Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(3), P. 3030 - 3064

Published: March 4, 2022

Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, fundamental function novel medical devices. The combination MNPs with commercial drugs (e.g., antibiotics, antifungals, and antivirals) may offer several opportunities to overcome some disadvantages their individual use enhance effectiveness. MNP conjugates multiple advantages. As drug delivery systems, the can extend circulation in body, facilitate intercellular targeting, improve stabilization, possess superior delivery. Concomitantly, they reduce required dose, minimize toxicity, broaden spectrum. this work, common strategies combine clinically used agents are underscored. Furthermore, comprehensive survey about synergistic effects, mechanism action, cytotoxicity is depicted.

Language: Английский

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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 234 - 234

Published: Jan. 23, 2024

Probiotics, known to be live microorganisms, have been shown improve or restore the gut microbiota, which in turn has linked improved health. It is believed that probiotics are modern equivalent of a panacea, with claims they may treat prevent different diseases both children and adults (e.g., from colic babies cardiovascular disease, respiratory infection, cancer adults). Ever since early 2000s, probiotic-based fermented foods had resurgence popularity, mostly due made regarding their health benefits. Fermented associated prevention irritable bowel syndrome, lactose intolerance, gastroenteritis, obesity, but also other conditions such as chronic diarrhea, allergies, dermatitis, bacterial viral infections, all closely related an unhealthy lifestyle. Recent ongoing developments microbiome/microbiota science given us new research directions for probiotics. The types, mechanisms, applications studied so far, those currently under study, great potential change scientific understanding probiotics’ nutritional human care. expansion fields study microbiome involvement its improvement foreshadow era significant changes. An expanding range candidate probiotic species emerging can address newly elucidated data-driven microbial niches host targets. In field, variants microbiome-modulating interventions being developed, including prebiotics, symbiotics, postbiotics, consortia, biotherapeutic products, genetically modified organisms, renewed interest polyphenols, fibers, ensure This manuscript aims analyze recent, emerging, anticipated trends (sources, doses, mechanism action, administered, side effects, risks) create vision development areas influence field.

Language: Английский

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Evidences and perspectives of the use of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for prevention and treatment of COVID-19: A bibliometric analysis and systematic review

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 120, P. 174 - 192

Published: Jan. 2, 2022

Language: Английский

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Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7165 - 7165

Published: Oct. 19, 2023

Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety natural modified peptides have been obtained studied, many others advancing in clinical trials, covering multiple therapeutic areas. As demand peptide-based therapies grows, so does need sustainable environmentally friendly synthesis methods. Traditional peptide synthesis, while effective, involves draining processes, generating significant waste consuming vast resources. The integration green chemistry offers alternatives, prioritizing eco-friendly reduction, energy conservation. This review delves into transformative potential applying principles by discussing relevant examples application such approaches production active ingredients (APIs) with a structure how these efforts critical an effective transition era field.

Language: Английский

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Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 8, 2021

Physical activity (PA) and nutrition are the essential components of a healthy lifestyle, as they can influence energy balance, promote functional ability various systems improve immunity. Infections their associated symptoms common frequent challenges to human health that causing severe economic social consequences around world. During aging, immune system undergoes dramatic aging-related changes/dysfunctions known immunosenescence. Clinically, immunosenescence refers gradual deterioration increases exposure infections, reduces vaccine efficacy. Such phenomenon is linked impaired responses lead dysfunction multiple organs, while lack physical activity, progressive loss muscle mass, concomitant decline in strength facilitate inflammation. In present review, we have discussed role PA, which boost alone synergistically. Evidence suggests long-term PA beneficial improving preventing infections. We further several nutritional strategies for system. Unfortunately, available evidence shows conflicting results. terms interaction with food intake, does not tend increase intake during short time course. However, overcoming deficiencies appears be most practical recommendation. Through balanced nutritious diet one fulfill bodily requirement optimal significantly impacts Supplementation single nutrient generally advisable. Rather incorporating fruits vegetables, whole grains, proteins probiotics may ensure adequate intake. Therefore, multi-nutrient supplements benefit people having deficiency spite sufficient diet. Along supplementation probiotics, bovine colostrum, plant-derived products foods provide additional benefits

Language: Английский

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Mapping the worldwide knowledge of antimicrobial substances produced by Lactobacillus spp.: A bibliometric analysis

Biochemical Engineering Journal, Journal Year: 2022, Volume and Issue: 180, P. 108343 - 108343

