Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 17, 2024
Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.
Language: Английский
Citations
46
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 1986 - 1986
Published: March 29, 2024
Introduction and objective: Many scientific reports confirm a systematic decline in male semen parameters over the last decades. This phenomenon has been observed all parts of world, its occurrence is associated, among others, with hazardous effects some environmental factors. The factors for which adverse effect on fertility proven include water, air, soil pollution, as well electromagnetic fields ionizing radiation. aim this article was evaluation selected reproductive capacity based an analysis current reports. Review methods: A literature review carried out using three databases: PubMed, EMBASE, Scopus. search limited to period from 2015 until end December 2023. Brief description state knowledge: Environmental factors, such heavy metals, tobacco smoke, pesticides, dioxins, furans, phthalates, bisphenols, are well-tested substances that exert fertility. harmful water air pollution functions may be expected; however, not fully proven. Summary: Results obtained by many researchers published date should evoke great concern regarding quality environment we live, fears about only fertility, but also aspects human health. majority pollutants affect body causing oxidative stress through their endocrine system.
Language: Английский
Citations
12
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117136 - 117136
Published: July 26, 2024
The continuous use of pesticides, such as dichlorvos, is a common agricultural and domestic practice. However, it associated with shortfalls like testicular toxicity through the induction oxidative stress-mediated signaling. On other hand, L-arginine, precursor nitric oxide, has been reported to exert antioxidant activities thus may attenuate dichlorvos-induced toxicity.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9116 - 9116
Published: Aug. 22, 2024
Drug residues that contaminate food and water represent a serious concern for human health. The major concerns regard the possible irrational use of these contaminants, since this might increase amplitude exposure. Multiple sources contribute to overall exposure including agriculture, domestic use, personal, public veterinary healthcare, increasing origin contamination. In review, we focus on crop pesticides drug because their extensive in modern agriculture farming, which ensures production security ever-growing population around world. We discuss with respect worldwide distribution impacts, special attention harmful effects reproduction embryo development, as well link epigenetic alterations, leading intergenerational transgenerational diseases. Among most commonly implicated causing such disorders are organophosphates, glyphosate antibiotics, tetracyclines being frequently reported. This review highlights importance finding new management strategies drugs. Moreover, due still limited knowledge inter- underlie need strengthen research field, so better clarify specific each contaminant long-term impact.
Language: Английский
Citations
6
Microscopy and Microanalysis, Journal Year: 2024, Volume and Issue: 30(5), P. 962 - 977
Published: Aug. 27, 2024
Abamectin is one of the most widely used pesticides due to its strong insecticidal and anthelmintic activities. Melatonin a neurohormone with potent antioxidant, anti-apoptotic, anti-inflammatory effects. This study aimed investigate potential ameliorative effects melatonin against abamectin-induced testicular toxicity in rats. Twenty-four rats were divided into four groups: control group (1 mL/kg/day corn oil), melatonin-treated (10 mg/kg/day), abamectin-treated (0.5 plus group. Test substances administered via oral gavage once daily for 28 days. While MDA 8-OHdG levels increased tissue treated abamectin, SOD, CAT, GPx, GST enzyme activities decreased significantly. interleukin-17 levels, TNF-α, caspase3 expression tissue, acetylcholinesterase activity decreased. At same time, serum gonadotropins (luteinizing follicle-stimulating hormones) testosterone Light microscope examinations tissues revealed severe histopathological changes, such as atrophic hyalinized seminiferous tubules, basement membrane irregularity, degeneration, spermatogenic cell loss, necrosis. Electron microscopy large vacuoles Sertoli cells, swelling vacuolization mitochondria, lysosomal structures, pyknotic nuclei. In contrast, supplementation significantly ameliorated through antiapoptotic, mechanisms.
