Recent advances in lignin antioxidant: Antioxidant mechanism, evaluation methods, influence factors and various applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 125992 - 125992

Published: Aug. 4, 2023

Language: Английский

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Molecular and Cellular Mechanisms of Osteoporosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15772 - 15772

Published: Oct. 30, 2023

Osteoporosis is a widespread systemic disease characterized by decrease in bone mass and an imbalance of the microarchitecture tissue. Experimental clinical studies devoted to investigating main pathogenetic mechanisms osteoporosis revealed important role estrogen deficiency, inflammation, oxidative stress, cellular senescence, epigenetic factors development resorption due osteoclastogenesis, decreased mineralization tissue formation reduced function osteoblasts caused apoptosis age-depended differentiation osteoblast precursors into adipocytes. The current review was conducted describe basic at molecular levels elucidate most promising therapeutic strategies therapy based on articles cited PubMed up September 2023.

Language: Английский

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Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 6, 2024

Sepsis is a potentially fatal condition characterized by organ dysfunction caused an imbalanced immune response to infection. Although increased inflammatory significantly contributes the pathogenesis of sepsis, several molecular mechanisms underlying progression sepsis are associated with cellular reactive oxygen species (ROS) generation and exhausted antioxidant pathways. This review article provides comprehensive overview involvement ROS in pathophysiology potential application antioxidants antimicrobial properties as adjunct primary therapies (fluid antibiotic therapies) against sepsis. delves into advantages disadvantages utilization therapeutic approach which has been explored variety animal models clinical trials. While suggested therapy suppress cases where intensified reaction occurs, use multiple agents can be beneficial they act additively or synergistically on different pathways, thereby enhancing defense. Furthermore, immunoadjuvant therapy, specifically septic patients displaying immunosuppressive tendencies, represents promising advancement therapy.

Language: Английский

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StackedEnC-AOP: prediction of antioxidant proteins using transform evolutionary and sequential features based multi-scale vector with stacked ensemble learning

BMC Bioinformatics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Aug. 4, 2024

Antioxidant proteins are involved in several biological processes and can protect DNA cells from the damage of free radicals. These regulate body's oxidative stress perform a significant role many antioxidant-based drugs. The current invitro-based medications costly, time-consuming, unable to efficiently screen identify targeted motif antioxidant proteins.

Language: Английский

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Peppermint and menthol: a review on their biochemistry, pharmacological activities, clinical applications, and safety considerations

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Jan. 3, 2024

In this manuscript, we conducted a comprehensive review of the diverse effects peppermint on human health and explored potential underlying mechanisms. Peppermint contains three main groups phytochemical constituents, including essential oils (mainly menthol), flavonoids (such as hesperidin, eriodictyol, naringenin, quercetin, myricetin, kaempferol), nonflavonoid phenolcarboxylic acids. exhibits antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, anti-cancer, anti-aging, analgesic properties may be effective in treating various disorders, gastrointestinal disorders (e.g., irritable bowel syndrome, dyspepsia, constipation, functional nausea/vomiting, gallbladder stones). addition, has therapeutic benefits for psychological cognitive health, dental urinary retention, skin wound healing, well anti-depressant anti-anxiety effects, it improve memory. However, paradoxical sleep quality alertness, been shown to patients with fatigue anxiety, while also increasing alertness under conditions monotonous work relaxation. We discuss its protective against toxic agents at recommended doses, safety toxicity. Overall, provides latest findings insights into clinical peppermint/menthol highlights natural agent conditions.

Language: Английский

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Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(10), P. 1630 - 1682

Published: Jan. 1, 2024

Many pathological conditions are predominantly associated with oxidative stress, arising from reactive oxygen species (ROS); therefore, the modulation of redox activities has been a key strategy to restore normal tissue functions. Current approaches involve establishing favorable cellular environment through administration therapeutic drugs and redox-active nanomaterials (RANs). In particular, RANs not only provide stable reliable means delivery but also possess capacity finely tune various interconnected components, including radicals, enzymes, proteins, transcription factors, metabolites. Here, we discuss roles that engineered play in spectrum conditions, such as cancer, neurodegenerative diseases, infections, inflammation. We visualize dual functions both generator scavenger ROS, emphasizing their profound impact on diverse The focus this review is solely inorganic (inorganic RANs). Additionally, deliberate challenges current RANs-based propose potential research directions for future clinical translation.

Language: Английский

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Free radicals and their impact on health and antioxidant defenses: a review

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated

Language: Английский

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In-vitro and in-silico evaluation of antihyperglycemic, antioxidant, anti-inflammatory activities of selected (2Z)-2-((E)(2'hydroxy)-4(benzylideneamino)phenyl)-3-(1-methyl-1H-imidazol-2-yl)acrylonitrile derivatives

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: unknown, P. 101592 - 101592

Published: Jan. 1, 2025

Language: Английский

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Dietary Patterns, Oxidative Stress, and Early Inflammation: A Systematic Review and Meta-Analysis Comparing Mediterranean, Vegan, and Vegetarian Diets

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 548 - 548

Published: Jan. 31, 2025

Background: Dietary habits influenced by lifestyle and cultural factors play a critical role in health modulating oxidative stress inflammation. While diets offer significant benefits, they may also pose risks, such as nutrient deficiencies, emphasizing the need for balanced approach. Exploring Mediterranean plant-based diet effects on inflammation biomarkers help improve outcomes disease prevention strategies. Methods: This study analyzed 65 studies following PRISMA guidelines to evaluate of healthy individuals. Results: The was weakly associated with reductions markers, including MDA (ROM: 0.80; 95% CI: 0.57–1.13; p = 0.2092) 8OHdG 0.81; 0.59–1.11; 0.1847), well markers CRP 0.72; 0.42–1.23; 0.1545) IL-6 1.23; 0.97–1.55; 0.08). vegetarian significantly reduced 0.82; 0.69–0.98; 0.0297), while vegan showed borderline reduction 0.56–1.17; 0.2544), suggesting lower systemic compared omnivorous diets. Conclusions: Although all three demonstrate potential reducing inflammation, antioxidant effects—especially diet—are than anticipated, indicating alternative mechanisms. Further research is essential confirm these findings clarify underlying mechanisms enhance preventive

Language: Английский

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Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 22, 2023

Cancer is a borderless global health challenge that continues to threaten human health. Studies have found oxidative stress (OS) often associated with the etiology of many diseases, especially aging process and cancer. Involved in OS reaction as key transcription factor, Nrf2 pivotal regulator cellular redox state detoxification. can prevent damage by regulating gene expression antioxidant response elements (ARE) promote process. generated an imbalance promotes accumulation mutations genome instability, thus establishment development different cancers. activation regulates plethora processes inducing proliferation, differentiation death, strongly OS-mediated What’s more, also involved anti-inflammatory effects metabolic disorders, neurodegenerative multidrug resistance. highly expressed multiple body parts digestive system, respiratory reproductive system nervous system. In oncology research, has emerged promising therapeutic target. Therefore, certain natural compounds drugs exert anti-cancer through signaling pathway, blocking pathway reduce some types tumor recurrence rates increase sensitivity chemotherapy. However, Nrf2’s dual role controversial impact cancer are inevitable consideration factors when treating this review, we summarized current biological characteristics its mechanism cells, discussed Keap1/Nrf2/ARE downstream genes, elaborated related pathways such AMPK/mTOR NF-κB. Besides, main target strategies using inhibitors or activators, well possible positive negative were reviewed. It be concluded serves important factor formation development, provides basis for targeted therapy

Language: Английский

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