Association between exposure to combustion-related air pollution and multiple sclerosis risk DOI Creative Commons
Anna Karin Hedström, David Segersson, Jan Hillert

et al.

International Journal of Epidemiology, Journal Year: 2023, Volume and Issue: 52(3), P. 703 - 714

Published: Jan. 11, 2023

Abstract Background Smoking and occupational pulmonary irritants contribute to multiple sclerosis (MS) development. We aimed study the association between ambient air pollution MS risk potential interaction with human leukocyte antigen (HLA)-DRB1*15:01 allele. Methods Exposure combustion-related was estimated as outdoor levels of nitrogen oxides (NOx) at participants’ residence locations, by spatially resolved dispersion modelling for years 1990–18. Using two population-based case-control studies (6635 cases, 8880 controls), NOx were associated calculating odds ratios (OR) 95% confidence intervals (CI) using logistic regression models. Interaction high HLA-DRB1*15:01 allele regarding calculated attributable proportion due (AP). In addition, a register performed comprising all cases in Sweden who had received their diagnosis 1993 2018 (n = 22 173), 10 controls per case randomly selected from National Population register. Results Residential risk. (3-year average) exceeding 90th percentile (24.6 µg/m3) an OR 1.37 (95% CI 1.10–1.76) compared below 25th (5.9 µg/m3), trend increasing (P <0.0001). A synergistic effect observed (exceeding lower quartile among controls) (AP 0.26, 0.13–0.29). Conclusions Our findings indicate that moderate may play role

Language: Английский

Impact of the mother's gut microbiota on infant microbiome and brain development DOI
Eman A. Mady, Ahmed S. Doghish, Walaa A. El‐Dakroury

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105195 - 105195

Published: April 24, 2023

Language: Английский

Citations

53
Thinking outside the box: non-canonical targets in multiple sclerosis DOI Open Access
Laura Bierhansl, Hans‐Peter Hartung, Orhan Aktaş

et al.

Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(8), P. 578 - 600

Published: June 6, 2022

Language: Английский

Citations

69
Gut microbiome-mediated regulation of neuroinflammation DOI Creative Commons
John W. Bostick,

Aubrey M. Schonhoff,

Sarkis K. Mazmanian

et al.

Current Opinion in Immunology, Journal Year: 2022, Volume and Issue: 76, P. 102177 - 102177

Published: April 21, 2022

Language: Английский

Citations

67
Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation DOI
Sebastian Zundler, Claudia Günther, Andreas E. Kremer

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(1), P. 50 - 64

Published: Aug. 9, 2022

Language: Английский

Citations

64
(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis DOI Creative Commons

Xingming Wang,

Lijia Chang, Xiayun Wan

et al.

Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 165, P. 105635 - 105635

Published: Jan. 24, 2022

Multiple sclerosis (MS) is the most common demyelinating disease that attacks central nervous system. We recently reported new antidepressant (R)-ketamine could ameliorate progression in experimental autoimmune encephalomyelitis model of MS. Cuprizone (CPZ) has been used to produce demyelination which resembles MS patients. This study was undertaken investigate whether affect CPZ-treated mice and remyelination after CPZ withdrawal. Repeated treatment with (10 mg/kg/day, twice weekly, for 6 weeks) significantly ameliorated activated microglia brain compared saline-treated mice. Furthermore, pretreatment ANA-12 (TrkB antagonist) blocked beneficial effects on The 16S rRNA analysis showed improved abnormal composition gut-microbiota decreased levels lactic acid In addition, there were significant correlations between (or microglial activation) relative abundance several microbiome, suggesting a link gut microbiota brain. Interestingly, facilitate conclusion, suggests through TrkB activation, gut-microbiota-microglia crosstalk may play role Therefore, it likely be therapeutic drug

Language: Английский

Citations

54
The importance of gut-brain axis and use of probiotics as a treatment strategy for multiple sclerosis DOI

Nitish Kumar,

Nalini Kanta Sahoo, Sidharth Mehan

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2023, Volume and Issue: 71, P. 104547 - 104547

Published: Feb. 2, 2023

Language: Английский

Citations

24
Risk of Common Neurological Disorders in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis DOI
Mohammad Zamani, Forough Ebrahimtabar, Shaghayegh Alizadeh‐Tabari

et al.