Language: Английский
Citations
5
Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6
Published: May 30, 2024
Background: Pyrethroids are natural organic compounds extracted from flowers of pyrethrums and commonly used as domestic commercial insecticides. Although it is effective in insect parasitic control, its associated toxicity, including spermotoxicity, remains a challenge globally. Currently, the available reports on effect pyrethroids semen quality conflicting, hence an evaluation detrimental pertinent. This study conducts detailed systematic review meta-analysis effects sperm quality. Materials methods: The present was performed according to Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Using pre-defined strategic protocol, internet search done using combined text words. criteria eligibility were selected based Population, Exposure, Comparator, Outcome, Study Designs (PECO) framework, relevant data collected. Appraisal Office Health Assessment Translation (OHAT) tool Risk Bias Grading Recommendations Assessment, Development, Evaluation (GRADE) Working Group guidelines certainty evidence. A quantitative conducted with Review Manager (RevMan). Results: Only 12 out 4, 050 studies screened eligible inclusion this study. China (4), Japan (3), Poland United States (2). All cross-sectional. total 2, male subjects included meta-analysis. Pyrethroid exposure significantly reduced motility. Region-stratified subgroup analyses revealed that pyrethroid motility among men States, decreased count Japan. also concentration but increased States. Conclusion: inconsistent evidence quality, findings showed have deleterious potentials motility, count, concentration. Studies focusing assessment pyrethroid-exposed men, especially at specific varying levels exposure, employing prospective cohort or controlled cross-sectional designs recommended.
Language: Английский
Citations
4
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116645 - 116645
Published: June 28, 2024
Language: Английский
Citations
4
European Journal of Obstetrics & Gynecology and Reproductive Biology, Journal Year: 2024, Volume and Issue: 300, P. 230 - 239
Published: July 17, 2024
Language: Английский
Citations
4
Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 99, P. 101303 - 101303
Published: July 30, 2024
Couple infertility is a common condition, defined as being unable to conceive after 12 months of regular unprotected sexual intercourse. Male Factor Infertility (MFI) responsible, alone or in combination with female factors, for about half the overall cases couple infertility. MFI gradually increasing prevalence, notable decline semen parameters over last decades. The aetiologies behind finding decreasing sperm counts are difficult pinpoint but might be due part rates overweight and obesity men childbearing age. Diabetes mellitus (DM) chronic metabolic disease, whose prevalence also increasing, rising up 10% population. International Federation estimates that there currently more than 500 million people living DM worldwide, vast majority whom suffering from type 2 (T2DM). There growing awareness relationship between unhealthy lifestyle, particular diet, MFI. Starting all these premises, aim this narrative review describe current evidence on link MFI, both terms cause of/a risk factor possible predictive marker T2DM. Finally, we will discuss consequence therapy assisted reproductive techniques.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
Seminal oxidative stress has been shown to be a key factor in the development of male infertility. However, benefits infertility treatments with antioxidants such as coenzyme Q10 (CoQ10) remains controversial. The aim present study was assess effects CoQ10 supplementation on semen quality, i.e., volume, total sperm number, concentration, motility, percentage progressive motility and morphology. In addition, circulating testosterone, luteinizing hormone (LH), follicle-stimulating (FSH), inhibin B levels were evaluated. A systematic review meta-analysis randomized controlled trials (RCTs) performed quality serum reproductive hormones. We conducted strategic literature search Cochrane, EMBASE, PubMed/MEDLINE, Scopus, Web Science databases collected only RCTs. data RCTs then meta-analyzed according PRISMA guidelines. Out 2,144 studies, eight classified eligible. studies included 877 subjects; 462 CoQ10-treated 415 untreated/placebo-treated. found significantly higher counts (SMD -13.38 [95% CI: -16.33, -10.43] P< 0.0001), -7.26 -10.15, -4.36] 0.00001) -6.386 -10.04, -2.73] P= 0.0006), normally formed -1.96 -3.29, -0.62] 0.004) subjects compared untreated/placebo-treated subjects. Nonetheless, there significant inter-study heterogeneity these studies. Moreover, testosterone -0.59 -0.79, -0.40] -0.92 -1.47, -0.37] 0.001) recorded lowered LH 1.77 1.26, 2.28] FSH concentrations 1.60 1.38, 1.81] 0.00001). Interestingly, no hormonal had effect volume 0.12 -0.13, 0.37] 0.34) concentration -6.69 -16.28, 2.90] 0.17). Our shows that increases count, proportion association levels. therefore supports view beneficial use treatment. further well-designed sufficiently large numbers are required reach final conclusion.
Language: Английский
Citations
0