Life Science Alliance,
Journal Year:
2024,
Volume and Issue:
7(7), P. e202402603 - e202402603
Published: May 3, 2024
Excess
abdominal
fat
is
a
sexually
dimorphic
risk
factor
for
cardio-metabolic
disease
and
approximated
by
the
waist-to-hip
ratio
adjusted
body
mass
index
(WHR
adjBMI
).
Whereas
this
trait
highly
heritable,
few
causal
genes
are
known.
We
aimed
to
identify
novel
drivers
of
WHR
using
systems
genetics.
used
two
independent
cohorts
adipose
tissue
gene
expression
constructed
sex-
depot-specific
Bayesian
networks
model
gene-gene
interactions
from
8,492
genes.
Using
key
driver
analysis,
we
identified
that,
in
silico
putatively
vitro,
regulate
many
others.
51–119
each
network
were
replicated
both
cohorts.
In
other
cell
types,
23
these
found
crucial
adipocyte
pathways:
Wnt
signaling
or
mitochondrial
function.
overexpressed
down-regulated
seven
human
subcutaneous
pre-adipocytes.
Key
ANAPC2
RSPO1
inhibited
adipogenesis,
whereas
PSME3
increased
adipogenesis.
activity.
differentiated
adipocytes,
MIGA1
UBR1
down-regulation
led
dysfunction.
These
five
function,
hypothesize
that
they
distribution.
Cell,
Journal Year:
2024,
Volume and Issue:
187(16), P. 4129 - 4143
Published: July 26, 2024
Obesity
causes
significant
morbidity
and
mortality
globally.
Research
in
the
last
three
decades
has
delivered
a
step-change
our
understanding
of
fundamental
mechanisms
that
regulate
energy
homeostasis,
building
on
foundational
discoveries
mouse
models
metabolic
disease.
However,
not
all
findings
made
rodents
have
translated
to
humans,
hampering
drug
discovery
this
field.
Here,
we
review
how
studies
mice
humans
informed
current
framework
for
discuss
their
challenges
limitations,
offer
perspective
human
may
play
an
increasingly
important
role
disease
identification
therapeutic
targets
future.
Annual Review of Animal Biosciences,
Journal Year:
2023,
Volume and Issue:
12(1), P. 261 - 281
Published: Dec. 8, 2023
The
study
of
adipose
tissue
(AT)
is
enjoying
a
renaissance.
White,
brown,
and
beige
adipocytes
are
being
investigated
in
adult
animals,
the
critical
roles
small
depots
like
perivascular
AT
becoming
clear.
But
most
profound
revision
dogma
has
been
its
cellular
composition
regulation.
Single-cell
transcriptomic
studies
revealed
that
comprise
well
under
50%
cells
white
AT,
substantial
portion
rest
immune
cells.
Altering
function
resident
leukocytes
can
induce
or
correct
metabolic
syndrome
and,
more
surprisingly,
alter
adaptive
responses
to
infection.
Although
field
dominated
by
obesity
research,
conditions
such
as
rapid
lipolysis,
infection,
heat
stress
impact
dynamics
well.
Recent
findings
rodents
lead
questions
should
be
explored
domestic
livestock
potential
avenues
for
improved
animal
resilience
stressors,
particularly
animals
age.
