G protein-coupled receptor (GPCR) pharmacogenomics DOI Creative Commons
Miles D. Thompson, David Reiner‐Link, Alessandro Berghella

et al.

Critical Reviews in Clinical Laboratory Sciences, Journal Year: 2024, Volume and Issue: 61(8), P. 641 - 684

Published: Aug. 9, 2024

The field of pharmacogenetics, the investigation influence one or more sequence variants on drug response phenotypes, is a special case pharmacogenomics, discipline that takes genome-wide approach. Massively parallel, next generation sequencing (NGS), has allowed pharmacogenetics to be subsumed by pharmacogenomics with respect identification associated responders and non-responders, optimal response, adverse reactions. A plethora rare common naturally-occurring GPCR must considered in context signals from across genome. Many fundamentals were established for G protein-coupled receptor (GPCR) genes because they are primary targets large number therapeutic drugs. Functional studies, demonstrating likely-pathogenic pathogenic variants, have been integral establishing models used

Language: Английский

Cannabis Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain DOI Creative Commons
Giuseppina Crescente, Giuseppe Minervini, Carmela Spagnuolo

et al.

Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 106 - 106

Published: Dec. 23, 2022

The management of orofacial pain to alleviate the quality life affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition conventional therapies, new alternatives are being sought, looking at use both natural synthetic products. Cannabis sativa L. represents an interesting source bioactive compounds, including non-psychoactive cannabinoids, flavonoids, terpenes, many which effective improving intensity. Here, we aim analyze possible mechanisms action hemp-derived compounds responsible modulatory effects on pain-related pathways. ability these act multiple through a synergistic effect, reducing release inflammatory mediators regulating response endocannabinoid system, makes them agents alternative formulations be used pain.

Language: Английский

Citations

50
New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in CNS Disorders DOI Open Access
Berhanu Geresu Kibret, Hiroki Ishiguro, Yasue Horiuchi

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 975 - 975

Published: Jan. 17, 2022

The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved the regulation of mental health. Consequently, its dysregulation associated with neuropsychiatric neurodegenerative disorders. Together, ECS expanded endocannabinoidome (eCBome) are composed genes coding for CB1 CB2 cannabinoid receptors (CB1R, CB2R), endocannabinoids (eCBs), metabolic enzyme machinery their synthesis catabolism. activation CB1R adverse effects on central nervous (CNS), which has limited therapeutic use drugs that bind this receptor. discovery functional neuronal CB2R raised new possibilities potential safe targeting treatment CNS Previous studies were not able to detect mRNA transcripts brain tissue suggested CB2Rs absent considered peripheral receptors. Studies done role as a target treating different disorders revealed important putative certain disorders, requires further clinical validation. This review addresses recent advances including, but to, anxiety, depression, schizophrenia, Parkinson’s disease (PD), Alzheimer’s (AD), Huntington’s (HD) addiction.

Language: Английский

Citations

46
The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update DOI Creative Commons

Volatiana Rakotoarivelo,

Thomas Z. Mayer,

Mélissa Simard

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(14), P. 3381 - 3381

Published: July 18, 2024

The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat disorders such as rheumatism or gout. Since the characterization cannabinoid receptors, CB

Language: Английский

Citations

11
Escitalopram reverses anxiety-like and despair behavior and affects endocannabinoid-related genes expression in the brain of adolescent male rats subjected to early life stress DOI Creative Commons

Jonasz Dragon,

Miłosz Gołyszny, Michał Zieliński

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 96 - 108

Published: Jan. 5, 2025

Language: Английский

Citations

1
Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review DOI Creative Commons
Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 22, 2021

Inflammatory bowel disease (IBD) is a general term used to describe group of chronic inflammatory conditions the gastrointestinal tract unknown etiology, including two primary forms: Crohn's (CD) and ulcerative colitis (UC). The endocannabinoid system (ECS) plays an important role in modulating many physiological processes intestinal homeostasis, modulation motility, visceral sensation, or immunomodulation inflammation IBD. It consists cannabinoid receptors (CB1 CB2), transporters for cellular uptake ligands, endogenous bioactive lipids (Anandamide 2-arachidonoylglycerol), enzymes responsible their synthesis degradation (fatty acid amide hydrolase monoacylglycerol lipase), manipulation which through agonists antagonists system, shows potential therapeutic ECS disease. This review summarizes components on inflammation, suggesting advantages cannabinoid-based therapies

Language: Английский

Citations

53
Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review DOI Creative Commons
Katia Pane, Serena Boccella, Francesca Guida

et al.

Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 170, P. 105773 - 105773

Published: May 25, 2022

Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study systematically identified preclinical studies aimed to investigate the possible gut contribution neuropathy and neuropathic pain. The systematic review is reported accordance with PRISMA checklist guidelines outlined updated 2020. We included research articles reporting neuropathy-related behavioral evaluations and/or neurological scores coupled analysis performed by high-throughput technologies last ten years. Two investigators a search through 3 electronic bibliographic databases for full-text (PubMed, Scopus, EMBASE) three registries (Prospero, SyRF, bioRxiv), cross-references, linear searches. assessed methodological quality via CAMARADES appraised heterogeneous body of evidence narrative synthesis. In total, there were 19 eligible studies. most these reports showed significant changes setting conditions. major microbiome remodeling was fecal transplantation. Mechanistic proof gut-CNS communication achieved measuring inflammatory mediators, metabolic products, or neurotransmitters. As limitation, we found considerable heterogeneity across conclude that current understanding findings suggested an association between pain modifications. provides basis further targeting managing symptoms other neuroinflammation-based CNS protocol registered on international database Prospero under registration number (257628).

Language: Английский

Citations

34
Cannabidiol for the treatment of autism spectrum disorder: hope or hype? DOI
João Francisco Cordeiro Pedrazzi, Frederico Rogério Ferreira, Danyelle Silva-Amaral

et al.

Psychopharmacology, Journal Year: 2022, Volume and Issue: 239(9), P. 2713 - 2734

Published: July 29, 2022

Language: Английский

Citations

32
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks DOI
Gerwyn Morris, Ken Walder, Stefan Kloiber

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 170, P. 105729 - 105729

Published: June 11, 2021

Language: Английский

Citations

33
(Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders DOI Creative Commons
Jyoti Sihag, Vincenzo Di Marzo

Lipids in Health and Disease, Journal Year: 2022, Volume and Issue: 21(1)

Published: Jan. 13, 2022

Abstract The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. diet modulates these bioactive lipids gut microbiome, both working in an entwined alliance. Mounting evidence suggests that, different ways a certain specialisation, signalling such as N -acylethanolamines (NAEs), 2-monoacylglycerols (2-MAGs), -acyl-amino acids (NAAs), along endocannabinoids (eCBs), can modulate physiological mechanisms underpinning appetite, food intake, macronutrient metabolism, pain sensation, blood pressure, mood, cognition, immunity. This knowledge has been primarily utilised pharmacology medicine develop many drugs targeting fine specific molecular pathways orchestrating eCB eCBome activity. Conversely, contribution dietary NAEs, 2-MAGs eCBs biological functions molecules little studied. In this review, we discuss importance (Wh) olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N) utrition (WHEN), management obesity related disorders.

Language: Английский

Citations

24
Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation DOI Creative Commons
Berhanu Geresu Kibret, Ana Canseco-Alba, Emmanuel S. Onaivi

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 16, 2023

Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)-“endocannabinoidome”, consists of endogenous ligands, eCBs, their canonical non-canonical receptor subtypes, synthesizing metabolizing enzymes. This modulates a wide range body functions acts as retrograde signaling within central nervous (CNS) by inhibition classical transmitters, plays vital modulatory function on dopamine, major neurotransmitter in CNS. Dopamine is involved different behavioral processes contributes to brain disorders—including Parkinson’s disease, schizophrenia, drug addiction. After synthesis neuronal cytosol, dopamine packaged into synaptic vesicles until released extracellular signals. Calcium dependent activation results vesicular release interacts with systems. The ECS, among others, regulation interaction occurs either through direct or indirect mechanisms. cross-talk between ECS dopaminergic has important influence various dopamine-related neurobiological pathologic conditions investigating this might help identify therapeutic targets options disorders CNS associated dysregulation.

Language: Английский

Citations

15