Experimental and Therapeutic Medicine,
Journal Year:
2023,
Volume and Issue:
25(5)
Published: March 23, 2023
Hundreds
of
papers
are
written
about
hypospadias
every
year
referring
to
all
aspects
the
pathology,
being
one
most
common
congenital
malformations.
The
present
study
conducted
a
scoping
review
articles
published
in
2021
main
issues
and
summarize
current
perspectives
achievements
field.
It
searched
for
keyword
'hypospadias'
three
popular
databases
(PubMed,
Scopus
Web
Science).
After
analysis
publications,
they
were
categorized
into
different
domains.
was
performed
respecting
Preferred
Reporting
Items
Systematic
reviews
Meta‑Analyses
extension
Scoping
Reviews
(PRISMA
ScR)
guidelines.
A
total
284
included.
These
142
journals.
accessed
Journal
Paediatric
Urology
with
54
articles.
identified
domains
related
surgical
techniques,
postoperative
care,
complications,
anesthesia,
anatomical
factors,
genetics,
environmental
endocrinology,
associated
malformations,
questionnaires
recommendations,
management,
biological
materials,
animal
models,
retrospective
studies
centers,
social
media,
bibliometrics,
small
gestational
age,
neoplasm,
or
fertility.
Promising
modifications
existing
techniques
presented
improved
outcomes
both
proximal
distal
types
hypospadias.
Relevant
etiological,
also
genetic
factors
clarified.
Aspects
peri‑
management
antibiotherapy,
analgesia,
dressing
future
use
novel
bioengineering
agents
prevent,
reduce
treat
occurring
complications
discussed.
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(2), P. 712 - 712
Published: Jan. 4, 2023
Some
chemical
components
in
sun
cream
filters
have
endocrine-disrupting
activity
or
can
be
carcinogenic,
neurotoxic,
bioaccumulative,
allergens,
toxic
for
human
reproduction.
It
is
important
that
sunscreens
safety
requirements.
The
objective
of
this
work
to
compare
used
conventional
commercial
and
those
are
considered
natural
products,
especially
focused
on
effects.
In
order
achieve
the
above
objective,
compositions
different
were
evaluated
compared,
taking
into
account
presence
whose
effects
website
specialized
cosmetics,
Environmental
Working
Group
(EWG),
Register
substances
mixtures
EU
Registration,
Evaluation,
Authorization
Restriction
Chemicals
(REACH)
Regulation.
currently
available
evidence
each
filter
their
degree
has
been
summarized.
Several
organic
present
a
potential
risk
health
environment;
however,
inorganic
such
as
titanium
dioxide
zinc
oxide
(ZnO
TiO2)
show
very
low
humans
they
not
absorbed
through
intact
damaged
tissues.
legislation
does
oblige
manufacturers
specify
concentration
substance,
which
provides
qualitative
but
quantitative
information
consumer.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6068 - 6068
Published: March 23, 2023
Dietary
selenium
(Se)
intake
within
the
physiological
range
is
critical
to
maintain
various
biological
functions,
including
antioxidant
defence,
redox
homeostasis,
growth,
reproduction,
immunity,
and
thyroid
hormone
production.
Chemical
forms
of
dietary
Se
are
diverse,
organic
(selenomethionine,
selenocysteine,
selenium-methyl-selenocysteine)
inorganic
(selenate
selenite).
Previous
studies
have
largely
investigated
compared
health
impacts
on
agricultural
stock
humans,
where
has
shown
benefits,
enhanced
growth
performance,
immune
nutritional
quality
meats,
with
reduced
oxidative
stress
inflammation,
finally
fertility
in
humans.
The
emergence
nanoparticles
presents
a
novel
innovative
technology.
Notably,
form
(SeNPs)
lower
toxicity,
higher
bioavailability,
excretion
animals,
linked
more
powerful
superior
activities
(at
comparable
dose)
than
traditional
chemical
Se.
As
result,
development
tailored
SeNPs
for
their
use
intensive
agriculture
as
candidate
therapeutic
drugs
human
pathologies
now
being
actively
explored.
