Structural Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(44)
Published: Aug. 24, 2022
Abstract Artemisinin and its derivatives (artemisinins) are first‐line chemotherapeutic agents of lethal malaria, which also showed tremendous value in many other diseases including chronic inflammation. Unfortunately, almost all artemisinins rapid‐acting medicines with an extremely short half‐life vivo, significantly limits their clinical application for these new adaptation diseases. In this study, a locally injectable long‐acting gene/artemisinin co‐delivery nano‐microplex consisting biodegradable hyaluronic acid (HA) microsphere releasable nano‐lipoplex is developed first, to obtain improved efficacy rheumatoid arthritis (RA). Briefly, cationic multicomponent drug‐embedded liposome pharmacological activity first reported based on two novel artemisinin (dAPC dACC), possess mimic phospholipids lipids, respectively. A artemisinin‐embedded lipoplex as medicative gene carrier here. An situ TNF‐α siRNA/artemisinin (MTAsi@MG) further prepared by immobilization siRNA/lipoplex porous microfluidic HA microspheres. Using intra‐articular injection, the sustaining therapy RA long‐term treatment realized. Undoubtedly, dAPC/dACC microspheres would be one most potent gene/drug systems therapy.
Language: Английский
Citations
49
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis, a novel form of regulated cell death characterized by dependence on iron and lipid peroxidation, has been implicated in wide range clinical conditions including neurological diseases, cardiovascular disorders, acute kidney failure, various types cancer. Therefore, it is critical to suppress cancer progression proliferation. Ferroptosis can be triggered cells some normal synthetic substances, such as erastin, Ras-selective lethal small molecule-3, or pharmaceuticals. Natural bioactive compounds are traditional drug discovery tools, have therapeutically used dietary additives pharmaceutical agents against malignancies. The fact that natural products multiple targets minimal side effects led notable advances anticancer research. Research indicated ferroptosis also induced during treatment. In this review, we focused the most recent developments emerging molecular processes significance To provide new perspectives future development ferroptosis-related medications, summary implications phytochemicals triggering through ROS production ferritinophagy induction variety
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112799 - 112799
Published: March 9, 2022
Lupus nephritis (LN) is an autoimmune disease with multiple system involvement and also one of the most serious forms organ damage in systemic lupus erythematosus (SLE), which mainly caused by formation deposition immune complexes glomeruli. More than 50% SLE patients have clinical manifestations renal damage. At present, treatment based on glucocorticoids immunosuppressants. However, due to adverse drug reactions frequent recurrence or aggravation after reduction withdrawal, prognosis remains poor; thus, it still important causes end-stage failure. Therefore, new strategies are urgently needed. This article aims review application traditional Chinese medicine natural extracts provide basic mechanisms a strategy clear effects high safety performance.
Language: Английский
Citations
28
International Immunopharmacology, Journal Year: 2022, Volume and Issue: 113, P. 109431 - 109431
Published: Nov. 13, 2022
Language: Английский
Citations
22
Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(16), P. 4839 - 4859
Published: April 18, 2022
The protective effect of plant active ingredients against non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prominent, and the terpenoids have always been main compounds in Chinese herbal medicine exerting hepatoprotective effects. However, related pharmacological effects, especially for monoterpenoids or iridoid glycosides, which obvious effects on improvement NAFLD, not systematically analyzed. objective this review to examine molecular mechanisms NAFLD. signaling pathways peroxisome proliferator-activated receptor, insulin, nuclear factor κB, toll-like adipocytokine, RAC-α serine/threonine protein kinase, mammalian target rapamycin, 5'-AMP-activated autophagy proven mediate effect. We further compared experimental data from animal models, including dosage these detail, demonstrated that they are effective safe candidate drugs This provides a reference development NAFLD as well research guideline potential uses monoterpenoids.
Language: Английский
Citations
20
Journal of Immunology Research, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 21
Published: June 22, 2022
Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy such as anti-PD-L1 antibody in treating cancers, myeloid-derived suppressor cells (MDSCs) that lead to formation protumor immunosuppressive microenvironment are one major contributors ICB resistance. Therefore, inhibition MDSC accumulation function is critical for further enhancing therapeutic a majority cancer patients. Artemisinin (ART), most effective antimalarial drug with tumoricidal immunoregulatory activities, potential option treatment. Although ART reported reduce levels 4T1 breast tumor model improve T cell lymphoma-bearing mice, how influences accumulation, function, molecular pathways well MDSC-mediated resistance melanoma or liver tumors remains unknown. Here, we blocks MDSCs by polarizing M2-like tumor-promoting phenotype towards M1-like antitumor one. This switch regulated via PI3K/AKT, mTOR, MAPK signaling pathways. Targeting could significantly growth various mouse models. More importantly, remarkably enhanced immunotherapy tumor-bearing mice through promoting infiltration proliferation. These findings indicate controls functional polarization targeting provides novel strategy enhance immunotherapy.
