Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(2), P. 564 - 578

Published: Oct. 24, 2022

Language: Английский

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Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: March 18, 2022

Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are limited therapeutic options for prevention and treatment SARS-CoV-2 infections. We evaluated antiviral activity sulforaphane (SFN), principal biologically active phytochemical derived from glucoraphanin, naturally occurring precursor present in high concentrations cruciferous vegetables. SFN inhibited vitro replication six strains SARS-CoV-2, including Delta Omicron, as well that seasonal HCoV-OC43. Further, remdesivir interacted synergistically to inhibit infection vitro. Prophylactic administration K18-hACE2 mice prior intranasal significantly decreased viral load lungs upper respiratory tract reduced lung injury pulmonary pathology compared untreated infected mice. diminished immune cell activation lungs, lower recruitment myeloid cells reduction T cytokine production. Our results suggest should be explored potential agent or

Language: Английский

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COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

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Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, prevalence various ocular complications has increased over time. SARS-CoV-2 infection been shown to have neurotropism and therefore lead not only peripheral inflammatory responses but also neuroinflammation. Because receptor for SARS-CoV-2, angiotensin-converting enzyme (ACE2), can be found in many intraocular tissues, disease 2019 (COVID-19) may contribute persistent neuroinflammation, microcirculation dysfunction symptoms. Increased awareness neuroinflammation future research on interventional strategies are important improving long-term outcomes, reducing burden, quality life. Therefore, aim this review is focus discuss current evidence perspectives, especially possible connections between conditions potential treatment strategies.

Language: Английский

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Comorbidities and clinical complications associated with SARS-CoV-2 infection: an overview

Clinical and Experimental Medicine, Journal Year: 2022, Volume and Issue: 23(2), P. 313 - 331

Published: April 1, 2022

Language: Английский

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Could the fibromyalgia syndrome be triggered or enhanced by COVID-19?

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(2), P. 633 - 651

Published: Feb. 27, 2023

Language: Английский

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Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 258 - 258

Published: Jan. 15, 2024

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is congenital blood disorder characterized by considerable phenotypic diversity. It comprises group of disorders, with sickle anemia (SCA) being most prevalent serious genotype. Although there have been some systematic reviews global data, worldwide statistics regarding SCD prevalence, morbidity, mortality remain scarce. In developed countries lower number patients, cutting-edge technologies led to development new treatments. However, developing settings where (SCD) more prevalent, medical management, rather than cure, still relies on use hydroxyurea, transfusions, analgesics. This that affects red cells, consequently affecting organs diverse manners. We discuss its etiology advent technologies, but aim this study understand various types nutrition-related studies involving individuals suffering from SCD, particularly Africa. The interplay environment, food, gut microbiota, along their respective genomes collectively known as microbiome, host metabolism responsible for mediating metabolic phenotypes modulating microbiota. addition, it serves purpose providing essential nutrients. Moreover, engages direct interactions homeostasis immune system, well indirect via metabolites. Nutrition interventions nutritional care are mechanisms addressing increased nutrient expenditures important aspects supportive management patients SCD. Underprivileged areas Sub-Saharan Africa should be accompanied efforts define promote Their importance key maintaining well-being quality life, especially because products limited, while native medicinal plant resources acknowledged.

Language: Английский

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High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 975 - 975

Published: July 23, 2024

Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity human health. Generated during mitochondrial respiration, inflammation, UV exposure pollution, these damage cells contribute pathologies like cardiovascular issues, neurodegeneration, cancer, metabolic syndromes. Lifestyle factors exert substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation equilibrium. Phytochemicals, abundant plants, such carotenoids, ascorbic acid, tocopherols polyphenols, offer diverse antioxidant mechanisms. They scavenge free radicals, chelate metal ions, modulate signalling pathways mitigate damage. Furthermore, plants thriving high-altitude regions are adapted extreme conditions, synthesize secondary metabolites, flavonoids phenolic compounds bulk quantities, which act form robust defence against including radiation temperature fluctuations. These promising sources for drug development, offering innovative strategies manage stress-related ailments enhance Understanding harnessing the potential of phytochemicals from represent crucial steps combating stress-induced disorders promoting overall wellbeing. This study offers comprehensive summary production physio-pathological aspects lifestyle-induced explores antioxidants. Additionally, it presents an appraisal medicinal antioxidants, highlighting their development creation therapeutic approaches.

Language: Английский

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Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes disease 19 (COVID-19) has numerous risk factors leading to severe with high mortality rate. Oxidative stress excessive production of reactive oxygen species (ROS) lower glutathione (GSH) levels seems be a common pathway associated the COVID-19 mortality. GSH is unique small but powerful molecule paramount for life. It sustains adequate redox cell signaling since physiologic level oxidative fundamental controlling life processes via signaling, oxidation and tissue damage. The water-soluble tripeptide (γ-L-glutamyl-L-cysteinyl-glycine) present in cytoplasm all cells. at 1–10 mM concentrations mammalian tissues (highest concentration liver) as most abundant non-protein thiol protects against stress. also activates Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related (Nrf2)-antioxidant response element (ARE) regulator pathway, releasing Nrf2 regulate expression genes control antioxidant, inflammatory immune system responses, facilitating activity. exists thiol-reduced disulfide-oxidized (GSSG) forms. Reduced prevailing form accounting >98% total GSH. GSSG their molar ratio are indicators functionality its alteration related various human pathological including COVID-19. plays prominent role SARS-CoV-2 infection following recognition viral S-protein by angiotensin converting enzyme-2 receptor pattern receptors like toll-like 4, activation transcription nuclear kappa B, subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) succeeded ROS production. depletion may have pathophysiology, host severity Therapies enhancing could become cornerstone reduce fatal outcomes increasing prevent subdue disease. value makes research field biology medicine key

Language: Английский

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Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity

BioMetals, Journal Year: 2022, Volume and Issue: 35(1), P. 125 - 145

Published: Jan. 7, 2022

Language: Английский

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