Integrating lipid metabolite analysis with MRI-based transformer and radiomics for early and late stage prediction of oral squamous cell carcinoma DOI Creative Commons
Wen Li, Yang Li,

Shiyu Gao

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 3, 2024

Abstract Background Oral Squamous Cell Carcinoma (OSCC) presents significant diagnostic challenges in its early and late stages. This study aims to utilize preoperative MRI biochemical indicators of OSCC patients predict the stage tumors. Methods involved 198 from two medical centers. A detailed analysis contrast-enhanced T1-weighted (ceT1W) T2-weighted (T2W) were conducted, integrating these with for a comprehensive evaluation. Initially, 42 clinical selected consideration. Through univariate multivariate analysis, only those p -values less than 0.05 retained model development. To extract imaging features, machine learning algorithms conjunction Vision Transformer (ViT) techniques utilized. These features integrated predictive modeling. The performance was evaluated using Receiver Operating Characteristic (ROC) curve. Results After rigorously screening indicators, four key markers model: cholesterol, triglyceride, very low-density lipoprotein cholesterol chloride. model, developed radiomics deep feature extraction ceT1W T2W images, showed lower Area Under Curve (AUC) 0.85 validation cohort when modalities alone. However, improved model’s performance, increasing AUC 0.87. Conclusion In this study, significantly following multimodal fusion, outperforming single-modality approach. Clinical relevance statement integration radiomics, ViT models, lipid metabolite promising non-invasive technique predicting staging OSCC.

Language: Английский

Anti-IL-6R Ab tocilizumab to treat paraneoplastic inflammatory syndrome of solid cancers DOI Creative Commons
Jean‐Yves Blay,

M. Brahmi,

Armelle Dufresne

et al.

ESMO Open, Journal Year: 2025, Volume and Issue: 10(1), P. 104088 - 104088

Published: Jan. 1, 2025

Paraneoplastic inflammatory syndrome (PIS) with fever and biological inflammation is a rare but severe condition often caused by the systemic production of interleukin 6 (IL-6) cancer cells. We report on efficacy tocilizumab, an anti-IL-6 receptor antibody, in 35 patients PIS. All solid cancers (sarcomas, lung carcinoma, breast carcinoma) diagnosed PIS from 2019 to 2024 treated tocilizumab were analyzed this single-center study (health authorities' approval R201-004-478). Patients' characteristics clinical effects administration are presented. Thirty-five (97%) had paraneoplastic fever. The median performance status (PS) was 2 (range 1-4). Forty percent lost 10% body weight. increased serum C-reactive protein (CRP) levels (median 212 mg/l), 74% 48% polymorphonuclear leukocyte (PMN) platelet counts, respectively. Ninety-four anemia. Tocilizumab given once 23 (66%) more than 12 patients. experienced resolution fever, 11 (31%) improved PS. CRP, PMN, count decreases observed 100%, 85%, 94% patients, Seventy-seven hemoglobin levels. CRP symptoms relapsed 4-6 weeks after receiving only one injection. efficient treatment for providing significant improvement abnormalities.

Language: Английский

Citations

2
Potential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer DOI Open Access
Manuel Sánchez‐de‐la‐Torre, Carolina Cubillos‐Zapata, Olivia J. Veatch

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1061 - 1061

Published: Feb. 7, 2023

Several epidemiological and clinical studies have suggested a relationship between obstructive sleep apnea (OSA) higher incidence or severity of cancer. This appears to be dependent on myriad factors. These include non-modifiable factors, such as age gender; modifiable preventable specific comorbidities (especially obesity), the use particular treatments, and, above all, histological type location Heterogeneity in OSA cancer is also related influences intermittent hypoxemia (a hallmark feature OSA), among others, metabolism microenvironment different types tumoral cells. The hypoxia inducible transcription factor (HIF-1α), molecule activated expressed situations hypoxemia, seems key enabling variety pathophysiological mechanisms that are becoming increasingly better recognized. appear operationally involved via alterations cellular functions (mainly involving immune system) molecular functions, by inducing modifications microbiome. This, turn, may individually collectively increase risk cancer, which then, further modulated genetic susceptibility individual. Here, we provide an updated brief review pathways been identified could explain We identify future challenges need overcome this intriguing field research.

