Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7910 - 7910
Published: April 26, 2023
Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).
Language: Английский
Citations
114
Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10
Published: June 5, 2023
Hypertensive heart disease constitutes functional and structural dysfunction pathogenesis occurring primarily in the left ventricle, atrium coronary arteries due to chronic uncontrolled hypertension. is underreported mechanisms underlying its correlates complications are not well elaborated. In this review, we summarize current understanding of hypertensive disease, discuss detail associated with development especially ventricular hypertrophy, atrial fibrillation, failure artery disease. We also briefly highlight role dietary salt, immunity genetic predisposition pathogenesis.
Language: Английский
Citations
47
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530
Published: July 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Language: Английский
Citations
8
Life, Journal Year: 2024, Volume and Issue: 14(2), P. 263 - 263
Published: Feb. 17, 2024
This comprehensive exploration delves into the intricate interplay of methylglyoxal (MG) and glyoxalase 1 (GLO I) in various physiological pathological contexts. The linchpin narrative revolves around role these small molecules age-related issues, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders. Methylglyoxal, a reactive dicarbonyl metabolite, takes center stage, becoming principal player development AGEs contributing to cell tissue dysfunction. dual facets GLO I-activation inhibition-unfold as potential therapeutic avenues. Activators, spanning synthetic drugs like candesartan natural compounds polyphenols isothiocyanates, aim restore I function. These molecular enhancers showcase promising outcomes conditions such diabetic retinopathy, kidney disease, beyond. On contrary, inhibitors emerge crucial players cancer treatment, offering new possibilities diseases associated with inflammation multidrug resistance. symphony molecules, from activators inhibitors, presents nuanced understanding MG regulation. From drugs, each element contributes orchestra, novel interventions personalized approaches pursuit health wellbeing. abstract concludes an emphasis on necessity rigorous clinical trials validate findings acknowledges importance individual variability complex landscape health.
Language: Английский
Citations
6
Hypertension, Journal Year: 2023, Volume and Issue: 81(2), P. 218 - 228
Published: Dec. 12, 2023
Hypertensive heart disease (HHD) can no longer be considered as the beneficial adaptive result of hypertrophy cardiomyocytes in response to pressure overload leading development left ventricular hypertrophy. The current evidence indicates that patients with HHD, pathological lesions myocardium lead maladaptive structural remodeling and subsequent alterations cardiac function, electrical activity, perfusion, all contributing poor outcomes. Diffuse myocardial interstitial fibrosis is probably most critically involved lesion these disorders. Therefore, this review, we will focus on histological characteristics, mechanisms, clinical consequences HHD. In addition, consider useful tools for noninvasive diagnosis well effective available therapeutic strategies prevent its or facilitate regression patient population. Finally, issue a call action need more fundamental research
Language: Английский
Citations
16
Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 261, P. 108685 - 108685
Published: July 6, 2024
Language: Английский
Citations
5
BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)
Published: April 6, 2023
Abstract Background Genetic factors have a certain proportion in the risk of hypertension. The purpose was to investigate relationship cytochrome P450 2C19 ( CYP2C19 ) polymorphisms with hypertension Hakka population. Methods study included 1,872 hypertensive patients and 1,110 controls. genotypes rs4244285 rs4986893 all individuals were detected analyzed. Results genotype allele distributions significantly different between group control group. *1/*1 most predominant among subjects (40.8%), followed by *1/*2 (40.5%). percentage *1, *2, *3 64.2%, 30.8%, 5.0%, respectively. intermediate metabolizers (IM) (49.3% vs. 42.9%), poor (PM) (14.3% 8.9%) P < 0.001), *2 (33.8% 25.7%, 0.001) higher than that Multivariate logistic regression (adjusted for gender, age, smoking, drinking) indicated *1/*2, *1/*3, *2/*2 may increase susceptibility And IM (IM EM: OR 1.514, 95% CI: 1.291–1.775, PM (PM 2.120, 1.638–2.743, + 1.617, 1.390–1.882, Conclusions loss-of-function (IM, genotypes) is independent factor susceptibility. Specifically, include *2/*2.
Language: Английский
Citations
11
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 729 - 729
Published: May 29, 2024
This review paper examines the evolution of photodynamic therapy (PDT) as a novel, minimally invasive strategy for treating atherosclerosis, leading global health concern. Atherosclerosis is characterized by accumulation lipids and inflammation within arterial walls, to significant morbidity mortality through cardiovascular diseases such myocardial infarction stroke. Traditional therapeutic approaches have primarily focused on modulating risk factors hypertension hyperlipidemia, with emerging evidence highlighting pivotal role inflammation. PDT, leveraging photosensitizer, specific-wavelength light, oxygen, offers targeted treatment inducing cell death in diseased tissues while sparing healthy ones. specificity, combined advancements nanoparticle technology improved delivery, positions PDT promising alternative traditional interventions. The explores mechanistic basis its efficacy preclinical studies, potential enhancing plaque stability reducing macrophage density plaques. It also addresses need further research optimize parameters, mitigate adverse effects, validate long-term outcomes. By detailing past developments, current progress, future directions, this aims highlight PDT’s revolutionizing atherosclerosis treatment, bridging gap from experimental clinical application.
Language: Английский
Citations
4
Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
The field of cardio-oncology has traditionally focused on the impact cancer and its therapies cardiovascular health. Mounting clinical preclinical evidence, however, indicates that reverse may also be true: disease can itself influence tumor growth metastasis. Numerous epidemiological studies have reported individuals with prevalent an increased incidence cancer. In parallel, using mouse models myocardial infarction, heart failure, cardiac remodeling support notion disorders accelerate solid tumors metastases. These findings ushered in a new burgeoning termed investigates cause pathophysiology emergence progression. Recent begun to illuminate mechanisms driving this relationship, including shared risk factors, reprogramming immune responses, changes gene expression, release factors result selective advantages for cells or their local milieu, thus exacerbating pathology. Here, we review evidence supporting relationship between cancer, mechanistic pathways enabling connection, implications these patient care.
Language: Английский
Citations
0
Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which significant contributor to the total global disease burden. Environmental chemicals, including mercury (Hg), may contribute hypertension onset development. Hg health concern, listed by World Health Organization (WHO) as top ten chemical of public concern. Most people are exposed some level Hg, with vulnerable groups, Indigenous peoples small-scale gold miners, at higher risk for exposure. We published systematic review meta-analysis in 2018 showing dose–response relationship between exposure hypertension. This critical summarizes biological effects (both organic inorganic form) on underlying mechanisms that facilitate development related outcomes updates association (total concentrations hair) BP outcomes. also evaluated weight evidence using Bradford Hill criteria. There strong inorganic) animal studies convincing contributes causing structural functional changes, vascular reactivity, vasoconstriction, atherosclerosis, dyslipidemia, thrombosis. The vast include impairments antioxidant defense mechanisms, increased ROS production, endothelial dysfunction, alteration renin–angiotensin system. found additional 16 recent epidemiological have reported last 5 years. Strong from shows positive elevated BP. mixed lower levels but suggests can affect even low doses when co-exposed other metals. Further research needed develop robust conversion factors among different biomarkers standardized measures Regulatory agencies should consider adopting 2 µg/g hair cut-off regulation, especially adults older than child-bearing age.
Language: Английский
Citations
0