Current Treatment Options in Oncology,
Journal Year:
2023,
Volume and Issue:
24(1), P. 30 - 44
Published: Jan. 1, 2023
Opinion
statement
The
potential
medicinal
properties
of
Cannabis
continue
to
garner
attention,
especially
in
the
brain
tumor
domain.
This
attention
is
centered
on
quality
life
and
symptom
management;
however,
it
amplified
by
a
significant
lack
therapeutic
choices
for
this
specific
patient
population.
While
literature
matter
young,
published
anecdotal
evidence
imply
that
cannabis
could
be
useful
treating
chemotherapy-induced
nausea
vomiting,
stimulating
appetite,
reducing
pain,
managing
seizures.
It
may
also
decrease
inflammation
cancer
cell
proliferation
survival,
resulting
benefit
overall
survival.
Current
poses
challenge
does
not
provide
standardized
guidance
dosing
above
indications
use
dominated
recreational
purposes.
Furthermore,
integrated
longitudinal
studies
are
needed
but
these
due
arcane
laws
surrounding
legality
such
substances.
increasing
need
evidence-based
arguments
about
harms
benefits
cannabis,
only
patients
other
medical
purposes,
desperately
needed.
Molecules,
Journal Year:
2019,
Volume and Issue:
24(5), P. 918 - 918
Published: March 6, 2019
The
endocannabinoid
system
(ECS)
has
lately
been
proven
to
be
an
important,
multifaceted
homeostatic
regulator,
which
influences
a
wide-variety
of
physiological
processes
all
over
the
body.
Its
members,
endocannabinoids
(eCBs;
e.g.,
anandamide),
eCB-responsive
receptors
(e.g.,
CB₁,
CB₂),
as
well
complex
enzyme
and
transporter
apparatus
involved
in
metabolism
ligands
were
shown
expressed
several
tissues,
including
skin.
Although
best
studied
functions
ECS
are
related
central
nervous
immune
processes,
experimental
efforts
last
two
decades
have
unambiguously
confirmed
that
cutaneous
cannabinoid
("c[ut]annabinoid")
signaling
is
deeply
maintenance
skin
homeostasis,
barrier
formation
regeneration,
its
dysregulation
was
implicated
contribute
highly
prevalent
diseases
disorders,
atopic
dermatitis,
psoriasis,
scleroderma,
acne,
hair
growth
pigmentation
keratin
diseases,
various
tumors,
itch.
current
review
aims
give
overview
available
skin-relevant
endo-
phytocannabinoid
literature
with
special
emphasis
on
putative
translational
potential,
highlight
promising
future
research
directions
existing
challenges.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: Jan. 14, 2021
Abstract
Cannabis
sativa
is
widely
used
for
medical
purposes
and
has
anti-inflammatory
activity.
This
study
intended
to
examine
the
activity
of
cannabis
on
immune
response
markers
associated
with
coronavirus
disease
2019
(COVID-19)
inflammation.
An
extract
fraction
from
C.
Arbel
strain
(F
CBD
)
substantially
reduced
(dose
dependently)
interleukin
(IL)-6
-8
levels
in
an
alveolar
epithelial
(A549)
cell
line.
F
contained
cannabidiol
(CBD),
cannabigerol
(CBG)
tetrahydrocannabivarin
(THCV),
multiple
terpenes.
Treatments
a
formulation
using
phytocannabinoid
standards
CBD:std
IL-6,
IL-8,
C–C
Motif
Chemokine
Ligands
(
CCLs
2
7,
angiotensin
I
converting
enzyme
ACE2
expression
A549
Treatment
induced
macrophage
(differentiated
KG1
line)
polarization
phagocytosis
vitro,
increased
CD36
type
II
receptor
Fc
region
IgG
FcγRII
expression.
treatment
also
IL-6
IL-8
macrophages.
,
while
maintaining
cells,
led
pro-inflammatory
IL
secretion
macrophages
comparison
.
The
may
show
superior
versus
cannabis-derived
reduction
lung
inflammation,
yet
there
need
caution
proposing
as
COVID-19.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(4), P. 660 - 660
Published: March 29, 2022
Cannabis
(Cannabis
sativa
L.)
plants
from
the
family
Cannabidaceae
have
been
used
since
ancient
times,
to
produce
fibers,
oil,
and
for
medicinal
purposes.
Psychoactive
delta-9-tetrahydrocannabinol
(THC)
nonpsychoactive
cannabidiol
(CBD)
are
main
pharmacologically
active
compounds
of
sativa.
These
have,
a
long
time,
under
extensive
investigation,
their
potent
antioxidant
inflammatory
properties
reported,
although
detailed
mechanisms
actions
not
fully
clarified.
CB1
receptors
suggested
be
responsible
analgesic
effect
THC,
while
CB2
may
account
its
immunomodulatory
properties.
Unlike
CBD
has
very
low
affinity
both
receptors,
behaves
as
negative
allosteric
modulator.
activity,
receptor
inverse
agonist,
could
important
anti-inflammatory
In
this
review,
we
discuss
chemical
bioavailability
THC
CBD,
action,
role
in
oxidative
stress
inflammation.
Journal of Ovarian Research,
Journal Year:
2019,
Volume and Issue:
12(1)
Published: Jan. 15, 2019
There
has
been
increasing
interest
in
the
role
of
endocannabinoids
as
critical
modulators
female
reproductive
processes.
Endocannabinoids
are
natural
ligands
cannabinoid,
vanilloid,
and
peroxisome
proliferator-activated
receptors.
Together
with
their
receptors,
enzymes
downstream
signaling
targets,
they
form
endocannabinoid
system
(ECS).
