Archives of Physiology and Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: Nov. 11, 2024
The
introduction
of
Tyrosine
Kinase
Inhibitors
(TKIs)
has
revolutionised
cancer
treatment,
yet
concerns
regarding
cardiovascular
toxicity
have
surfaced.
This
piece
delves
into
the
interplay
between
AMP-activated
protein
kinase
(AMPK)
signalling
and
TKI-induced
toxicity.
study
unravels
intricate
relationship
AMPK
activation
toxicity,
aiming
to
ascertain
whether
can
play
a
strategic
role
in
mitigating
adverse
effects.
Beyond
unravelling
mechanistic
insights,
research
sets
stage
for
future
therapeutic
approaches,
envisioning
as
pivotal
connection
balancing
effective
treatment
with
well-being.
As
advances,
potential
not
only
addresses
challenges
but
also
shapes
landscape
personalised
anticancer
therapies.
article
explores
mechanisms
AMPK's
impact
on
health,
implications
alleviating
TKI-associated
toxicities.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1270 - 1270
Published: Oct. 18, 2024
Periodontitis
affects
up
to
40%
of
adults
over
60
years
old
and
is
a
consequence
gingivitis.
characterized
by
chronic
inflammation,
periodontal
damage,
alveolar
bone
resorption.
The
nuclear
factor
erythroid
2-related
2
(NFE2L2
or
NRF2)/Kelch-like
ECH-Associated
Protein
1
(KEAP1)
(NRF2/KEAP1)
signaling
pathway
plays
key
role
in
periodontitis
modulating
redox
balance
inflammation
the
periodontium.
However,
NRF2
expression
decreased
gingival
tissues
patients
with
while
oxidative
stress
significantly
increased
this
pathology.
Oxidative
lipopolysaccharide
(LPS)
produced
gram-negative
bacteria
favor
production
inflammatory
causing
favoring
bone.
In
review,
we
analyzed
current
literature
regarding
natural
synthetic
compounds
NRF2/KEAP1
vitro
vivo
models
order
evaluate
new
potential
treatments
that
can
improve
outcome
disease.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(11), P. 1928 - 1928
Published: Oct. 29, 2023
Chronic
liver
disease
(CLD)
affects
a
significant
portion
of
the
global
population,
leading
to
substantial
number
deaths
each
year.
Distinct
forms
like
non-alcoholic
fatty
(NAFLD)
and
alcoholic
(ALD),
though
they
have
different
etiologies,
highlight
shared
pathologies
rooted
in
oxidative
stress.
Central
metabolism,
mitochondria
are
essential
for
ATP
production,
gluconeogenesis,
acid
oxidation,
heme
synthesis.
However,
diseases
NAFLD,
ALD,
fibrosis,
mitochondrial
function
is
compromised
by
inflammatory
cytokines,
hepatotoxins,
metabolic
irregularities.
This
dysfunction,
especially
electron
leakage,
exacerbates
production
reactive
oxygen
species
(ROS),
augmenting
damage.
Amidst
this,
nuclear
factor
erythroid
2-related
2
(NRF2)
emerges
as
cellular
protector.
It
not
only
counters
stress
regulating
antioxidant
genes
but
also
maintains
health
overseeing
autophagy
biogenesis.
The
synergy
between
NRF2
modulation
introduces
new
therapeutic
potentials
CLD,
focusing
on
preserving
integrity
against
threats.
review
delves
into
intricate
role
shedding
light
innovative
strategies
its
prevention
treatment,
through
pathways.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 9835 - 9835
Published: June 7, 2023
Periodontitis
is
a
chronic
infectious
disease
characterized
by
the
destruction
of
connective
tissue
and
alveolar
bone
that
eventually
leads
to
tooth
loss.
Ferroptosis
an
iron-dependent
regulated
cell
death
involved
in
ligature-induced
periodontitis
vivo.
Studies
have
demonstrated
curcumin
has
potential
therapeutic
effect
on
periodontitis,
but
mechanism
still
unclear.
The
purpose
this
study
was
investigate
protective
effects
alleviating
ferroptosis
periodontitis.
Ligature-induced
periodontal-diseased
mice
were
used
detect
curcumin.
level
superoxide
dismutase
(SOD),
malondialdehyde
(MDA)
total
glutathione
(GSH)
gingiva
assayed.
