Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3561 - 3575

Published: April 8, 2024

Rheumatoid arthritis (RA) is an inflammatory disease accompanied by abnormal synovial microenvironment (SM). Sesquiterpene lactones (SLs) are the main anti-inflammatory ingredients of many traditional herbs utilized in RA treatment.

Language: Английский

---

Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: March 7, 2024

Abstract Background Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from impairments by attenuating neuronal hippocampal CA1 region. Methods STZ-induced T2DM were treated with (40 mg/kg, i.p.), or cotreated and Nrf2 inhibitor MEL385 inducer erastin for 4 weeks. Cognitive performance was determined Morris water maze Y tests. Hippocampal ROS, MDA, GSH, Fe 2+ contents detected assay kits. Nrf2, p-Nrf2, HO-1, GPX4 proteins assessed Western blotting. neuron injury mitochondrial morphology observed using H&E staining transmission electron microscope, respectively. Results Artemisinin reversed diabetic impairments, decreased concentrations MDA , increased levels p-Nr2, GSH. Moreover, alleviated loss However, these neuroprotective effects abolished ML385 erastin. Conclusion effectively ameliorates neuropathological changes learning memory decline mice; underlying mechanism involves activation to inhibit hippocampus. Graphical

Language: Английский

---

Coptisine alleviates colitis through modulating gut microbiota and inhibiting TXNIP/NLRP3 inflammasome

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118680 - 118680

Published: Aug. 8, 2024

Language: Английский

---

Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review

Metabolites, Journal Year: 2023, Volume and Issue: 13(6), P. 728 - 728

Published: June 6, 2023

Ongoing research explores the underlying causes of ulcerative colitis and Crohn’s disease. Many experts suggest that dysbiosis in gut microbiota genetic, immunological, environmental factors play significant roles. The term “microbiota” pertains to collective community microorganisms, including bacteria, viruses, fungi, reside within gastrointestinal tract, with a particular emphasis on colon. When there is an imbalance or disruption composition microbiota, it referred as dysbiosis. Dysbiosis can trigger inflammation intestinal cells disrupt innate immune system, leading oxidative stress, redox signaling, electrophilic inflammation. Nod-like Receptor (NLR) Family Pyrin Domain Containing 3 (NLRP3) inflammasome, key regulator found immunological epithelial cells, crucial inducing inflammatory diseases, promoting responses regulating integrity epithelium. Its downstream effectors include caspase-1 interleukin (IL)-1β. present study investigated therapeutic potential 13 medicinal plants, such Litsea cubeba, Artemisia anomala, Piper nigrum, Morus macroura, Agrimonia pilosa, 29 phytocompounds artemisitene, morroniside, protopine, ferulic acid, quercetin, picroside II, hydroxytyrosol vitro vivo models bowel diseases (IBD), focus their effects NLRP3 inflammasome. observed these treatments included reductions IL-1β, tumor necrosis factor-alpha, IL-6, interferon-gamma, caspase levels, increased expression antioxidant enzymes, IL-4, IL-10, well regulation microbiota. These could potentially provide substantial advantages treating IBD few no adverse caused by synthetic anti-inflammatory immunomodulated drugs. However, additional necessary validate findings clinically develop effective benefit individuals who suffer from diseases.

Language: Английский

---

Artemisinins: Promising drug candidates for the treatment of autoimmune diseases

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 44(2), P. 867 - 891

Published: Dec. 6, 2023

Abstract Autoimmune diseases are characterized by the immune system's attack on one's own tissues which highly diverse and differ in severity, causing damage virtually all human systems including connective tissue (e.g., rheumatoid arthritis), neurological system multiple sclerosis) digestive inflammatory bowel disease). Historically, treatments normally include pain‐killing medication, anti‐inflammatory drugs, corticosteroids, immunosuppressant drugs. However, given above characteristics, treatment of autoimmune has always been a challenge. Artemisinin is natural sesquiterpene lactone initially extracted separated from Chinese medicine Artemisia annua L., long history curing malaria. Artemisinin's derivatives such as artesunate, dihydroartemisinin, artemether, artemisitene, so forth, family artemisinins with antimalarial activity. Over past decades, accumulating evidence have indicated promising therapeutic potential diseases. Herein, we systematically summarized research regarding immunoregulatory properties artemisinin its derivatives, discussing their viability toward major underlying mechanisms. This review will provide new directions for basic clinical translational artemisinins.

Language: Английский

---

Artemisinin antagonizes cognitive disorder in hyperuricemia through glutamate receptor-interacting protein 1-suppressed pyroptosis

Neuroreport, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The prevalence of hyperuricemia (HUA) is climbing worldwide and persistent elevation serum uric acid impairs cognitive function. This study aimed to explore the mechanisms Artemisinin (Art) antagonizing disorder in HUA by suppressing pyroptosis. A mouse model was established intraperitoneal injection 300 mg/kg potassium oxonate (PO) C57BL/6 mice for 14 days. were simultaneously treated with Art, an agonist pyroptosis Polyphyllin VI (PPVI), or glutamate receptor-interacting protein 1 (GRIP1) knockdown lentiviral plasmid. After treatment, acid, IL-6, TNF-ɑ levels examined, as well hippocampal IL-1β IL-18 levels, function assessed Morris water maze test. Pathological changes CA1 hippocampus observed. Cleave-caspase-1, GSDMD-N, GRIP1 level quantified western blot. PO induction, escape latency time spent target quadrant increased mice, cell arrangement loose disorganized, obvious inflammatory infiltration serious damage being observed, had elevated cleaved-caspase-1, IL-1β, IL-18. Art treatment reduced improved mice. Administration PPVI aggravated Art-treated dysfunction inhibiting through upregulation GRIP1. blunts suffering from upregulating

Language: Английский

---

NLRC4, inflammation and colorectal cancer (Review)

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(4)

Published: Sept. 4, 2024

Chronic inflammation is recognized as a major risk factor for cancer and involved in every phase of the disease. Inflammasomes are central to inflammatory response play crucial role development. The present review summarizes Nod‑like receptor C4 (NLRC4) colorectal (CRC). Reviews literature were conducted using Web Science, PubMed CNKI, with search terms including 'NLRC4', 'colorectal cancer', 'auto‑inflammatory diseases' 'prognosis'. Variants NLRC4 can cause recessive immune dysregulation autoinflammation or lead ulcerative colitis heterozygous factor. Additionally, genetic mutations inflammasome components may increase susceptibility cancer. considered tumor suppressor CRC. CRC signaling pathways currently understood involve five key aspects (caspase 1, NLRP3/IL‑8, IL‑1β/IL‑1, NAIP p53). mechanisms by which be threefold (through pyroptosis, apoptosis, necroptosis PANoptosis; regulating response; protecting intestinal epithelial cells prevent CRC). However, impact on remains unclear. In conclusion, significant that protects against through various mechanisms. association between warrants further investigation.

Language: Английский

---

Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(9), P. 223 - 223

Published: Sept. 20, 2024

Artemisinin is an endoperoxide sesquiterpene lactone isolated from

Language: Английский

---

Artemisitene: a promising natural drug candidate with various biological activities needs to confirm the interactional targets

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

OPINION article Front. Pharmacol., 15 June 2023Sec. Pharmacology of Anti-Cancer Drugs Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1221291

Language: Английский

---

Exploring Pyroptosis-related Signature Genes and Potential Drugs in Ulcerative Colitis by Transcriptome Data and Animal Experimental Validation

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: April 24, 2024

Language: Английский

---