EBioMedicine, Journal Year: 2022, Volume and Issue: 84, P. 104286 - 104286
Published: Sept. 27, 2022
Alterations in the gut microbiome have been associated with HIV infection, but relative impact of versus other factors on has difficult to determine cross-sectional studies.
Language: Английский
MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Nov. 24, 2024
Abstract Lung cancer (LC) continues to pose the highest mortality and exhibits a common prevalence among all types of cancer. The genetic interaction between human eukaryotes microbial cells plays vital role in orchestrating every physiological activity host. dynamic crosstalk gut lung microbiomes gut–lung axis communication network has been widely accepted as promising factors influencing LC progression. advent 16s rDNA sequencing technique opened new horizons for elucidating microbiome its potential pathophysiological other infectious diseases using molecular approach. Numerous studies have reported direct involvement host tumorigenesis processes their impact on current treatment strategies such radiotherapy, chemotherapy, or immunotherapy. metabolomic cross‐interaction, microbiome‐dependent immune modulation, close association microbiota composition outcomes strongly suggest that designing microbiome‐based investigating molecules targeting holobiome could offer alternatives develop effective therapeutic principles treatment. This review aims highlight progression possibility manipulating altered ecology targets.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 17, 2024
The intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis prognosis, crucial improving patient outcomes. This comprehensive review synthesizes current findings on microbiome's contribution to CRC pathogenesis, highlighting its potential as a biomarker non-invasive screening strategies. We explore mechanisms through which influences CRC, including roles in inflammation, metabolism, immune response modulation. Furthermore, we assess viability of microbial signatures predictive tools offering insights into personalized treatment approaches. Our analysis underscores necessity advanced metagenomic studies elucidate complex microbiome-CRC nexus, aiming refine diagnostic accuracy prognostic assessment clinical settings. propels forward understanding capabilities, paving way microbiome-based interventions management.
Language: Английский
Citations
6
Journal of Diabetes Research, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 13
Published: Nov. 11, 2020
Background. Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to increasing prevalence and various complications, diabetes brings about a huge financial burden DM patients. Nowadays, more studies reveal relationship between gut microbial community. We aimed explore alteration in composition function microbiome T2DM Methods. A total 137 patients with 179 age- gender-matched healthy controls selected from people sample center First Affiliated Hospital Zhengzhou University were divided into group Con group, respectively. collected their venous blood for laboratory tests stool samples 16S rRNA sequencing. The comparison two groups including both is presented.Results. found that α-diversity bacterial taxa had an evident decrease compared group. At phylum level, obvious Bacteroidetes marked increase Proteobacteria, Actinobacteria, Verrucomicrobia. genus Bacteroides Prevotella decreased while Escherichia-Shigella, Lachnospiraceae_incertae_sedis, Subdoligranulum, Enterococcus, Klebsiella different degrees expansion ROC based on 246 optimum OTUs very high test efficiency AUC 92.25% training set 90.48% set. As prediction function, was predicted be active environmental information processing human but less metabolism. Conclusion. observed These changes may provide new treatment strategy research targets.
Language: Английский
Citations
46
Pain, Journal Year: 2021, Volume and Issue: 163(5), P. 861 - 877
Published: Aug. 13, 2021
Abstract Recent findings linked gastrointestinal disorders characterized by abdominal pain to gut microbiota composition. The present work aimed evaluate the power of as a visceral modulator and, consequently, relevance its manipulation therapeutic option in reversing postinflammatory persistence. Colitis was induced mice intrarectally injecting 2,4-dinitrobenzenesulfonic acid (DNBS). effect faecal transplantation from viscerally hypersensitive DNBS-treated and naive donors evaluated control rats after an antibiotic-mediated depletion. Faecal DNBS long-lasting hypersensitivity rats. Pain threshold trend correlated with major modifications composition short chain fatty acids. By contrast, no significant alterations colon histology, permeability, monoamines levels were detected. Finally, manipulating animals, counteraction persistent achieved. results provide novel insights into relationship between intestinal hypersensitivity, highlighting potential microbiota-targeted interventions.
Language: Английский
Citations
36
EBioMedicine, Journal Year: 2022, Volume and Issue: 84, P. 104286 - 104286
Published: Sept. 27, 2022
Alterations in the gut microbiome have been associated with HIV infection, but relative impact of versus other factors on has difficult to determine cross-sectional studies.
Language: Английский
Citations
27