Dietary regulation in health and disease

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 23, 2022

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan delaying ageing various species such as yeast, drosophila, rodent, primate human. It emerges develop precision-nutrition therapeutics slow age-related biological processes treat diverse diseases. However, nutritive advantages frequently diversify among individuals well organs tissues, which brings challenges this field. In review, we summarize different forms of dietary interventions extensively prescribed improvement disease treatment pre-clinical or clinical. We discuss nutrient-mediated mechanisms including metabolic regulators, metabolism pathways, epigenetic circadian clocks. Comparably, describe diet-responsive effectors by influence endocrinic, immunological, microbial neural states responsible improving health preventing multiple diseases humans. Furthermore, expatiate patterns dietotheroapies, fasting, calorie-restricted diet, ketogenic high-fibre plants-based protein restriction diet with specific reduction amino acids microelements, potentially affecting morbid states. Altogether, emphasize profound nutritional therapy, highlight crosstalk explored critical factors individualized therapeutic approaches predictors.

Language: Английский

---

Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 650 - 650

Published: Jan. 14, 2025

Sphingolipidomic mass spectrometry has provided valuable information-and surprises-about sphingolipid structures, metabolism, and functions in normal biological processes disease. Nonetheless, many noteworthy compounds are not routinely determined, such as the following: most of sphingoid bases that mammals biosynthesize de novo other than sphingosine (and sometimes sphinganine) or acquire from exogenous sources; infrequently considered metabolites bases, N-(methyl)n-derivatives; "ceramides" common N-acylsphingosines; complex sphingolipids sphingomyelins simple glycosphingolipids, including glucosyl- galactosylceramides, which usually reported "monohexosylceramides". These subspecies discussed, well some circumstances when they likely to be seen (or present missed) due experimental conditions can influence uptake diet microbiome, artifacts produced during extraction analysis. If these factors kept mind design interpretation lipidomic studies, investigators surprised by how often appear thereby advance knowledge about them.

Language: Английский

---

Unsaturated Fatty Acids in Mental Disorders: An Umbrella Review of Meta‐Analyses

Advances in Nutrition, Journal Year: 2022, Volume and Issue: 13(6), P. 2217 - 2236

Published: Aug. 30, 2022

Unsaturated fatty acids might be involved in the prevention of and improvement mental disorders, but evidence on these associations has not been comprehensively assessed. This umbrella review aimed to appraise credibility published evaluating between unsaturated disorders. In this review, systematic reviews meta-analyses studies comparing (including supplementation, dietary intake, blood concentrations) participants with disorders healthy individuals were included. We reanalyzed summary estimates, between-study heterogeneity, predictive intervals, publication bias, small-study effects, excess significance bias for each meta-analysis. Ninety-five from 29 included, encompassing 43 supplementation interventions, 32 factors, 20 biomarkers. Suggestive was only observed which higher intake fish associated reduced risk depression (RR: 0.78; 95% CI: 0.69, 0.89) Alzheimer disease 0.74; 0.63, 0.87), total PUFAs a lower mild cognitive impairment 0.71; 0.61, 0.84). Evidence showed that PUFA favorable had weak anxiety, depression, attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), dementia, impairment, Huntington's disease, schizophrenia (P-random effects <0.001-0.040). There also effect decreased circulating n-3 (ɷ-3) among patients ADHD, ASD, bipolar disorder, <10-6-0.037). Our results suggest levels may relieve symptoms or reduce various disorders; however, strength generally weak. Future high-quality research is needed identify whether interventions should prioritized alleviate

Language: Английский

---

HIV-1 Tat-mediated microglial ferroptosis involves the miR-204–ACSL4 signaling axis

Redox Biology, Journal Year: 2023, Volume and Issue: 62, P. 102689 - 102689

Published: April 1, 2023

This study was focused on exploring the role of HIV-1 Tat protein in mediating microglial ferroptosis. Exposure mouse primary cells (mPMs) to resulted induction ferroptosis, which characterized by increased expression Acyl-CoA synthetase long-chain family member 4 (ACSL4), turn, leading generation oxidized phosphatidylethanolamine, elevated levels lipid peroxidation, upregulated labile iron pool (LIP) and ferritin heavy chain-1 (FTH1), decreased glutathione peroxidase-4 mitochondrial outer membrane rupture. Also, inhibition ferroptosis ferrostatin-1 (Fer-1) or deferoxamine (DFO) treatment suppressed ferroptosis-related changes mPMs. Similarly, knockdown ACSL4 gene silencing also inhibited induced Tat. Furthermore, peroxidation release proinflammatory cytokines, such as TNFα, IL6, IL1β activation. Pretreatment mPMs with Fer-1 DFO further blocked Tat-mediated activation vitro reduced cytokines. We identified miR-204 an upstream modulator ACSL4, downregulated exposed Transient transfection mimics while inhibiting These findings were validated transgenic rats well HIV + ve human brain samples. Overall, this underscores a novel mechanism(s) underlying involving miR-204-ACSL4 signaling.