Language: Английский

Citations

27
Candidate Biomarker of Response to Immunotherapy In Small Cell Lung Cancer DOI

Yili Shen,

Zhicong Liu, Yi Chen

et al.

Current Treatment Options in Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

1
Neutrophil to Lymphocyte Ratio in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis DOI Open Access
Juan P. Rodrigo, Mario Sánchez‐Canteli, Asterios Triantafyllou

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 802 - 802

Published: Jan. 28, 2023

Neutrophil-to-lymphocyte ratio (NLR) has been associated with survival in various cancers, including head and neck cancer. However, there is limited information on its role oropharyngeal squamous cell carcinomas (OPSCC) according to HPV status. This prompted the present meta-analysis. Studies were selected when prognostic value of NLR prior treatment was evaluated OPSCC patients, cutoff available, by time-to-event analysis. A total 14 out 492 articles, 7647 analyzed. The results showed a worse prognosis for patients high NLR: combined hazard ratios (HR) overall (OS) an elevated 1.56 (95% confidence interval (CI) 1.21–2.02; p = 0.0006), disease-free 1.52 CI 1.34–1.73; < 0.00001), recurrence-free 1.86 1.50–2.30; 0.00001). exclusive HPV-positive patients: HR OS subgroup 4.05 1.90–8.62 (p 0.0003), HPV-negative 0.92 0.47–1.80; 0.82). not influenced treatment: treated radiotherapy/chemoradiotherapy (RT/CRT) 1.48 1.09–2.01; 0.01), surgery (±RT/CRT) 1.72 1.08–2.72; 0.02). In conclusion, relates outcomes OPSCC.

Language: Английский

Citations

15
Value of markers of systemic inflammation for the prediction of postoperative progression in patients with pancreatic neuroendocrine tumors DOI Creative Commons
Liu Yang,

Mengfei Fu,

Li Yu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 1, 2024

Background Non-invasive prognostic predictors for rare pancreatic neuroendocrine tumors (PNETs) are lacking. We aimed to approach the value of preoperative systemic inflammatory markers in patients with PNETs. Methods The clinical data 174 PNETs undergoing surgical treatment were retrospectively analyzed explore correlation neutrophil lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR), and white blood cell (PWR) clinicopathological parameters progression tumor after operation. optimal cutoff values area under curve (AUC) receiver operating characteristic (ROC) estimated. Univariate multivariate Cox proportional hazards models used assess relation between NLR, LMR, PLR, progression-free survival (PFS), examined by Kaplan–Meier log-rank tests. Results scores NLR ( P = 0.039) PLR 0.011) group significantly higher than those group, LMR was lower 0.001). best before operation 2.28, 4.36, 120.91. proportions high 0.007) 0.013) obviously increased, proportion development low that &lt; K-M showed rate 0.004), 0.001), 0.018). results model suggested (HR 3.128, 95% CI: 1.107~8.836, 0.031) an independent predictor PFS. Conclusion inflammation, especially can predict postoperative

Language: Английский

Citations

4
Multi-Drug Resistance and Breast Cancer Progression via Toll-Like Receptors (TLRs) Signaling DOI

Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hussein Zwamel

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3015 - 3030

Published: Aug. 7, 2024

Language: Английский

Citations

4
Prognostic value of neutrophil to lymphocyte ratio in gastric cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis DOI Creative Commons

