The association between dietary inflammatory index with some cardio-metabolic risk indices among the patients with type 2 diabetes from Hoveyzeh cohort study: a cross-sectional study DOI Creative Commons
Mehran Rahimlou,

Amirhossein Ramezani Ahmadi,

Bahman Cheraghian

et al.

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 19, 2024

Abstract Background The dietary inflammatory index (DII) serves as a tool to assess the impact of an individual’s diet. This study aimed investigate association between DII and some cardio-metabolic risk indices among patients with T2DM. Methods Data from Hoveyzeh Cohort Study, encompassing 2045 adults T2DM, were analyzed. scores calculated based on food frequency questionnaires. Anthropometric measurements biochemical tests performed factors. Results Higher positively associated elevated triglyceride levels, triglyceride-glucose (TyG) index, lipid accumulation product (LAP), anthropometric including body shape (ABSI), roundness (BRI), mass (BMI), hip, waist circumferences (WC), waist-to-height ratio (all P trend < 0.05). Notably, no significant was observed fasting blood sugar (FBS) levels (P > Additionally, intake analysis revealed negative correlation fiber, fruits, vegetables, legumes, fish, seafood, dairy products, magnesium, vitamins A, C, D, E Conversely, higher increased consumption red meat, processed refined cereals, potatoes, soft drinks Conclusion underscores critical link inflammation, assessed by score, multitude factors in while did not find it identified robust associations novel indicative risk. These findings highlight potential interventions cornerstone strategy for managing T2DM mitigating its complications.

Language: Английский

Exploring the causal relationships between type 2 diabetes and neurological disorders using a Mendelian randomization strategy DOI Creative Commons

Yongfang Wei,

Shuling Xu,

Zhaoquan Wu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40412 - e40412

Published: Nov. 15, 2024

While there is ample evidence indicating an increased occurrence of general neurological conditions among individuals with diabetes, has been limited exploration into the cause-and-effect connection between type 2 diabetes (T2D) and specific disorders, including like carpal tunnel syndrome Bell’s palsy. We used Mendelian randomization (MR) approach to investigate causal effects T2D on 67 diseases. primarily utilized inverse-variance weighted method for analysis, also employed median MR-Egger methods in our study. To detect correct potential outliers, MR-PRESSO analysis was used. Heterogeneity assessed using Cochrane Q-values. The MR analyses found a possible relationship risk increase 8 diseases at suggestive level ( P < .05). Notably, positive findings that met false discovery rate threshold, nerve, nerve root, plexus disorders (odds ratio [OR] = 1.11; 95% confidence interval [CI] 1.08–1.15); (OR 1.05; CI 1.03–1.07) 1.10; 1.05–1.16) were identified. Our affirm association certain disorders.

Language: Английский

Citations

26
Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives DOI Creative Commons
Menghua Liu, Rumeng Chen,

Zhiwei Zheng

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 14, 2025

Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular cellular within inflammatory microenvironment atherosclerosis, hypertension diabetic cardiomyopathy. In oxidized low-density lipoprotein (ox-LDL) pro-inflammatory cytokines such as Interleukin-6 (IL-6) Tumor Necrosis Factor-alpha (TNF-α) activate immune cells contributing foam cell formation arterial wall thickening. Hypertension involves activation renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction local mediated by T cells. cardiomyopathy, high-glucose environment leads accumulation advanced glycation end products (AGEs), activating Receptor for Advanced Glycation Endproducts (RAGE) triggering responses that further damage cardiac microvascular function. summary, different types metabolic cardiovascular diverse; understanding these deeply will aid developing more effective individualized treatment strategies.

