Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 25, 2024
Abstract
Lichen-forming
fungi
(LFF)
are
prolific
producers
of
functionally
and
structurally
diverse
secondary
metabolites,
most
which
taxonomically
exclusive
delivering
lineage-specific
roles.
But
there
evolutionary
conserved
biosynthetic
pathways
in
lichens?
Based
on
the
current
evidence
it
seems
aren’t
any.
This
notion
is
derived
from
polyketide-derivatives
as
biochemical
investigations
lichens
focused
PKSs
whereas
other
class
compounds
remain
mostly
unexplored.
Here
we
present
first
systematic
identification
comparison
lichenized
fungal
terpene
synthases
ever-present
LFF,
however,
they
have
never
been
systematically
analyzed.
We
gathered
111
genomes
LFF
representing
60
genera
23
families
implemented
genome
mining
gene
clustering
approaches
to
identify
group
clusters
into
networks
similar
clusters.
Our
large-scale
analysis
led
733
BGCs
with
varying
degrees
mutual
similarity,
them
were
unique.
Remarkably,
found
two
widely
distributed
homologous
–
both
squalene/phytoene
-
putatively
involved
sterol/ergosterol
biosynthesis.
These
contain
same
core
gene,
but
different
sets
accessory
genes.
indicates
an
early
duplication
event,
followed
by
losses
gains
genes,
leading
architecture
show
that
sequence
divergence,
duplications,
rearrangement
major
factors
driving
evolution
this
cluster
across
LFF.
study
shows
do
a
cluster,
bringing
indication
may
form
essential
content
lichens.
Fungal Diversity,
Journal Year:
2024,
Volume and Issue:
125(1), P. 1 - 71
Published: March 20, 2024
Abstract
The
field
of
mycology
has
grown
from
an
underappreciated
subset
botany,
to
a
valuable,
modern
scientific
discipline.
As
this
study
grown,
there
have
been
significant
contributions
science,
technology,
and
industry,
highlighting
the
value
fungi
in
era.
This
paper
looks
at
current
research,
along
with
existing
limitations,
suggests
future
areas
where
scientists
can
focus
their
efforts,
mycology.
We
show
how
become
important
emerging
diseases
medical
discuss
trends
potential
drug
novel
compound
discovery.
explore
phylogenomics,
its
potential,
outcomes
address
question
phylogenomics
be
applied
fungal
ecology.
In
addition,
functional
genomics
studies
are
discussed
importance
unravelling
intricate
mechanisms
underlying
behaviour,
interactions,
adaptations,
paving
way
for
comprehensive
understanding
biology.
look
research
building
materials,
they
used
as
carbon
sinks,
biocircular
economies.
numbers
always
great
interest
often
written
about
estimates
varied
greatly.
Thus,
we
needs
order
obtain
more
reliable
estimates.
aspects
machine
learning
(AI)
it
mycological
research.
Plant
pathogens
affecting
food
production
systems
on
global
scale,
such,
needed
area,
particularly
disease
detection.
latest
data
High
Throughput
Sequencing
if
still
gaining
new
knowledge
same
rate
before.
A
review
nanotechnology
is
provided
addressed.
Arbuscular
Mycorrhizal
Fungi
addressed
acknowledged.
Fungal
databases
becoming
important,
therefore
provide
major
databases.
Edible
medicinal
huge
medicines,
especially
Asia
prospects
discussed.
Lifestyle
changes
(e.g.,
endophytes,
pathogens,
and/or
saprobes)
also
extremely
trend
special
issue
Diversity.
Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(8), P. 834 - 834
Published: Aug. 8, 2023
The
use
of
microorganisms
in
industry
has
enabled
the
(over)production
various
compounds
(e.g.,
primary
and
secondary
metabolites,
proteins
enzymes)
that
are
relevant
for
production
antibiotics,
food,
beverages,
cosmetics,
chemicals
biofuels,
among
others.
Industrial
strains
commonly
obtained
by
conventional
(non-GMO)
strain
improvement
strategies
random
screening
selection.
However,
recombinant
DNA
technology
made
it
possible
to
improve
microbial
adding,
deleting
or
modifying
specific
genes.
Techniques
such
as
genetic
engineering
genome
editing
contributing
development
industrial
strains.
Nevertheless,
there
is
still
significant
room
further
improvement.
In
this
review,
we
will
focus
on
classical
recent
methods,
tools
technologies
used
fungal
with
potential
be
applied
at
an
scale.