Furthermore,
mRNA
expression
levels
acsl4,
slc7a11,
gpx4
tfr1
measured
using
qPCR
protein
ACSL4,
SLC7A11,
GPX4
TfR1
investigated
Western
blot
immunocytochemistry
(IHC).
Curcumin
reduced
MDA
increased
GSH.
Additionally,
proven
significantly
increase
SLC7A11
inhibit
ACSL4
TfR1.
In
conclusion,
plays
role
inhibiting
mice.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(5), P. e0303556 - e0303556
Published: May 16, 2024
Echinatin
is
an
active
ingredient
in
licorice,
a
traditional
Chinese
medicine
used
the
treatment
of
inflammatory
disorders.
However,
protective
effect
and
underlying
mechanism
echinatin
against
acute
lung
injury
(ALI)
still
unclear.
Herein,
we
aimed
to
explore
echinatin-mediated
anti-inflammatory
effects
on
lipopolysaccharide
(LPS)-stimulated
ALI
its
molecular
mechanisms
macrophages.
In
vitro
,
markedly
decreased
levels
nitric
oxide
(NO)
prostaglandin
E2
(PGE
2
)
LPS-stimulated
murine
MH-S
alveolar
macrophages
RAW264.7
by
suppressing
inducible
synthase
cyclooxygenase-2
(COX-2)
expression.
Furthermore,
reduced
LPS-induced
mRNA
expression
release
interleukin-1β
(IL-1β)
IL-6
cells.
Western
blotting
CETSA
showed
that
repressed
activation
mitogen-activated
protein
kinase
(MAPK)
nuclear
factor-kappa
B
(NF-κB)
pathways
through
targeting
transforming
growth
factor-beta-activated
1
(TAK1).
directly
interacted
with
Kelch-like
ECH-associated
(Keap1)
activated
factor
erythroid
2-related
(Nrf2)
pathway
enhance
heme
oxygenase-1
(HO-1)
vivo
ameliorated
injury,
production
IL-1β
IL-6.
These
findings
demonstrated
exerted
via
blocking
TAK1-MAPK/NF-κB
activating
Keap1-Nrf2-HO-1
pathway.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(2), P. 72 - 72
Published: Jan. 23, 2025
Periodontal
diseases,
including
gingivitis
and
periodontitis,
are
chronic
inflammatory
conditions
of
the
teeth’
supporting
structures
that
can
lead
to
progressive
tissue
destruction
loss
if
left
untreated.
Basic
treatments
like
scaling
root
planing,
alone
or
combined
with
antimicrobial
agents,
standard
care.
However,
increasing
prevalence
antibiotic
resistance
need
for
new
ideas
in
therapy,
adjunctive
ozone
therapy
have
gained
attention.
Ozone
(O3),
a
triatomic
oxygen
molecule,
is
used
because
its
strong
antimicrobial,
anti-inflammatory,
regenerative
activity
and,
hence,
as
potential
tool
periodontal
therapy.
This
review
use
disease
breaks
down
multifaceted
mechanism
which
includes
selective
action
against
biofilm-associated
pathogens,
immunomodulatory
effects
on
host
cells,
stimulation
repair.
O3
disrupts
microbial
biofilms,
enhances
immune
cell
function,
promotes
healing
by
activating
Nuclear
Factor
Erythroid
2-Related
2
(Nrf2)
Mitogen-Activated
Protein
Kinase
(MAPK)
signaling
pathways
regulate
oxidative
stress,
inflammation,
apoptosis.
Additional
findings
include
ability
upregulate
growth
factors
extracellular
matrix
proteins,
significant
regeneration.
also
discusses
application
lines,
emphasizing
impact
viability,
proliferation,
differentiation.
Advances
techniques,
properties
O3,
demonstrated
clinical
benefits.
Challenges,
standardized
dosages,
effective
delivery
systems,
long-term
studies,
addressed
ensure
safe
integration.
dual
capabilities,
offers
an
innovative
approach
treatment.
Future
research
focusing
optimized
protocols
evidence-based
guidelines
essential
fully
realize
enhancing
health
improving
patient
outcomes.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 807 - 807
Published: Feb. 10, 2025
Periodontal
disease
is
a
chronic
inflammatory
condition
that
destroys
the
tooth-supporting
structures
due
to
host's
immune
response
microbial
biofilms.
