Effects of Active Ingredients in Alcoholic Beverages and Their De-Alcoholized Counterparts on High-Fat Diet Bees: A Comparative Study DOI Creative Commons

Guanghe Fan,

Xiaofei Wang,

Cuicui Gao

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1693 - 1693

Published: April 9, 2024

The mechanisms by which alcohol, alcoholic beverages, and their de-alcoholized derivatives affect animal physiology, metabolism, gut microbiota have not yet been clarified. polyphenol, monosaccharide, amino acid, organic acid contents of four common beverages (Chinese Baijiu, beer, Chinese Huangjiu, wine) counterparts were analyzed. research further explored how these non-alcoholic versions obesity microbiota, using a high-fat diet bee model created with 2% palm oil (PO). results showed that wine, possessing the highest polyphenol content, its form, particularly when diluted five-fold (WDX5), markedly improved health markers PO-fed bees, including weight, triglycerides, total cholesterol levels in blood lymphocytes. WDX5 treatment notably increased presence beneficial microbes such as Bartonella, Gilliamella, Bifidobacterium, while decreasing Bombilactobacillus abundance. Moreover, was found to closely resemble sucrose water (SUC) terms microbial function, significantly boosting short-chain fatty acids, lipopolysaccharide associated enzymatic pathways, thereby favorably affecting metabolic regulation stability bees.

Language: Английский

Assessing the nutritional quality of Pleurotus ostreatus (oyster mushroom) DOI Creative Commons
Magdalene Eno Effiong,

Chidinma Precious Umeokwochi,

Israel Sunmola Afolabi

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 16, 2024

There is a huge gap between food production and the exploding population demands in various parts of world, especially developing countries. This increases chances malnutrition, leading to increased disease incidence need for functional foods reduce mortality. Pleurotus ostreatus are edible mushrooms that cheaply sourced rich nutrient with potential be harnessed toward addressing present future crisis while serving as prevention treatment. study evaluated nutritional, proximate, vitamins amino acids contents . The proximate composition this revealed it contains 43.42% carbohydrate, 23.63% crude fiber, 17.06% protein, 8.22% ash, 1.21% lipid moisture content 91.01 6.46% fresh dry samples ostreatus, respectively monosaccharide disaccharide profile presence glucose (55.08 g/100 g), xylose (7.19 fructose (19.70 galactose (17.47 trehalose (7.37 chitobiose (11.79 maltose (29.21 sucrose (51.60 g) lower amounts cellobiose (0.01 erythrose (0.48 other unidentified sugars. Potassium, Iron Magnesium were highest minerals 12.25 mg, 9.66 mg 7.00 amounts, respectively. vitamin A (2.93 IU/100 C (16.46 mg/100 E (21.50 B B2 having concentration 92.97 mg/kg. acid scores showed had more non-essential (564.17 than essential (67.83 ratio 0.11. Lysine (23.18 was aspartic (492.12 mg/kg) It higher acidic acids, 492.12 g (77.87%), followed by neutral 106.66 (16.88%) least basic 23.18 (3.67%). Based on nutritional assessment analyzed study, can concluded serve an important source exploited meet increasing micronutrient deficiencies many

Language: Английский

Citations

32
Modulation of the Gut Microbiota with Prebiotics and Antimicrobial Agents from Pleurotus ostreatus Mushroom DOI Creative Commons
Gréta Törős, Hassan El-Ramady, József Prokisch

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(10), P. 2010 - 2010

Published: May 16, 2023

Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm mushroom contains bioactive compounds with both antimicrobial and prebiotic properties, which are distributed in the mycelium, fruiting body, spent substrate. The is rich nondigestible carbohydrates like chitin glucan, act as prebiotics support growth activity of beneficial gut bacteria, thereby maintaining a healthy balance microbiota reducing risk antibiotic resistance. mushrooms, including polysaccharides (glucans, chitin) secondary metabolites (phenolic compounds, terpenoids, lectins), exhibit antibacterial, antiviral, antifungal activities. When mushrooms consumed, these can help preventing spread harmful bacteria gut, infections development Nonetheless, further research necessary to determine efficacy against different pathogens fully comprehend its properties. Overall, consuming diet mushroom-based foods have positive impact on human digestion health. A microbiome reduce need for antibiotics.

