Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering realize biologically-active and/or cell-containing living layers at the tissue-device that enable seamless biointegration novel cell-mediated therapeutic opportunities. This review maps field of electronics discusses key recent developments in tissue-like regenerative bioelectronics, from biomaterials surface-functionalized bioactive coatings 'biohybrid' 'all-living' interfaces. We define contextualize terminology this emerging highlight how biological components can bridge gap clinical translation.

Language: Английский

---

Nature-Inspired Surface Modification Strategies for Implantable Devices

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101615 - 101615

Published: Feb. 25, 2025

Language: Английский

---

Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications

Materials Horizons, Journal Year: 2022, Volume and Issue: 9(7), P. 1850 - 1865

Published: Jan. 1, 2022

Exploring new avenues for clinical management of chronic wounds holds the key to eliminating socioeconomic burdens and health-related concerns associated with this silent killer. Engineered biomaterials offer great promise repair regeneration because their ability deliver therapeutics, protect wound environment, support skin matrices facilitate tissue growth. This mini review presents recent advances in biomaterial functionalities enhancing healing demonstrates a move from sub-optimal methods multi-functionalized treatment approaches. In context, we discuss recently reported characteristics such as bioadhesiveness, antimicrobial properties, proangiogenic attributes, anti-inflammatory properties that promote healing. addition, highlight necessary mechanical mass transport biomaterials. Then, characteristic various templates, including hydrogels, cryogels, nanomaterials, biomolecule-functionalized materials. These can be microfabricated into structures, smart patches, microneedles, electrospun scaffolds, 3D-bioprinted advance field scaffolds effective Finally, provide an outlook on future while emphasizing need detailed functional behaviour inflammatory response studies complex vivo environment superior outcomes reduced regulatory hurdles.

Language: Английский

---

Corrosion in Mg-alloy biomedical implants- the strategies to reduce the impact of the corrosion inflammatory reaction and microbial activity

Journal of Magnesium and Alloys, Journal Year: 2022, Volume and Issue: 10(12), P. 3306 - 3326

Published: Dec. 1, 2022

The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure be caused by variety factors, the are peri‑implant infection (or implant-related infection), excessive inflammatory response pain aseptic loosening. Orthopedic surgeons now have options treating these issues, including revision surgery, has demonstrated to effective. If reaction corrosion avoided, it will enormous social benefits. This review provide summary inflammation reactions due antimicrobial properties Mg alloy-based implants covering both vitro vivo studies. strategies on hindering/overcoming enhancing activity discussed this review.

Language: Английский

---

Carbon Nanotube and Its Derived Nanomaterials Based High Performance Biosensing Platform

Biosensors, Journal Year: 2022, Volume and Issue: 12(9), P. 731 - 731

Published: Sept. 6, 2022

After the COVID-19 pandemic, development of an accurate diagnosis and monitoring diseases became a more important issue. In order to fabricate high-performance sensitive biosensors, many researchers scientists have used kinds nanomaterials such as metal nanoparticles (NPs), oxide NPs, quantum dots (QDs), carbon including graphene nanotubes (CNTs). Among them, CNTs been considered biosensing channel candidates due their excellent physical properties high electrical conductivity, strong mechanical properties, plasmonic so on. Thus, in this review, CNT-based systems are introduced various sensing approaches electrochemical, optical, methods reported. Moreover, platforms showed sensitivity selectivity against not only viruses but also virus DNA structures. So, based on amazing potential CNTs-based systems, healthcare public health can be significantly improved.

Language: Английский

---

In vitro evaluation of the biodegradability of chitosan–genipin hydrogels

Materials Advances, Journal Year: 2022, Volume and Issue: 3(21), P. 7946 - 7959

Published: Jan. 1, 2022

Lysozyme hydrolyses β-(1,4) linkages between d -glucosamine and N -acetyl- units in chitosan, degrades one of the bifunctional crosslinks chitosan–genipin hydrogels. Degraded particles have potential to be renally excreted vivo .

Language: Английский

---

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Materials, Journal Year: 2023, Volume and Issue: 16(12), P. 4267 - 4267

Published: June 8, 2023

This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials fundamental components in tissue engineering (TE) scaffolds play critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, non-toxicity, ensure ability function effectively with an host response. With ongoing research advancements medical implants, objective this review is explore recently developed implantable scaffold materials The categorization paper includes fossil-based (e.g., PCL, PVA, PU, PEG, PPF), natural or bio-based HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, hydrogels), hybrid PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, PLA/bioceramics). these both hard soft TE considered, particular focus on physicochemical, mechanical, biological properties. Furthermore, interactions between immune system context scaffold-driven regeneration discussed. Additionally, briefly mentions concept situ TE, which leverages self-renewal capacities affected tissues highlights crucial role played by biopolymer-based strategy.

Language: Английский

---

Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges

APL Bioengineering, Journal Year: 2023, Volume and Issue: 7(3)

Published: Sept. 1, 2023

Implantable sensors have revolutionized the way we monitor biophysical and biochemical parameters by enabling real-time closed-loop intervention or therapy. These technologies align with new era of healthcare known as 5.0, which encompasses smart disease control detection, virtual care, intelligent health management, monitoring, decision-making. This review explores diverse biomedical applications implantable temperature, mechanical, electrophysiological, optical, electrochemical sensors. We delve into engineering principles that serve foundation for their development. also address challenges faced researchers designers in bridging gap between sensor research clinical adoption emphasizing importance careful consideration requirements challenges. highlight need future to explore issues such long-term performance, biocompatibility, power sources, well potential transform across multiple disciplines. It is evident immense field medical technology. However, remains wide, there are still major obstacles overcome before they can become a widely adopted part practice.

Language: Английский

---

Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics

Science Advances, Journal Year: 2023, Volume and Issue: 9(12)

Published: March 22, 2023

The development of neural interfaces with superior biocompatibility and improved tissue integration is vital for treating restoring neurological functions in the nervous system. A critical factor to increase resolution mapping neuronal inputs onto implants. For this purpose, we have developed a new category interface comprising induced pluripotent stem cell (iPSC)-derived myocytes as biological targets peripheral nerve that are grafted flexible electrode arrays. We show long-term survival functional biohybrid device carrying human iPSC-derived cells forearm bundle freely moving rats, following 4 weeks implantation. By improving tissue-electronics an intermediate layer, demonstrated enhanced electrical recording vivo first step toward restorative therapies using regenerative bioelectronics.

Language: Английский

---

Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(3)

Published: Jan. 10, 2023

Implants are widely used in medical applications and yet macrophage-mediated foreign body reactions caused by implants severely impact their therapeutic effects. Although the extensive use of multiple surface modifications has been introduced to provide some mitigation fibrosis, little is known about how macrophages recognize stiffness implant thus influence cell behaviors. Here, we demonstrated that macrophage sensing leads differential inflammatory activation, resulting different degrees fibrosis. The potential mechanism for early adhesion stages tends involve membrane deformations on substrates with stiffnesses. Combining theory experiments, show exert traction stress substrate through altered curvature, leading uneven distribution curvature-sensing protein Baiap2, cytoskeleton remodeling inflammation inhibition. This study introduces a physical model feedback cellular based deformation, offering perspectives future material design targeted therapies.

Language: Английский

---