Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management—A Narrative Review DOI Open Access
Ewelina Młynarska, Jakub Wasiak, Agata Gajewska

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1938 - 1938

Published: June 19, 2024

Type 2 diabetes is a disease with significant health consequences for the individual. Currently, new mechanisms and therapeutic approaches that may affect this are being sought. One of them association type microbiota. Through enteric nervous system gut–microbiota axis, microbiota affects functioning body. It has been proven to have real impact on influencing glucose lipid metabolism insulin sensitivity. With dysbiosis, there increased bacterial translocation through disrupted intestinal barrier inflammation in In diabetes, microbiota’s composition altered with, example, more abundant class Betaproteobacteria. The these disorders linked involving short-chain fatty acids, branched-chain amino lipopolysaccharide, among others. Interventions focusing gut gaining traction as promising approach management. Studies currently conducted effects supply probiotics prebiotics, well fecal transplantation, course diabetes. Further research will allow us fully develop our knowledge subject possibly best treat prevent

Language: Английский

The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis DOI
Yulin Ye, Limin Liu, Zelin Feng

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 214, P. 219 - 235

Published: Feb. 15, 2024

Language: Английский

Citations

14
Unraveling the Microbiome–Human Body Axis: A Comprehensive Examination of Therapeutic Strategies, Interactions and Implications DOI Open Access
Gabriel Olteanu, Maria-Alexandra Pană, Ștefan Busnatu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5561 - 5561

Published: May 20, 2024

This review scrutinizes the intricate interplay between microbiome and human body, exploring its multifaceted dimensions far-reaching implications. The microbiome, comprising diverse microbial communities inhabiting various anatomical niches, is increasingly recognized as a critical determinant of health disease. Through an extensive examination current research, this elucidates dynamic interactions host physiology across multiple organ systems. Key topics include establishment maintenance microbiota diversity, influence factors on composition, bidirectional communication pathways cells. Furthermore, we delve into functional implications dysbiosis in disease states, emphasizing role shaping immune responses, metabolic processes, neurological functions. Additionally, discusses emerging therapeutic strategies aimed at modulating to restore host–microbe homeostasis promote health. Microbiota fecal transplantation represents groundbreaking approach management dysbiosis-related diseases, offering promising avenue for restoring balance within gut ecosystem. innovative therapy involves transfer from healthy donor individual suffering dysbiosis, aiming replenish beneficial populations mitigate pathological imbalances. By synthesizing findings fields, offers valuable insights complex relationship highlighting avenues future research clinical interventions.

Language: Английский

Citations

12
Sex-specific differences in intestinal microbiota associated with cardiovascular diseases DOI Creative Commons
Helena García-Fernández, Antonio P. Arenas-de Larriva, Javier López-Moreno

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 19, 2024

Abstract Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations intestinal microbiota between and women afflicted with CHD delineate these against non-CVD control group for each sex. Methods Our research was conducted framework of CORDIOPREV study, clinical trial which involved 837 165 CHD. We contrasted our findings reference 375 individuals (270 men, 105 women) without CVD. The examined through 16S metagenomics on Illumina MiSeq platform data processed Quiime2 software. Results results showed sex-specific variation (beta diversity) microbiota, while alpha-biodiversity remained consistent across both sexes. Linear discriminant analysis effect size (LEfSe) revealed sex-centric alterations linked Moreover, using random forest (RF) methodology, we identified seven bacterial taxa—g_UBA1819 (Ruminococcaceae), g_Bilophila, g_Subdoligranulum, g_Phascolarctobacterium, f_Barnesiellaceae, g_Ruminococcus, an unknown genus from Ruminococcaceae family (Ruminococcaceae incertae sedis)—as key discriminators diagnosed same taxa also emerged as critical CHD-afflicted individuals, when analyzed separately by Conclusion suggest dysbiosis CHD, potentially contributing sex disparity observed CVD incidence. Trial registration Clinical Trials.gov.Identifier NCT00924937. Graphical

Language: Английский

Citations

10
Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation DOI Creative Commons
Bozhong Shi, Haoyu Li, Xiaomin He

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 27, 2024

The gut microbiome is known as the tenth system of human body that plays a vital role in intersection between health and disease. considerable inter-individual variability microbiota poses both challenges great prospects promoting precision medicine cardiovascular diseases (CVDs). In this review, based on development, evolution, influencing factors full life circle, we summarized recent advances characteristic alteration CVDs throughout different stages, depicted their pathological links mechanism, well highlight achievements targeting prevention, diagnosis treatment. Personalized strategies could be tailored according to characteristics including microbiota-blood metabolites combined prediction diagnosis, dietary interventions, lifestyle improvements, probiotic or prebiotic supplements. However, fulfill promise lifelong health, more mechanism studies should progress from correlation causality decipher novel mechanisms linking specific microbes CVDs. It also promising use burgeoning artificial intelligence machine learning target for developing screening new therapeutic interventions.

Language: Английский

Citations

10
Microbiome interactions with different risk factors in development of myocardial infarction DOI Creative Commons

Manisha Bijla,

Sunil Saini, Ajai Kumar Pathak

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 189, P. 112409 - 112409

Published: March 27, 2024

Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % deaths. The intricate web risk factors MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by human gut microbiota, their diversity, richness, dysbiosis, along with respective metabolites. Host genetic factors, especially allelic variations in signaling inflammatory markers, greatly affect progression or severity disease. Despite established significance microbiome-nutrient-metabolite interplay associations CVDs, unexplored terrain gut-heart-oral axis has risen a critical knowledge gap. Moreover, pivotal role microbiome complex host genetics, compounded age-related changes, emerges an area vital importance development MI. In addition, distinctive disease susceptibility gender-based ancestral differences, adds crucial insights to association increased Here, we aimed provide overview on interactions (oral gut) major (tobacco alcohol consumption, diet, hypertension gender, aging) MI therapeutic regulation.