This
review
highlights
reproductive
performances,
role
modulating
heat
inflammation
varying
modes
synthesis
SeNPs.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 3, 2024
Congenital
cryptorchidism,
also
known
as
undescended
testis,
is
the
condition
where
one
or
both
testes
are
not
in
place
scrotum
at
birth
and
of
most
common
defects
boys.
Temporal
trends
geographic
variation
prevalence
cryptorchidism
from
1%
to
9%
have
been
reported
prospective
cohort
studies.
The
develop
abdominal
cavity
descend
two
phases,
which
should
be
completed
by
gestational
week
35.
Thus,
risk
higher
preterm
In
many
cases
a
spontaneous
descent
occurs
during
first
months
life
surge
gonadotropins
testosterone.
If
not,
testis
usually
brought
down
scrotum,
typically
surgery,
increase
future
fertility
chances
facilitate
cancer
surveillance.
increasing
frequency
impaired
semen
quality
testicular
cancer,
with
associated,
represents
concern
for
male
reproductive
health
general
need
understand
its
factors.
closely
related
factors
(preterm
birth,
low
weight
intrauterine
growth
restriction),
especially
maternal
smoking
seems
factor.
Evidence
accumulating
that
prenatal
exposure
environmental
chemicals,
including
endocrine
disrupting
compounds.
This
association
has
corroborated
rodents
supported
ecological
Conducting
human
studies
assess
effect
chemicals
their
interactions
is,
however,
challenged
widespread
concomitant
all
humans
wide
range
combined
highly
complex.
Best Practice & Research Clinical Endocrinology & Metabolism,
Journal Year:
2022,
Volume and Issue:
36(1), P. 101619 - 101619
Published: Jan. 1, 2022
Cryptorchidism,
i.e.,
undescended
testis,
is
one
of
the
most
common
genital
malformations
in
newborn
male
babies.
The
birth
rate
cryptorchidism
varies
from
1.6
to
9.0
%.
Etiology
disrupted
testicular
descent
complex
and
predisposing
causes
include
genetic,
hormonal,
environmental,
lifestyle
maternal
factors.
Testicular
occurs
two
major
steps
hormones
normal
function
hypothalamic–pituitary–testicular
axis
are
important
for
descent.
Several
gene
mutations
associated
with
syndromic
but
they
rarely
found
boys
isolated
testis.
regression
can
also
cause
an
empty
scrotum.
Normal
phenotype
indicates
that
boy
has
had
functioning
testis
during
development.
Torsion
many
cases
reason
vanishing
remains
elusive.
In
this
narrative
review
we
discuss
genetics
regression.
Best Practice & Research Clinical Obstetrics & Gynaecology,
Journal Year:
2022,
Volume and Issue:
86, P. 102298 - 102298
Published: Dec. 16, 2022
Semen
quality
has
declined
especially
among
Western
men.
Experimental
and
epidemiological
studies
have
shown
potential
links
between
exposure
to
environmental
toxicants
poor
male
fertility.
Some
exposures
in
utero
can
disrupt
fetal
testicular
function
result
cryptorchidism,
low
semen
quality,
serum
testosterone
levels,
Environmental
childhood
adulthood
also
adversely
affect
germ
cells,
Sertoli
Leydig
or
the
hypothalamic-pituitary-testicular
axis,
resulting
impaired
In
this
review,
we
report
latest
results
from
human
that
investigated
role
of
endocrine
disrupting
chemicals,
heavy
metals,
tobacco
smoking,
alcohol
drinking,
use
marijuana
Current
evidence
suggests
relationship
these
factors
fertility;
however,
some
showed
conflicting
which
need
further
investigation.
Journal of King Saud University - Science,
Journal Year:
2022,
Volume and Issue:
34(4), P. 102006 - 102006
Published: April 1, 2022
Microplastics
(MPs),
an
emerging
ubiquitous
pollutant
in
the
aquatic
ecosystem,
pose
serious
health
concerns
to
survival
of
fauna,
especially
top
predators
(e.g.,
mammals).
