Early mortality critically impedes improvements in thyroid cancer survival through a half century DOI
Filip Tichánek, Asta Försti,

Vaclv Liska

et al.

European Journal of Endocrinology, Journal Year: 2023, Volume and Issue: 189(3), P. 355 - 362

Published: Aug. 31, 2023

Abstract Objectives We analyze survival in thyroid cancer from Denmark (DK), Finland (FI), Norway (NO), and Sweden (SE) over a 50-year period (1971-2020), additionally consider concomitant changes incidence mortality. Design Population-based study. Methods Relative 1-, 5/1 (conditional)-, 5-year data were obtained the NORDCAN database for years 1971-2020. Incidence mortality rates also assessed. Results A novel consistent observation was that 1-year worse than 5/1-year but difference between these decreased with time. (mean 4 countries) reached 92.7% men 95.6% women; 88.0% 93.7% women. Survival increased most DK which started at low level best end. Male female 3- 4-fold, respectively. In same time, halved women, it by 2/3. Conclusions documented relative first year subsequent years, likely because of rare anaplastic cancer. Overall patients Nordic countries course 50 years; close to 90% 95% Even though overdiagnosis may explain some increase, is unlikely influence substantial increase survival. The unmet need diagnosing treating aggressive tumors before metastatic spread.

Language: Английский

Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis DOI Creative Commons

Xiaojie Hu,

Yuquan Chen,

Yiting Shen

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 13, 2022

Although Hashimoto's thyroiditis is associated with cardiovascular disease and malignancy, the global status of not well characterized across regions. Our objective was to evaluate prevalence trends in adults regions different economic income levels around world.For this systematic review meta-analysis, we searched PubMed, Embase, MEDLINE, Scopus, Web Science databases, 48 random-effects representative studies from inception June 2022 were included without language restrictions obtain overall worldwide. In addition, stratified by time publication, geographic region, level region residence, gender, diagnostic method, etc.A total 11,399 retrieved, which met research criteria: 20 Europe, 16 Asia, five South America, three North Africa. Furthermore, there are two projects involving 19 countries 22,680,155 participants. The 7.5 (95%CI 5.7-9.6%), while low-middle-income group 11.4 2.5-25.2%). Similarly, 5.6 (95%Cl 3.9-7.4%) upper-middle-income group, high-income 8.4 5.6-11.8). varied region: Africa (14.2 [95% CI 2.5-32.9%]), Oceania (11.0% 7.8-14.7%]), America Europe 8.0, 7.8% (95% Cl 0.0-29.5%) 5.8 2.8-9.9%) Asia. our investigator heterogeneity high (I2), results using a sensitivity analysis showed robustness reliability findings. People living areas more likely develop thyroiditis, than people areas, women's risk about four times higher men's.Global patients as many males, discrepancies levels. especially Africa, therefore local health departments should take strategic measures prevent, detect, treat thyroiditis. At same time, hidden medical burden other diseases caused also be done well.https://www.crd.york.ac.uk/prospero/, identifier: CRD 42022339839.

Language: Английский

Citations

124
A Narrative Review of the 2023 Korean Thyroid Association Management Guideline for Patients with Thyroid Nodules DOI Creative Commons
Eun Kyung Lee, Young Joo Park, Chan Kwon Jung

et al.

Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 39(1), P. 61 - 72

Published: Feb. 15, 2024

The 2023 Korean Thyroid Association (KTA) Management Guideline for Patients with Nodules constitute an update of the 2016 KTA guideline thyroid nodules and cancers that focuses specifically on nodules. aim to offer updated guidance based new evidence reflects changes in clinical practice since guideline. To guideline, a comprehensive literature search was conducted from January 2022 May 2022. included studies, reviews, other involving human subjects were published English MEDLINE (PubMed), Embase, relevant databases. Additional significant trials research studies up April also reviewed. limitations current are discussed, suggestions areas need further identified. purpose this review is provide summary management released give balanced insight comparison recent guidelines societies.

Language: Английский

Citations

11
The role of the hypothalamic–pituitary–thyroid axis in thyroid cancer DOI
Laura Abaandou, Raisa Ghosh, Joanna Kłubo-Gwieździńska

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Specific effects on the thyroid relevant for performing a dietary cumulative risk assessment of pesticide residues: 2024 update DOI Creative Commons

Federica Crivellente,

Antonio F. Hernández,

Anna Lanzoni

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(3)

Published: March 1, 2024

Abstract EFSA updated its previous work on the establishment of specific effects that are considered relevant for grouping pesticide residues targeting thyroid and performing retrospective assessment dietary cumulative risk (CRA). The two already selected in 2019 leading to groups (CAGs) 'hypothyroidism' 'C-cell hypertrophy, hyperplasia neoplasia' were reconfirmed. Compared 2019, list indicators can be used identify these was refined only include histopathological changes. In a second phase work, data will extracted from dossiers active substances (a.s.) as plant protection products. criteria including a.s. into CAGs also updated, together with hazard characterisation methodology lines evidence assessing CAG-membership probabilities. tasks related extraction hypothyroidism C-cell neoplasia beyond scope this report. This part CRA process has been outsourced subject separate

Language: Английский

Citations

7
Autoimmune Thyroid Disease and Differentiated Thyroid Carcinoma: A Review of the Mechanisms That Explain an Intriguing and Exciting Relationship DOI Open Access
Hernando Vargas‐Uricoechea

World Journal of Oncology, Journal Year: 2024, Volume and Issue: 15(1), P. 14 - 27

Published: Jan. 20, 2024

Autoimmune thyroid disease is a complex and highly frequent disease, where wide variety of genetic, epigenetic environmental factors (among others) come together interact, characterized by the presence two clinical outcomes: hypothyroidism (in Hashimoto's thyroiditis) hyperthyroidism Graves-Basedow disease). For its part, differentiated carcinoma (mainly papillary carcinoma) most common type cancer affecting (and one prevalent worldwide). An important co-occurrence between autoimmune has been documented. In this article, studies that have evaluated possible associations relationships are systematically described summarized. To date, underlying mechanism explains association inflammation; however, characteristics designs do not yet allow causal relationship entities to be established. These aspects made it difficult establish "causality" in continuum pathogenesis both conditions.

