Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(5), P. 535 - 535
Published: May 16, 2024
Psoriasis
is
a
chronic
recurrent
inflammatory
autoimmune
pathology
with
significant
genetic
component
and
several
interferences
of
immunological
cells
their
cytokines.
The
complex
orchestration
psoriasis
pathogenesis
related
to
the
synergic
effect
immune
cells,
polygenic
alterations,
autoantigens,
other
external
factors.
major
act
IL-23/IL-17
axis,
strongly
influencing
pattern
established
during
disease
activity,
visible
as
continuous
perpetuation
pro-inflammatory
response
keratinocyte
activation
proliferation,
leading
development
psoriatic
lesions.
Genome-wide
association
studies
(GWASs)
offer
better
view
pathogenic
pathways,
approximately
one-third
psoriasis’s
impact
on
associated
MHC
region,
loci
located
chromosome
6.
most
eloquent
factor
psoriasis,
PSORS1,
was
identified
in
I
site.
Among
factors
involved
its
etiology,
dysbiosis,
due
or
stimulus,
induces
burst
consequences;
both
cutaneous
gut
microbiome
get
process.
Cutting-edge
research
comprehensive
insights
into
pathogenesis,
fostering
novel
genetic,
epigenetic,
factors,
have
generated
spectacular
improvement
over
past
decades,
securing
path
toward
specific
targeted
immunotherapeutic
approach
delayed
progression
arthritis.
This
review
aimed
insight
various
domains
that
underline
how
they
influence
evolution.
mechanism
multifaceted
involves
an
interplay
cellular
humoral
immunity,
which
affects
susceptible
microbiota
background.
An
in-depth
understanding
role
forms
basis
for
developing
individualized
therapeutic
targets
can
improve
management.
Brain Behavior and Immunity Integrative,
Journal Year:
2024,
Volume and Issue:
5, P. 100046 - 100046
Published: Jan. 1, 2024
Gut
microbiota
consists
a
majority
of
bacteriodetes,
firmicutes,
actinobacteria,
proteobacteria,
fusobacteria,
verrucomicrobiota
which
has
evolved
long
way
alongside
humans
where
it
helps
in
digestion
and
even
other
complex
functions
include
development
gut
lymphoid
tissue,
vitamin
synthesis,
polarization
specific
immune
responses,
prevention
colonization
by
pathobionts.
Innate
adaptive
immunity
been
set
the
body
contrast
to
involving
helper
T
cells
cytotoxic
along
with
immunoglobulins.
Hence
immunomodulatory
action
is
already
studied
explained
mast
cell
degranulation.
A
few
factors
like
age,
diet,
antibiotics,
others
shape
normal
flora
into
dysbiosis
possibly
through
translocation
microbes,
molecular
mimicry,
altered
metabolite
production
bringing
unfavoured
immunological
actions
imbalance
improper
permeability
causing,
autoimmunity.
Changes
microbes
from
phylum
proteobacteria
bring
changes
that
lead
various
autoimmune
diseases
multiple
sclerosis,
type
1
diabetes
mellitus,
rheumatoid
arthritis
etc.
This
review
explains
possible
mechanisms
causes
leading
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 29, 2024
Background
Accumulating
evidence
suggests
that
alterations
in
gut
microbiota
composition
are
associated
with
the
hidradenitis
suppurativa
(HS).
However,
causal
association
between
and
HS
remain
undetermined.
Methods
We
performed
a
bidirectional
two-sample
Mendelian
randomization
(MR)
analysis
using
genome-wide
study
summary
data
of
from
MiBioGen
consortium
which
concluded
18,340
individuals
analyzed
by
Consortium,
comprising
211
microbiota.
were
acquired
strictly
defined
collected
FinnGenbiobank
analysis,
included
211,548
European
ancestors
(409
patients,
211,139
controls).
