Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106693 - 106693
Published: Feb. 1, 2025
Language: Английский
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)
Published: March 18, 2025
Language: Английский
Citations
1
MedComm, Journal Year: 2024, Volume and Issue: 5(4)
Published: April 1, 2024
Abstract Exosomes are indispensable for intercellular communications. Tumor microenvironment (TME) is the living environment of tumor cells, which composed various components, including immune cells. Based on TME, immunotherapy has been recently developed eradicating cancer cells by reactivating antitumor effect The communications between and TME crucial development, metastasis, drug resistance. play an important role in mediating these regulating reprogramming affects sensitivity immunotherapy. Therefore, it imperative to investigate exosomes impact Here, we review communication remodeling efficacy immunotherapy, as well summarize underlying mechanisms. Furthermore, also introduce potential application artificially modified delivery systems drugs. Further efforts this field will provide new insights roles progression, thus helping us uncover effective strategies treatment.
Language: Английский
Citations
8
Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)
Published: May 25, 2024
Abstract Ovarian cancer accounts for more deaths than any other female reproductive tract cancer. The major reasons the high mortality rates include delayed diagnoses and drug resistance. Hence, improved diagnostic therapeutic options ovarian are a pressing need. Extracellular vesicles (EVs), that exosomes provide hope in both aspects. They natural lipid nanovesicles secreted by all cell types carry molecules reflect status of parent cell. This facilitates their potential use as biomarkers an early diagnosis. Additionally, EVs can be loaded with exogenous cargo, have features such stability favorable pharmacokinetic properties. makes them ideal tumor-targeted delivery biological moieties. International Society Vesicles (ISEV) based on Minimal Information Studies (MISEV) recommends usage term “small extracellular (sEVs)” includes particles 30–200 nm size. However, majority studies reported literature relevant to this review used “exosomes”. Therefore, will “exosomes” interchangeably sEVs consistency avoid confusion readers. review, initially summarizes different isolation detection techniques developed study cancer-derived these diagnosis devastating disease. It addresses role exosome contents pathogenesis cancer, discusses strategies limit exosome-mediated progression, provides therapy Finally, it states future research directions essential needed successfully transition from laboratory gynecologic-oncology clinic.
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 27, 2024
Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed deliver different drugs, aiming achieve low-toxicity low-immunogenicity targeted delivery. Signaling pathways exosome contents also used safer more effective immunotherapy against tumors. Exosomes derived from range sources, exhibit characteristics well clinical application advantages therapies. In this review, we analyzed main sources have great potential broad prospects therapy. Moreover, compared therapeutic advantages, providing new ideas exosomes.
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 9, 2024
Natural killer (NK) cells are innate lymphocytes possessing potent tumor surveillance and elimination activity. Increasing attention is being focused on the role of NK in integral antitumor strategies (especially immunotherapy). Of note, therapeutic efficacy considerable dependent two parameters: infiltration cytotoxicity microenvironment (TME), both which impaired by several obstacles (e.g., chemokines, hypoxia). Strategies to overcome such barriers needed. Radiotherapy a conventional modality employed cure solid tumors. Recent studies suggest that radiotherapy not only damages directly, but also enhances recognition immune through altering molecular expression or via
Language: Английский
Citations
7
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: April 3, 2024
Exosomes are small extracellular vesicles secreted by cells, ranging in size from 30 to 150 nm. They contain proteins, nucleic acids, lipids, and other bioactive molecules, which play a crucial role intercellular communication material transfer. In tumor immunity, exosomes present various functions while the following two of great importance: regulating immune response serving as delivery carriers. This review starts with introduction formation, compositions, functions, isolation, characterization, applications exosomes, subsequently discusses current status immunotherapy, recent exosome-based immunity regulation antitumor drug delivery. Finally, challenge future prospects proposed hope demonstrate inspiration for targeted readers field.
Language: Английский
Citations
7
Journal of Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 24, 2024
Language: Английский
Citations
7
Life Sciences, Journal Year: 2023, Volume and Issue: 331, P. 122021 - 122021
Published: Aug. 13, 2023
Language: Английский
Citations
14
International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(3)
Published: Jan. 19, 2024
Gastric cancer is one of the most common malignancies and has relatively high morbidity mortality rates. Exosomes are nanoscale extracellular vesicles that originate from a diverse array cells may be found throughout various bodily fluids. These endogenous nanocarriers in their natural state with unique ability to transport lipids, proteins, DNA RNA. contain DNA, RNA, lipids other bioactive components have crucial roles transmission information regulation cell activities gastric cancer. This paper begins an exploration composition, formation release mechanisms exosomes. Subsequently, role exosomes tumor microenvironment reviewed terms immune population, nonimmune population factors. Finally, current status challenges exosome‑based research on progression, diagnosis therapeutic methods summarized. holistic review offers insight guide future directions for potentially pave way novel interventions management
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 5, 2024
The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.
Language: Английский
Citations
4