Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 29, 2024
Intervertebral
disk
degeneration
(IDD)
is
a
common
clinical
spinal
disease
and
one
of
the
main
causes
low
back
pain
(LBP).
Generally
speaking,
IDD
considered
natural
degenerative
process
with
age.
However,
deepening
research,
people
have
discovered
that
not
only
related
to
age,
but
also
has
many
factors
can
induce
accelerate
its
progression.
In
addition,
pathogenesis
remains
unclear,
resulting
in
limited
traditional
treatment
methods
cannot
effectively
prevent
treat
IDD.
Conservative
may
lead
patients’
dependence
on
drugs,
relief
effect
obvious.
Similarly,
surgical
highly
invasive,
longer
recovery
time
higher
recurrence
rate.
With
exploration,
intestinal
microorganisms
are
an
important
symbiotic
microbial
community
human
body
closely
occurrence
development
various
diseases.
Changes
their
metabolites
affect
body’s
inflammatory
response,
immune
regulation,
metabolic
processes,
thereby
affecting
health
intervertebral
disk.
this
context,
gut
microbiota
received
considerable
attention
as
potential
target
for
delaying
or
treating
This
article
first
introduces
impact
microbes
distal
organs,
then
focuses
three
mechanisms
by
which
influence
Finally,
we
summarized
interfering
metabolites.
Further
understanding
between
will
help
formulate
reasonable
strategies
achieve
ideal
therapeutic
effects.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
166, P. 115401 - 115401
Published: Aug. 28, 2023
Lipid
metabolism
is
a
complex
process
that
maintains
the
normal
physiological
function
of
human
body.
The
disorder
lipid
has
been
implicated
in
various
diseases,
such
as
cardiovascular
diseases
and
bone
diseases.
Intervertebral
disc
degeneration
(IDD),
an
age-related
degenerative
disease
musculoskeletal
system,
characterized
by
high
morbidity,
treatment
cost,
chronic
recurrence.
may
promote
pathogenesis
IDD,
potential
mechanisms
are
complex.
Leptin,
resistin,
nicotinamide
phosphoribosyltransferase
(NAMPT),
fatty
acids,
cholesterol
while
lipocalin,
adiponectin,
progranulin
(PGRN)
exhibit
protective
activity
against
IDD
development.
contributes
to
extracellular
matrix
(ECM)
degradation,
cell
apoptosis,
cartilage
calcification
intervertebral
discs
(IVDs)
activating
inflammatory
responses,
endoplasmic
reticulum
(ER)
stress,
oxidative
stress
inhibiting
autophagy.
Several
lines
agents
have
developed
target
disorder.
Inhibition
be
effective
strategy
for
therapeutic
management
IDD.
However,
in-depth
understanding
molecular
mechanism
promoting
development
still
needed.
International Journal of Biological Sciences,
Journal Year:
2025,
Volume and Issue:
21(3), P. 1174 - 1186
Published: Jan. 13, 2025
This
study
explored
the
role
of
ferroptosis
in
intervertebral
disc
degeneration
(IVDD),
and
identified
GATA6
as
a
key
regulator
this
process.
A
ferroptosis-related
gene
risk
coefficient
model
was
constructed
using
differential
expression
analysis
GSE70362
dataset.
The
significant
factor
IVDD
progression.
shown
to
promote
nucleus
pulposus
cells
(NPCs)
by
regulating
AKR1C3
through
TLR2
pathway.
In
vitro
vivo
experiments
demonstrated
that
knockdown
reduced
ferroptosis,
improved
cell
viability,
mitigated
extracellular
matrix
degradation,
whereas
overexpression
exacerbated
these
processes.
Furthermore,
found
be
crucial
for
GATA6-mediated
modulation
TLR2-AKR1C3
axis
significantly
impacted
NPCs.
These
findings
suggest
targeting
its
downstream
pathway
may
provide
new
therapeutic
approaches
IVDD.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 7, 2024
Ferroptosis,
an
iron-dependent
form
of
programmed
cell
death,
introduces
a
novel
perspective
on
cellular
demise.
This
study
investigates
the
regulatory
network
exosomal
non-coding
RNAs
(ncRNAs),
including
miRNAs,
circRNAs,
and
lncRNAs,
in
ferroptosis
modulation.
The
primary
goal
is
to
examine
pathological
roles
ferroptosis-related
ncRNAs,
particularly
ischemic
reperfusion
injuries.
research
reveals
intricate
molecular
interactions
governing
interplay
between
ncRNAs
ferroptosis,
elucidating
their
diverse
different
non-malignant
contexts.
Attention
given
impact
diseases,
cardiac,
cerebral,
liver,
kidney
injuries,
as
well
lung,
wound,
neuronal
Beyond
theoretical
exploration,
provides
insights
into
potential
therapeutic
applications,
emphasizing
significance
mesenchymal
stem
cells
(MSCs)-derived
exosomes.
Findings
underscore
pivotal
role
MSC-derived
modulating
responses
related
regulation,
introducing
cutting-edge
dimension.
recognition
emphasizes
importance
exosomes
crucial
mediators
with
broad
implications.
