BMC Endocrine Disorders,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: June 19, 2024
Abstract
Background
The
dietary
inflammatory
index
(DII)
serves
as
a
tool
to
assess
the
impact
of
an
individual’s
diet.
This
study
aimed
investigate
association
between
DII
and
some
cardio-metabolic
risk
indices
among
patients
with
T2DM.
Methods
Data
from
Hoveyzeh
Cohort
Study,
encompassing
2045
adults
T2DM,
were
analyzed.
scores
calculated
based
on
food
frequency
questionnaires.
Anthropometric
measurements
biochemical
tests
performed
factors.
Results
Higher
positively
associated
elevated
triglyceride
levels,
triglyceride-glucose
(TyG)
index,
lipid
accumulation
product
(LAP),
anthropometric
including
body
shape
(ABSI),
roundness
(BRI),
mass
(BMI),
hip,
waist
circumferences
(WC),
waist-to-height
ratio
(all
P
trend
<
0.05).
Notably,
no
significant
was
observed
fasting
blood
sugar
(FBS)
levels
(P
>
Additionally,
intake
analysis
revealed
negative
correlation
fiber,
fruits,
vegetables,
legumes,
fish,
seafood,
dairy
products,
magnesium,
vitamins
A,
C,
D,
E
Conversely,
higher
increased
consumption
red
meat,
processed
refined
cereals,
potatoes,
soft
drinks
Conclusion
underscores
critical
link
inflammation,
assessed
by
score,
multitude
factors
in
while
did
not
find
it
identified
robust
associations
novel
indicative
risk.
These
findings
highlight
potential
interventions
cornerstone
strategy
for
managing
T2DM
mitigating
its
complications.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(46), P. e40412 - e40412
Published: Nov. 15, 2024
While
there
is
ample
evidence
indicating
an
increased
occurrence
of
general
neurological
conditions
among
individuals
with
diabetes,
has
been
limited
exploration
into
the
cause-and-effect
connection
between
type
2
diabetes
(T2D)
and
specific
disorders,
including
like
carpal
tunnel
syndrome
Bell’s
palsy.
We
used
Mendelian
randomization
(MR)
approach
to
investigate
causal
effects
T2D
on
67
diseases.
primarily
utilized
inverse-variance
weighted
method
for
analysis,
also
employed
median
MR-Egger
methods
in
our
study.
To
detect
correct
potential
outliers,
MR-PRESSO
analysis
was
used.
Heterogeneity
assessed
using
Cochrane
Q-values.
The
MR
analyses
found
a
possible
relationship
risk
increase
8
diseases
at
suggestive
level
(
P
<
.05).
Notably,
positive
findings
that
met
false
discovery
rate
threshold,
nerve,
nerve
root,
plexus
disorders
(odds
ratio
[OR]
=
1.11;
95%
confidence
interval
[CI]
1.08–1.15);
(OR
1.05;
CI
1.03–1.07)
1.10;
1.05–1.16)
were
identified.
Our
affirm
association
certain
disorders.
Frontiers in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 14, 2025
Cardiometabolic
diseases
(CMD)
are
leading
causes
of
death
and
disability
worldwide,
with
complex
pathophysiological
mechanisms
in
which
inflammation
plays
a
crucial
role.
This
review
aims
to
elucidate
the
molecular
cellular
within
inflammatory
microenvironment
atherosclerosis,
hypertension
diabetic
cardiomyopathy.
In
oxidized
low-density
lipoprotein
(ox-LDL)
pro-inflammatory
cytokines
such
as
Interleukin-6
(IL-6)
Tumor
Necrosis
Factor-alpha
(TNF-α)
activate
immune
cells
contributing
foam
cell
formation
arterial
wall
thickening.
Hypertension
involves
activation
renin-angiotensin
system
(RAS)
alongside
oxidative
stress-induced
endothelial
dysfunction
local
mediated
by
T
cells.
cardiomyopathy,
high-glucose
environment
leads
accumulation
advanced
glycation
end
products
(AGEs),
activating
Receptor
for
Advanced
Glycation
Endproducts
(RAGE)
triggering
responses
that
further
damage
cardiac
microvascular
function.
summary,
different
types
metabolic
cardiovascular
diverse;
understanding
these
deeply
will
aid
developing
more
effective
individualized
treatment
strategies.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 25, 2025
Diabetes
is
a
growing
health
concern
in
developing
countries,
causing
considerable
mortality
rates.
