Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review) DOI Open Access

Horea Gozar,

Zsolt Bara,

Emilia Dicu

et al.

Experimental and Therapeutic Medicine, Journal Year: 2023, Volume and Issue: 25(5)

Published: March 23, 2023

Hundreds of papers are written about hypospadias every year referring to all aspects the pathology, being one most common congenital malformations. The present study conducted a scoping review articles published in 2021 main issues and summarize current perspectives achievements field. It searched for keyword 'hypospadias' three popular databases (PubMed, Scopus Web Science). After analysis publications, they were categorized into different domains. was performed respecting Preferred Reporting Items Systematic reviews Meta‑Analyses extension Scoping Reviews (PRISMA ScR) guidelines. A total 284 included. These 142 journals. accessed Journal Paediatric Urology with 54 articles. identified domains related surgical techniques, postoperative care, complications, anesthesia, anatomical factors, genetics, environmental endocrinology, associated malformations, questionnaires recommendations, management, biological materials, animal models, retrospective studies centers, social media, bibliometrics, small gestational age, neoplasm, or fertility. Promising modifications existing techniques presented improved outcomes both proximal distal types hypospadias. Relevant etiological, also genetic factors clarified. Aspects peri‑ management antibiotherapy, analgesia, dressing future use novel bioengineering agents prevent, reduce treat occurring complications discussed.

Language: Английский

Toxicity of Different Chemical Components in Sun Cream Filters and Their Impact on Human Health: A Review DOI Creative Commons

Sonia Santander Ballestín,

María José Luesma Bartolomé

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(2), P. 712 - 712

Published: Jan. 4, 2023

Some chemical components in sun cream filters have endocrine-disrupting activity or can be carcinogenic, neurotoxic, bioaccumulative, allergens, toxic for human reproduction. It is important that sunscreens safety requirements. The objective of this work to compare used conventional commercial and those are considered natural products, especially focused on effects. In order achieve the above objective, compositions different were evaluated compared, taking into account presence whose effects website specialized cosmetics, Environmental Working Group (EWG), Register substances mixtures EU Registration, Evaluation, Authorization Restriction Chemicals (REACH) Regulation. currently available evidence each filter their degree has been summarized. Several organic present a potential risk health environment; however, inorganic such as titanium dioxide zinc oxide (ZnO TiO2) show very low humans they not absorbed through intact damaged tissues. legislation does oblige manufacturers specify concentration substance, which provides qualitative but quantitative information consumer.

Language: Английский

Citations

43

Physiological Benefits of Novel Selenium Delivery via Nanoparticles DOI Open Access

Alice L.S. Au,

Albaraa Mojadadi,

Jia-Ying Shao

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6068 - 6068

Published: March 23, 2023

Dietary selenium (Se) intake within the physiological range is critical to maintain various biological functions, including antioxidant defence, redox homeostasis, growth, reproduction, immunity, and thyroid hormone production. Chemical forms of dietary Se are diverse, organic (selenomethionine, selenocysteine, selenium-methyl-selenocysteine) inorganic (selenate selenite). Previous studies have largely investigated compared health impacts on agricultural stock humans, where has shown benefits, enhanced growth performance, immune nutritional quality meats, with reduced oxidative stress inflammation, finally fertility in humans. The emergence nanoparticles presents a novel innovative technology. Notably, form (SeNPs) lower toxicity, higher bioavailability, excretion animals, linked more powerful superior activities (at comparable dose) than traditional chemical Se. As result, development tailored SeNPs for their use intensive agriculture as candidate therapeutic drugs human pathologies now being actively explored. This review highlights reproductive performances, role modulating heat inflammation varying modes synthesis SeNPs.

Language: Английский

Citations

34

Endocrine disrupting chemicals and their effects on the reproductive health in men DOI
Aswin Thacharodi, Saqib Hassan,

Gururaj Acharya

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116825 - 116825

Published: Aug. 5, 2023

Language: Английский

Citations

34

Environmental exposure to industrial air pollution is associated with decreased male fertility DOI Creative Commons
Joemy M. Ramsay, Kiarad Fendereski, Joshua J. Horns

et al.

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 120(3), P. 637 - 647

Published: May 15, 2023

Citations

26

The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals DOI Creative Commons
Stine A. Holmboe, Astrid Beck, Anna‐Maria Andersson

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

Congenital cryptorchidism, also known as undescended testis, is the condition where one or both testes are not in place scrotum at birth and of most common defects boys. Temporal trends geographic variation prevalence cryptorchidism from 1% to 9% have been reported prospective cohort studies. The develop abdominal cavity descend two phases, which should be completed by gestational week 35. Thus, risk higher preterm In many cases a spontaneous descent occurs during first months life surge gonadotropins testosterone. If not, testis usually brought down scrotum, typically surgery, increase future fertility chances facilitate cancer surveillance. increasing frequency impaired semen quality testicular cancer, with associated, represents concern for male reproductive health general need understand its factors. closely related factors (preterm birth, low weight intrauterine growth restriction), especially maternal smoking seems factor. Evidence accumulating that prenatal exposure environmental chemicals, including endocrine disrupting compounds. This association has corroborated rodents supported ecological Conducting human studies assess effect chemicals their interactions is, however, challenged widespread concomitant all humans wide range combined highly complex.

Language: Английский

Citations

10

Genetics of cryptorchidism and testicular regression DOI Creative Commons

Heidi P. Elamo,

Helena E. Virtanen, Jorma Toppari

et al.

