Probiotics for oral health: a critical evaluation of bacterial strains DOI Creative Commons
Rachelle E. Beattie

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: June 24, 2024

Oral health is critical for total body and well-being; however, little improvement in oral status has occurred the U.S. over past 20 years. Tooth decay gum disease remain highly prevalent, with more than 90% 50% of adults suffering from these conditions, respectively. To combat this lack improvement, alternative approaches to dental care are now being suggested. One such therapy probiotics care. In cavity, probiotic strains have been shown reduce levels pathogens, inhibit formation caries, bacteria that cause halitosis. However, as market expands, many products contain bacterial species no documented benefits leading confusion mistrust among consumers clinicians. This enhanced by regulatory which puts onus safety efficacy on manufacturer rather a central body. The overarching goal review provide clinicians evidence supporting (or refuting) marketed sale United States. includes defining what constitutes an product strain level analysis candidate genera Streptococcus, Lactobacillus, Bifidobacterium, Bacillus. Additionally, prebiotics postbiotics will be discussed. Finally, set considerations provided empower decision making. Together, improve understanding US professionals consumers.

Language: Английский

Quorum Sensing of Bifidobacteria: Research and Progress DOI
Huahui Li, Bin He,

Ning Ma

et al.

Microbiological Research, Journal Year: 2025, Volume and Issue: 294, P. 128102 - 128102

Published: Feb. 13, 2025

Language: Английский

Citations

2
Genetically engineered bacterium: Principles, practices, and prospects DOI Creative Commons
Yiting Liu, Jing Feng,

Hangcheng Pan

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 13, 2022

Advances in synthetic biology and the clinical application of bacteriotherapy enable use genetically engineered bacteria (GEB) to combat various diseases. GEB act as a small ‘machine factory’ intestine or other tissues continuously produce heterologous proteins molecular compounds and, thus, diagnose cure disease work an adjuvant reagent for treatment by regulating immune system. Although achievements GEBs therapy diseases are promising, practical implementation this new therapeutic modality remains grand challenge, especially at initial stage. In review, we introduce development their advantages management, summarize latest research advances microbial genetic techniques, discuss administration routes, performance indicators limitations used platforms management. We also present several examples applications cancers metabolic further highlight great potential near future.

Language: Английский

Citations

53
Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy DOI Creative Commons
Yaoyuan Zhang, Zhu Xiao, Xinyuan Yu

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 2, 2023

Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient absorption prevents pathogenic entry, harmful metabolites, endotoxin absorption. Recent advances have highlighted association between severely damaged barriers diabetes, obesity, fatty liver, cardiovascular diseases. Evidence indicates that an abated leads to endotoxemia associated with systemic inflammation, insulin resistance, lipid accumulation, accelerating obesity liver Nonetheless, specific mechanism of damage effective improvement remain be explored. Here, we discuss crosstalk changes metabolic disease. This paper also highlights how improve gut from perspective natural medicine, microbiota remodeling, lifestyle interventions, bariatric surgery. Finally, potential challenges prospects for regulation barrier-metabolic disease axis are discussed, which may provide theoretical guidance treatment

Language: Английский

Citations

40
Effect of Bifidobacterium on osteoclasts: TNF-α/NF-κB inflammatory signal pathway-mediated mechanism DOI Creative Commons
Yue Wu, Yunjiao Yang,

Lan Wang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 9, 2023

Osteoporosis is a systemic multifactorial bone disease characterized by low quality and density microstructure damage, increasing fragility fracture vulnerability. Increased osteoclast differentiation activity are important factors contributing to loss, which common pathological manifestation of diseases such as osteoporosis. TNF-a/NF-κB an inflammatory signaling pathway with key regulatory role in regulating formation, the classical RANKL/RANK/OPG assists formation. Activation this promotes formation osteoclasts accelerates process Recent studies emerging evidence have consistently demonstrated potential probiotics modulate health. Secretions Bifidobacterium , genus probiotic bacteria phylum Actinobacteria, short-chain fatty acids, equol, exopolysaccharides, indicated beneficial effects on This review discusses molecular mechanisms describes secretions produced their health through pathway, opening up new directions for future research.

Language: Английский

Citations

32
Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes DOI
Kai Luo, Guo‐Chong Chen, Yanbo Zhang

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 169 - 186

Published: Jan. 22, 2024

Language: Английский

Citations

15
Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs) DOI Creative Commons

Davendra Ramkumar,

Aileen M. Marty,

Japhia Ramkumar

et al.

