Pyroptosis and degenerative diseases of the elderly

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(2)

Published: Feb. 9, 2023

Abstract Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins the gasdermin family. Widely recognized signaling cascades include classical, non-classical, caspase-3-dependent E and caspase-8-dependent D pathways. Additional pyroptotic pathways have been subsequently reported. With rising prevalence advanced age, role pyroptosis in degenerative diseases elderly has attracted increased research attention. This article reviews primary mechanisms summarizes progress such as presbycusis, age-related macular degeneration, Alzheimer’s disease, intervertebral disc osteoarthritis.

Language: Английский

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Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 12, 2023

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.

Language: Английский

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The Role of Regulated Programmed Cell Death in Osteoarthritis: From Pathogenesis to Therapy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5364 - 5364

Published: March 10, 2023

Osteoarthritis (OA) is a worldwide chronic disease that can cause severe inflammation to damage the surrounding tissue and cartilage. There are many different factors lead osteoarthritis, but abnormally progressed programmed cell death one of most important risk induce osteoarthritis. Prior studies have demonstrated death, including apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, cuproptosis, has great connection with In this paper, we review role types in generation development OA how signal pathways modulate regulate OA. Additionally, provides new insights into radical treatment osteoarthritis rather than conservative treatment, such as anti-inflammation drugs or surgical operation.

Language: Английский

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Ferroptosis inhibitors: past, present and future

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Language: Английский

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Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms signaling pathways. In this review, we delve into the cellular metabolic pathways copper, highlighting role copper biomolecule synthesis, mitochondrial respiration, antioxidant defense. Furthermore, elucidate relationship between cuproptosis-related genes (CRGs) cancer prognosis, analyzing their expression patterns across various tumor types impact on patient outcomes. Our review also uncovers potential therapeutic applications chelators, ionophores, copper-based nanomaterials oncology. addition, discuss emerging cuproptosis remodeling microenvironment, enhancing immune infiltration, converting "cold tumors" "hot that respond better to immunotherapy. short, underscores pivotal importance biology highlights translational a novel target.

Language: Английский

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Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: June 28, 2022

Neurodegenerative diseases are a diverse class of attributed to chronic progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord, including Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis multiple sclerosis. The pathogenesis neurodegenerative is complex diverse, often involving mitochondrial dysfunction, neuroinflammation, epigenetic changes. However, has not been fully elucidated. Recently, accumulating evidence revealed that ferroptosis, newly discovered iron-dependent lipid peroxidation-driven type programmed cell death, provides another explanation for occurrence progression diseases. Here, we provide an overview process regulation mechanisms summarize current research progresses support contribution ferroptosis A comprehensive understanding emerging roles will shed light on development novel therapeutic technologies strategies slowing down these

Language: Английский

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The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113611 - 113611

Published: Sept. 5, 2022

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, programmed cell death of each neurovascular unit during post-stroke hypoxia reperfusion play an important role the pathological cascade. Ferroptosis, a characterized by iron-regulated accumulation lipid peroxidation, is caused abnormal metabolism lipids, glutathione (GSH), iron, can accelerate acute central nervous system injury. Recent studies gradually uncovered process ferroptosis stroke. Some drugs iron chelators, ferrostatin-1 (Fer-1) liproxstatin-1 (Lip-1) protect nerves after injury stroke inhibiting ferroptosis. In addition, combined with our previous on mediated natural compounds this review summarized progress regulation mechanism chemical components herbal recent years, order provide reference information for future research lead development inhibitors.

Language: Английский

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Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 25, 2022

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and a heterogeneous disease with complex molecular genetic changes. Because relatively high recurrence rate OC, it crucial to understand associated mechanisms drug resistance discover potential target for rational targeted therapy. Cell genetically determined process. Active orderly cell prevalent during development living organisms plays critical role regulating life homeostasis. Ferroptosis, novel type discovered recent years, distinct from apoptosis necrosis mainly caused by imbalance between production degradation intracellular lipid reactive oxygen species triggered increased iron content. Necroptosis regulated non-cysteine protease–dependent programmed necrosis, morphologically exhibiting same features as occurring via unique mechanism different apoptotic signaling pathway. Pyroptosis form characterized formation membrane pores subsequent lysis well release pro-inflammatory contents mediated abscisin family. Studies have shown ferroptosis, necroptosis, pyroptosis are involved progression variety diseases, including tumors. In this review, we summarized advances occurrence, development, therapeutic OC.

Language: Английский

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Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity

Aging and Disease, Journal Year: 2023, Volume and Issue: 14(3), P. 670 - 670

Published: Jan. 1, 2023

The biomechanical properties of extracellular matrices (ECM) and their consequences for cellular homeostasis have recently emerged as a driver aging. Here we review the age-dependent deterioration ECM in context our current understanding aging processes. We discuss reciprocal interactions longevity interventions with remodeling. And relevance dynamics captured by matrisome matreotypes associated health, disease, longevity. Furthermore, highlight that many established compounds promote homeostasis. A large body evidence to qualify hallmark is emerging, data invertebrates promising. However, direct experimental proof activating sufficient slow mammals lacking. conclude further research required anticipate conceptual framework biomechanics will provide new strategies health during

Language: Английский

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Bioinformatics Prediction and Experimental Validation Identify a Novel Cuproptosis-Related Gene Signature in Human Synovial Inflammation during Osteoarthritis Progression

Biomolecules, Journal Year: 2023, Volume and Issue: 13(1), P. 127 - 127

Published: Jan. 7, 2023

Osteoarthritis (OA) is the one of most common joint diseases worldwide. Cuproptosis, which had been discovered lately, a novel form cell death induced by copper. Our purpose to study relationship between cuproptosis-related genes (CRGs) and inflammatory microenvironments in patients with OA identify characteristic biomarkers. First, combinatory analysis transcriptome data from five datasets identified differentially expressed CRGs associated OA. Then, we applied single-sample gene set enrichment (ssGSEA) evaluate immune-cell infiltration immune-function levels normal controls, respectively. Hub for were mined based on random forest (RF) model, nomogram prediction model was constructed them. In total, four through bioinformatics confirmed RT-qPCR. FDX1 LIPT1 at high level OA, while DBT DLST higher group. 10 found be significantly correlated immune landscape. Four hub subsequently obtained RF as potential biomarkers We an predictive these (DBT, DLST, FDX1, LIPT1).

Language: Английский

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