Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154948 - 154948
Published: July 2, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Language: Английский
Citations
237
npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: April 2, 2024
Abstract Gamma-aminobutyric acid (GABA) plays a crucial role in the central nervous system as an inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with neurological diseases, such Alzheimer’s and Parkinson’s disease, psychological disorders, including anxiety, depression, stress. Since GABA has long been believed to not cross blood–brain barrier, effects circulating on brain neglected. However, emerging evidence demonstrated that changes both levels gut microbiota composition play modulating mental health. This recent research raised possibility may be potent mediator gut–brain axis. review article will cover up-to-date information about GABA-producing microorganisms isolated from human food sources, explanation why those produce GABA, factors inducing gut–GABA production, suggesting linking between health, stress, epilepsy, autism spectrum disorder, attention deficit hyperactivity novel regarding homocarnosine-a predominant peptide is putative downstream regulating functions. help us understand how GABA-homocarnosine metabolism significant Nonetheless, it could support further use production-inducing agents treat disorders.
Language: Английский
Citations
44
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: July 20, 2024
Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1560 - 1560
Published: Feb. 12, 2025
Guhong injection (GH) is a compound preparation widely utilized in the treatment of cerebrovascular diseases. Accumulating evidence indicates that gut microbiota implicated development ischemic stroke (IS). However, although therapeutic potential GH IS may be mediated through microbiota, intricate relationships among gut-brain axis, biomarkers, and target proteins remain to completely explained. A rat model middle cerebral artery occlusion (MCAO) was investigate impact on IS. Our 16S rRNA sequence analysis revealed markedly enhanced α-diversity intestinal microbiome rectified imbalance short-chain fatty acids (SCFAs). Metabolomic indicated reversed 45 biomarkers 6 disordered metabolic pathways MCAO rats. Among these, arachidonic acid, α-linolenic fructose, mannose were closely associated with comprising Lactobacillus modulated by GH. Furthermore, IS-related signaling pathways, including inflammation, autophagy, oxidative stress, apoptosis, significantly three microbial species influenced The efficacy context multiple involving SCFAs, proteins. This process partly relies axis.
Language: Английский
Citations
1
LWT, Journal Year: 2023, Volume and Issue: 187, P. 115269 - 115269
Published: Sept. 1, 2023
Oxidative stress is a hallmark of many cancers. Probiotics with antioxidant properties have been found to alleviate oxidative stress. Lactiplantibacillus plantarum ZJ316 (L. ZJ316) an exceptional strain that shows excellent hydrogen peroxide (H2O2) tolerance, sensitivity the seven antibiotics (ampicillin, gentamicin, kanamycin, erythromycin, glycine, tetracycline and chloramphenicol) recommended by European Food Safety Authority (EFSA), exhibits good cell hydrophobicity Caco-2 adhesion ability, but its mechanism unclear. This study showed L. can withstand 2.5 mmol/L H2O2 both intact cells fermentation supernatant exhibit strong free radical scavenging ability. Furthermore, homogenate fermented (ZJ316 FS) performed higher activity enzymes. In addition, mRNA level genes in regulated redox homeostasis orderly manner, demonstrating at transcriptional level. summary, has properties, no hemolytic drug resistance transfer, indicating holds potential be utilized as modulator probiotic functional foods.
Language: Английский
Citations
17
Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 309 - 330
Published: June 21, 2024
Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating existence microbiome–oxidative interaction. However, biochemical basis this interaction still unclear. In narrative review, possible pathways microbiota and are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, melatonin also appear to roles. Moreover, relationship between microbiome obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, medications considered. An investigation correlation bacterial community features OS parameter changes under normal pathological conditions might provide information for determination new methods. Furthermore, such could contribute establishing a foundation determining linkers microbiome–OS association.
Language: Английский
Citations
7
Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: April 16, 2024
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 4, 2024
Abstract The gut microbiota plays a crucial role in neural development and progression of disorders like Parkinson’s disease (PD). Probiotics have been suggested to impact neurodegenerative diseases via gut-brain axis. This study aims investigate the therapeutic potential Lacticaseibacillus rhamnosus E9, high exopolysaccharide producer, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model PD. C57BL/6 mice subjected MPTP were fed L. E9 for fifteen days sacrificed after last administration. Motor functions determined by open-field, catalepsy, wire-hanging tests. ileum brain tissues collected ELISA, qPCR, immunohistochemistry analyses. cecum content was obtained analysis. supplementation alleviated MPTP-induced motor dysfunctions accompanied decreased levels striatal TH dopamine. also reduced level ROS striatum DAT expression while increasing DR1. Furthermore, improved intestinal integrity enhancing ZO-1 Occludin reversed dysbiosis induced MPTP. In conclusion, deficits damage as well barrier modulating PD mice. These findings suggest that holds managing through
Language: Английский
Citations
6
Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 550 - 550
Published: Jan. 20, 2023
Multiple sclerosis (MS), a distinct autoimmune neuroinflammatory disorder, affects millions of people worldwide, including Saudi Arabia. Changes in the gut microbiome are linked to development neuroinflammation via mechanisms that not fully understood. Prebiotics and probiotics camel milk has been fermented have variety health benefits. In this study, Bacillus amyloliquefaciens-supplemented (BASY) was used assess its preventive effect on MS symptoms myelin oligodendrocyte glycoprotein (MOG)-immunized C57BL6J mice model. To end, MOG-induced experimental encephalomyelitis (EAE) established level disease index, pathological scores, anti-inflammatory markers BASY-treated using macroscopic microscopic examinations, qPCR immunoblot were investigated. The results demonstrate BASY significantly reduced EAE increased total microbial load (2.5 fold), improved levels short-chain fatty acids propionic, butyric caproic diseased group. Additionally, myeloperoxidase (MPO) proinflammatory cytokines (IL-1β, IL-6, IL-17, TNF-α) (TGF-β) regulated by treatment. Significant suppression MPO VCAM noticed group (from 168 111 µM from 34 27 pg/mL, respectively), comparison treatment expression inflammatory cytokines, progression related transcripts, protein markers. conclusion, may be develop probiotic-based diet promote host health. cumulative findings study confirm significant neuroprotection They could also suggest novel approach MS-associated disorders.
Language: Английский
Citations
11
Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1138 - 1138
Published: April 12, 2024
The intestinal epithelial barrier can prevent the invasion of pathogenic microorganisms and food antigens to maintain a consistent homeostasis. However, an imbalance in this result various diseases, such as inflammatory bowel disease, malnutrition, metabolic disease. Thus, aim study was select probiotic strains with barrier-enhancing ability cell-based model further investigate them for their improving effects on colitis mouse weaned piglet models. results showed that selected specific cell-free fermentation supernatants (CFSs) from Ligilactobacillus salivarius P1, Lactobacillus gasseri P12, Limosilactobacillus reuteri G7 promoted cell growth proliferation, strengthening line Caco-2 model. Further, administration CFSs L. were found ameliorate DSS-induced mice. Additionally, spray-dried powders CFS three examined model, only powder could feed/gain ratio serum levels D-lactate endotoxin. In conclusion, new potential strain, G7, ameliorating both
Language: Английский
Citations
4