One Health, Journal Year: 2024, Volume and Issue: 18, P. 100734 - 100734

Published: April 20, 2024

Non-communicable diseases (NCDs) pose a global health challenge, leading to substantial morbidity, mortality, and economic strain. Our review underscores the escalating incidence of NCDs worldwide highlights potential regenerative agriculture (RA) products in mitigating these diseases. We also explore efficacy dietary interventions NCD management prevention, emphasizing superiority plant-based diets over those high processed foods red meat. Examining role gut microbiome various diseases, including liver disorders, allergies, metabolic syndrome, inflammatory bowel disease, colon cancer, we find compelling evidence implicating its influence on disease development. Notably, modifications can positively affect microbiome, fostering symbiotic relationship with host making this critical strategy prevention treatment. Investigating agricultural practices, identify parallels between soil/plant human studies, suggesting crucial link soil health, plant- animal-derived food quality, well-being. Conventional/Industrial (IA) characterized part by use chemical inputs, have adverse effects diversity, ecosystems. In contrast, RA prioritizes through natural processes, includes avoiding synthetic crop rotation, integrating livestock. Emerging suggests that from systems surpasses IA-produced quality nutritional value. Recognizing interconnection human, plant, microbiomes, promoting RA-produced emerges as improve environmental sustainability. By climate change impacts carbon sequestration water cycling, offers dual benefits for planetary Emphasizing pivotal diet practices combating addressing concerns, adoption regional becomes imperative. Increasing integration into local enhance availability, affordability while safeguarding planet's future.

Language: Английский

Citations

12
The Impact of Probiotic Bifidobacterium on Liver Diseases and the Microbiota DOI Creative Commons
Gabriel Henrique Hizo, Pabulo Henrique Rampelotto

Life, Journal Year: 2024, Volume and Issue: 14(2), P. 239 - 239

Published: Feb. 8, 2024

Recent studies have shown the promising potential of probiotics, especially bacterial genus Bifidobacterium, in treatment liver diseases. In this work, a systematic review was conducted, with focus on that employed advanced Next Generation Sequencing (NGS) technologies to explore Bifidobacterium as probiotic for treating pathologies such Non-Alcoholic Fatty Liver Disease (NAFLD), Steatohepatitis (NASH), Alcoholic (ALD), Cirrhosis, and Hepatocelullar Carcinoma (HCC) its impact microbiota. Our results indicate is safe effective lesions. It successfully restored balance intestinal microbiota improved biochemical clinical parameters NAFLD, ALD, Cirrhosis. No significant adverse effects were identified. While more research needed establish efficacy NASH HCC, evidence suggests managing

Language: Английский

Citations

10
Postbiotics-promising role as energetic biomolecules, safety regulations, and nutritional aspects DOI
Gitanjali S. Deokar, Sanjay J. Kshirsagar, Yogita Shinde

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 709 - 736

Published: Jan. 1, 2025

Language: Английский

Citations

1
Alterations in gut microbiome and metabolite profiling during in vitro fermentation of duckweed (Wolffia globosa) and its extracts by gut bacteria from obese adults DOI Creative Commons

Sirajit Dhamaratana,

Pawadee Methacanon, Paiboon Tunsagool

et al.

Future Foods, Journal Year: 2025, Volume and Issue: unknown, P. 100608 - 100608

Published: March 1, 2025

Language: Английский

Citations

1
Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet DOI Open Access
Yanzhou Hu, Jia Xu,

Yao Sheng

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1868 - 1868

Published: April 29, 2022

Pleurotus ostreatus (PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating gut microbiota, we administered mice low-fat diet or high-fat containing different dosages (mass fraction: 0%, 2.5%, 5% 10%). The body weight, adipose tissue GTT, ITT, blood lipids, serum biomarkers liver/kidney function, microbiota function were measured analyzed after 6 weeks treatment. results showed prevented obesity, maintained glucose homeostasis beneficially modulated microbiota. modified composition functions in obese make them similar to those lean mice, which contributed weight loss. significantly increased relative abundance Oscillospira, Lactobacillus group Bifidobacterium, while decreased Bacteroides Roseburia. prediction upregulated lipid metabolism, carbohydrate bile acid biosynthesis, it downregulated adipocytokine signaling pathway steroid hormone biosynthesis. Correlation analysis further suggested potential relationship among In conclusion, all indicated that ameliorated at least partly by

Language: Английский

Citations

33