Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway DOI Open Access
Eileen McGowan, Yiguang Lin, Size Chen

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(3), P. 535 - 535

Published: Jan. 21, 2022

Incidence of gastrointestinal (GI) cancers is increasing, and late-stage diagnosis makes these difficult to treat. Chronic low-grade inflammation are recognized risks for most GI cancers. The mucosal immune system maintains healthy homeostasis signalling molecules made from saturated fats, bioactive sphingolipids, play essential roles in immunity. Sphingosine-1-phosphate (S1P), a sphingolipid, key mediator balanced response. Disruption the S1P pathway underlies systemic chronic metabolic inflammatory disorders, including diabetes cancers, providing strong rationale using modulators treat pathological inflammation. Here, we discuss effects sphingolipids with focus on associated increased risk carcinogenesis. Contemporary information involvement digestive system, top bottom, reviewed. Further, use novel receptor currently clinical trials their potential as first-line drugs clinic diseases. Recently, ozanimod (ZeposiaTM) etrasimod have been approved ulcerative colitis eosinophilic oesophagitis, respectively, which may longer term benefits reducing

Language: Английский

Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications DOI Open Access
Fen Zhang, Raphaela Iris Lau, Qin Liu

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(5), P. 323 - 337

Published: Oct. 21, 2022

Language: Английский

Citations

192
Functional roles of sphingolipids in immunity and their implication in disease DOI Creative Commons

Mingyu Lee,

Suh Yeon Lee,

Yoe‐Sik Bae

et al.

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(6), P. 1110 - 1130

Published: June 1, 2023

Abstract Sphingolipids, which are components of cellular membranes and organ tissues, can be synthesized or degraded to modulate responses according environmental cues, the balance among different sphingolipids is important for directing immune responses, regardless whether they originate, as intra- extracellular events. Recent progress in multiomics-based analyses methodological approaches has revealed that human health diseases closely related homeostasis sphingolipid metabolism, disease-specific alterations enzymes prognostic markers disease progression. Accumulating clinical data from genome-wide association studies preclinical models provide support notion missing pieces supplement our understanding functions involved proteins nucleotides have been established. In this review, we analyze sphingolipid-related reported understand roles metabolism. We discuss defects metabolism disease, along with functional cells. also introduce several summaries research on modulators review should helpful studying investigation experimental molecular medicines.

Language: Английский

Citations

70
The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus DOI Creative Commons
Duygu Ağagündüz, Mehmet Arif İçer, Özge Yeşildemir

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: April 2, 2023

Abstract Type 2 diabetes mellitus (T2DM), one of the main types Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, sociodemographic factors are known as related to high T2DM risk. Dietary lipids metabolism significant metabolic modulators T2DM-related complications. Besides, accumulated evidence suggests that altered gut microbiota which plays an important role health host contributes significantly involving or improved At this point, dietary may affect physiology via interaction with microbiota. increasing literature lipidomics novel parameters detected holistic analytical techniques have roles pathogenesis progression T2DM, through various mechanisms action including gut-brain axis modulation. A better understanding some nutrients interactions will help develop new strategies for prevention treatment T2DM. However, issue has not yet been entirely discussed literature. The present review provides up-to-date knowledge on nutritional considering lipids- given.

Language: Английский

Citations

48
Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies DOI Open Access
Alfred H. Merrill

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 650 - 650

Published: Jan. 14, 2025

Sphingolipidomic mass spectrometry has provided valuable information-and surprises-about sphingolipid structures, metabolism, and functions in normal biological processes disease. Nonetheless, many noteworthy compounds are not routinely determined, such as the following: most of sphingoid bases that mammals biosynthesize de novo other than sphingosine (and sometimes sphinganine) or acquire from exogenous sources; infrequently considered metabolites bases, N-(methyl)n-derivatives; "ceramides" common N-acylsphingosines; complex sphingolipids sphingomyelins simple glycosphingolipids, including glucosyl- galactosylceramides, which usually reported "monohexosylceramides". These subspecies discussed, well some circumstances when they likely to be seen (or present missed) due experimental conditions can influence uptake diet microbiome, artifacts produced during extraction analysis. If these factors kept mind design interpretation lipidomic studies, investigators surprised by how often appear thereby advance knowledge about them.

Language: Английский

Citations

3
Dietary lipids from body to brain DOI Creative Commons

Custers,

E.M. Emma,

Kiliaan

et al.