Traditional
periodontal
treatments,
such
as
scaling
and
root
planing,
pharmacological
interventions,
surgical
procedures,
have
significant
limitations,
including
difficulty
accessing
deep
pockets,
biofilm
recolonization,
development
of
antibiotic
resistance.
In
light
these
challenges,
natural
bioactive
compounds
derived
from
plants,
herbs,
other
sources
offer
promising
alternative
their
anti-inflammatory,
antioxidant,
antimicrobial,
tissue-regenerative
properties.
This
review
focuses
on
molecular
mechanisms
through
which
compounds,
curcumin,
resveratrol,
epigallocatechin
gallate
(EGCG),
baicalin,
carvacrol,
berberine,
essential
oils,
Gum
Arabic,
exert
therapeutic
effects
in
disease.
Bioactive
inhibit
critical
pathways
like
NF-κB,
JAK/STAT,
MAPK
while
activating
protective
Nrf2/ARE,
reducing
cytokine
production
oxidative
stress.
They
also
activity
matrix
metalloproteinases
(MMPs),
preventing
tissue
degradation
promoting
healing.
addition,
demonstrated
potential
disrupt
bacterial
biofilms
by
interfering
with
quorum
sensing,
targeting
cell
membranes,
enhancing
efficacy.Bioactive
modulate
system
shifting
balance
pro-inflammatory
anti-inflammatory
responses
efferocytosis,
helps
resolve
inflammation
supports
regeneration.
However,
despite
challenges
related
poor
bioavailability,
stability
oral
cavity,
absence
large-scale
clinical
trials
need
be
addressed.
Future
strategies
should
prioritize
advanced
delivery
systems
nanoparticles
hydrogels
enhance
bioavailability
sustain
release,
alongside
long-term
studies
assess
human
populations.
Furthermore,
combining
traditional
treatments
could
provide
synergistic
benefits
managing
aims
explore
disease,
emphasizing
action
offering
insights
into
integration
conventional
therapies
for
more
comprehensive
approach
health.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 24, 2025
Periodontitis
is
a
significant
global
public
health
issue
associated
with
the
onset
and
progression
of
various
systemic
diseases,
thereby
requiring
additional
research
clinical
attention.
Although
ferroptosis
cuproptosis
have
emerged
as
areas
in
medical
field,
their
precise
roles
pathogenesis
periodontitis
remain
unclear.
We
aim
to
systematically
summarize
current
on
periodontal
disease
investigate
glutathione
pathway
autophagy
connecting
during
periodontitis.
Further,
we
propose
that
homeostatic
imbalance
copper
iron,
driven
by
pathogens,
may
contribute
elevated
oxidative
stress,
representing
potential
unifying
link
between
involved
This
article
presents
comprehensive
overview
molecular
mechanisms
underlying
periodontitis,
offering
novel
theoretical
insights
into
its
therapeutic
targets.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 3, 2025
Periodontitis
is
a
chronic
inflammatory
disease
arising
from
local
microorganisms
and
the
host's
own
aberrant
immune
regulation.
Ginsenoside
Rg1(GS-Rg1)
an
active
extract
of
ginseng
known
for
its
anti-inflammatory
osteogenesis
effects.
However,
GS-Rg1
has
not
been
shown
to
treat
periodontitis
exact
mechanism
remains
elucidated.
Orthodontic
wires
inoculated
with
Porphyromonas
gingivalis
were
wrapped
around
gingiva
first
molar
in
rats
induce
periodontitis.
Inflammatory
factor
secretion
was
analyzed
using
RT-PCR
immunohistochemistry.
The
number
osteoclasts
osteogenic
factors
TRAP
staining
immunofluorescence.
destruction
periodontal
tissues
evaluated
Micro-CT
H&E
staining.
Keap1/Nrf2
pathway
protein
expression
Western-Blot
RT-PCR.
Applying
significantly
reduced
IL-6
increased
transforming
growth
TGF-β1.
Additionally,
decreased
osteoclast
numbers
RUNX2
OCN
expression.
Furthermore,
found
enhance
related
Nrf2
while
reducing
Keap1
may
effectively
alleviate
through
pathway.
In
conclusion,
our
study
provided
preclinical
evidence
support
as
potential
therapeutic
agent
treating