Language: Английский

Citations

37
Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review DOI Creative Commons
Jan Lazur, Kamil Hnatyk, Katarzyna Kała

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 623 - 623

Published: March 2, 2023

Major Depression Disease is a common mental illness that affects more than 322 million people worldwide and it one of the leading causes physical disability. The etiology depression complex interplay psychological, social, biological factors. Currently, psychopharmacotherapy based mainly on monoamine theory, which states caused by an insufficient level monoamines such as serotonin, norepinephrine, and/or dopamine. Due to relatively low efficacy typical antidepressant high prevalence treatment-resistant (~30%), seeking new ways prophylaxis, adjuvant therapy, or novel compounds with activity, priority. According studies analyzed mushroom consumption patterns prevalence, was concluded ingestion lowers odds depression. Medicinal mushrooms are considered functional foods because their ability synthesize accumulate different types metabolites, enhance health-promoting properties. review aims explain activity edible/medicinal elucidating mechanism from perspectives: edible source serotonin precursors psilocybin rapid-acting antidepressant. These exhibit anti-neuroinflammatory antioxidant activities impact neurotrophin expression, neurogenesis process, influence gut–brain axis.

Language: Английский

Citations

34
Extraction and bioactivities of the chemical composition from Pleurotus ostreatus: a review DOI Creative Commons

Qingchun Zhao,

Xiaopeng Liu,

Lili Cui

et al.

Journal of Future Foods, Journal Year: 2023, Volume and Issue: 4(2), P. 111 - 118

Published: Aug. 11, 2023

Pleurotus ostreatus as an edible mushroom with pharmacological potential, belonging to class basidiomycetes of kingdom Mycota is known have immense therapeutic properties. P. contains polysaccharides, proteins, sterols, volatile oils and polyphenols. has a variety biological activities, including anti-oxidant, anti-hyperlipidemic, anti-tumor, immunoregulatory bacteriostatic. This paper summarizes the extraction methods, chemical components activities ostreatus, find it good resources develop medicine health food.

Language: Английский

Citations

24
Role of herbal medicine and gut microbiota in the prevention and treatment of obesity DOI
Qiao Zhang,

Yaya Bai,

Wenxiao Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 305, P. 116127 - 116127

Published: Jan. 2, 2023

Language: Английский

Citations

22
The benefits of edible mushroom polysaccharides for health and their influence on gut microbiota: a review DOI Creative Commons
Qilong Zhao, Yu Jiang, Qian Zhao

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 6, 2023

The gut microbiome is a complex biological community that deeply affects various aspects of human health, including dietary intake, disease progression, drug metabolism, and immune system regulation. Edible mushroom polysaccharides (EMPs) are bioactive fibers derived from mushrooms possess range beneficial properties, anti-tumor, antioxidant, antiviral, hypoglycemic, immunomodulatory effects. Studies have demonstrated EMPs resistant to digestive enzymes serve as crucial source energy for the microbiome, promoting growth bacteria. also positively impact health by modulating composition microbiome. This review discusses extraction purification processes EMPs, their potential improve conditions regulating application prospects. Furthermore, this paper provides valuable guidance recommendations future studies on consumption in management.

Language: Английский

Citations

13
Gut microbiota profiling revealed the regulating effects of salidroside on iron metabolism in diabetic mice DOI Creative Commons
Jing Shi, Qin Zhao,

Dou Dou Hao

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 23, 2022

Background Diabetes is a common metabolic disease that associated with gut microbiota dysbiosis and iron metabolism. Salidroside (SAL) the main ingredient of traditional Chinese herb Rhodiola, previous studies have shown SAL could reshape limit accumulation. Therefore, it possible can act as an alternative therapy for diabetes, its underlying mechanism worth exploring. Methods was used to treat diabetic db/db mice. Serum glucose levels histopathology myocardial fibres were evaluated. The composition determined by 16S rRNA Illumina sequencing technology. Results Treatment significantly reduced blood ameliorated cardiomyopathy in mice, which accompanied inhibited ferroptosis Furthermore, results showed induced change composition. Overall, increase proportion probiotic bacteria decrease Lactobacillus improve microbiota. Specifically, increased ratio Bacteroidetes Firmicutes most significant biomarker genus between MD group group. In addition, COG KEGG analyses suggested mainly participated nutrient metabolism, among them metabolism abundance Lactobacillus. Conclusions reduce level protect against might be mediated regulation findings promising complementary option diabetes therapy.

Language: Английский

Citations

21
Abelmoschus Manihot ameliorates the levels of circulating metabolites in diabetic nephropathy by modulating gut microbiota in non‐obese diabetes mice DOI Creative Commons

Ruiya Shi,

Yingjun Tao,

Haitao Tang

et al.

