexican Americans seem be at high risk their white counterparts. Secular changes agricultural policies, diet, food environment, physical activity, sleep all contributed upward diabesity epidemic. Despite marginal improvements activity environment changed drastically obesogenic one increased portion sizes limited access healthy choices disadvantaged populations. Interventions improve are critical as raise cardiovascular disease by ≈2-fold. Among those mellitus, significant sex differences occur such completely eliminates or attenuates advantages female. Given substantial burden future research efforts should adopt translational approach find sustainable holistic solutions preventing these costly diseases.

Language: Английский

Citations

793

Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion DOI Open Access
Nathaniel F. Watson, M. Safwan Badr, Gregory Belenky

et al.

SLEEP, Journal Year: 2015, Volume and Issue: 38(8), P. 1161 - 1183

Published: July 31, 2015

The American Academy of Sleep Medicine and Research Society recently released a Consensus Statement regarding the recommended amount sleep to promote optimal health in adults. This paper describes methodology, background literature, voting process, results for consensus statement. In addition, we address important assumptions challenges encountered during process. Finally, outline future directions that will advance our understanding need place duration broader context health.

Language: Английский

Citations

702

Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression DOI Creative Commons
Maki Jike, Osamu Itani, Norio Watanabe

et al.

Sleep Medicine Reviews, Journal Year: 2017, Volume and Issue: 39, P. 25 - 36

Published: July 4, 2017

We examined the dose–response relationship between long sleep duration and health outcomes including mortality incidence of diabetes mellitus, hypertension, cardiovascular diseases, stroke, coronary heart obesity, depression dyslipidemia. collected data from 5,134,036 participants 137 prospective cohort studies. For independent variable, we categorized at baseline as having or normal duration. Risk ratios (RRs) for incident conditions during follow-up were calculated through meta-analyses adjusted individual Meta-regression analyses performed to investigate association each outcome specific thresholds sleep. Long was significantly associated with (RR, 1.39; 95% CI, 1.31–1.47), mellitus (1.26, 1.11–1.43), disease (1.25, 1.14–1.37), stroke (1.46, 1.26–1.69), (1.24, 1.13–1.37), obesity (1.08, 1.02–1.15). not related hypertension (1.01, 0.95–1.07). Insufficient available found statistically significant linear associations longer increased disease. Future studies should address whether is causal modifiable.

Language: Английский

Citations

616

Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes DOI Creative Commons
Hubert Kolb, Stéphan Martin

BMC Medicine, Journal Year: 2017, Volume and Issue: 15(1)

Published: July 4, 2017

Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed account for rapid global increase type 2 diabetes prevalence incidence recent decades. In this review, we present a comprehensive overview factors contributing risk, including aspects diet quality quantity, little physical activity, increased monitor viewing time or sitting general, exposure noise fine dust, short disturbed sleep, smoking, stress depression, low socioeconomic status. these promote an body mass index. Since loss β-cell function is ultimate cause developing overt diabetes, environmental changes must have resulted higher risk damage those at genetic risk. Multiple mechanistic pathways may come into play. Strategies prevention should aim promoting 'diabetes-protective lifestyle' whilst simultaneously enhancing resistance human organism pro-diabetic factors. More research on diabetes-protective mechanisms seems warranted.

Language: Английский

Citations

584

Sleep, Health, and Society DOI
Michael A. Grandner

Sleep Medicine Clinics, Journal Year: 2016, Volume and Issue: 12(1), P. 1 - 22

Published: Dec. 20, 2016

Language: Английский

Citations

582

Circadian clocks and insulin resistance DOI
Dirk Jan Stenvers, Frank A. J. L. Scheer, Patrick Schrauwen

et al.

Nature Reviews Endocrinology, Journal Year: 2018, Volume and Issue: 15(2), P. 75 - 89

Published: Dec. 7, 2018

Language: Английский

Citations

560

Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures DOI Creative Commons
Gregory D. Potter, Debra J. Skene, Joséphine Arendt

et al.

Endocrine Reviews, Journal Year: 2016, Volume and Issue: 37(6), P. 584 - 608

Published: Oct. 20, 2016

Abstract Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior physiology in humans. Relatively recent changes to our environments, such as the introduction artificial lighting, can disorganize circadian system, from level molecular clocks that regulate cellular activities synchronization between daily cycles solar day. Sleep/wake are intertwined with global trends indicate these, too, increasingly subject disruption. A large proportion world's population is at increased risk environmentally driven rhythm sleep disruption, a minority individuals also genetically predisposed misalignment disorders. The consequences disruption system profound include myriad metabolic ramifications, some which may be compounded by adverse effects on dietary choices. If not addressed, deleterious will continue cause widespread health problems; therefore, implementation numerous behavioral pharmaceutical interventions help restore alignment enhance important.

Language: Английский

Citations

557

Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies DOI Creative Commons
Jiawei Yin,

Xiaoling Jin,

Zhilei Shan

et al.

Journal of the American Heart Association, Journal Year: 2017, Volume and Issue: 6(9)

Published: Sept. 10, 2017

Background Effects of extreme sleep duration on risk mortality and cardiovascular outcomes remain controversial. We aimed to quantify the dose‐response relationships with all‐cause mortality, total disease, coronary heart stroke. Methods Results PubMed Embase were systematically searched for prospective cohort studies published before December 1, 2016, that examined associations between at least 1 4 in generally healthy populations. U‐shaped indicated all outcomes, lowest observed ≈7‐hour per day, which was varied little by sex. For when <7 hours pooled relative (RR) 1.06 (95% CI , 1.04–1.07) 1‐hour reduction; >7 RR 1.13 1.11–1.15) increment. 1.03–1.08) reduction 1.12 1.08–1.16) increment duration. 1.07 1.03–1.12) 1.05 1.00–1.10) stroke, 1.01–1.09) 1.18 1.14–1.21) Conclusions Our findings indicate both short long is associated an increased events.

Language: Английский

Citations

550

Why sleep matters -- the economic costs of insufficient sleep: A cross-country comparative analysis DOI Open Access
Marco Hafner, Martin Štěpánek,

Jirka Taylor

et al.

RAND Corporation eBooks, Journal Year: 2016, Volume and Issue: unknown

Published: Jan. 1, 2016

The Centers for Disease Control and Prevention (CDC) in the United States has declared insufficient sleep a "public health problem." Indeed, according to recent CDC study, more than third of American adults are not getting enough on regular basis. However, is exclusively US problem, equally concerns other industrialised countries such as Kingdom, Japan, Germany, or Canada. According some evidence, proportion people sleeping less recommended hours rising associated with lifestyle factors related modern 24/7 society, psychosocial stress, alcohol consumption, smoking, lack physical activity excessive electronic media use, among others. This alarming been found be range negative social outcomes, including success at school labour market. Over last few decades, example, there growing evidence suggesting strong association between short duration elevated mortality risks. Given potential adverse effects health, well-being productivity, consequences sleep-deprivation have far-reaching economic consequences. Hence, order raise awareness scale public-health issue, comparative quantitative figures need provided policy- decision-makers, well recommendations solutions that can help tackling problem.

Language: Английский

Citations

549