The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria DOI Creative Commons
Sarah Libring, Emily D. Berestesky, Cynthia A. Reinhart‐King

et al.

Clinical & Experimental Metastasis, Journal Year: 2024, Volume and Issue: 41(5), P. 567 - 587

Published: March 15, 2024

Abstract As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well migration, fate decisions, many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function cancer cells has found renewed interest, from suggested potential clinical biomarkers mitochondria-targeting therapies. Here, we will focus on the effect movement breast progression. Mitochondria move both within cell, such localize areas high energetic need, between where stroma have been shown donate their via multiple methods including tunneling nanotubes. The donation seen increase aggressiveness chemoresistance which increased recent efforts uncover mechanisms transfer. metabolism energetics gaining attention targets, better understanding implications required developing effective, targeted therapeutics patients.

Language: Английский

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy DOI Creative Commons
Qiang Lü,

Dongquan Kou,

Shenghan Lou

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

Citations

144
Exosomes as smart drug delivery vehicles for cancer immunotherapy DOI Creative Commons
Huan Zhang, Simiao Wang,

Man Sun

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 17, 2023

Exosomes (Exos) as drug delivery vehicles have been widely used for cancer immunotherapy owing to their good biocompatibility, low toxicity, and immunogenicity. Some Exos-based strategies such tuning of immunosuppressive tumor microenvironment, immune checkpoint blockades, vaccines also investigated in recent years, which all showed excellent therapeutic effects malignant tumor. Furthermore, some systems (DDSs) undergone clinic trails, indicating that Exos are a promising carrier. In this review, order promote the development DDSs immunotherapy, biogenesis composition Exos, summarized. Meanwhile, clinical translation challenges discussed. We hope review will provide guidance immunotherapy.

Language: Английский

Citations

56
Engineering exosome-based biomimetic nanovehicles for wound healing DOI Creative Commons

Alireza Joorabloo,

Tianqing Liu

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 463 - 480

Published: March 15, 2023

Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life may result tissue infection, necrosis, loss local systemic functions. Hence, novel approaches to accelerate healing being actively explored over the last decade. Exosomes as important mediators intercellular communications promising natural nanocarriers due their biocompatibility, low immunogenicity, drug loading targeting capacities, innate stability. More importantly, exosomes developed a versatile pharmaceutical engineering platform for repair. This review provides an overview biological physiological functions derived from variety origins during phases, strategies exosomal engineering, therapeutic applications skin regeneration.

Language: Английский

Citations

48
Current Knowledge and Future Perspectives of Exosomes as Nanocarriers in Diagnosis and Treatment of Diseases DOI Creative Commons
Zaijun Zou, Li Han, Gang Xu

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4751 - 4778

Published: Aug. 1, 2023

Abstract: Exosomes, as natural nanocarriers, characterized with low immunogenicity, non-cytotoxicity and targeted delivery capability, which have advantages over synthetic nanocarriers. Recently, exosomes shown great potential diagnostic markers for diseases are also considered a promising cell-free therapy. Engineered significantly enhanced the efficacy precision of delivering therapeutic agents, currently being extensively employed in investigations various ailments, including oncology, inflammatory disorders, degenerative conditions. Particularly, engineered enable agent loading, modification, evasion MPS phagocytosis, intelligent control, bioimaging, been developed multifunctional nano-delivery platforms recent years. The utilization bioactive scaffolds that loaded exosome has to substantially augment retention, extend release, enhance efficacy. This approach advanced from conventional hydrogels nanocomposite hydrogels, nanofiber 3D printing, resulting superior physical biological properties effectively address limitations scaffolds. Additionally, plant-derived exosomes, can participate gut flora remodeling via oral administration, an ideal platform treatment intestinal diseases. Consequently, there is interest nanocarriers applications. comprehensive review provides overview biogenesis, composition, isolation methods exosomes. it examines pathological mechanisms diseases, tumors, Furthermore, this highlights significance microbial-derived Strategies specific applications scaffold-loaded further summarized, especially some new techniques such large-scale loading technique, macromolecular development nano-scaffold-loaded delivery. benefits using gut-related discussed. challenges, opportunities, prospects exosome-based disease diagnosis summarized both preclinical clinical viewpoints. Keywords: diagnosis,

Language: Английский

Citations

44
Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review DOI Creative Commons
Zhen Chen, Min Xiong, Jiaqi Tian