Additionally,
functional
genomics,
transcriptomics,
proteomics
metabolomics
together
implementation
manipulation
techniques
expression
discussed.
Applied Microbiology,
Journal Year:
2025,
Volume and Issue:
5(1), P. 8 - 8
Published: Jan. 15, 2025
This
paper
examines
the
role
of
filamentous
fungi
in
enhancing
sustainable
extraction
vegetable
oils
from
oilseeds.
Fungi
such
as
Aspergillus,
Penicillium,
Fusarium,
Trichoderma,
and
Rhizopus
are
highlighted
for
their
ability
to
produce
hydrolytic
enzymes,
including
lipases,
cellulases,
hemicellulases,
which
break
down
plant
cell
walls
facilitate
oil
release.
biotechnological
approach
not
only
improves
yield
but
also
reduces
operational
costs
environmental
impacts,
contributing
development
goals.
The
integration
oleaginous
fungi,
capable
accumulating
lipids,
is
discussed
a
promising
avenue
boosting
production
efficiency.
Furthermore,
this
underscores
importance
combining
traditional
knowledge
with
modern
advancements.
respects
local
cultural
practices
while
optimizing
processes,
ensuring
minimal
ecological
disruption.
use
oilseed
degradation
represents
significant
step
towards
more
eco-friendly
cost-effective
production,
making
it
valuable
contribution
agricultural
industrial
practices.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(14), P. 10039 - 10055
Published: Jan. 1, 2024
African
swine
fever
virus
(ASFV)
has
emerged
as
a
serious
threat
to
the
pork
industry
resulting
in
significant
economic
losses
and
heightened
concerns
about
food
security.
With
no
known
cure
presently
available,
existing
control
measures
center
on
animal
quarantine
culling.
Considering
severity
challenges
posed
by
ASFV,
it
is
imperative
discover
new
treatment
strategies
implement
additional
prevent
its
further
spread.
This
study
recognized
potential
of
1830
fungal
metabolites
from
medicinal
fungi
antiviral
compounds
against
base
excision
repair
(BER)
proteins
specifically
Mycology: An International Journal on Fungal Biology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 26
Published: March 18, 2024
The
rising
global
demand
for
sustainable
and
eco-friendly
practices
has
led
to
a
burgeoning
interest
in
circular
bioeconomy,
wherein
waste
materials
are
repurposed
into
valuable
resources.
Lignocellulosic
waste,
abundant
agricultural
residues
forestry
by-products,
represents
significant
untapped
resource.
This
article
explores
the
potential
of
fungal-mediated
processes
valorisation
lignocellulosic
highlighting
their
role
transforming
these
recalcitrant
bio-based
products.
articles
delve
diverse
enzymatic
metabolic
capabilities
fungi,
which
enable
them
efficiently
degrade
metabolise
materials.
paper
further
highlights
key
fungal
species
mechanisms
involved
breakdown
complex
biomass,
emphasising
importance
understanding
intricate
biochemical
pathways
optimising
conversion
processes.
insights
will
significantly
contribute
advancing
biotechnology
bioeconomy
applications,
fostering
paradigm
shift
towards
more
resource-efficient
environmentally
friendly
approach
management
product
manufacturing.
DNA,
Journal Year:
2024,
Volume and Issue:
4(4), P. 427 - 454
Published: Nov. 14, 2024
Genetic
engineering
has
revolutionized
our
ability
to
modify
microorganisms
for
various
applications
in
agriculture,
medicine,
and
industry.
This
review
examines
recent
advances
genetic
techniques
bacteria,
fungi,
oomycetes,
with
a
focus
on
CRISPR-Cas
systems.
In
CRISPR-Cas9
enabled
precise
genome
editing,
enhancing
antibiotic
production
metabolic
engineering.
For
despite
challenges
associated
their
complex
cell
structures,
CRISPR/Cas9
advanced
the
of
enzymes
secondary
metabolites.
significant
plant
pathogens,
modified
Agrobacterium-mediated
transformation,
CRISPR/Cas12a
have
contributed
developing
disease-resistant
crops.
provides
comparative
analysis
efficiencies
across
these
addresses
ethical
regulatory
considerations.
Future
research
directions
include
refining
tools
improve
efficiency
expand
applicability
non-model
organisms.
comprehensive
overview
highlights
transformative
potential
microbiology
its
implications
addressing
global
biotechnology.