Language: Английский

Citations

10
Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action DOI Open Access
Justyna Godos, Giovanni Luca Romano, Samuele Laudani

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2471 - 2471

Published: July 30, 2024

Cardiovascular diseases (CVDs) are one of the main causes mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role improving cardiovascular health. Flavan-3-ols represent subclass great interest for their possible health benefits. In this review, we summarized results clinical studies on vascular outcomes flavan-3-ol supplementation focused microbiota CVD. Clinical trials included review showed that with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure improves endothelial function. Studies catechins green tea demonstrated better when involving individuals. From mechanistic point view, emerging evidence suggests microbial metabolites may play observed effects. Their function extends beyond previous belief ROS scavenging activity encompasses direct impact gene expression protein Although appear effects health, further needed clarify confirm these potential benefits rising involvement microbiota.

Language: Английский

Citations

9
The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review DOI

Soroush Oraee,

Mohammadreza Alinejadfard,

Sajjad Mahdavi

et al.

Toxicology and Environmental Health Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

1
Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism DOI Creative Commons
Lin Li,

Senjie Zhong,

Jiahao Ye

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality morbidity rates globally. Shenmai injection (SMI), form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF. Recent research suggests that Medicine (TCM) may induce beneficial changes microbial-host co-metabolism, potentially providing cardiovascular protection. This study used rat model hypertensive heart (H-HF) to explore the mechanism SMI. The possible compounds key targets SMI against H-HF were investigated using network pharmacology. pharmacodynamics validated animal model, with analysis fecal gut microbiota integrating metabolomics 16S rRNA sequencing. Metorigin metabolite traceability MetaboAnalyst platform utilized action mechanism. To evaluate serum TMAO levels, targeted was performed. Finally, looked at intrinsic relationships among modifications intestinal flora, profile changes, clarify how they might be treat H-HF. According sequencing, reestablishing homeostasis microbiota, affects vital metabolic pathways, such as energy metabolism, amino acid bile metabolism. Increased levels identified risk factor for H-HF, able downregulate TMAO-related metabolites. Network pharmacology 13 active components targeting 46 proteins, resulting differential expression 8 metabolites 24 microbes. In conclusion, this highlights alleviating its potential modulate co-metabolism. Through comprehensive discussion interconnected components, targets, metabolites, it provided fresh light on therapeutic Not applicable.

Language: Английский

Citations

1
The gut microbiota and its role in the development of cardiovascular disease DOI
Carlos Escobar, Xavier Aldeguer, David Vivas

et al.

Expert Review of Cardiovascular Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 7, 2025

The pathophysiology of cardiovascular diseases encompasses a complex interplay genetic and environmental risk factors. Even if traditional factors are treated to target, there remains residual risk. This manuscript reviews the potential role gut microbiota in development disease, as target. A systematic search was conducted until 30 October 2024 on PubMed (MEDLINE), using MeSH terms [Gut microbiota] + [Dysbiosis] [Cardiovascular] [TMAO] [bile acids] [short-chain fatty acids]. term dysbiosis implies changes equilibrium, with modifications composition functionality series additional factors: reduced diversity uniformity microorganisms; short-chain acid-producing bacteria; increased permeability; release metabolites, such trimethylamine N-oxide, betaine, phenylalanine, tryptophan-kynurenine, phenylacetylglutamine, lipopolysaccharides; secondary bile acid excretion, leading inflammation, oxidative stress, endothelial dysfunction facilitating onset pathological conditions, including obesity, hypertension, diabetes, atherosclerosis, heart failure. Attempts restore balance through different interventions, mainly diet, have been shown positively affect individual components metabolites reduce disease. In addition, probiotics prebiotics potentially useful. Fecal transplantation is promising therapy.

Language: Английский

Citations

1
Risk of stroke in patients with inflammatory bowel disease: a systematic review and meta-analysis DOI Creative Commons
Chao Luo,

Lingpei Liu,

Di Zhu

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

Current studies suggest a potential link between inflammatory bowel disease (IBD), comprising Crohn's (CD) and ulcerative colitis (UC), cardiovascular diseases, such as stroke. This study aimed to assess the risk of stroke in IBD patients compared general population. Systematic search was done PubMed, Embase, CENTRAL, Scopus, CINAHL databases for published till September 2023. Using random-effects model, hazard ratios (HRs) with 95% confidence intervals (CIs) occurrence were calculated. Subgroup analyses estimate pooled HR 95%CI CD, UC, overall cases separately. Publication bias assessment by Begg's Egger's tests. Thirteen 2,802,955 participants included. had significantly higher stroke, 1.30 [95% CI 1.21–1.39]. analysis demonstrated an 1.35 1.22–1.49] CD 1.15 1.09–1.22] UC. Substantial heterogeneity detected across studies, no substantial publication bias. Sensitivity affirmed stability findings. general, particular are associated Our findings further emphasize importance management strategies care. PROSPERO, CRD42023470602.

Language: Английский

Citations

1