Language: Английский

Citations

2
Efficient diagnosis of diabetes mellitus using an improved ensemble method DOI Creative Commons

Blessing Oluwatobi Olorunfemi,

Adewale Opeoluwa Ogunde, Ahmad Almogren

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

Diabetes is a growing health concern in developing countries, causing considerable mortality rates. While machine learning (ML) approaches have been widely used to improve early detection and treatment, several studies shown low classification accuracies due overfitting, underfitting, data noise. This research employs parallel sequential ensemble ML paired with feature selection techniques boost accuracy. The Pima India Data from the UCI Repository served as dataset. preprocessing included cleaning dataset by replacing missing values column means selecting highly correlated features using forward backward methods. was split into two parts: training (70%), testing (30%). Python for Jupyter Notebook, there were design phases. first phase utilized J48, Classification Regression Tree (CART), Decision Stump (DS) create random forest model. second employed same algorithms alongside methods—XG Boost, AdaBoostM1, Gradient Boosting—using an average voting algorithm binary classification. Evaluation revealed that XG Boosting achieved of 100%, performance metrics including F1 score, MCC, Precision, Recall, AUC-ROC, AUC-PR all equal 1.00, indicating reliable predictions diabetes presence. Researchers practitioners can leverage predictive model developed this work make quick mellitus, which could save many lives.

Language: Английский

Citations

2
Synthesis of modified 1,3,4-thiadiazole incorporating substituted thiosemicarbazide derivatives: Elucidating the in vitro and in silico studies to develop promising anti-diabetic agent DOI Creative Commons

Shahzad Ahmad Abbasi,

Fazal Rahim, Rafaqat Hussain

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 101556 - 101556

Published: May 24, 2024

Hybrid molecules based on the 1,3,4-thiadiazole were always choice of different researchers due to their significant application in medicinal as well pharmaceutical application. In present study, twenty analogs 1,3,4-thiadiazole-bearing thiosemicarbazide moiety (1–20) synthesized and screened for anti-diabetic profile. The compounds spectroscopically characterized through spectroscopic techniques such 1HNMR, 13CNMR, HREI-MS. Comparing whole set afforded standard glimepiride drugs (16.01 ± 0.02 μM), inhibition profiles against α-amylase ranged from 21.02 0.08 54.08 0.04 μM. synthetic normal (IC50 = 14.06 0.05 range α-glucosidase activity was likewise variable, ranging 18.04 0.07 μM IC50 51.05 0.03 (against α-glucosidase). Compound 19 demonstrated high potency among produced since it had both ortho-nitro substitution at aryl ring. pattern substitutions around ring used all determine structure–activity relationship. addition, a molecular docking study conducted potent examine interactions between active residues targeted enzymes with compound. molecule showed types amino acid. outcome demonstrates that these provide several essential sites enzymes, hence strengthening enzymatic future prediction drug competitors.

Language: Английский

Citations

9
Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications DOI Creative Commons
Kunhui He, Rumeng Chen,

Shuling Xu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

Diabetes and its complications significantly affect individuals’ quality of life. The etiology diabetes mellitus associated is complex not yet fully understood. There an increasing emphasis on investigating the effects endocrine disruptors diabetes, as these substances can impact cellular processes, energy production, utilization, ultimately leading to disturbances in homeostasis. Mitochondria play a crucial role generation, any impairment organelles increase susceptibility diabetes. This review examines most recent epidemiological pathogenic evidence concerning link between including complications. analysis suggests that disruptor-induced mitochondrial dysfunction—characterized by disruptions electron transport chain, dysregulation calcium ions (Ca 2+ ), overproduction reactive oxygen species (ROS), initiation signaling pathways related apoptosis—may be key mechanisms connecting development

Language: Английский

Citations

8
Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights DOI
Sajjad ur Rahman, Aftab Alam, Zahida Parveen

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107501 - 107501

Published: May 31, 2024

Language: Английский

Citations

7
Diabetes-related lower limb wounds: Antibiotic susceptibility pattern and biofilm formation DOI Creative Commons
Raha Orfali, Safina Ghaffar,

Lateefa AlAjlan

et al.

Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(6), P. 102069 - 102069

Published: April 14, 2024

The expeditious incidence of diabetes mellitus in Riyadh, Saudi Arabia, there is a significant increase the total number people with diabetic foot ulcers. For lower limb wound infections (DLWs) to be effectively treated, information on prevalence bacteria that cause this region as well their patterns antibiotic resistance significant. Growing evidence indicates biofilm formers are present chronic DFU and these promote emergence multi-drug resistant (MDR) strains therapeutic rejection. current study targeted isolate from wounds caused by specifically at hospitals Riyadh assess bacterium's antibiotics propensity develop biofilms. Totally 63 pathogenic microbes were identified 70 patients suffering DFU. Sixteen (25.4%) bacterial gram-positive, 47 (74.6%) gram-negative. Most gram-negative tigecycline, nitrofurantoin, ampicillin, amoxicillin, cefalotin, cefoxitin. Several susceptible piperacillin, meropenem, amikacin, gentamicin, imipenem, ciprofloxacin, trimethoprim. most demonstrated 100% susceptibility all pathogens was meropenem. Serratia marcescens Staphylococcus aureus shown have formers. MDR comprised about 87.5% former strains. To best our knowledge, Arabia first where common infections. Our research findings would deliver evidence-based alternative strategies effective treatment approaches for treatment.

Language: Английский

Citations

6
Discovering the anti-diabetic potential of thiosemicarbazone derivatives: In vitro α-glucosidase, α-amylase inhibitory activities with molecular docking and DFT investigations DOI

Saba Gul,

Ahmed A. Elhenawy,

Qaisar Ali

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138671 - 138671

Published: May 19, 2024

Language: Английский

Citations

5
Global disease burden of breast cancer attributable to high fasting plasma glucose: a comprehensive analysis from the global burden of disease study DOI Creative Commons
Jing Zhang, Jiawei He,

Yunyan Lu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Background High fasting plasma glucose (HFPG) has been identified as one of the risk factors associated with development breast cancer. The worldwide distribution cancer attributable to HFPG was not comprehensively investigated. Methods We utilized data from Global Burden Disease Study 2021 explore HFPG-related deaths, disability adjusted life years (DALYs) and corresponding age-standardized rates (ASRs). average annual percentage change (AAPC) estimated (EAPC) were employed evaluate temporal trend. Results global effect resulted in nearly 30,570 deaths 819,550 DALYs 2021, representing an rate (ASMR) 0.66 (95% UI -0.19-1.57) (ASDR) 18.05 -5.31-42.71). In regions low, low-middle, middle SDI, ASRs increased significantly over time. highest ASMR ASDR observed several countries, such Palau, American Samoa, Cook Islands, Marshall United Arab Emirates. There a positive correlation between Socio-Demographic Index (SDI) countries where SDI below 0.75. escalation death primarily driven by epidemiological population growth regions. Conclusions Substantial disparities exist across diverse burden attributed HFPG. It is urgent regulate glycemic levels, improve healthcare infrastructures, provide cost-effective care less developed developing that endure disproportionately heavier health burden.

Language: Английский

Citations

0
Burden and risk factors of colorectal cancer in Europe from 1990 to 2021 DOI
Tao Zhang, Shuai Wang, Dongming Li

et al.

European Journal of Cancer Prevention, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Background Colorectal cancer (CRC) poses a significant health burden in Europe, but comprehensive studies on this region are limited. Methods Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, we analyzed regional distribution temporal trends CRC early-onset Europe 1990 to 2021. Decomposition analysis was applied quantify contributions population growth, aging, epidemiological changes. The research also evaluated major risk factors associated with CRC. Results found be higher than global average. While age-standardized incidence rate (ASIR) increased, both mortality (ASMR) disability-adjusted life years (ASDR) decreased. Early-onset exhibits similar characteristics patterns change. Males had significantly females. Population aging primary driver increased Europe. factor revealed that low whole grain intake high red meat consumption were contributors elevated ASMR ASDR Additionally, BMI fasting plasma glucose showed an increasing trend. Conclusion overall remains level, ASIR decreasing ASDR. Targeted prevention control strategies should developed based for Older adults men prioritized interventions.

Language: Английский

Citations

0