Tumor-associated macrophages in non-small-cell lung cancer: From treatment resistance mechanisms to therapeutic targets DOI Creative Commons
Zhenjun Huang,

Ziqi Xiao,

Li‐Qing Yu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104284 - 104284

Published: Feb. 2, 2024

Non-small cell lung cancer (NSCLC) remains one of the leading causes cancer-related deaths worldwide. Different treatment approaches are typically employed based on stage NSCLC. Common clinical methods include surgical resection, drug therapy, and radiation therapy. However, with introduction utilization immune checkpoint inhibitors, has entered a new era, completely revolutionizing landscape for various cancers significantly improving overall patient survival. Concurrently, resistance often poses critical challenge, many patients experiencing disease progression following an initial response due to resistance. Increasing evidence suggests that tumor microenvironment (TME) plays pivotal role in Tumor-associated macrophages (TAMs) within TME can promote NSCLC by secreting cytokines activating signaling pathways, interacting other cells. Therefore, this article will focus elucidating key mechanisms TAMs analyze how targeting reduce levels NSCLC, providing comprehensive understanding principles overcome

Language: Английский

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies DOI Creative Commons
Ruixue Bai, Yunong Li, Lingyan Jian

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Sept. 8, 2022

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and key driver for cancer malignancy, it thought to be major target in treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells tumor microenvironment (TME), which have large impact on development immunotherapy. TAMs massively accumulate within hypoxic regions. represent deadly combination because has been suggested induce pro-tumorigenic macrophage phenotype. Hypoxia not only directly affects polarization, but also an indirect effect by altering communication between macrophages. For example, can influence expression chemokines exosomes, both profound impacts recipient cells. Recently, demonstrated intricate interaction TME relevant poor prognosis increased malignancy. However, there no comprehensive literature reviews molecular mechanisms underlying hypoxia-mediated TAMs. Therefore, this review aim collect all recently available data topic provide insights developing novel therapeutic strategies reducing effects hypoxia.

Language: Английский

Citations

161
Biomaterials tools to modulate the tumour microenvironment in immunotherapy DOI
Yu Chao, Zhuang Liu

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(2), P. 125 - 138

Published: Jan. 25, 2023

Language: Английский

Citations

140
Cancer nanomedicine: a review of nano-therapeutics and challenges ahead DOI Creative Commons
M. Joyce Nirmala, Uma Kizhuveetil, Athira Johnson

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(13), P. 8606 - 8629

Published: Jan. 1, 2023

Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.

Language: Английский

Citations

108
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy DOI Creative Commons
Belén Toledo,

Linrui Zhu Chen,

María Paniagua-Sancho

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: June 11, 2024

Abstract Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associated macrophages (TAMs). These specialized immune cells play crucial roles growth, angiogenesis, regulation, metastasis, and chemoresistance. TAMs encompass various subpopulations, primarily classified into M1 M2 subtypes based on their differentiation activities. macrophages, characterized by a pro-inflammatory phenotype, exert anti-tumoural effects, while with an anti-inflammatory function protumoural regulators. highly versatile respond to stimuli from other constituents within (TME), such growth factors, cytokines, chemokines, enzymes. induce polarization towards one phenotype another, leading complex interactions TME components influencing both pro-tumour anti-tumour processes. This review comprehensively deeply covers literature origin well intricate interplay between TME, dual nature promoting pro- Moreover, delves primary pathways implicated macrophage polarization, examining diverse that regulate this process. role shaping functions macrophages. In addition, advantages limitations current clinical interventions reviewed, including enhancing TAM phagocytosis, inducing exhaustion, inhibiting recruitment, polarizing M1-like phenotype. conclusion, treatment strategies targeting precision medicine show promise, overcoming several obstacles is still necessary achieve accessible efficient immunotherapy.

Language: Английский

Citations

51
Advances on immunotherapy for osteosarcoma DOI Creative Commons
Shengnan Yu, Xudong Yao

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 9, 2024

Language: Английский

Citations

40
Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities DOI Creative Commons

Yujing Qian,

Yujia Yin,

Xiaocui Zheng

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 7, 2024

Abstract Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by intrinsic factors, such as origins and transcription but also external signals from the tumor microenvironment (TME), inflammatory metabolic reprogramming. Metabolic reprogramming has rendered TAM to exhibit spectrum of activities ranging pro-tumorigenic anti-tumorigenic, closely associated with progression clinical prognosis. This review implicates diversity phenotypes functions, how this heterogeneity been re-evaluated advent single-cell technologies, impact TME on TAMs. We current therapies targeting metabolism offer new insights for TAM-dependent anti-tumor immunotherapy focusing critical role different programs

Language: Английский

Citations

21
MRI‐Guided Tumor Therapy Based on Synergy of Ferroptosis, Immunosuppression Reversal and Disulfidptosis DOI
Shuai Guo, Zongheng Li,

Ruilong Zhou

et al.

Small, Journal Year: 2024, Volume and Issue: 20(29)

Published: March 3, 2024

Triple negative breast cancer (TNBC) cells have a high demand for oxygen and glucose to fuel their growth spread, shaping the tumor microenvironment (TME) that can lead weakened immune system by hypoxia increased risk of metastasis. To disrupt this vicious circle improve therapeutic efficacy, strategy is proposed with synergy ferroptosis, immunosuppression reversal disulfidptosis. An intelligent nanomedicine GOx-IA@HMON@IO successfully developed realize strategy. The Fe release behaviors indicate glutathione (GSH)-responsive degradation HMON. results titanium sulfate assay, electron spin resonance (ESR) spectra, 5,5'-Dithiobis-(2-nitrobenzoic acid (DTNB) assay T

Language: Английский

Citations

18
Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer DOI
Parham Jabbarzadeh Kaboli, Hsiao‐Fan Chen, Ali Babaeizad

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216780 - 216780

Published: March 8, 2024

Language: Английский

Citations

16
Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models DOI Creative Commons
Stefano Pierini,

Rashid Gabbasov,

Maria Cecília Oliveira-Nunes

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 15, 2025

Language: Английский

Citations

5
Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer DOI Creative Commons
Yongmei Zhao, Yuan‐Lin Zheng, Yan Zhu

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 2, 2022

The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance stimuli, which creates macrophage-dominant immunosuppressive microenvironment. In our study, docetaxel (DTX) as chemotherapeutic modularity was loaded into macrophage-derived exosomes (M1-Exo) with proinflammatory nature establish DTX-M1-Exo drug delivery system. We found that induced naïve M0 polarize phenotype, while failed repolarize upon Interleukin 4 restimulation due impaired mitochondrial function. This suggests can achieve long-term robust activation in vivo results further confirmed has beneficial effect on infiltration and tissues. Thus, novel polarization strategy via combined chemotherapy immunotherapy great antitumor efficacy.

Language: Английский

Citations

65