Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(4), P. 228 - 228
Published: April 17, 2023
A
novel
type
of
porous
films
based
on
the
ZnO-incorporated
chitosan-poly(methacrylic
acid)
polyelectrolyte
complex
was
developed
as
a
wound
healing
material.
The
structure
established
by
Fourier-transform
infrared
spectroscopy
(FTIR),
X-ray
diffraction
(XRD),
and
energy
dispersive
(EDX)
analysis.
Scanning
electron
microscope
(SEM)
porosity
studies
revealed
that
pore
size
increased
with
increase
in
zinc
oxide
(ZnO)
concentration.
maximum
ZnO
content
exhibited
improved
water
swelling
degree
(1400%),
controlled
biodegradation
(12%)
for
28
days,
64%,
tensile
strength
0.47
MPa.
Moreover,
these
presented
antibacterial
activity
toward
Staphylococcus
aureus
Micrococcus
sp.
due
to
existence
particles.
Cytotoxicity
demonstrated
had
no
cytotoxicity
against
mouse
mesenchymal
stem
(C3H10T1/2)
cell
line.
These
results
reveal
could
be
used
an
ideal
material
application.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
263, P. 129858 - 129858
Published: Feb. 29, 2024
Tissue
engineering
(TE)
demands
scaffolds
that
have
the
necessary
resistance
to
withstand
mechanical
stresses
once
implanted
in
our
body,
as
well
excellent
biocompatibility.
Hydrogels
are
postulated
interesting
materials
for
this
purpose,
especially
those
made
from
biopolymers.
In
study,
microstructure
and
rheological
performance,
functional
biological
properties
of
chitosan
collagen
hydrogels
(CH/CG)
crosslinked
with
different
coupling
agents,
both
natural
such
d-Fructose
(F),
genipin
(G)
transglutaminase
(T)
synthetic,
using
a
combination
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
hydrochloride
N-hydroxysuccinimide
(EDC/NHS)
will
be
assessed.
FTIR
tests
were
carried
out
determine
if
proposed
crosslinking
reactions
each
agent
occurred
expected,
obtaining
positive
results
aspect.
Regarding
characterization
system,
two
main
trends
observed,
which
it
could
established
G
EDC-NHS
turned
more
effective
beneficial
than
other
producing
significant
improvements
respect
base
CH/CG
hydrogel.
addition,
vitro
demonstrated
potential
application
TE
these
systems,
G,
T
EDC-NHS.
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 194 - 194
Published: March 12, 2025
Honey
has
long
been
recognized
for
its
medicinal
properties,
particularly
in
wound
healing.
Recent
advancements
material
science
have
led
to
the
development
of
honey-containing
hydrogels,
combining
natural
healing
properties
honey
with
versatile
characteristics
hydrogel
matrices.
These
hydrogels
offer
numerous
advantages,
including
high
moisture
retention,
biocompatibility,
and
controlled
release
bioactive
compounds,
making
them
highly
effective
applications.
Hydrogels
hold
significant
potential
advancing
medical
applications,
cutaneous
injuries.
The
diverse
honey,
antimicrobial,
anti-inflammatory,
anti-eschar
effects,
shown
promise
accelerating
tissue
regeneration.
According
studies,
they
are
maintaining
a
good
swelling
ratio
index,
Water
Vapour
Transmission
Rate
(WVTR),
contact
angle,
tensile
elongation
at
break,
vitro
biodegradation
rate,
viscosity
porosity
analysis,
lowering
bacterial
infections,
encouraging
rapid
regeneration
notable
FTIR
peaks
SEM
average
pore
sizes.
However,
limitations
such
as
low
bioavailability
inefficiencies
direct
application
reduce
their
therapeutic
effectiveness
site.
Integrating
into
can
help
preserve
mechanisms
while
enhancing
ability
facilitate
skin
recovery.
This
review
explores
underlying
management
presents
an
extensive
analysis
reported
literature
over
past
eight
years.
It
emphasizes
physicochemical
mechanical
honey-incorporated
promoting
regeneration,
supported
by
evidence
from
both
vivo
studies.
While
honey-based
therapies
demonstrated
promising
outcomes
animal
clinical
studies
remain
limited.
Despite
that,
honey’s
incorporation
systems,
however,
offers
potent
fusion
contemporary
technology
qualities,
marking
substantial
breakthrough
treatment.
European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2024,
Volume and Issue:
200, P. 114326 - 114326
Published: May 15, 2024
Glioblastoma
(GBM)
is
a
highly
deadly
brain
tumor
that
does
not
respond
satisfactorily
to
conventional
treatment.
The
non-alkylating
agent
gemcitabine
(GEM)
has
been
proposed
for
treating
GBM.
It
can
overcome
MGMT
protein-mediated
resistance,
major
limitation
of
therapy
with
the
alkylating
temozolomide
(TMZ).
However,
GEM's
high
systemic
toxicity
and
poor
permeability
across
blood-brain
barrier
(BBB)
pose
significant
challenges
its
delivery
brain.
Thus,
mucoadhesive
poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
coated
chitosan
(CH),
suitable
intranasal
GEM
delivery,
were
in
this
work.
A
central
composite
design
(CCD)
was
implemented
NPs
optimization,
appropriate
characteristics
administration
obtained.
vitro
studies
revealed
possess
excellent
properties
ability
selectively
release
simulated
tissue
environment.
using
two
human
GBM
cell
lines
(U215
T98G)
NPs'
promote
antiproliferative
activity
sensitize
cells
effect
TMZ.
findings
work
demonstrate
developed
CH-GEM-NPs
are
systems
GEM,
both
as
single
chemosensitizer
gold
standard
therapy.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2482 - 2482
Published: May 27, 2023
The
prospective
applications
of
chitosan-based
hydrogels
(CBHs),
a
category
biocompatible
and
biodegradable
materials,
in
biomedical
disciplines
such
as
tissue
engineering,
wound
healing,
drug
delivery,
biosensing
have
garnered
great
interest.
synthesis
characterization
processes
used
to
create
CBHs
play
significant
role
determining
their
characteristics
effectiveness.
qualities
might
be
greatly
influenced
by
tailoring
the
manufacturing
method
get
certain
traits,
including
porosity,
swelling,
mechanical
strength,
bioactivity.
Additionally,
methods
aid
gaining
access
microstructures
properties
CBHs.
Herein,
this
review
provides
comprehensive
assessment
state-of-the-art
with
focus
on
affiliation
between
particular
domains
biomedicine.
Moreover,
highlights
beneficial
wide
application
stimuli-responsive
main
obstacles
prospects
for
future
CBH
development
are
also
covered
review.
