Toxicity of Different Chemical Components in Sun Cream Filters and Their Impact on Human Health: A Review

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(2), P. 712 - 712

Published: Jan. 4, 2023

Some chemical components in sun cream filters have endocrine-disrupting activity or can be carcinogenic, neurotoxic, bioaccumulative, allergens, toxic for human reproduction. It is important that sunscreens safety requirements. The objective of this work to compare used conventional commercial and those are considered natural products, especially focused on effects. In order achieve the above objective, compositions different were evaluated compared, taking into account presence whose effects website specialized cosmetics, Environmental Working Group (EWG), Register substances mixtures EU Registration, Evaluation, Authorization Restriction Chemicals (REACH) Regulation. currently available evidence each filter their degree has been summarized. Several organic present a potential risk health environment; however, inorganic such as titanium dioxide zinc oxide (ZnO TiO2) show very low humans they not absorbed through intact damaged tissues. legislation does oblige manufacturers specify concentration substance, which provides qualitative but quantitative information consumer.

Language: Английский

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Genetics of cryptorchidism and testicular regression

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2022, Volume and Issue: 36(1), P. 101619 - 101619

Published: Jan. 1, 2022

Cryptorchidism, i.e., undescended testis, is one of the most common genital malformations in newborn male babies. The birth rate cryptorchidism varies from 1.6 to 9.0 %. Etiology disrupted testicular descent complex and predisposing causes include genetic, hormonal, environmental, lifestyle maternal factors. Testicular occurs two major steps hormones normal function hypothalamic–pituitary–testicular axis are important for descent. Several gene mutations associated with syndromic but they rarely found boys isolated testis. regression can also cause an empty scrotum. Normal phenotype indicates that boy has had functioning testis during development. Torsion many cases reason vanishing remains elusive. In this narrative review we discuss genetics regression.

Language: Английский

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Physiological Benefits of Novel Selenium Delivery via Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6068 - 6068

Published: March 23, 2023

Dietary selenium (Se) intake within the physiological range is critical to maintain various biological functions, including antioxidant defence, redox homeostasis, growth, reproduction, immunity, and thyroid hormone production. Chemical forms of dietary Se are diverse, organic (selenomethionine, selenocysteine, selenium-methyl-selenocysteine) inorganic (selenate selenite). Previous studies have largely investigated compared health impacts on agricultural stock humans, where has shown benefits, enhanced growth performance, immune nutritional quality meats, with reduced oxidative stress inflammation, finally fertility in humans. The emergence nanoparticles presents a novel innovative technology. Notably, form (SeNPs) lower toxicity, higher bioavailability, excretion animals, linked more powerful superior activities (at comparable dose) than traditional chemical Se. As result, development tailored SeNPs for their use intensive agriculture as candidate therapeutic drugs human pathologies now being actively explored. This review highlights reproductive performances, role modulating heat inflammation varying modes synthesis SeNPs.

Language: Английский

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Endocrine disrupting chemicals and their effects on the reproductive health in men

Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116825 - 116825

Published: Aug. 5, 2023

Language: Английский

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Environmental exposure to industrial air pollution is associated with decreased male fertility

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 120(3), P. 637 - 647

Published: May 15, 2023

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The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

Congenital cryptorchidism, also known as undescended testis, is the condition where one or both testes are not in place scrotum at birth and of most common defects boys. Temporal trends geographic variation prevalence cryptorchidism from 1% to 9% have been reported prospective cohort studies. The develop abdominal cavity descend two phases, which should be completed by gestational week 35. Thus, risk higher preterm In many cases a spontaneous descent occurs during first months life surge gonadotropins testosterone. If not, testis usually brought down scrotum, typically surgery, increase future fertility chances facilitate cancer surveillance. increasing frequency impaired semen quality testicular cancer, with associated, represents concern for male reproductive health general need understand its factors. closely related factors (preterm birth, low weight intrauterine growth restriction), especially maternal smoking seems factor. Evidence accumulating that prenatal exposure environmental chemicals, including endocrine disrupting compounds. This association has corroborated rodents supported ecological Conducting human studies assess effect chemicals their interactions is, however, challenged widespread concomitant all humans wide range combined highly complex.