Language: Английский
Citations
20
International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 48 - 58
Published: Jan. 7, 2025
Colonization of the erythrocytic stages Plasmodium falciparum has become a challenging aspect in every drug delivery system because it is responsible for each clinical manifestation and life-threatening complication malaria. With emergence resistance malarial parasites recent past, developing vaccine against malaria still long-drawn-out affair. However, reports recombinant protein-based from Glaxo Smith Kline have initiated new ray hope. In such scenario, onus reliable disease remains mainstay fighting This review delves into various attempts carried out by researchers past to develop parasite throws light on very outcome that provides targeted infected erythrocyte using nanotechnology-based approach. Considering eventful journey beginning, was discovery chloroquine created an epoch treatment Due its low cost high efficacy, became most widely used antimalarial. Until 1960s, Chloroquine (CQ) best solution but scenario changed 1970s due widespread falciparum, vivax parts world. This, turn, led development novel systems liposomes Solid Lipid Nanoparticles (SLN) more effective site-specific erythrocytes. Such later use approach which included nanospheres nanoparticulate carriers.
Language: Английский
Citations
0
Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e42066 - e42066
Published: Jan. 1, 2025
Artemisinin is a sesquiterpene lactone extracted from the chrysanthemum plant, Artemisia annua. It known for its curative effects in treatment of pulmonary hypertension, leukemia, diabetes, malaria, and other diseases, owing to abundant biological activity. In recent years, with development plant secondary metabolite research, potential pharmacological artemisinin-based drugs have received increasing attention; particular, reports their application ophthalmology-related diseases gradually increased. Recently, studies confirmed that artemisinin plays therapeutic roles eye through regulation signaling pathways, such asNrf2/HO-1/Keap1, TLR/MyD88/NF-κb, PI3K/AKT/mTOR, FASN/Kmal-mTOR/SREBP1, factors, as protein kinase B, AMP-activated kinase, tumor necrosis factor alpha, nod-like receptor 3, vascular endothelial growth factor, malonyl-coenzyme A cytochrome C. However, since ocular are often caused by various how can play good disease prevention role modulating these factors needs be further verified, most current focus on vitro animal experiments, lacking sufficient information clinical trial studies. To better explore perfect mechanism action ophthalmic promote artemisinin, this study reviews latest progress uveitis, uveal melanoma, age-related macular degeneration, diabetic retinopathy, neovascularization, dry eye, it will provide theoretical support large-scale future.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 31, 2025
Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it effective in treating some of the liver diseases. Beyond its hepatoprotective effects, an expanding body research has underscored immunoregulatory properties SCO, indicating potential therapeutic benefits for autoimmune and other inflammatory Over past decade, significant advances been made understanding mechanistic insights into effects on immune-mediated diseases well SCO impact various immune cells, including mast monocytes, macrophages, neutrophils T affects broad range intracellular signaling pathways, TLR4/Myd88/NFκB, TGFβR/Smad3 JNK/Sab/SHP-1 etc. Therefore, this review not only summarizes immunomodulatory immune-based (IMIDs), such bowel disease, osteoarthritis, allergic rhinitis, acute lung injury, type 1 diabetes neuroinflammatory etc., but provides comprehensive summary hepatic diseases, non-alcoholic steatohepatitis, fulminant failure fibrosis. In review, we include impacts TGFβR/Smad3, Nrf2/P38, JAK2/STAT3 Further researches may help understand in-depth mechanisms action pave way development novel drugs to prevent treat disorders thereby significantly advancing innovations pharmaceutical applications.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 253 - 253
Published: Feb. 21, 2025
Inflammation is associated with the pathophysiology of type 2 diabetes and COVID-19. Phytochemicals have potential to modulate inflammation, expression SARS-CoV-2 viral entry receptors (angiotensin-converting enzyme (ACE2) transmembrane protease, serine (TMPRSS2)) glucose transport in gut. This study assessed impact phytochemicals on these processes. We screened 12 alongside 10 pharmaceuticals three plant extracts, selected for known or hypothesised effects COVID-19 risk, their ACE2 TMPRSS2 differentiated Caco-2/TC7 human intestinal epithelial cells. Genistein, apigenin, artemisinin sulforaphane were most promising ones, as by downregulation TMPRSS2, thus they used subsequent experiments. The cells then co-stimulated pro-inflammatory cytokines interleukin-1 beta (IL-1β) tumour necrosis factor-alpha (TNF-α) ≤168 h induce which are multiple pathways, including nuclear factor kappa-light-chain-enhancer activated B (NF-κB) pathway. Target gene (ACE2, SGLT1 (sodium-dependent transporter 1) GLUT2 (glucose 2)) was measured droplet digital PCR, while (IL-6), (IL-8) proteins using ELISA both normal inflamed IL-1β TNF-α treatment upregulated ACE2, expression. increased duration cytokine exposure, coupled a significant decrease IL-8, over time. Pearson correlation analysis revealed that increase strongly IL-8 (r = -0.77, p < 0.01). regulation followed same pattern implying common mechanism. Although none decreased inflammation-induced secretion, genistein normalised increases TMPRSS2. association between expression, particularly evident inflammatory conditions, suggests regulatory Genistein downregulated may help lower postprandial glycaemic response risk severity healthy individuals those metabolic disorders.
Language: Английский
Citations
0