While
machine
learning
(ML)
approaches
have
been
widely
used
to
improve
early
detection
and
treatment,
several
studies
shown
low
classification
accuracies
due
overfitting,
underfitting,
data
noise.
This
research
employs
parallel
sequential
ensemble
ML
paired
with
feature
selection
techniques
boost
accuracy.
The
Pima
India
Data
from
the
UCI
Repository
served
as
dataset.
preprocessing
included
cleaning
dataset
by
replacing
missing
values
column
means
selecting
highly
correlated
features
using
forward
backward
methods.
was
split
into
two
parts:
training
(70%),
testing
(30%).
Python
for
Jupyter
Notebook,
there
were
design
phases.
first
phase
utilized
J48,
Classification
Regression
Tree
(CART),
Decision
Stump
(DS)
create
random
forest
model.
second
employed
same
algorithms
alongside
methods—XG
Boost,
AdaBoostM1,
Gradient
Boosting—using
an
average
voting
algorithm
binary
classification.
Evaluation
revealed
that
XG
Boosting
achieved
of
100%,
performance
metrics
including
F1
score,
MCC,
Precision,
Recall,
AUC-ROC,
AUC-PR
all
equal
1.00,
indicating
reliable
predictions
diabetes
presence.
Researchers
practitioners
can
leverage
predictive
model
developed
this
work
make
quick
mellitus,
which
could
save
many
lives.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
8, P. 101556 - 101556
Published: May 24, 2024
Hybrid
molecules
based
on
the
1,3,4-thiadiazole
were
always
choice
of
different
researchers
due
to
their
significant
application
in
medicinal
as
well
pharmaceutical
application.
In
present
study,
twenty
analogs
1,3,4-thiadiazole-bearing
thiosemicarbazide
moiety
(1–20)
synthesized
and
screened
for
anti-diabetic
profile.
The
compounds
spectroscopically
characterized
through
spectroscopic
techniques
such
1HNMR,
13CNMR,
HREI-MS.
Comparing
whole
set
afforded
standard
glimepiride
drugs
(16.01
±
0.02
μM),
inhibition
profiles
against
α-amylase
ranged
from
21.02
0.08
54.08
0.04
μM.
synthetic
normal
(IC50
=
14.06
0.05
range
α-glucosidase
activity
was
likewise
variable,
ranging
18.04
0.07
μM
IC50
51.05
0.03
(against
α-glucosidase).
Compound
19
demonstrated
high
potency
among
produced
since
it
had
both
ortho-nitro
substitution
at
aryl
ring.
pattern
substitutions
around
ring
used
all
determine
structure–activity
relationship.
addition,
a
molecular
docking
study
conducted
potent
examine
interactions
between
active
residues
targeted
enzymes
with
compound.
molecule
showed
types
amino
acid.
outcome
demonstrates
that
these
provide
several
essential
sites
enzymes,
hence
strengthening
enzymatic
future
prediction
drug
competitors.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 15, 2024
Diabetes
and
its
complications
significantly
affect
individuals’
quality
of
life.
The
etiology
diabetes
mellitus
associated
is
complex
not
yet
fully
understood.
There
an
increasing
emphasis
on
investigating
the
effects
endocrine
disruptors
diabetes,
as
these
substances
can
impact
cellular
processes,
energy
production,
utilization,
ultimately
leading
to
disturbances
in
homeostasis.
Mitochondria
play
a
crucial
role
generation,
any
impairment
organelles
increase
susceptibility
diabetes.
This
review
examines
most
recent
epidemiological
pathogenic
evidence
concerning
link
between
including
complications.
analysis
suggests
that
disruptor-induced
mitochondrial
dysfunction—characterized
by
disruptions
electron
transport
chain,
dysregulation
calcium
ions
(Ca
2+
),
overproduction
reactive
oxygen
species
(ROS),
initiation
signaling
pathways
related
apoptosis—may
be
key
mechanisms
connecting
development
Saudi Pharmaceutical Journal,
Journal Year:
2024,
Volume and Issue:
32(6), P. 102069 - 102069
Published: April 14, 2024
The
expeditious
incidence
of
diabetes
mellitus
in
Riyadh,
Saudi
Arabia,
there
is
a
significant
increase
the
total
number
people
with
diabetic
foot
ulcers.