Insights
unveil
promising
avenues
for
targeted
interventions,
capitalizing
providing
comprehensive
foundation
future
strategies.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 678 - 678
Published: March 18, 2024
Oxeiptosis
is
a
reactive
oxygen
species
(ROS)-induced
pathway
of
cell
death.
The
involvement
circular
RNAs
(circRNAs)
has
been
confirmed
in
the
incidence
and
progression
intervertebral
disc
degeneration
(IVDD).
However,
whether
oxeiptosis
occurs
IVDD
how
circRNAs
regulate
still
unclear.
In
this
study,
we
discovered
that
could
be
induced
nucleus
pulposus
cells
(NPCs),
circFOXO3
was
significantly
upregulated
after
induction.
Transfection
using
small
interfering
RNA
(siRNA)
inhibited
NPCs.
Mechanistically,
acid-sensing
ion
channel
subunit
1
(ASIC1)
expression
by
functioning
as
molecular
sponge
for
miR-185-3p
miR-939-5p.
Subsequent
rescue
experiments
validated
NPCs
via
miR-185-3p/miR-939-5p-ASIC1
axis.
Further
research
on
ASIC1
functions
indicated
regulation
achieved
affecting
Calcium
(Ca2+)
influx
mediated
ASIC1.
A
mouse
model
established,
silencing
vivo
found
to
inhibit
development
activation
oxeiptosis-related
pathway.
Overall,
one
factors
contributing
mediating
oxeiptosis.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(7)
Published: Sept. 12, 2024
Low
back
pain
significantly
impacts
individuals'
quality
of
life,
with
intervertebral
disc
degeneration
(IDD)
being
a
primary
contributor
to
this
condition.
Currently,
IDD
treatment
primarily
focuses
on
symptom
management
and
does
not
achieve
definitive
cure.
The
cartilage
endplate
(CEP),
crucial
nutrient-supplying
tissue
the
disc,
plays
pivotal
role
in
degeneration.
This
review
examines
mechanisms
underlying
CEP
degeneration,
summarizing
recent
advancements
understanding
structure
function
CEP,
involvement
various
signaling
pathways,
roles
stem
cells
(CESCs)
exosomes
(Exos)
process.
aim
is
provide
comprehensive
reference
for
future
research
CEP.
Despite
progress
IDD,
remain
incompletely
elucidated.
Future
poses
significant
challenges,
necessitating
further
investigations
elucidate
complexities
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 2, 2024
Intervertebral
disc
degeneration
(IVDD)
is
the
leading
cause
of
low
back
pain,
where
and
death
nucleus
pulposus
cells
within
intervertebral
(IVD)
can
be
obviously
revealed.
This
result
in
an
imbalance
extracellular
matrix
due
to
loss
proteoglycans
water
content,
which
further
lead
catabolic
anabolic
dysfunction
IVD.
Recently,
cartilage
endplate
(CEP)
during
aging
has
drawn
large
attention
its
essential
functions
contributing
nutrient
exchange
maintaining
IVD
homeostasis.
Furthermore,
inflammation
disturbed
homeostasis
CEP
not
only
accelerate
degradation
matrix,
but
also
exacerbate
IVDD
by
causing
cell
through
other
pathological
factors.
Here
this
review,
we
summarized
possible
factors
underlying
mechanisms
inflammation-induced
IVDD,
including
exosomes
degeneration,
calcification,
ferroptosis,
mechanical
changes,
senescence.
Besides,
changes
miRNAs,
pain-related
neural
reflex
arc
pathways
associated
with
are
reviewed.
In
addition,
new
strategies
specifically
designed
for
discussed
last
section.
We
hope
paper
offer
some
insights
advancing
novel
treating
serve
as
a
valuable
reference
researchers
field.
Acta Biochimica et Biophysica Sinica,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Intervertebral
disc
degeneration
(IDD)
is
a
major
cause
of
low
back
pain
(LBP),
and
effective
therapies
are
still
lacking.
Reactive
oxygen
species
(ROS)
stress
induces
NLRP3
inflammasome
activation,
this,
along
with
extracellular
matrix
metabolism
(ECM)
degradation
in
nucleus
pulposus
cells
(NPCs),
plays
crucial
role
the
progression
IDD.
Daphnetin
(DAP)
biologically
active
phytochemical
extracted
from
plants
Genus
Daphne,
which
possesses
various
bioactivities,
including
antioxidant
properties.
In
present
study,
we
demonstrate
that
DAP
significantly
attenuates
tert-butyl
hydroperoxide
(TBHP)-induced
ECM
degradation,
oxidative
activation
NPCs.
Furthermore,
could
facilitate
mitophagy
to
increase
removal
damaged
mitochondria,
consequently
reducing
mitochondrial
ROS
accumulation
alleviating
activation.
Mechanistically,
unveil
activates
by
stimulating
Nrf2/PINK1
signaling
pathway
TBHP-induced
vivo
experiments
further
corroborate
protective
effect
against
IDD
rat
model
induced
puncture.
Accordingly,
our
findings
reveal
be
promising
therapeutic
candidate
for
treatment