Glyphosate and glufosinate ammonium, herbicides commonly used on genetically modified crops, and their interaction with microplastics: Ecotoxicity in anuran tadpoles

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 804, P. 150177 - 150177

Published: Sept. 8, 2021

Language: Английский

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Effects of glyphosate and glyphosate-based herbicides like Roundup™ on the mammalian nervous system: A review

Environmental Research, Journal Year: 2022, Volume and Issue: 214, P. 113933 - 113933

Published: July 19, 2022

Language: Английский

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Endocrine Disrupting Chemicals in Polycystic Ovary Syndrome: The Relevant Role of the Theca and Granulosa Cells in the Pathogenesis of the Ovarian Dysfunction

Cells, Journal Year: 2022, Volume and Issue: 12(1), P. 174 - 174

Published: Dec. 31, 2022

Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder among women of reproductive age. The pathogenesis PCOS remains elusive; however, there evidence suggesting potential contribution genetic interactions or predispositions combined with environmental factors. Among these, disrupting chemicals (EDCs) have been proposed to potentially contribute etiology PCOS. Granulosa and theca cells are known cooperate maintain ovarian function, any disturbance can lead disorders, such as This article provides a review recent knowledge on pathophysiology, role granulosa in pathogenesis, linking exposure EDCs disorders

Language: Английский

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Pesticides exposure and compromised fitness in wild birds: Focusing on the reproductive endocrine disruption

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 199, P. 105800 - 105800

Published: Jan. 28, 2024

Language: Английский

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Urinary concentrations and determinants of glyphosate and glufosinate in pregnant Canadian participants in the MIREC study

Environmental Research, Journal Year: 2022, Volume and Issue: 217, P. 114842 - 114842

Published: Nov. 18, 2022

Glyphosate is the most widely applied herbicide in agriculture. Glufosinate a broad spectrum used to manage glyphosate-resistant weeds. Despite widespread use of these herbicides, biomonitoring data – which inform risk assessment and management are sparse. To identify determinants urinary concentrations herbicides their metabolites pregnancy. We measured glyphosate, glufosinate, primary aminomethylphosphonic acid (AMPA) 3-methylphosphinicopropionic (3-MPPA) single spot urine specimen collected during first trimester pregnancy from Maternal-Infant Research on Environmental Chemicals (MIREC) study. MIREC recruited about 2000 pregnant women 10 Canadian cities between 2008 2011. UItra-Performance Liquid Chromatography coupled tandem mass spectrometry (UPLC-MS/MS) with sensitive limits detection quantify analyte concentrations. examined according maternal sociodemographics, sample collection characteristics, reported pesticide use, consumption fruits, vegetables, legumes, grain products. ANOVA models specific gravity-standardized chemical as dependent variable determine associations determinants. Among biobanked samples (n = 1829–1854), 74% 72% had detectable glyphosate AMPA, respectively. In contrast, one six percent glufosinate 3-MPPA, The geometric mean (95% CI) AMPA were 0.112 (0.099–0.127) μg/L 0.159 (0.147–0.172) μg/L, observed dose-response relationship whole bread higher Season self-reported not associated increased any analyte. detected majority this predominantly urban cohort. Diet was probable route exposure.

Language: Английский

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Metabolomic Changes in Rat Serum after Chronic Exposure to Glyphosate-Based Herbicide

Metabolites, Journal Year: 2024, Volume and Issue: 14(1), P. 50 - 50

Published: Jan. 13, 2024

Glyphosate-based herbicides (GBHs) have gained extensive popularity in recent decades. For many years, glyphosate has been regarded as harmless or minimally toxic to mammals due the absence of its primary target, shikimic acid pathway humans. Nonetheless, mounting evidence suggests that may cause adverse health effects humans via other mechanisms. In this study, we described metabolomic changes serum experimental rats exposed chronic GBH using highly sensitive LC-MS/MS technique. We investigated possible relationship between exposure and neurological disorders. Our findings suggest can alter spatial learning memory expression some important metabolites are linked neurophysiological disorders young rats, with female showing higher susceptibility compared males. This indicates more likely show early symptoms disorder on male rats. observed four (paraxanthine, epinephrine, L-(+)-arginine, D-arginine) showed significant involvement suggested by ingenuity analysis. conclusion, our results indicate increase risk developing

Language: Английский

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Pesticides as endocrine disruptors: programming for obesity and diabetes

Endocrine, Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 27, 2022

Language: Английский

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Determination of glyphosate and AMPA in indoor settled dust by hydrophilic interaction liquid chromatography with tandem mass spectrometry and implications for human exposure

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 446, P. 130654 - 130654

Published: Dec. 23, 2022

Language: Английский

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Dinitramine induces implantation failure by cell cycle arrest and mitochondrial dysfunction in porcine trophectoderm and luminal epithelial cells

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 435, P. 128927 - 128927

Published: April 14, 2022

Language: Английский

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Effects of glyphosate-based herbicides and glyphosate exposure on sex hormones and the reproductive system: From epidemiological evidence to mechanistic insights

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 102, P. 104252 - 104252

Published: Aug. 20, 2023

Language: Английский

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