Siheng Zhang,

Chao Qiu, Hanzhi Yu

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: April 18, 2023

The neutrophil to lymphocyte ratio (NLR) is a cost-effective and easily identifiable inflammatory biomarker that has been shown be closely associated with tumor prognosis predict survival in patients multiple malignancies. However, the predictive value of NLR gastric cancer (GC) treated immune checkpoint inhibitors (ICIs) not fully explored. Therefore, we conducted meta-analysis explore potential as predictor this population.We systematically searched PubMed, Cochrane Library, EMBASE databases from inception present for observational researches on its relationship progression or GC receiving ICIs. To assess prognostic significance overall (OS) progression-free (PFS), used fixed random-effect models derive combine hazard ratios (HRs) 95% confidence intervals (CIs). We also examined between treatment efficacy by calculating relative risks (RRs) CIs objective response rate (ORR) disease control (DCR) ICIs.Nine studies 806 were eligible. OS PFS data obtained 9 5 studies, respectively. In nine was poor survival, pooled HR 1.98 (95% CI 1.67- 2.35, p < 0.001), indicating significant association high worse OS. subgroup analyses based study characteristics confirm robustness our findings. A reported five 1.49 0.99- 2.23, = 0.056), which significantly associated. Pooling four correlation ORR/DCR patients, observed ORR (RR 0.51, 0.003), but no DCR 0.48, 0.111).In summary, indicates increased linked addition, lowering can improve ORR. Thus, serve Nevertheless, further high-quality prospective are required verify findings future.

Language: Английский

Citations

10
Identification of a novel inflammation-related gene signature for predicting inflammatory breast cancer survival DOI
Weiyu Bai,

Qinggang Hao,

Zhimeng Zhang

et al.

Genome Instability & Disease, Journal Year: 2023, Volume and Issue: 4(3), P. 154 - 175

Published: June 13, 2023

Language: Английский

Citations

10
Farnesol Inhibits Cell Viability and Activates Apoptosis in Glioma C6 Cells via Downregulating Phosphoinositide 3-kinase (PI3K)/Protein Kinase B (AKT)/Mammalian Target of Rapamycin (mTOR) Pathway DOI Creative Commons
Chao Gao, Shu-Jem Su, Qi Guan

et al.

Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Background Gliomas are the most aggressive and devastating brain tumors, with a poor prognosis due to their complex etiology, diverse clinical manifestations, limited efficacy of existing treatment methods. Purpose The present work was conducted understand anticancer activities farnesol against glioma C6 cells. Methods effects on in vitro free radical scavenging were evaluated at various dosages (1–100 µM). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test used assess influence growth cells nonmalignant Vero apoptotic levels investigated using 4′,6-diamidino-2-phenylindole (DAPI) dual staining assays. oxidative stress markers, inflammatory biomarkers, protein levels, phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR) pathway proteins assessed respective kits. Results results assays proved antioxidant properties farnesol. MTT assay findings demonstrated significant reduction cell viability following fluorescent onset apoptosis farnesol-treated Furthermore, effectively increased stress, reduced marker PI3K, AKT, mTOR expression also successfully downregulated by Conclusion current demonstrate that suppresses triggers Thus, it has capacity be an effective agent treat glioma. Nonetheless, additional is still necessary future determine specific molecular mechanisms involved farnesol-induced

Language: Английский

Citations

0
Cancer cells impact the microrheology of endothelial cells during physical contact or through paracrine signalling DOI Creative Commons

Georgia M. Kefala,

Daria Tsvirkun,

Valérie Laurent

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 8, 2025

During the process of metastasis, cancer cells transmigrate through endothelial barrier vascular walls. Cancer interact with cells, leading to changes their mechanical properties. While this interaction has been extensively studied from perspective (CCs), properties endothelium remain underexplored, even though they may play a crucial role in regulating process. In study, we used microrheology AFM-based approach demonstrate that (ECs) are altered when cultured either CC-conditioned medium or direct contact cells. We found viscoelasticity ECs decreased diluted medium. Furthermore, cell at short times (less than 30 min) also showed significantly lower stiffness and viscoelastic moduli. parallel, observed reduction quantity actin fibers clusters within EC cytoskeleton, resulting less structured network facilitate CC transmigration. Overall, our findings indicated rheological can be directly physical CCs indirectly via CC-secreted substances. This suggests actively responds presence rather serving only as passive barrier.

Language: Английский

Citations

0