Language: Английский

Citations

6
The Impact of Environmental Factors on the Development of Autoimmune Thyroiditis—Review DOI Creative Commons
Wojciech Cyna, Aleksandra Wojciechowska, Weronika Szybiak-Skora

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1788 - 1788

Published: Aug. 7, 2024

Autoimmune thyroiditis (Hashimoto’s thyroiditis) is the most common autoimmune disease. It often manifests itself as hypothyroidism but may also present with euthyroidism or even hyperthyroidism. The etiopathogenesis of still unclear. However, in addition to genetic and epigenetic factors, many environmental factors are known increase risk developing AIT. In this review, we aimed collect analyze data connected development. Our review indicates iodine intake, vitamin D deficiency, selenium viral infections caused by Epstein–Barr Virus (EBV), Human parvovirus B19 (PVB19), herpesvirus 6A (HHV-6A) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bacterial infection Helicobacter pylori, microbiome disruption, medications such interferon-alpha tyrosine kinase inhibitors, well stress, climate, smoking can influence occurrence thyroiditis. Having knowledge allows for making changes one’s diet lifestyle that will reduce disease alleviate course

Language: Английский

Citations

6
2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules DOI Open Access
Young Joo Park, Eun Kyung Lee, Young Shin Song

et al.

International Journal of Thyroidology, Journal Year: 2023, Volume and Issue: 16(1), P. 1 - 31

Published: May 30, 2023

Young Joo Park, Eun Kyung Lee, Shin Song, Soo Hwan Kang, Bon Seok Koo, Sun Wook Kim, Dong Gyu Na, Seung-Kuk Baek, So Won Oh, Min Kyoung Sang-Woo Ah Yong Sang Ji Ye Dong-Jun Lim, Leehi Joo, Yuh-Seog Jung, Chan Kwon Yoon Cho, Yun Jae Chung, Bae Ka Hee Yi, Ho-Cheol Kang and Do Joon Park. Int J Thyroidol 2023;16:1-31. https://doi.org/10.11106/ijt.2023.16.1.1

Citations

16
Causal role of immune cells in Hashimoto’s thyroiditis: Mendelian randomization study DOI Creative Commons

Zhendan Zhao,

Yuehua Gao,

Xiao‐Qing Pei

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 13, 2024

Objectives Hashimoto’s thyroiditis (HT) is a common autoimmune disease whose etiology involves complex interplay between genetics and environment. Previous studies have demonstrated an association immune cells HT. However, the casual relationship was not clear. We aimed to explore causal associations signatures of Methods In this study, bidirectional two-sample Mendelian randomization (MR) analysis conducted investigate potential 731 cell HT by using genome-wide study (GWAS) data. Heterogeneity horizontal pleiotropy were detected through extensive sensitivity analyses. Results The increased levels six phenotypes observed be causally associated with risk P < 0.01, which CD3 on CM CD8br, CD39+ secreting Treg, HLA DR CD33dim DR+ CD11b−, CD4 CD62L− plasmacytoid DC %DC, CD45RA+ CD4+. addition, FSC-A T CD62L monocyte 0.01. also had effects CCR2 monocyte, CD25 resting CD62L+ myeloid 0.05. Conclusions we genetic connection traits HT, thereby providing guidance direction for future treatment clinical research.

Language: Английский

Citations

4
Multifocal metastatic papillary thyroid carcinoma: a case report and literature review DOI Creative Commons
S. Sheptukha, Victoria Hoperia, O. Mostiuk

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(1), P. 95 - 99

Published: Feb. 23, 2025

Background. Papillary thyroid carcinoma (PTC) is the most common form of malignant tumor gland, accounting for about 1 % all newly diagnosed neoplasms. The average age onset PTC 50 years, with a predominance female patients (3 : 1). In cases, long course and favorable prognosis characterize PTC. However, certain pathological features may indicate aggressive metastatic disease. results diagnosis treatment are described in clinical case multifocal presence vascular, extra-organic invasion metastases necessitate selection more monitoring. Materials methods. We analyzed primary medical documentation, surgical protocol, blood examination, instrumental, cytological pathohistological studies 34-year-old female. Results. patient was based on preoperative fine-needle aspiration biopsy (FNAB) underwent thyroidectomy, central lateral neck dissection. Pathological examination confirmed background chronic thyroiditis, to lymph nodes. postoperative period, ablation I131. Conclusions. Performing FNAB subsequent analysis period critical establishing determining extent surgery. Effective followed by crucial radioiodine therapy.

Language: Английский

Citations

0
Hashimoto’s thyroiditis recognition from multi-modal data via global cross-attention and distance-aware training DOI
Quankeng Huang, Wenchao Jiang,

Junhang Li

et al.

Medical Image Analysis, Journal Year: 2025, Volume and Issue: 102, P. 103515 - 103515

Published: March 2, 2025

Language: Английский

Citations

0