Published: Jan. 15, 2022

Language: Английский

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The Relationship Between Pediatric Gut Microbiota and SARS-CoV-2 Infection

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: July 8, 2022

This is the first study on gut microbiota (GM) in children affected by coronavirus disease 2019 (COVID-19). Stool samples from 88 patients with suspected severe acute respiratory syndrome 2 (SARS-CoV-2) infection and 95 healthy subjects were collected (admission: 3–7 days, discharge) to GM profile 16S rRNA gene sequencing relationship severity. The group was divided COVID-19 (68), Non–COVID-19 (16), MIS-C (multisystem inflammatory children) (4). Correlations among ecology, predicted functions, multiple machine learning (ML) models, response provided for cohorts. of cohort resulted as dysbiotic, lowest α-diversity compared CTRLs a specific β-diversity. Its appeared enriched Faecalibacterium , Fusobacterium Neisseria reduced Bifidobacterium Blautia Ruminococcus Collinsella Coprococcus Eggerthella Akkermansia ( p < 0.05). All paired-comparisons disclosed comparable results through all time points. comparison between cohorts highlighted reduction Abiotrophia characterized an increase Veillonella Clostridium Dialister Streptococcus decrease Granulicatella Prevotella CTRLs. Stratifying severity, associated “moderate” lower “mild” “asymptomatic” deprived Lachnospira Acidaminococcus Oscillospora Alistipes Bacteroides. ML models identified Staphylococcus Anaerostipes Dorea Roseburia Haemophilus Gemmiger Corynebacterium Bilophila Phascolarctobacterium Oscillospira microbial markers COVID-19. KEGG ortholog (KO)–based prediction functional 28 39 KO-associated pathways CTRLs, respectively. Finally, Bacteroides Sutterella correlated proinflammatory cytokines regardless Unlike adult profiles, marker pediatric GM. durable modification patients’ suggested prompt quenching SARS-CoV-2 since symptoms. fatty acid amino degradation proposed traits, possibly restrained severity SARS-CoV-2–infected children. Altogether, this evidence provides characterization COVID-19–related

Language: Английский

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The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2872 - 2872

Published: July 13, 2022

The core microbiome, which refers to a set of consistent microbial features across populations, is major interest in microbiome research and has been addressed by numerous studies. Understanding the can help identify elements that lead dysbiosis, treatments for microbiome-related health states. However, defining complex task at several levels. In this review, we consider current state human research. We knowledge gained, factors limiting our ability achieve reliable description fields most likely improve ability. DNA sequencing technologies methods analyzing metagenomics amplicon data will facilitate higher accuracy resolution describing microbiome. more effort should be invested characterizing microbiome's interactions with its host, including immune system nutrition. Other components holobiontic also emphasized, such as fungi, protists, lower eukaryotes, viruses, phages. Most importantly, collaborative experts microbiology, nutrition, immunology, medicine, systems biology, bioinformatics, machine learning probably required traits

Language: Английский

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A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 225 - 225

Published: Jan. 13, 2023

Herpes labialis remains exceedingly prevalent and is one of the most common human viral infections throughout world. Recurrent herpes evolves from initial infection by simplex virus type 1 (HSV-1) which subsequently presents with or without symptoms. Reactivation this triggered psychosocial factors such as stress, febrile environment, ultraviolet light susceptibility, specific dietary inadequacy. This also characterized uninterrupted transitions between chronic-latent acute-recurrent phases, allowing to opportunistically avoid immunity warrant transmission other vulnerable hosts simultaneously. review comprehensively evaluates current evidence on epidemiology, pathogenesis, modes, clinical manifestations, management options infections.

Language: Английский

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Exploring the potential impact of probiotic use on drug metabolism and efficacy

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114468 - 114468

Published: March 1, 2023

Probiotics are frequently consumed as functional food and widely used dietary supplements, but also recommended in treating or preventing various gastrointestinal diseases. Therefore, their co-administration with other drugs is sometimes unavoidable even compulsory. Recent technological developments the pharmaceutical industry permitted development of novel drug-delivery systems for probiotics, allowing addition to therapy severely ill patients. Literature data regarding changes that probiotics could impose on efficacy safety chronic medication scarce. In this context, present paper aims review currently by international medical community, evaluate relationship between gut microbiota pathologies high impact worldwide and, most importantly, assess literature reports concerning ability influence pharmacokinetics/pharmacodynamics some drugs, especially those narrow therapeutic indexes. A better understanding potential drug metabolism, contribute improving management, facilitating individualized updating treatment guidelines.

Language: Английский

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