It
is
challenging
investigate
toxicological
profile
MPs
mammals
due
their
diverse
behaviour,
physico-chemical
properties,
and
other
technical
ethical
issues.
This
study
reviewed
current
burden
occurrence
various
tissues
mammals,
its
composition
(heavy
metals,
pesticides,
pathogens),
possible
effects
on
individual
population
levels
mammals.
Aquatic
are
constantly
exposed
directly
indirectly
via
food-web.
The
a
wide
range
toxic
heavy
pathogens
added
during
manufacturing
or
adsorbed
from
surrounding
environments
bioaccumulated
for
years.
Due
long
life-span
body
masses,
these
pollutants
can
cause
several
issues
that
drastically
reduce
size
ultimately
extinction,
vulnerable
populations.
Still
today
presence
deep
largely
remains
unknown
We
therefore
suggest
global
assessment
risks
associated
with
consumption
by
habitats.
Andrology,
Journal Year:
2022,
Volume and Issue:
10(7), P. 1250 - 1271
Published: July 6, 2022
Abstract
Background
The
environment
plays
a
key
role
in
male
infertility,
changing
the
incidence
various
populations,
and
pesticides
are
one
of
most
studied
hazards.
use
latter
has
never
decreased,
jeopardizing
safety
workers
general
population.
Objective
Our
purpose
was
to
summarize
results
studies
discussing
association
between
fertility.
Methods
A
comprehensive
literature
search
performed
through
MEDLINE
via
PubMed,
Scopus,
Web
Science.
Only
human
were
considered.
Semen
parameters
DNA
integrity
considered
evaluate
effect
on
men.
Results
total
64
that
investigated
their
impact
terms
semen
(51
studies)
chromatin
(25
included.
frequently
affected
sperm
count,
motility,
morphology,
although
reduction
ejaculate
volume
concentration
occur
several
cases.
tangible
worsening
quality
associated
with
organochlorines
organophosphates.
Furthermore,
pesticide
exposure,
especially
pyrethroids,
related
higher
fragmentation
index
chromosome
aneuploidy
articles.
Conclusion
epidemiological
evidence
supports
fertility
for
exposed
population
quality,
fragmentation,
aneuploidy.
Environment International,
Journal Year:
2022,
Volume and Issue:
170, P. 107576 - 107576
Published: Oct. 14, 2022
Non-persistent
endocrine-disrupting
chemicals
(EDCs),
including
phthalates
and
phenols,
are
ubiquitous
in
both
the
environment
human
body.
A
growing
body
of
epidemiologic
studies
have
identified
concerning
links
between
EDCs
adverse
reproductive
developmental
health
effects.
Despite
consistent
evidence,
risk
assessments
policy
interventions
often
arrive
late.
This
presents
an
urgent
need
to
identify
evidence-based
for
implementation
at
clinical
community
levels
reduce
EDC
exposure,
especially
susceptible
populations.
The
life
cycle
(menarche
menopause
females
after
pubertal
onset
males)
includes
some
most
vulnerable
periods
environmental
exposures,
such
as
preconception
perinatal
stages,
representing
a
key
window
opportunity
intervene
prevent
unfavorable
outcomes.
review
aims
synthesize
assess
behavioral,
dietary,
residential
EDC-driven
develop
recommendations
subsequent,
larger-scale
that
address
knowledge-gaps
current
during
cycle.
We
selected
21
primary
evaluation,
addition
four
supplemental
interventions.
Among
these,
accessible
(web-based)
educational
resources,
targeted
replacement
(known)
toxic
products,
personalization
intervention
through
meetings
support
groups,
were
promising
strategies
reducing
concentrations.
However,
we
document
paucity
phthalate
phenol
exposures
years,
among
men.
Accordingly,
recommend
additional,
larger
community-based
exposure.
Specifically,
future
should
focus
on
short-term,
mid-,
long-term
exposure
reduction
phenols.
latter,
especially,
is
required
development
public
guidelines
promote
globally.