The
inverse
variance
weighted
method
(IVW),
median
(WME),
simple
model,
median,
MR-Egger
used
to
determine
changes
pathogenic
bacterial
taxa,
followed
sensitivity
including
horizontal
pleiotropy
analysis.
MR
Steiger
test
evaluated
strength
leave-one-out
assessed
reliability
results.
Additionally,
reverse
was
carried
out
seek
for
possible
causality.
Results
By
combining
findings
all
steps,
we
identified
four
namely,
Family
XI,
Porphyromonadaceae,
Clostridium
innocuum
group
Lachnospira.
risk
might
be
positively
high
relative
abundance
(Odds
ratio,
OR
2.17,
p
=
0.00038)
Lachnospira
(OR
2.45,
0.017)
but
negatively
XI
0.67,
0.049)
Porphyromonadaceae
0.29,
0.014).
There
no
noticeable
outliers,
pleiotropy,
or
heterogeneity.
Furthermore,
there
proof
causation
found
study.
Conclusion
This
indicates
have
anti-protective
effect
on
HS,
whereas
protective
HS.
Our
reveals
exists
beneficial
detrimental
offers
potentially
methods
therapy
avoidance
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(18), P. 10355 - 10365
Published: April 15, 2024
The
genus
Bifidobacterium
has
been
widely
used
in
functional
foods
for
health
promotion
due
to
its
beneficial
effects
on
human
health,
especially
the
gastrointestinal
tract
(GIT).
In
this
study,
we
characterize
anti-inflammatory
potential
of
probiotic
strain
pseudocatenulatum
G7,
isolated
from
a
healthy
male
adult.
G7
secretion
inhibited
inflammatory
response
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
macrophages.
Moreover,
oral
administration
bacteria
alleviated
severity
colonic
inflammation
dextran
sulfate
sodium
(DSS)-treated
colitis
mice,
which
was
evidenced
by
decreased
disease
activity
index
(DAI)
and
enhanced
structural
integrity
colon.
16S
rRNA
gene
sequencing
result
illustrated
that
DSS-induced
gut
microbiota
dysbiosis,
accompanied
modulated
bile
acids
short-chain
fatty
acid
(SCFA)
levels.
Overall,
our
results
demonstrated
both
vitro
vivo
models,
provided
solid
foundation
further
development
novel
probiotic.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(5), P. 535 - 535
Published: May 16, 2024
Psoriasis
is
a
chronic
recurrent
inflammatory
autoimmune
pathology
with
significant
genetic
component
and
several
interferences
of
immunological
cells
their
cytokines.
The
complex
orchestration
psoriasis
pathogenesis
related
to
the
synergic
effect
immune
cells,
polygenic
alterations,
autoantigens,
other
external
factors.
major
act
IL-23/IL-17
axis,
strongly
influencing
pattern
established
during
disease
activity,
visible
as
continuous
perpetuation
pro-inflammatory
response
keratinocyte
activation
proliferation,
leading
development
psoriatic
lesions.
Genome-wide
association
studies
(GWASs)
offer
better
view
pathogenic
pathways,
approximately
one-third
psoriasis’s
impact
on
associated
MHC
region,
loci
located
chromosome
6.
most
eloquent
factor
psoriasis,
PSORS1,
was
identified
in
I
site.
Among
factors
involved
its
etiology,
dysbiosis,
due
or
stimulus,
induces
burst
consequences;
both
cutaneous
gut
microbiome
get
process.
Cutting-edge
research
comprehensive
insights
into
pathogenesis,
fostering
novel
genetic,
epigenetic,
factors,
have
generated
spectacular
improvement
over
past
decades,
securing
path
toward
specific
targeted
immunotherapeutic
approach
delayed
progression
arthritis.
This
review
aimed
insight
various
domains
that
underline
how
they
influence
evolution.
mechanism
multifaceted
involves
an
interplay
cellular
humoral
immunity,
which
affects
susceptible
microbiota
background.
An
in-depth
understanding
role
forms
basis
for
developing
individualized
therapeutic
targets
can
improve
management.