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2022, Volume and Issue: 36(1), P. 101619 - 101619

Published: Jan. 1, 2022

Cryptorchidism, i.e., undescended testis, is one of the most common genital malformations in newborn male babies. The birth rate cryptorchidism varies from 1.6 to 9.0 %. Etiology disrupted testicular descent complex and predisposing causes include genetic, hormonal, environmental, lifestyle maternal factors. Testicular occurs two major steps hormones normal function hypothalamic–pituitary–testicular axis are important for descent. Several gene mutations associated with syndromic but they rarely found boys isolated testis. regression can also cause an empty scrotum. Normal phenotype indicates that boy has had functioning testis during development. Torsion many cases reason vanishing remains elusive. In this narrative review we discuss genetics regression.

Language: Английский

Citations

39

Environmental toxicants and male fertility DOI Creative Commons
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen

et al.

Best Practice & Research Clinical Obstetrics & Gynaecology, Journal Year: 2022, Volume and Issue: 86, P. 102298 - 102298

Published: Dec. 16, 2022

Semen quality has declined especially among Western men. Experimental and epidemiological studies have shown potential links between exposure to environmental toxicants poor male fertility. Some exposures in utero can disrupt fetal testicular function result cryptorchidism, low semen quality, serum testosterone levels, Environmental childhood adulthood also adversely affect germ cells, Sertoli Leydig or the hypothalamic-pituitary-testicular axis, resulting impaired In this review, we report latest results from human that investigated role of endocrine disrupting chemicals, heavy metals, tobacco smoking, alcohol drinking, use marijuana Current evidence suggests relationship these factors fertility; however, some showed conflicting which need further investigation.

Language: Английский

Citations

37

The adverse health effects of increasing microplastic pollution on aquatic mammals DOI Creative Commons
Ghulam Nabi,

Shahid Ahmad,

Sana Ullah

et al.

Journal of King Saud University - Science, Journal Year: 2022, Volume and Issue: 34(4), P. 102006 - 102006

Published: April 1, 2022

Microplastics (MPs), an emerging ubiquitous pollutant in the aquatic ecosystem, pose serious health concerns to survival of fauna, especially top predators (e.g., mammals). It is challenging investigate toxicological profile MPs mammals due their diverse behaviour, physico-chemical properties, and other technical ethical issues. This study reviewed current burden occurrence various tissues mammals, its composition (heavy metals, pesticides, pathogens), possible effects on individual population levels mammals. Aquatic are constantly exposed directly indirectly via food-web. The a wide range toxic heavy pathogens added during manufacturing or adsorbed from surrounding environments bioaccumulated for years. Due long life-span body masses, these pollutants can cause several issues that drastically reduce size ultimately extinction, vulnerable populations. Still today presence deep largely remains unknown We therefore suggest global assessment risks associated with consumption by habitats.

Language: Английский

Citations

36

The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies DOI Creative Commons
Carlo Giulioni,

Valentina Maurizi,

Daniele Castellani

et al.

Andrology, Journal Year: 2022, Volume and Issue: 10(7), P. 1250 - 1271

Published: July 6, 2022

Abstract Background The environment plays a key role in male infertility, changing the incidence various populations, and pesticides are one of most studied hazards. use latter has never decreased, jeopardizing safety workers general population. Objective Our purpose was to summarize results studies discussing association between fertility. Methods A comprehensive literature search performed through MEDLINE via PubMed, Scopus, Web Science. Only human were considered. Semen parameters DNA integrity considered evaluate effect on men. Results total 64 that investigated their impact terms semen (51 studies) chromatin (25 included. frequently affected sperm count, motility, morphology, although reduction ejaculate volume concentration occur several cases. tangible worsening quality associated with organochlorines organophosphates. Furthermore, pesticide exposure, especially pyrethroids, related higher fragmentation index chromosome aneuploidy articles. Conclusion epidemiological evidence supports fertility for exposed population quality, fragmentation, aneuploidy.

Language: Английский

Citations

36

Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps DOI Creative Commons
Leah J. Martin, Yu Zhang, Olivia First

et al.

Environment International, Journal Year: 2022, Volume and Issue: 170, P. 107576 - 107576

Published: Oct. 14, 2022

Non-persistent endocrine-disrupting chemicals (EDCs), including phthalates and phenols, are ubiquitous in both the environment human body. A growing body of epidemiologic studies have identified concerning links between EDCs adverse reproductive developmental health effects. Despite consistent evidence, risk assessments policy interventions often arrive late. This presents an urgent need to identify evidence-based for implementation at clinical community levels reduce EDC exposure, especially susceptible populations. The life cycle (menarche menopause females after pubertal onset males) includes some most vulnerable periods environmental exposures, such as preconception perinatal stages, representing a key window opportunity intervene prevent unfavorable outcomes. review aims synthesize assess behavioral, dietary, residential EDC-driven develop recommendations subsequent, larger-scale that address knowledge-gaps current during cycle. We selected 21 primary evaluation, addition four supplemental interventions. Among these, accessible (web-based) educational resources, targeted replacement (known) toxic products, personalization intervention through meetings support groups, were promising strategies reducing concentrations. However, we document paucity phthalate phenol exposures years, among men. Accordingly, recommend additional, larger community-based exposure. Specifically, future should focus on short-term, mid-, long-term exposure reduction phenols. latter, especially, is required development public guidelines promote globally.

Language: Английский

Citations

36