Progress in Lipid Research, Journal Year: 2021, Volume and Issue: 85, P. 101144 - 101144

Published: Dec. 13, 2021

Dietary habits have drastically changed over the last decades in Western societies. The diet, rich saturated fatty acids (SFA), trans (TFA), omega-6 polyunsaturated (n-6 PUFA) and cholesterol, is accepted as an important factor development of metabolic disorders, such obesity diabetes type 2. Alongside these diseases, nutrition associated with prevalence brain disorders. Although clinical epidemiological studies revealed that diseases disorders might be related, underlying pathology multifactorial, making it hard to determine causal links. Neuroinflammation can a result unhealthy diets may cause alterations peripheral metabolism. Especially, dietary are interest, they act signalling molecules responsible for inflammatory processes. Diets n-6 PUFA, SFA TFA increase neuroinflammation, whereas monounsaturated (MUFA), omega-3 (n-3) PUFA sphingolipids (SL) diminish neuroinflammation. Moreover, pro- anti-inflammatory indirectly influence neuroinflammation via adipose tissue, microbiome, intestine vasculature. Here, we review impact on health. In particular, will discuss role lipids pathways directly applicable inflammation neuronal function.

Language: Английский

Citations

67
Alterations of the gut microbiota and metabolomics in children with e-waste lead exposure DOI
Xiang Zeng, Zhijun Zeng, Qihua Wang

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 434, P. 128842 - 128842

Published: April 2, 2022

Language: Английский

Citations

43
FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer DOI Creative Commons
Chunjie Xu, Lei Gu, Li-Peng Hu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 11, 2023

Abstract Colonocyte metabolism shapes the microbiome. Metabolites are main mediators of information exchange between intestine and microbial communities. Arachidonic acid (AA) is an essential polyunsaturated fatty its role in colorectal cancer (CRC) remains unexplored. In this study, we show that AA feeding promotes tumor growth AOM/DSS intestinal specific Apc −/− mice via modulating microecology increased gram-negative bacteria. Delta-5 desaturase (FADS1), a rate-limiting enzyme, upregulated CRC effectively mediates synthesis. Functionally, FADS1 regulates high microenvironment-induced enriched microbes. Elimination microbe abolishes effect. Mechanistically, microbes activate TLR4/MYD88 pathway cells contributes FADS1-AA axis to metabolize prostaglandin E2 (PGE2). Cumulatively, report potential cancer-promoting mechanism converts raising synthesized PGE2 gram-negative.

Language: Английский

Citations

42
Changes in Human Milk Fat Globule Composition Throughout Lactation: A Review DOI Creative Commons
Caroline Thum, Clare Wall, Li Day

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 12, 2022

There has been a growing interest in understanding how the relative levels of human milk fat globule (MFG) components change over course lactation, they differ between populations, and implications these changes for health infant. In this article, we describe studies published last 30 years which have investigated MFG term milk, focusing on lactation highlighting infant maternal factors that may influence changes. We then consider potential benefits some membrane (MFGM) derived ingredients relate to compositional functional aspects throughout lactation. The results show concentrations phospholipids, gangliosides, cholesterol, fatty acids proteins vary such are likely reflect changing requirements is lack consistent trends phospholipids gangliosides across different methodological approaches. Other as diet geographical location shown MFGM composition. majority research conducted using from bovine animal models clearly demonstrated role supporting cognitive immune infants at stages growth development.

Language: Английский

Citations

40
Role of the microbiome in regulation of the immune system DOI Creative Commons
Songhui Kim,

Cebile Ndwandwe,

Hannah Devotta

et al.

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Language: Английский

Citations

1
The Application of Metabolomics in Recent Colorectal Cancer Studies: A State-of-the-Art Review DOI Open Access

Andrew Gold,

Fouad Choueiry, Ning Jin

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(3), P. 725 - 725

Published: Jan. 30, 2022

Colorectal cancer (CRC) is a highly prevalent disease with poor prognostic outcomes if not diagnosed in early stages. Current diagnosis techniques are either invasive or lack sufficient sensitivity. Thus, identifying diagnostic biomarkers of CRC high sensitivity and specificity desirable. Metabolomics represents an analytical profiling technique great promise such typically close tie the phenotype specific disease. We thus conducted systematic review studies reported from January 2012 to July 2021 relating detection through metabolomics provide collection knowledge for future development. identified thirty-seven characterizing CRC, many which provided metabolites/metabolic profile-based models specificity. These demonstrated that number metabolites can be differentially regulated patients compared healthy controls, adenomatous polyps, across stages CRC. Among these metabolite biomarkers, especially dysregulated were certain amino acids, fatty lysophosphatidylcholines. Additionally, we discussed contribution gut bacterial population pathogenesis their modulation fecal pools summarized established links literature between microbial genera altered levels patients. Taken together, conclude presents itself as promising effective method biomarker detection.

Language: Английский

Citations

38