Macrophage plasticity: signaling pathways, tissue repair, and regeneration

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: Aug. 1, 2024

Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.

Language: Английский

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Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 23, 2023

There are several autoimmune and rheumatic diseases affecting different organs of the human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) joints, Type 1 diabetes (T1D) pancreas, Sjogren’s syndrome (SS) salivary glands, while systemic lupus erythematosus (SLE) almost every organ Autoimmune characterized by production autoantibodies, activation immune cells, increased expression pro-inflammatory cytokines, type I interferons. Despite improvements in treatments diagnostic tools, time it takes for patients to be diagnosed is too long, main treatment these still non-specific anti-inflammatory drugs. Thus, there an urgent need better biomarkers, as well tailored, personalized treatment. This review focus on SLE affected this disease. We have used results from various involved with aim identify advanced methods possible biomarkers utilized diagnosis SLE, disease monitoring, response

Language: Английский

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Overcoming cancer risk in inflammatory bowel disease: new insights into preventive strategies and pathogenesis mechanisms including interactions of immune cells, cancer signaling pathways, and gut microbiota

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 15, 2024

Inflammatory bowel disease (IBD), characterized primarily by gastrointestinal inflammation, predominantly manifests as Crohn’s (CD) and ulcerative colitis (UC). It is acknowledged that Inflammation plays a significant role in cancer development patients with IBD have an increased risk of various cancers. The progression from inflammation to carcinogenesis result the interplay between immune cells, gut microbiota, carcinogenic signaling pathways epithelial cells. Long-term chronic can lead accumulation mutations cells abnormal activation pathways. Furthermore, Immune play pivotal both acute phases IBD, contributing transformation tumorigenesis. And frequently exhibit dysbiosis intestinal microbiome. Disruption microbiota subsequent dysregulation are central pathogenesis associated colorectal (CAC). proactive management combined regular endoscopic tumor screenings represents most direct effective strategy prevent IBD-associated cancer.

Language: Английский

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The potential and promise for clinical application of adoptive T cell therapy in cancer

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 1, 2024

Abstract Adoptive cell therapy has revolutionized cancer treatment, especially for hematologic malignancies. T cells are the most extensively utilized in adoptive therapy. Currently, tumor-infiltrating lymphocytes, receptor-transgenic and chimeric antigen receptor three main therapies. Tumor-infiltrating lymphocytes kill tumors by reinfusing enlarged that naturally target tumor-specific antigens into patient. have ability to specifically destroy tumor via precise recognition of exogenous receptors with major histocompatibility complex. Chimeric transfer genes specific structural domains activation signals cells, allowing attack without assistance Many barriers been demonstrated affect clinical efficacy therapy, such as heterogeneity loss, hard trafficking infiltration, immunosuppressive microenvironment exhaustion. Several strategies improve explored, including multispecific combination immune checkpoint blockade, targeting microenvironment, etc. In this review, we will summarize current status application, followed bottlenecks addition, discuss promising result even more incredible advancements solid if aforementioned problems can be handled. Graphical abstract

Language: Английский

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p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF-κB/AP-1 pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155941 - 155941

Published: Aug. 6, 2024

Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease (IBD), presents with limited current drug treatment options. Consequently, the search for safe and effective UC prevention is imperative. Our prior studies have demonstrated that phenolic compound p-Hydroxybenzaldehyde (HD) from Nostoc commune, effectively mitigates intestinal inflammation. However, mechanisms underlying HD's anti-inflammatory effects remain unclear.

Language: Английский

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Advances in Melanoma: From Genetic Insights to Therapeutic Innovations

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1851 - 1851

Published: Aug. 14, 2024

Advances in melanoma research have unveiled critical insights into its genetic and molecular landscape, leading to significant therapeutic innovations. This review explores the intricate interplay between alterations, such as mutations BRAF, NRAS, KIT, pathogenesis. The MAPK PI3K/Akt/mTOR signaling pathways are highlighted for their roles tumor growth resistance mechanisms. Additionally, this delves impact of epigenetic modifications, including DNA methylation histone changes, on progression. microenvironment, characterized by immune cells, stromal soluble factors, plays a pivotal role modulating behavior treatment responses. Emerging technologies like single-cell sequencing, CRISPR-Cas9, AI-driven diagnostics transforming research, offering precise personalized approaches treatment. Immunotherapy, particularly checkpoint inhibitors mRNA vaccines, has revolutionized therapy enhancing body’s response. Despite these advances, mechanisms remain challenge, underscoring need combined therapies ongoing achieve durable comprehensive overview aims highlight current state transformative impacts advancements clinical practice.

Language: Английский

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Integrating UHPLC-Q-TOF-MS/MS, Network Pharmacology, Bioinformatics and Experimental Validation to Uncover the Anti-cancer Mechanisms of TiaoPi AnChang Decoction in Colorectal Cancer

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118576 - 118576

Published: July 14, 2024

Language: Английский

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Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The incidence of skin cancer is currently increasing, and conventional treatment options inadequately address the demands disease management. Fortunately, recent rapid advancement immunotherapy, particularly immune checkpoint inhibitors (ICIs), has ushered in a new era for numerous patients. However, efficacy immunotherapy remains suboptimal due to impact tumor microenvironment (TME). Tumor-associated macrophages (TAMs), major component TME, play crucial roles invasion, metastasis, angiogenesis, evasion, significantly impacting development. Consequently, TAMs have gained considerable attention years, their been extensively studied various tumors. specific regulatory mechanisms remain unclear. This paper aims elucidate origin classification TAMs, investigate interactions between cells, comprehensively understand precise by which contribute pathogenesis different types cancer, finally discuss current strategies targeting cancer. With emphasis on interrelationship this posits that therapeutic modalities centered hold promise augmenting harmonizing with prevailing clinical interventions thereby charting novel trajectory advancing landscape immunotherapeutic approaches

Language: Английский

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CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117474 - 117474

Published: Sept. 23, 2024

Language: Английский

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A Novel Exploration of COL11A1's Role in Regulating Myeloid-Derived Suppressor Cell Activation within the Colon Cancer Microenvironment

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101181 - 101181

Published: Jan. 1, 2025

Language: Английский

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