Language: Английский

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The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies

Andrology, Journal Year: 2022, Volume and Issue: 10(7), P. 1250 - 1271

Published: July 6, 2022

Abstract Background The environment plays a key role in male infertility, changing the incidence various populations, and pesticides are one of most studied hazards. use latter has never decreased, jeopardizing safety workers general population. Objective Our purpose was to summarize results studies discussing association between fertility. Methods A comprehensive literature search performed through MEDLINE via PubMed, Scopus, Web Science. Only human were considered. Semen parameters DNA integrity considered evaluate effect on men. Results total 64 that investigated their impact terms semen (51 studies) chromatin (25 included. frequently affected sperm count, motility, morphology, although reduction ejaculate volume concentration occur several cases. tangible worsening quality associated with organochlorines organophosphates. Furthermore, pesticide exposure, especially pyrethroids, related higher fragmentation index chromosome aneuploidy articles. Conclusion epidemiological evidence supports fertility for exposed population quality, fragmentation, aneuploidy.

Language: Английский

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Environmental toxicants and male fertility

Best Practice & Research Clinical Obstetrics & Gynaecology, Journal Year: 2022, Volume and Issue: 86, P. 102298 - 102298

Published: Dec. 16, 2022

Semen quality has declined especially among Western men. Experimental and epidemiological studies have shown potential links between exposure to environmental toxicants poor male fertility. Some exposures in utero can disrupt fetal testicular function result cryptorchidism, low semen quality, serum testosterone levels, Environmental childhood adulthood also adversely affect germ cells, Sertoli Leydig or the hypothalamic-pituitary-testicular axis, resulting impaired In this review, we report latest results from human that investigated role of endocrine disrupting chemicals, heavy metals, tobacco smoking, alcohol drinking, use marijuana Current evidence suggests relationship these factors fertility; however, some showed conflicting which need further investigation.

Language: Английский

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The adverse health effects of increasing microplastic pollution on aquatic mammals

Journal of King Saud University - Science, Journal Year: 2022, Volume and Issue: 34(4), P. 102006 - 102006

Published: April 1, 2022

Microplastics (MPs), an emerging ubiquitous pollutant in the aquatic ecosystem, pose serious health concerns to survival of fauna, especially top predators (e.g., mammals). It is challenging investigate toxicological profile MPs mammals due their diverse behaviour, physico-chemical properties, and other technical ethical issues. This study reviewed current burden occurrence various tissues mammals, its composition (heavy metals, pesticides, pathogens), possible effects on individual population levels mammals. Aquatic are constantly exposed directly indirectly via food-web. The a wide range toxic heavy pathogens added during manufacturing or adsorbed from surrounding environments bioaccumulated for years. Due long life-span body masses, these pollutants can cause several issues that drastically reduce size ultimately extinction, vulnerable populations. Still today presence deep largely remains unknown We therefore suggest global assessment risks associated with consumption by habitats.

Language: Английский

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Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps

Environment International, Journal Year: 2022, Volume and Issue: 170, P. 107576 - 107576

Published: Oct. 14, 2022

Non-persistent endocrine-disrupting chemicals (EDCs), including phthalates and phenols, are ubiquitous in both the environment human body. A growing body of epidemiologic studies have identified concerning links between EDCs adverse reproductive developmental health effects. Despite consistent evidence, risk assessments policy interventions often arrive late. This presents an urgent need to identify evidence-based for implementation at clinical community levels reduce EDC exposure, especially susceptible populations. The life cycle (menarche menopause females after pubertal onset males) includes some most vulnerable periods environmental exposures, such as preconception perinatal stages, representing a key window opportunity intervene prevent unfavorable outcomes. review aims synthesize assess behavioral, dietary, residential EDC-driven develop recommendations subsequent, larger-scale that address knowledge-gaps current during cycle. We selected 21 primary evaluation, addition four supplemental interventions. Among these, accessible (web-based) educational resources, targeted replacement (known) toxic products, personalization intervention through meetings support groups, were promising strategies reducing concentrations. However, we document paucity phthalate phenol exposures years, among men. Accordingly, recommend additional, larger community-based exposure. Specifically, future should focus on short-term, mid-, long-term exposure reduction phenols. latter, especially, is required development public guidelines promote globally.

Language: Английский

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