While
ECS
is
known
to
modulate
pain
neurodevelopment,
it
also
impact
where
affects
folliculogenesis,
oocyte
maturation,
ovarian
endocrine
secretion.
In
addition,
oviductal
embryo
transport,
implantation,
uterine
decidualization
placentation.
a
complex
interplay
between
hypothalamic-pituitary-ovarian
axis,
an
intricate
crosstalk
steroid
hormone
production
Exogenous
cannabinoids,
derived
from
plants
such
Cannabis
sativa,
for
cannabinoid
These
have
shown
clinical
outcomes
related
dysregulation,
including
multiple
sclerosis,
Alzheimer's
disease,
amyotrophic
lateral
along
adverse
effects
on
reproduction.
The
aim
this
review
describe
discuss
data
human,
animal,
vitro
studies
that
support
important
tissues
particular,
we
will
some
mechanisms
by
which
can
affect
function
both
physiological
pathophysiological
states.
Cancers,
Journal Year:
2020,
Volume and Issue:
12(9), P. 2447 - 2447
Published: Aug. 28, 2020
Cannabis
or
its
derivatives
are
widely
used
by
patients
with
cancer
to
help
symptoms
and
treatment
side
effects.
However,
cannabis
has
potent
immunomodulatory
properties.
To
determine
if
consumption
during
immunotherapy
affects
therapy
outcomes,
we
conducted
a
prospective
observatory
study
including
102
(68
34
plus
cannabis)
consecutive
advanced
cancers
who
initiated
immunotherapy.
correlated
significant
decrease
in
time
tumor
progression
overall
survival.
On
the
other
hand,
use
of
reduced
therapy-related
immune-related
adverse
events.
We
also
tested
possibility
that
may
affect
immune
system
microenvironment
through
alteration
endocannabinoid
system.
analyzed
panel
serum
endocannabinoids
(eCBs)
eCB-like
lipids,
measuring
their
levels
before
after
both
groups.
Levels
eCBs
immunotherapy,
showed
no
differences
between
users
nonusers.
Nevertheless,
four
eCB
compounds
were
associated
patients'
survival
time.
Collectively,
considerable
effects,
among
needs
be
carefully
considered
due
potential
effects
on
system,
especially
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(12), P. 4448 - 4448
Published: June 23, 2020
The
Cannabis
plant
contains
numerous
components,
including
cannabinoids
and
other
active
molecules.
phyto-cannabinoid
activity
is
mediated
by
the
endocannabinoid
system.
Cannabinoids
affect
nervous
system
play
significant
roles
in
regulation
of
immune
While
not
yet
registered
as
a
drug,
potential
cannabinoid-based
medicines
for
treatment
various
conditions
has
led
many
countries
to
authorize
their
clinical
use.
However,
data
from
basic
medical
research
dedicated
currently
limited.
A
variety
pathological
involve
dysregulation
For
example,
cancer,
surveillance
cancer
immuno-editing
result
tolerance.
On
hand,
autoimmune
diseases
increased
causes
tissue
damage.
Immuno-modulating
therapies
can
regulate
therefore
immune-regulatory
properties
cannabinoids,
suggest
use
therapy
related
disorders.
In
this
contemporary
review,
we
discuss
immunity
explore
emerging
about
effects
on
response
different
pathologies.
addition,
complexities
using
treatments
each
these
conditions.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 10, 2022
This
review
presents
several
aspects
of
the
innovative
concept
sebaceous
immunobiology,
which
summarizes
numerous
activities
gland
including
its
classical
physiological
and
pathophysiological
tasks,
namely
sebum
production
development
seborrhea
acne.
Sebaceous
lipids,
represent
90%
skin
surface
lipids
in
adolescents
adults,
are
markedly
involved
barrier
function
perifollicular
dermal
innate
immune
processes,
leading
to
inflammatory
diseases.
Innovative
experimental
techniques
using
stem
cell
sebocyte
models
have
clarified
roles
distinct
cells
physiology
control
mechanisms.
The
represents
an
integral
part
pilosebaceous
unit
status
is
connected
hair
follicle
morphogenesis.
Interestingly,
professional
contribute
differentiation
homeostasis,
whereas
regulation
by
antigen-independent.
Inflammation
very
earliest
changes
Sebocytes
behave
as
potent
regulators,
integrating
into
responses
skin.
Expressing
mediators,
sebocytes
also
polarization
cutaneous
T
towards
Th17
phenotype.
In
addition,
response
infiltrate
depends
on
factors
produced
glands,
mostly
lipids.
Human
vitro
express
functional
pattern
recognition
receptors,
likely
interact
with
bacteria
acne
pathogenesis.
Sex
steroids,
peroxisome
proliferator-activated
receptor
ligands,
neuropeptides,
endocannabinoids
a
selective
apoptotic
process
complex
sebocyte-induced
immunological
reaction
acquired
congenital
diseases,
diseases
atopic
dermatitis.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(4), P. 885 - 885
Published: Feb. 10, 2022
The
plant
Cannabis
sativa
has
been
in
use
medicinally
for
several
thousand
years.
It
over
540
metabolites
thought
to
be
responsible
its
therapeutic
effects.
Two
of
the
key
phytocannabinoids
are
cannabidiol
(CBD)
and
tetrahydrocannabinol
(THC).
Unlike
THC,
CBD
does
not
have
potentially
intoxicating
Preclinical
clinical
research
indicates
that
a
wide
range
effects,
many
them
relevant
management
cancer.
In
this
article,
we
explore
some
potential
mechanisms
action
cancer,
evidence
efficacy
integrative
cancer
including
side
effects
associated
with
treatment,
demonstrating
integration
orthodox
care.