Microbial Biotechnology, Journal Year: 2022, Volume and Issue: 16(4), P. 813 - 826

Published: Dec. 30, 2022

Abstract Huangkui capsule (HKC), a traditional Chinese medicine, has been used for medication of kidney diseases, including diabetic nephropathy (DN). The current study aimed to evaluate the effects HKC in modulation gut microbiota and amelioration metabolite levels by using non‐obese diabetes (NOD) mice with DN. from three parts intestines (duodenum, ileum colon) NOD without treatment were analysed 16S rDNA sequencing techniques. Untargeted metabolomics plasma liquid mass spectrometry. Results showed that administration ameliorated DN flora duodenum more sensitive intervention, while colon had on metabolism. bacterial genera such as Faecalitalea Muribaculum significantly increased negatively correlated most altered metabolites after treatment, Phyllobacterium , Weissella Akkermansia an opposite trend. metabolites, mainly amino acids fatty methionine sulfoxide, BCAAs cis‐7‐Hexadecenoic acid, exhibited distinct return normal treatment. thereby provides experimental evidence suggesting may modulate subsequently ameliorate

Language: Английский

Citations

21
Long-term simulated microgravity alters gut microbiota and metabolome in mice DOI Creative Commons
Yuan Lu, Rong Zhang, Xin‐Lou Li

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: March 24, 2023

Spaceflight and microgravity has a significant impact on the immune, central nervous, bone, muscle support cardiovascular systems. However, limited studies are available adverse effects of long-term intestinal microbiota, metabolism, its relationships. In this study, ground-based simulated (SMG) mouse model was established to evaluate gut microbiota metabolome. After 8 weeks SMG, alterations metabolites were detected using 16S rRNA sequencing untargeted metabolomics. Compared control, no differences in α-diversity observed at 2, 4 8. Nevertheless, there clear community structures different time points. The phylum Verrucomicrobia significantly declined from 2 yet relative abundance Actinobacteria Deferribacteres expanded remarkably SMG decreased genus Allobaculum increased Bacteroides throughout period weeks. Besides, Genus Akkermansia , Gracilibacter Prevotella Odoribacter Rothia Sporosarcina Clostridium, Mucispirillum identified as biomarkers for group. Desulfovibrio_c21_c20, Akkermansia_muciniphila Ruminococcus_gnavus dropped week which tend recover 4, except . Bacteroides_uniformis Faecalibacterium_prausnitzii significantly, while Ruminococcus_flavefaciens Mucispirillum_schaedleri elevated Furthermore, metabolome analysis showed that 129 upregulated 146 downregulated SMG. Long-term most affected steroid hormone biosynthesis, tryptophan, cysteine, methionine, arginine, proline histidine metabolism. Correlated suggested potential beneficial taxa Allobaculum, Faecalibacterium negatively associated with histidine, but positively biosynthesis. Yet Bacteroides, Lachnospiraceae_Clostridium, Rothia, Bilophila, Coprococcus correlated proline, These results suggest altered then further disturbed metabolic pathways, have great help understand provide clues revealing mechanisms involved diseases.

Language: Английский

Citations

12
Exploring the Effects of Different Drying Methods on Related Differential Metabolites of Pleurotus citrinopileatus Singer Based on Untargeted Metabolomics DOI Creative Commons
Huan Lu,

Simin Peng,

Ning Xu

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(12), P. 1594 - 1594

Published: June 7, 2024

Singer (PCS) has attracted increasing attention as a raw material for medicine and food. Its quality is greatly affected by the accumulation of metabolites, which varies with applied drying methods. In this study, we utilize an approach based on ultra-high-performance liquid chromatography/Q Exactive mass spectrometry (UHPLC-QE-MS) to reveal metabolic profiles PCS from three different methods (natural air-drying, NAD; hot-air-drying, HAD; vacuum freeze-drying, VFD). The results showed that lipids, amino acids their derivatives were all important secondary metabolites produced during NAD, HAD VFD treatments, key differential including fifteen lipids seven acids. Meanwhile, was best way long-term preservation dried PCS. Hot-drying methods, especially HAD, can improve medicinal component Furthermore, KEGG enrichment analysis highlighted 16 pathways indicated acid metabolism might be metabolite pathway process. Our study elucidates relationship between or determine mechanisms affecting PCS, finally provides reference values further development application in functional food medications.

Language: Английский

Citations

4