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed a lipid bilayer membrane containing various biologically active cargoes such as proteins, lipids, nucleic acids. Engineered exosomes generated through genetic modification of parent show promise drug delivery vehicles, they have been demonstrated to great therapeutic potential for treating cancer, cardiovascular, neurological, immune diseases, but systematic knowledge is lacking regarding optimization loading assessment efficacy. This review summarizes current approaches engineering evaluating their effects, techniques assessing exosome release kinetics, cell targeting, biodistribution, pharmacokinetics, outcomes critically examined. Additionally, this synthesizes the latest applications in clinical translation. The compiled provides framework rational design rigorous therapeutics. Continued advancement robust characterization methods reporting standards will accelerate development technologies pave way studies. Graphical

Language: Английский

Citations

40
Polysaccharide hydrogel platforms as suitable carriers of liposomes and extracellular vesicles for dermal applications DOI Creative Commons
Leila Pourtalebi Jahromi,

Markus Rothammer,

Gregor Fuhrmann

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115028 - 115028

Published: July 28, 2023

Lipid-based nanocarriers have been extensively investigated for their application in drug delivery. Particularly, liposomes are now clinically established treating various diseases such as fungal infections. In contrast, extracellular vesicles (EVs) - small cell-derived nanoparticles involved cellular communication just recently sparked interest carriers but development is still at the preclinical level. To drive this further, methods and technologies exploited context of liposome research should be applied domain EVs to facilitate accelerate clinical translation. One crucial steps EV-based therapeutics designing them proper dosage forms specific applications. This review offers a comprehensive overview state-of-the-art polysaccharide-based hydrogel platforms designed artificial natural with delivery skin. We discuss physicochemical biological properties try create sound basis optimization EV-embedded hydrogels versatile therapeutic avenues.

Language: Английский

Citations

26
Engineered biological nanoparticles as nanotherapeutics for tumor immunomodulation DOI Creative Commons

Juwita N. Rahmat,

Jiayi Liu,

Taili Chen

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5862 - 5903

Published: Jan. 1, 2024

Schematic of the immunomodulatory approaches for tipping balance towards anti-cancer immunity. This image was created with BioRender.com.

Language: Английский

Citations

11
Mutual regulation of PD-L1 immunosuppression between tumor-associated macrophages and tumor cells: a critical role for exosomes DOI Creative Commons

Banglu Wang,

Daoan Cheng,

Danyu Ma

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 9, 2024

Abstract Tumor cells primarily employ the PD-1/PD-L1 pathway to thwart anti-tumor capabilities of T lymphocytes, inducing immunosuppression. This occurs through direct interaction PD-L1 with PD-1 on lymphocyte surfaces. Recent research focusing tumor microenvironment has illuminated pivotal role immune cells, particularly tumor-associated macrophages (TAMs), in facilitating PD-L1-mediated Exosomes, characterized by their ability convey information and be engulfed significantly contribute promoting TAM involvement establishing immunosuppression within microenvironment. In addition receiving signals from tumor-derived exosomes that promote expression, TAMs also exert control over expression release exosomes. paper aims summarize mechanisms which participate this process, identify crucial factors influence these mechanisms, explore innovative strategies for inhibiting or reversing tumor-promoting effects targeting

Language: Английский

Citations

10
Artificial cell-derived vesicles by extrusion, a novel docetaxel drug delivery system for lung cancer. DOI
Javiera Carrasco-Rojas, Gabriela Zavala, Rafaël Contreras

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106693 - 106693

Published: Feb. 1, 2025

Language: Английский

Citations

1
Special Issue: Nanotherapeutics in Women's Health Emerging Nanotechnologies for Triple‐Negative Breast Cancer Treatment DOI Creative Commons
Sofia Torres Quintas, Ana Manuela Canha Borges, Maria José Oliveira

et al.

Small, Journal Year: 2023, Volume and Issue: unknown

Published: March 28, 2023

Breast cancer appears as the major cause of cancer-related deaths in women, with more than 2 260 000 cases reported worldwide 2020, resulting 684 996 deaths. Triple-negative breast (TNBC), characterized by absence estrogen, progesterone, and human epidermal growth factor type receptors, represents ≈20% all cancers. TNBC has a highly aggressive clinical course is prevalent younger women. The standard therapy for advanced chemotherapy, but responses are often short-lived, high rate relapse. lack therapeutic targets limited options confer to individuals suffering from poorest prognosis among patients, remaining challenge. In recent years, advances nanomedicine provided innovative options, nanoformulations play an important role overcoming shortcomings left conventional therapies: payload degradation its low solubility, stability, circulating half-life, difficulties regarding biodistribution due physiological biological barriers. this integrative review, field treatment, including novel nanoparticle-, exosome-, hybrid-based formulations summarized their drawbacks challenges discussed future applications.

Language: Английский

Citations

22