Language: Английский

---

An overview of food lipids toward food lipidomics

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2023, Volume and Issue: 22(6), P. 4302 - 4354

Published: Aug. 24, 2023

Abstract Increasing evidence regarding lipids’ beneficial effects on human health has changed the common perception of consumers and dietary officials about role(s) food lipids in a healthy diet. However, are wide group molecules with specific nutritional bioactive properties. To understand their true functional value, robust methods needed for accurate identification quantification. Specific analytical strategies crucial to target classes, especially ones present trace amounts. Finding unique comprehensive methodology cover full lipidome each foodstuff is still challenge. This review presents an overview nutritionally relevant foods new trends lipid analysis type/class lipids. Food classes described following LipidMaps classification, fatty acids, endocannabinoids, waxes, C 8 compounds, glycerophospholipids, glycerolipids (i.e., glycolipids, betaine lipids, triglycerides), sphingolipids, sterols, sercosterols (vitamin D), isoprenoids carotenoids retinoids A)), quinones coenzyme Q, vitamin K, E), terpenes, oxidized oxylipin highlighted. The uniqueness group: oil‐, protein‐, starch‐rich, as well marine foods, fruits, vegetables (water‐rich) its composition, included. effect cooking, processing, storage, addition importance lipidomics quality authenticity, also discussed. A critical challenges future approaches computational global basis increase consumer awareness significant role security worldwide presented.

Language: Английский

---

Mediterranean diet, mental health, cognitive status, quality of life, and successful aging in southern Italian older adults

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 175, P. 112143 - 112143

Published: March 16, 2023

Healthy successful aging with preserved mental and cognitive health is expected to be one of the most important challenges growing old population globally. Studies investigating these multi-dimensional aspects senescence are identify potential targets for early prevention. The aim this study was investigate relation between adherence Mediterranean diet health, quality life, in middle-age older adults living Sicily, southern Italy. Data from a sample 883 individuals collected including information on food intake (through 110-item frequency questionnaire), sleep Pittsburgh index) depressive symptoms Center Epidemiological Depression Short Form), life Manchester Assessment Quality Life), status Portable Mental Status Questionnaire), overall Successful Aging Index). Multivariate logistic regression analyses were conducted assess association outcomes investigated. After adjustment confounding factors, highest quartile less likely have impairment (OR = 0.19, 95 % CI: 0.04, 0.86), 0.08, 0.46) more good 14.04, 6.81, 28.93); significant results also found third 1.65, 1.03, 2.64). Moreover, 1.01, 2.68). In conclusion, supports hypothesis that provides positive trajectory toward healthy aging, major benefits health.

Language: Английский

---

Recent Advances in Biomimetic Strategies for the Immunotherapy of Glioblastoma

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122694 - 122694

Published: June 28, 2024

Language: Английский

---

Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Abstract Background Sweet potato ( Ipomoea batatas (L.) Lam.) is a member of the family Convolvulaceae. Much research has highlighted its variable biological actions in treatment many disorders. Our study focused on quantitative analysis two Egyptian sweet cultivars (Abees and A195). First, we applied proximate analysis, measured total phenolic, flavonoid contents, performing an HPLC standardization their ethanolic extracts using chlorogenic acid standard. Furthermore, were formulated as topical creams (3% w/w 5% w/w) evaluated for anti-skin aging activity d -galactose-induced skin mouse model. Results revealed that both have high nutritional importance. Abees exhibited higher phenolic contents than A195, while A195 contained concentration acid. Both showed concentration-dependent activity, with cream demonstrating lowest visual skin-aging score, highest catalase (CAT) superoxide dismutase (SOD), malondialdehyde (MDA). Restoration thickness collagen content was observed group, caused noticeable decrease SMAD7 expression. Decreased been correlated to upregulating TGF-β/SMAD3-induced production aged skin. Conclusion This elaborates importance, roots recommend further preclinical clinical investigations potato.

Language: Английский

---

The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

The intricate relationship between dietary habits and cognitive function is gaining increasing attention, with a focus on the gut-brain axis as modifiable target for intervention. This review synthesizes evidence impact of patterns, particularly Mediterranean diet, plant-based diets, low-carbohydrate health. These rich in antioxidants, anti-inflammatory compounds, neuroprotective nutrients, are suggested to slow decline reduce risk neurodegenerative disorders through mechanisms such reduced inflammation oxidative stress, enhanced neurogenesis. diet has been associated improved performance delay elderly populations. However, challenges intervention implementation, including adherence individual variability, remain. Future research must adopt multidisciplinary approach, incorporating long-term, large-scale, multicenter randomized controlled trials assess enduring impacts various patterns function, considering socioeconomic cultural factors. underscores potential interventions prevent mitigate impairment, ultimately aiming improve quality life.

Language: Английский

---

Lipid metabolism, remodelling and intercellular transfer in the CNS

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

---