Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

---

Biomaterials for Drug Delivery and Human Applications

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 456 - 456

Published: Jan. 18, 2024

Biomaterials embody a groundbreaking paradigm shift in the field of drug delivery and human applications. Their versatility adaptability have not only enriched therapeutic outcomes but also significantly reduced burden adverse effects. This work serves as comprehensive overview biomaterials, with particular emphasis on their pivotal role delivery, classifying them terms biobased, biodegradable, biocompatible nature, highlighting characteristics advantages. The examination delves into extensive array applications for biomaterials encompassing diverse medical fields such cancer therapy, cardiovascular diseases, neurological disorders, vaccination. explores actual challenges within this domain, including potential toxicity complexity manufacturing processes. These emphasize necessity thorough research continuous development regulatory frameworks. second aim review is to navigate through compelling terrain recent advances prospects envisioning healthcare landscape where they empower precise, targeted, personalized delivery. transform staggering, promise treatments tailored individual patient needs, offering hope improved efficacy, fewer side effects, brighter future practice.

Language: Английский

---

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 216 - 216

Published: March 22, 2024

Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.

Language: Английский

---

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 188 - 188

Published: March 8, 2024

Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements an ideal wound dressing, making them promising for care. These features include, among others, the ability to absorb and retain large amounts water capacity closely mimic native structures, such as extracellular matrix, facilitating cellular processes like proliferation differentiation. The polymers used in hydrogel formulations exhibit broad spectrum properties, allowing be classified into two main categories: natural collagen chitosan, synthetic polyurethane polyethylene glycol. This review offers comprehensive overview critical analysis key can constitute hydrogels, beginning with brief contextualization polymers. It delves their function, origin, chemical structure, highlighting sources extraction obtaining. Additionally, this encompasses intrinsic properties these roles healing process, accompanied, whenever available, by explanations underlying mechanisms action. also addresses limitations describes some studies on effectiveness isolated promoting skin regeneration healing. Subsequently, we briefly discuss application strategies hydrogels derived from potential promote process. achieved due role stimulation angiogenesis, example, or through incorporation substances growth factors drugs, antimicrobials, imparting new hydrogels. In addition substance incorporation, is related serve three-dimensional matrix cell culture, whether it involves loading cells recruiting site, where they proliferate scaffold form tissue. latter strategy presupposes biosensors real-time monitoring conditions, temperature pH. Future prospects then ultimately addressed. As far aware, manuscript represents first approach brings together critically analyzes fundamental aspects both constituting context cutaneous will foundational point future studies, aiming contribute development effective environmentally friendly dressing wounds.

Language: Английский

---

Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 66 - 66

Published: Jan. 15, 2025

Biosensors, which combine physical transducers with biorecognition elements, have seen significant advancement due to the heightened interest in rapid diagnostic technologies across a number of fields, including medical diagnostics, environmental monitoring, and food safety. In particular, polydiacetylene (PDA) is gaining attention as an ideal material for label-free colorimetric biosensor development its unique color-changing properties response external stimuli. PDA forms through self-assembly diacetylene monomers, color change occurring conjugated backbone twists stimuli such temperature, pH, chemical interactions. This enables detection biomarkers, metal ions, toxic compounds. Moreover, combination polymeric structures hydrogels further enhances sensitivity structural stability PDA-based biosensors, making them reliable effective complex biological conditions. review comprehensively examines recent research trends applications PDA–polymeric structure hybrid while discussing future directions potential advancements this field.

Language: Английский

---

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Implantable drug delivery systems are crucial for achieving sustained of active compounds to specific sites or systemic circulation. In this study, a novel reservoir‐type implant combining biodegradable rate‐controlling membrane with drug‐containing core prepared using direct compression techniques is developed. The composed poly(caprolactone) (PCL), and risperidone (RIS) served as the model drug. Characterization both membranes compressed pellets includes hardness testing, optical coherence tomography, mercury intrusion porosimetry, surface morphology observation. vitro release studies RIS reveal that higher loading in extended‐release duration up 70 days when incorporated into four layers. Increasing number layers slows rate further, ranging from 170 depending on thickness. Biocompatibility demonstrate these implantable devices non‐toxic biocompatible cells vitro. vivo conduct male Wistar rats RIS, plasma levels showing significant increase post‐implantation at relatively constant 49 days. These results indicate developed implants have potential provide long‐acting

Language: Английский

---

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Materials, Journal Year: 2023, Volume and Issue: 16(12), P. 4267 - 4267

Published: June 8, 2023

This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials fundamental components in tissue engineering (TE) scaffolds play critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, non-toxicity, ensure ability function effectively with an host response. With ongoing research advancements medical implants, objective this review is explore recently developed implantable scaffold materials The categorization paper includes fossil-based (e.g., PCL, PVA, PU, PEG, PPF), natural or bio-based HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, hydrogels), hybrid PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, PLA/bioceramics). these both hard soft TE considered, particular focus on physicochemical, mechanical, biological properties. Furthermore, interactions between immune system context scaffold-driven regeneration discussed. Additionally, briefly mentions concept situ TE, which leverages self-renewal capacities affected tissues highlights crucial role played by biopolymer-based strategy.

Language: Английский

---

Electrospun PVA Fibers for Drug Delivery: A Review

Polymers, Journal Year: 2023, Volume and Issue: 15(18), P. 3837 - 3837

Published: Sept. 20, 2023

Innovation in biomedical science is always a field of interest for researchers. Drug delivery, being one the key areas science, has gained considerable significance. The utilization simple yet effective techniques such as electrospinning undergone significant development drug delivery. Various polymers PEG (polyethylene glycol), PLGA (Poly(lactic-co-glycolic acid)), PLA(Polylactic acid), and PCA (poly(methacrylate citric acid)) have been utilized to prepare electrospinning-based delivery systems (DDSs). Polyvinyl alcohol (PVA) recently attention because its biocompatibility, biodegradability, non-toxicity, ideal mechanical properties these are factors developing DDSs. Moreover, it shown promising results DDSs individually when combined with natural synthetic chitosan polycaprolactone (PCL). Considering outstanding PVA, aim this review paper was therefore summarize recent advances by highlighting potential electrospun PVA systems.

Language: Английский

---

Research progress on the application of inkjet printing technology combined with hydrogels

Applied Materials Today, Journal Year: 2023, Volume and Issue: 36, P. 102036 - 102036

Published: Dec. 22, 2023

Language: Английский

---

Polymer hydrogels: Classification and recent advances

Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: 61(5), P. 265 - 288

Published: March 19, 2024

Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.

Language: Английский

---