Microbial Mechanisms of Rheumatoid Arthritis Pathogenesis

Current Rheumatology Reports, Journal Year: 2024, Volume and Issue: 26(4), P. 124 - 132

Published: Feb. 1, 2024

Language: Английский

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Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034

Published: Jan. 12, 2025

Language: Английский

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Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Investigating the causal relationship between the gut microbiome and rheumatoid arthritis: mediating effects of immune cells

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 15, 2025

Rheumatoid arthritis (RA) is a complex autoimmune and inflammatory disease that significantly impacts the quality of life for millions worldwide. In recent years, gut microbiota has garnered extensive attention as potential health-modulating factor, with associations identified between it various diseases, including RA. This study aims to investigate causal relationship RA using Mendelian Randomization (MR) analysis, further examines mediating role immune cells in this connection. A MR analytical method was employed by us, integrating genome-wide association (GWAS) data from FinnGen, MiBioGen, research led Valeria Orrù her team systematically examine relationships microbiota, cells, Initially, we performed bidirectional univariable analysis RA, consciously avoiding any possible reverse influences. Following this, applied multivariable adjustments on showed positive two-step methodology overall genetic predictive cell-mediated risk developing Our results demonstrate notable connections different particular, Mollicutes, Ruminococcaceae UCG002, Butyricimonas displayed while other Rikenellaceae, Lactobacillaceae, Veillonella, negative associations. Additionally, reduction abundance certain Lachnospiraceae Ruminococcus1, which were excluded our validated accuracy methods such "leave-one-out." Immune CD3 found activated CD4 regulatory T express CD39, serve function development To summarize, focused species id. 945, recognizing crucial contributors predictions clarifies intricate links emphasizing mechanism. These findings not only enhance understanding pathogenesis but also provide new perspectives intervention targets future prevention treatment strategies. Future should specific mechanisms underlying interactions among considering validation these across diverse populations.

Language: Английский

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Microbiota-derived metabolites in inflammatory bowel disease

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 4, 2025

Abstract Understanding the role of gut microbiota in pathogenesis inflammatory bowel diseases (IBD) has been an area intense research over past decades. Patients with IBD exhibit alterations their microbial composition compared to healthy controls. However, studies focusing solely on taxonomic analyses have struggled deliver replicable findings across cohorts regarding which species drive distinct patterns IBD. The focus therefore shifted studying functionality microbes, especially by investigating effector molecules involved immunomodulatory functions microbiota, namely metabolites. Metabolic profiles are altered IBD, and several metabolites shown play a causative shaping immune animal models. Therefore, understanding complex communication between metabolites, host bears great potential unlock new biomarkers for diagnosis, disease course therapy response as well novel therapeutic options treatment In this review, we primarily promising classes thought exert beneficial effects generally decreased Though results from human trials promising, they not so far provided large-scale break-through IBD-therapy improvement. We propose tailored personalized supplementation based multi-omics analysis accounts individual metabolic patients rather than one-size-fits-all approaches.

Language: Английский

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Gut bacteriome, mycobiome and virome alterations in rheumatoid arthritis

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 9, 2023

Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease of the joints which causes significant pain, functional disability, and mortality. Although aberrant immune cell activation induced by imbalance between T helper Th1/Th17 Treg cells implicated in RA development, its etiopathogenesis remains unclear. The presence mucosal inflammation systemic IgA-isotype-autoantibodies (anti-citrullinated peptide antibodies rheumatoid factor) pre-clinical supports origin hypothesis involving altered microbiota development. gut comprises diverse bacteria, fungal viral components, are critical developing host immunity. Alterations microbial abundance known to exacerbate or attenuate responses microenvironment subsequently affecting joints. Further, these changes can provide biomarkers for activity outcome RA. Most research till date has been focused on describing bacterial components Studies mycobiome virome relatively new burgeoning field. Given paucity specific studies RA, this review, discusses recent findings alterations bacterial, fungal, as well their role regulating spectrum immune-pathogenic events occurring might be explored future potential therapeutic target. we an overview inter-kingdom interactions fungi, viruses current understanding modulation managing also summarised.

Language: Английский

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Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses

Arthritis Research & Therapy, Journal Year: 2023, Volume and Issue: 25(1)

Published: March 2, 2023

Abstract Background We aimed to investigate the gut microbiota of patients with established rheumatoid arthritis (RA) who have been managed disease-modifying anti-rheumatic drugs (DMARDs) for a long time. focused on factors that might affect composition microbiota. Furthermore, we investigated whether predicts future clinical responses conventional synthetic DMARDs (csDMARDs) in an insufficient response initial therapy. Methods recruited 94 RA and 30 healthy participants. Fecal microbiome was analyzed by 16S rRNA amplificon sequencing; resulting raw reads were processed based QIIME2. Calypso online software used data visualization compare microbial between groups. For moderate-to-high disease activity, treatment changed after stool collection, observed 6 months later. Results The different from Young (< 45 years) had reduced richness, evenness, distinct compositions when compared older individuals. Disease activity factor levels not associated composition. Overall, biological csDMARDs, except sulfasalazine TNF inhibitors, respectively, RA. However, combination Subdoligranulum Fusicatenibacter genera good second-line csDMARDs showed first-line csDMARDs. Conclusion Gut is Thus, has potential predict some

Language: Английский

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New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 766 - 766

Published: April 28, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage and even permanent disability, seriously affecting patients’ quality of life. At present, the complete cure for RA not achievable, only relieve symptoms reduce pain patients. Factors such as environment, genes, sex induce RA. Presently, non-steroidal anti-inflammatory drugs, DRMADs, glucocorticoids are commonly used in treating In recent years, some biological agents have also been applied clinical practice, but most side effects. Therefore, finding new mechanisms targets necessary. This review summarizes potential discovered from perspective epigenetics mechanisms.

Language: Английский

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Decoding the Microbiome’s Influence on Rheumatoid Arthritis

Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2170 - 2170

Published: Aug. 28, 2023

The aim is better to understand and critically explore present the available data from observational studies on pathogenetic role of microbiome in development rheumatoid arthritis (RA). electronic databases PubMed, Scopus, Web Science were screened for relevant literature published last ten years. primary outcomes investigated included influence gut pathogenesis arthritis, exploring changes microbiota diversity relative abundance microbial taxa individuals with RA healthy controls (HCs). risk bias was assessed using GRADE criteria. Ten identified qualitative assessment. A total 647 represented literature, addition 16 psoriatic (PsA) 247 HCs. biospecimens comprised fecal samples across all 16S rDNA sequencing representing method biological analyses. Significant differences observed compared that HCs: a decrease Faecalibacterium, Fusicatenibacter, Enterococcus, Megamonas increases Eggerthellales, Collinsella, Prevotella copri, Klebsiella, Escherichia, Eisenbergiella, Flavobacterium. There are significant alterations This includes an increase copri Lactobacillus reductions Collinsella. Collectively, these proposed induce inflammatory responses degrade integrity intestinal barrier; however, further needed confirm this relationship.

Language: Английский

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Associations between rheumatoid arthritis and intestinal flora, with special emphasis on RA pathologic mechanisms to treatment strategies

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 188, P. 106563 - 106563

Published: Feb. 6, 2024

Language: Английский

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