Isolation of a Virulent Clostridium perfringens Strain from Elaphurus davidianus and Characterization by Whole-Genome Sequence Analysis DOI Creative Commons
Zhao Zhang, Xiao Wang, Siyuan Li

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 7169 - 7186

Published: July 8, 2024

(

THE ROLE OF TRADITIONAL CHINESE MEDICINE IN ADDRESSING THE CHALLENGES OF CLOSTRIDIAL GAS GANGRENE: A MULTIFACETED APPROACH DOI

Pavithra Bharathy,

Punniyakoti T. Veeraveedu

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100198 - 100198

Published: March 1, 2025

Language: Английский

Citations

0
Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways DOI Creative Commons
Xinyue Tian,

Jingyang Li,

Siyu Liu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e33161 - e33161

Published: June 1, 2024

Poultry necrotic enteritis is an important enteric disease which might be controlled by antibiotics. However, with the excessive use of antibiotics, phenomenon drug resistance Clostridium perfringens becoming increasingly prominent. Anemoside B4 exhibits anti-inflammatory, antioxidant and immunomodulatory effects. This study was performed to estimate effect on chicken induced C. in vivo vitro. In experiment we investigated efficacy growth curve, biofilm formation, haemolytic activity, virulence-related gene expression NF-κB PI3K/AKT/mTOR activation Caco-2 cells perfringens. The results showed that 12.5–50 μg/mL had no antibacterial activity but could inhibit attenuate weaken PI3K/Akt/mTOR triggered cells. experiment, 60 17-day-old healthy White Leghorns were randomly divided into six groups. growing laying hens control group fed a basic diet, those five challenged groups diet (infection group), added 0.43 g/kg (0.43 Ane 0.86 (0.86 1.72 (1.72 group) 40 mg/kg lincomycin (lincomycin respectively. All infected 1 × 109 CFU from day 17–20. Blood intestinal samples obtained, data demonstrated improved blood biochemical parameters, attenuated jejunum tissue injury, increased spleen, thymus, bursa fabricius index, decreased lesion scores ileum. jejunum, downregulated IL-1β, IL-6, IL-10, TNF-α IFN-γ at mRNA levels. Moreover, significantly enhanced both protein levels tight junctions ZO-1, Claudin-1 MUC-2 jejunum. weakened p-P65, p-PI3K, p-Akt p-mTOR Diets supplemented alleviated perfringens-induced inhibiting signalling pathways improving barrier functions.

Language: Английский

Citations

2
Latest research progress on anti-microbial effects, mechanisms of action, and product developments of dietary flavonoids: A systematic literature review DOI

J. Q. Luo,

Jinhai Luo,

Zhili Sheng

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 156, P. 104839 - 104839

Published: Dec. 13, 2024

Language: Английский

Citations

2
A Supramolecular Antibiotic Targeting Drug-Resistant Pseudomonas aeruginosa through the Inhibition of Virulence Factors and Activation of Acquired Immunity DOI Creative Commons
Cheng Jiang, Lei Zheng, Yujie Yan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(32), P. 41828 - 41842

Published: Aug. 1, 2024

The bacterium

Language: Английский

Citations

1
Vaccination with formulations targeting Eimeria maxima and Clostridium perfringens conferred comprehensive protection using a dual-infection challenge model of necrotic enteritis DOI Creative Commons
Qingzheng Zhang, Yue Yuan,

Xianglin Pu

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(2), P. 104687 - 104687

Published: Dec. 17, 2024

Language: Английский

Citations

0
Isolation of a Virulent Clostridium perfringens Strain from Elaphurus davidianus and Characterization by Whole-Genome Sequence Analysis DOI Creative Commons
Zhao Zhang, Xiao Wang, Siyuan Li

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 7169 - 7186

Published: July 8, 2024

(

Citations

0