For
lower
limb
wound
infections
(DLWs)
to
be
effectively
treated,
information
on
prevalence
bacteria
that
cause
this
region
as
well
their
patterns
antibiotic
resistance
significant.
Growing
evidence
indicates
biofilm
formers
are
present
chronic
DFU
and
these
promote
emergence
multi-drug
resistant
(MDR)
strains
therapeutic
rejection.
current
study
targeted
isolate
from
wounds
caused
by
specifically
at
hospitals
Riyadh
assess
bacterium's
antibiotics
propensity
develop
biofilms.
Totally
63
pathogenic
microbes
were
identified
70
patients
suffering
DFU.
Sixteen
(25.4%)
bacterial
gram-positive,
47
(74.6%)
gram-negative.
Most
gram-negative
tigecycline,
nitrofurantoin,
ampicillin,
amoxicillin,
cefalotin,
cefoxitin.
Several
susceptible
piperacillin,
meropenem,
amikacin,
gentamicin,
imipenem,
ciprofloxacin,
trimethoprim.
most
demonstrated
100%
susceptibility
all
pathogens
was
meropenem.
Serratia
marcescens
Staphylococcus
aureus
shown
have
formers.
MDR
comprised
about
87.5%
former
strains.
To
best
our
knowledge,
Arabia
first
where
common
infections.
Our
research
findings
would
deliver
evidence-based
alternative
strategies
effective
treatment
approaches
for
treatment.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 13, 2025
Background
High
fasting
plasma
glucose
(HFPG)
has
been
identified
as
one
of
the
risk
factors
associated
with
development
breast
cancer.
The
worldwide
distribution
cancer
attributable
to
HFPG
was
not
comprehensively
investigated.
Methods
We
utilized
data
from
Global
Burden
Disease
Study
2021
explore
HFPG-related
deaths,
disability
adjusted
life
years
(DALYs)
and
corresponding
age-standardized
rates
(ASRs).
average
annual
percentage
change
(AAPC)
estimated
(EAPC)
were
employed
evaluate
temporal
trend.
Results
global
effect
resulted
in
nearly
30,570
deaths
819,550
DALYs
2021,
representing
an
rate
(ASMR)
0.66
(95%
UI
-0.19-1.57)
(ASDR)
18.05
-5.31-42.71).
In
regions
low,
low-middle,
middle
SDI,
ASRs
increased
significantly
over
time.
highest
ASMR
ASDR
observed
several
countries,
such
Palau,
American
Samoa,
Cook
Islands,
Marshall
United
Arab
Emirates.
There
a
positive
correlation
between
Socio-Demographic
Index
(SDI)
countries
where
SDI
below
0.75.
escalation
death
primarily
driven
by
epidemiological
population
growth
regions.
Conclusions
Substantial
disparities
exist
across
diverse
burden
attributed
HFPG.
It
is
urgent
regulate
glycemic
levels,
improve
healthcare
infrastructures,
provide
cost-effective
care
less
developed
developing
that
endure
disproportionately
heavier
health
burden.
European Journal of Cancer Prevention,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Background
Colorectal
cancer
(CRC)
poses
a
significant
health
burden
in
Europe,
but
comprehensive
studies
on
this
region
are
limited.
Methods
Using
data
from
the
Global
Burden
of
Diseases
(GBD),
Injuries,
and
Risk
Factors
Study
2021,
we
analyzed
regional
distribution
temporal
trends
CRC
early-onset
Europe
1990
to
2021.
Decomposition
analysis
was
applied
quantify
contributions
population
growth,
aging,
epidemiological
changes.
The
research
also
evaluated
major
risk
factors
associated
with
CRC.
Results
found
be
higher
than
global
average.
While
age-standardized
incidence
rate
(ASIR)
increased,
both
mortality
(ASMR)
disability-adjusted
life
years
(ASDR)
decreased.
Early-onset
exhibits
similar
characteristics
patterns
change.
Males
had
significantly
females.
Population
aging
primary
driver
increased
Europe.
factor
revealed
that
low
whole
grain
intake
high
red
meat
consumption
were
contributors
elevated
ASMR
ASDR
Additionally,
BMI
fasting
plasma
glucose
showed
an
increasing
trend.
Conclusion
overall
remains
level,
ASIR
decreasing
ASDR.
Targeted
prevention
control
strategies
should
developed
based
for
Older
adults
men
prioritized
interventions.