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 25, 2024

Abstract Background Several studies investigated the risks of neurological conditions in patients with inflammatory bowel disease (IBD), some variability findings. We aimed to perform a systematic review and meta-analysis available evidence elucidate association between IBD common disorders. Methods conducted literature search through Embase, PubMed, Scopus, ProQuest databases from inception June 30, 2023, identify cohort assessing risk developing stroke, all-cause dementia, Parkinson’s (PD), multiple sclerosis (MS), seizure/epilepsy, peripheral neuropathy adult compared non-IBD population. combined hazard ratios (HRs) 95% confidence intervals (CIs) compute pooled estimates using random-effects model. Results In total, 22 were included, which 9 reported 7074 stroke events 202 460 patients, 5 3783 dementia diagnoses 109 602 7 932 PD 354 792 1 study 6 MS 35 581 patients. observed increased incident (pooled HR = 1.19; CI, 1.06-1.31), 1.22; 1.05-1.38), 1.39; 1.20-1.58), (HR 2.89; 1.02-8.42). No eligible found on seizure/epilepsy. Conclusions Inflammatory may be modestly associated PD. Further longitudinal are warranted investigate potential links MS, neuropathy, as well their clinical significance.

Language: Английский

Citations

9
Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis DOI Creative Commons

Junjie Jian,

Jun Wei

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 6, 2025

Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight novel interaction between iron-dependent cell death, known as ferroptosis, gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven lipid peroxidation tightly linked to iron metabolism, pivotal contributor oxidative stress observed in Concurrently, affect systemic immunity neurological health, emerges an important regulator homeostasis inflammatory responses, thereby influencing ferroptotic pathways. This review investigates how microbiota dysbiosis ferroptosis impact MS, emphasizing their potential therapeutic targets. Through integrated examination mechanistic pathways clinical evidence, we discuss targeting these interactions could lead interventions that not only modulate disease progression but also offer personalized treatment strategies based on profiling. synthesis aims at deepening insights into microbial contributions implications setting stage for future research exploration.

Language: Английский

Citations

1
The Inflammatory Mechanism of Parkinson’s Disease: Gut Microbiota Metabolites Affect the Development of the Disease Through the Gut–Brain Axis DOI Creative Commons
Ai Gao, Jiaqi Lv, Yanwei Su

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 159 - 159

Published: Feb. 6, 2025

Parkinson's disease is recognized as the second most prevalent neurodegenerative disorder globally, with its incidence rate projected to increase alongside ongoing population growth. However, precise etiology of remains elusive. This article explores inflammatory mechanisms linking gut microbiota disease, emphasizing alterations in and their metabolites that influence disease's progression through bidirectional transmission signals along gut-brain axis. Building on this mechanistic framework, further discusses research methodologies treatment strategies focused metabolites, including metabolomics detection techniques, animal model investigations, therapeutic approaches such dietary interventions, probiotic treatments, fecal transplantation. Ultimately, aims elucidate relationship between underlying thereby paving way for novel avenues condition.

Language: Английский

Citations

1
Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain DOI Creative Commons

Xingming Wang,

Akifumi Eguchi, Yong Yang

et al.

Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 176, P. 105951 - 105951

Published: Dec. 6, 2022

Multiple sclerosis (MS) is the most common demyelinating disease that attacks central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling patients with MS. Given role vagus nerve in gut-microbiota-brain axis development MS, we performed this study to investigate whether subdiaphragmatic vagotomy (SDV) affects CPZ-treated mice. SDV significantly ameliorated and microglial activation brain compared sham-operated Furthermore, 16S ribosomal RNA analysis revealed improved abnormal gut microbiota composition An untargeted metabolomic demonstrated blood levels metabolites mice Notably, there were correlations between or relative abundance several microbiome populations, suggesting a link brain. There also metabolites. Together, these data suggest CPZ through via nerve.

Language: Английский

Citations

38