International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 6296 - 6296
Published: June 4, 2022
Notch
signaling
dysregulation
encourages
breast
cancer
progression
through
different
mechanisms
such
as
stem
cell
maintenance,
proliferation
and
migration/invasion.
Furthermore,
is
a
crucial
driver
regulating
juxtracrine
paracrine
communications
between
tumor
stroma.
The
complex
interplay
the
abnormal
pathway
orchestrating
activation
of
other
signals
cellular
heterogeneity
contribute
towards
remodeling
microenvironment.
These
changes,
together
with
evolution
treatment
pressure,
drive
drug
resistance.
Preclinical
studies
have
shown
that
targeting
can
prevent
or
reverse
resistance,
reducing
eliminating
cells.
In
present
review,
we
will
summarize
current
scientific
evidence
highlights
involvement
within
microenvironment,
angiogenesis,
extracellular
matrix
remodeling,
tumor/stroma/immune
system
its
in
therapy
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 22, 2024
Abstract
Stroke
is
a
leading
cause
of
mortality
and
long-term
disability
globally,
with
acute
ischemic
stroke
(AIS)
being
the
most
common
subtype.
Despite
significant
advances
in
reperfusion
therapies,
their
limited
time
window
associated
risks
underscore
necessity
for
novel
treatment
strategies.
Stem
cell-derived
extracellular
vesicles
(EVs)
have
emerged
as
promising
therapeutic
approach
due
to
ability
modulate
post-stroke
microenvironment
facilitate
neuroprotection
neurorestoration.
This
review
synthesizes
current
research
on
potential
stem
EVs
AIS,
focusing
origin,
biogenesis,
mechanisms
action,
strategies
enhancing
targeting
capacity
efficacy.
Additionally,
we
explore
innovative
combination
therapies
discuss
both
challenges
prospects
EV-based
treatments.
Our
findings
reveal
that
exhibit
diverse
effects
such
promoting
neuronal
survival,
diminishing
neuroinflammation,
protecting
blood-brain
barrier,
angiogenesis
neurogenesis.
Various
strategies,
including
modifications
cargo
modifications,
been
developed
improve
efficacy
EVs.
Combining
other
treatments,
therapy,
cell
transplantation,
nanomedicine,
gut
microbiome
modulation,
holds
great
promise
improving
outcomes.
However,
heterogeneity
need
standardized
protocols
EV
production
quality
control
remain
be
addressed.
represent
avenue
offering
address
limitations
Further
needed
optimize
translate
benefits
clinical
practice,
an
emphasis
ensuring
safety,
overcoming
regulatory
hurdles,
specificity
delivery
target
tissues.
Graphical
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11850 - 11850
Published: Nov. 4, 2024
Retinal
vascular
diseases
encompass
several
retinal
disorders,
including
diabetic
retinopathy,
retinopathy
of
prematurity,
age-related
macular
degeneration,
and
occlusion;
these
disorders
are
classified
as
similar
groups
due
to
impaired
vascularization.
The
aim
this
review
is
address
the
main
signaling
pathways
involved
in
pathogenesis
identify
crucial
molecules
importance
their
interactions.
Vascular
endothelial
growth
factor
(VEGF)
recognized
a
central
molecule
abnormal
neovascularization
key
phenomenon
thus,
anti-VEGF
therapy
now
most
successful
form
treatment
for
disorders.
Interaction
between
angiopoietin
2
Tie2
receptor
results
aberrant
signaling,
resulting
loss
pericytes,
neovascularization,
inflammation.
Notch
hypoxia-inducible
factors
ischemic
conditions
induce
pathological
disruption
blood-retina
barrier.
An
increase
pro-inflammatory
cytokines-TNF-α,
IL-1β,
IL-6-and
activation
microglia
create
persistent
inflammatory
milieu
that
promotes
breakage
blood-retinal
barrier
neovascularization.
Toll-like
nuclear
factor-kappa
B
important
dysregulation
immune
response
diseases.
Increased
production
reactive
oxygen
species
oxidative
damage
follow
inflammation
together
vicious
cycle
because
each
amplifies
other.
Understanding
complex
interplay
among
various
pathways,
cascades,
enables
development
new
more
therapeutic
options.
Frontiers in Oncology,
Journal Year:
2021,
Volume and Issue:
11
Published: July 20, 2021
Despite
the
recent
advances
in
cancer
patient
management
and
development
of
targeted
therapies,
systemic
chemotherapy
is
currently
used
as
a
first-line
treatment
for
many
types.
After
an
initial
partial
response,
patients
become
refractory
to
standard
therapy
fostering
rapid
tumor
progression.
Compelling
evidence
highlights
that
resistance
chemotherapeutic
regimens
peculiarity
subpopulation
cells
within
mass,
known
stem
(CSCs).
This
cellular
compartment
endowed
with
tumor-initiating
metastasis
formation
capabilities.
CSC
chemoresistance
sustained
by
plethora
grow
factors
cytokines
released
neighboring
microenvironment
(TME),
which
mainly
composed
adipocytes,
cancer-associated
fibroblasts
(CAFs),
immune
endothelial
cells.
TME
strengthens
refractoriness
therapies
enhancing
survival
signaling
pathways,
DNA
repair
machinery,
expression
drug
efflux
transporters
anti-apoptotic
proteins.
In
last
years
efforts
have
been
made
understand
CSC-TME
crosstalk
develop
therapeutic
strategy
halting
this
interplay.
Here,
we
report
combinatorial
approaches,
perturb
interaction
network
between
CSCs
different
component
TME.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 6296 - 6296
Published: June 4, 2022
Notch
signaling
dysregulation
encourages
breast
cancer
progression
through
different
mechanisms
such
as
stem
cell
maintenance,
proliferation
and
migration/invasion.
Furthermore,
is
a
crucial
driver
regulating
juxtracrine
paracrine
communications
between
tumor
stroma.
The
complex
interplay
the
abnormal
pathway
orchestrating
activation
of
other
signals
cellular
heterogeneity
contribute
towards
remodeling
microenvironment.
These
changes,
together
with
evolution
treatment
pressure,
drive
drug
resistance.
Preclinical
studies
have
shown
that
targeting
can
prevent
or
reverse
resistance,
reducing
eliminating
cells.
In
present
review,
we
will
summarize
current
scientific
evidence
highlights
involvement
within
microenvironment,
angiogenesis,
extracellular
matrix
remodeling,
tumor/stroma/immune
system
its
in
therapy
